FlyBase Allele Report: Hsap\APP[2xAPP.SP.UAS]

General Information

Symbol

Hsap\APP^2xAPP.SP.UAS

Species

H. sapiens

Name

FlyBase ID

FBal0285873

Feature type

allele

Associated gene

Hsap\APP

Associated Insertion(s)

Carried in Construct

P{UAS-2xAβ}

Also Known As

UAS-Aβ42, UAS-Aβ42^2X, UAS-Aβ42(Human)

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Casas-Tinto et al., 2011)

Progenitor genotype

Carried in construct

P{UAS-2xAβ}

Cytology

Description

UAS regulatory sequences and a hsp70 minimal promoter drive expression of two copies of a 161 nucleotide fragment of Hsap\APP containing the Aβ sequence (corresponding to 1-42 amino acid residues. To ensure this fragment is secreted, a 232 nucleotide fragment containing the signal peptide from the aos gene.

(Casas-Tinto et al., 2011)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hsap\APP

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Alzheimer's disease

CEA

(Kizil et al., 2022, Fernandez-Funez et al., 2016, Minjarez et al., 2016, Fernandez-Funez et al., 2015, Casas-Tinto et al., 2011)

model of Alzheimer's disease 1

CEC

(Catterson et al., 2023, Deshpande et al., 2023, Kim et al., 2023, Xu et al., 2023)

CEA

(Deshpande et al., 2024, Yu et al., 2020, Coelho et al., 2018, Martín-Peña et al., 2018, Sarkar et al., 2018, Martin-Peña et al., 2017)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of Alzheimer's disease

is exacerbated by Rho1^RNAi.UAS.cBa

(Minjarez et al., 2016)

is exacerbated by Pgm1^HMS01333

(Minjarez et al., 2016)

is ameliorated by Hsap\HSPA1L^UAS.sec

(Fernandez-Funez et al., 2016)

is ameliorated by Hsap\HSPA1L^K71E.UAS.sec

(Fernandez-Funez et al., 2016)

is ameliorated by Mmus\Xbp1^UAS.cCTa

(Casas-Tinto et al., 2011)

is ameliorated by Xbp1^d08698

(Casas-Tinto et al., 2011)

is exacerbated by Xbp1^GD4745

(Casas-Tinto et al., 2011)

is ameliorated by Mus\scFv^{9.UAS.Tag:MYC,Tag:polyHis}

(Fernandez-Funez et al., 2015)

is ameliorated by Mus\scFv^{42.2.UAS.Tag:MYC,Tag:polyHis}

(Fernandez-Funez et al., 2015)

is ameliorated by Zzzz\scFv^{42.2.UAS.Tag:MYC,Tag:polyHis}

(Fernandez-Funez et al., 2015)

is ameliorated by Zzzz\scFv^{9.UAS.Tag:MYC,Tag:polyHis}

(Fernandez-Funez et al., 2015)

is exacerbated by Gcat^HMC02902

(Kizil et al., 2022)

model of Alzheimer's disease 1

is ameliorated by Nsun2^UAS.cAa

(Kim et al., 2023)

is ameliorated by Hsap\NAT9^UAS.cMa

(Deshpande et al., 2023)

is ameliorated by Mnat9^AAA.UAS

(Deshpande et al., 2023)

is ameliorated by Mnat9^AcDel.UAS

(Deshpande et al., 2023)

is exacerbated by Mnat9^KK109382

(Deshpande et al., 2023)

is ameliorated by Mnat9^{UAS.ORF.GW.Tag:HA}

(Deshpande et al., 2023)

is ameliorated by Hsap\NAT9^AAA.UAS

(Deshpande et al., 2023)

is ameliorated by Zzzz\scFv^{42.2.UAS.Tag:MYC,Tag:polyHis}

(Martin-Peña et al., 2017)

is ameliorated by Zzzz\scFv^{9.UAS.Tag:MYC,Tag:polyHis}

(Martin-Peña et al., 2017)

is exacerbated by Rab4^UASp.YFP

(Yu et al., 2020)

is exacerbated by Rab7^UAS.GFP

(Yu et al., 2020)

is ameliorated by EndoA^UAS.cVa

(Yu et al., 2020)

is exacerbated by Rab10^UASp.YFP

(Yu et al., 2020)

is ameliorated by Amph^A.UAS

(Yu et al., 2020)

is ameliorated by EndoA^UAS.cUa

(Yu et al., 2020)

is exacerbated by Rab10^UAS.cUa

(Yu et al., 2020)

is exacerbated by Rab11^{UAS.ORF.Tag:HA}

(Yu et al., 2020)

is exacerbated by Rab4^UAS.cUa

(Yu et al., 2020)

is ameliorated by Rab5^UAS.EGFP

(Yu et al., 2020)

is exacerbated by Rab8^{UAS.ORF.GW.Tag:HA}

(Yu et al., 2020)

is ameliorated by lap^A.UAS

(Yu et al., 2020)

is exacerbated by lap^HMS01939

(Yu et al., 2020)

is ameliorated by Hsap\HSPA1L^UAS.cWa

(Martín-Peña et al., 2018)

is ameliorated by Hsap\HSPA1L^UAS.sec

(Martín-Peña et al., 2018)

is exacerbated by Jra^Asp.B.UAS

(Sarkar et al., 2018)

is exacerbated by hep^Act.UAS.cUa

(Sarkar et al., 2018)

is exacerbated by Diap1^UAS.cHa

(Coelho et al., 2018)

is exacerbated by azot^GD7219

(Coelho et al., 2018)

is exacerbated by azot^KK111538

(Coelho et al., 2018)

is ameliorated by azot^mCherry

(Coelho et al., 2018)

is exacerbated by fwe^{RNAi.UASp.Lhp}

(Coelho et al., 2018)

is ameliorated by Col4a1^UAS.mRFP1

(Catterson et al., 2023)

is ameliorated by LanB1^EP-600

(Catterson et al., 2023)

is ameliorated by bumpel^{UAS.ORF.GW.Tag:HA}

(Xu et al., 2023)

is exacerbated by mir-277⁸⁴

(Deshpande et al., 2024)

is ameliorated by mir-277^UAS.cUa

(Deshpande et al., 2024)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

(Coelho et al., 2018)

abnormal eye color, with Scer\GAL4^elav-C155

(Casas-Tinto et al., 2011)

abnormal eye color, with Scer\GAL4^GMR.PF

(Casas-Tinto et al., 2011)

abnormal locomotor behavior | progressive, with Scer\GAL4^elav.PU

(Fernandez-Funez et al., 2016, Fernandez-Funez et al., 2015)

abnormal locomotor behavior | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

(Yu et al., 2020)

abnormal memory | adult stage | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

(Coelho et al., 2018)

abnormal neuroanatomy, with Scer\GAL4^ey-OK107

(Fernandez-Funez et al., 2015)

abnormal neuroanatomy | adult stage, with Scer\GAL4^ey-OK107

(Fernandez-Funez et al., 2016)

abnormal neuroanatomy | adult stage | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

(Coelho et al., 2018)

abnormal neuroanatomy | larval stage, with Scer\GAL4^GMR.long

(Deshpande et al., 2023)

abnormal size | adult stage, with Scer\GAL4^ey-OK107

(Fernandez-Funez et al., 2016)

abnormal size | adult stage, with Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

abnormal size | larval stage | somatic clone, with Scer\GAL4^GMR.PF

(Coelho et al., 2018)

decreased occurrence of cell division | adult stage | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

(Coelho et al., 2018)

decreased rate of adult locomotory behavior | progressive | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

(Xu et al., 2023)

decreased size | adult stage, with Scer\GAL4^GMR.long

(Deshpande et al., 2023)

decreased size | adult stage, with Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

increased cell death | adult stage, with Scer\GAL4^ey-OK107

(Fernandez-Funez et al., 2016)

increased cell death | adult stage, with Scer\GAL4^GMR.PF

(Coelho et al., 2018)

increased cell death | adult stage, with Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

increased cell death | adult stage | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

(Coelho et al., 2018)

increased cell death | larval stage, with Scer\GAL4^GMR.long

(Deshpande et al., 2023)

increased cell death | larval stage, with Scer\GAL4^GMR.PF

(Coelho et al., 2018)

increased cell death | larval stage, with Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

increased cell death | progressive, with Scer\GAL4^ey-OK107

(Fernandez-Funez et al., 2015)

increased cell death | third instar larval stage, with Scer\GAL4^e22c

(Arnés et al., 2017)

increased mortality during development, with Scer\GAL4^elav-C155

(Casas-Tinto et al., 2011)

melanotic necrosis | adult stage, with Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

partially lethal - majority die, with Scer\GAL4^elav-C155

(Deshpande et al., 2023)

short lived, with Scer\GAL4^elav.PU

(Fernandez-Funez et al., 2016)

short lived | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

(Catterson et al., 2023, Xu et al., 2023, Yu et al., 2020, Coelho et al., 2018)

short lived | RU486 conditional, with Scer\GAL4^GS.nSyb.PB

(Catterson et al., 2023)

some die during larval stage, with Scer\GAL4^elav-C155

(Deshpande et al., 2023)

some die during P-stage, with Scer\GAL4^elav-C155

(Deshpande et al., 2023)

visible, with Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2015)

visible | adult stage, with Scer\GAL4^GMR.long

(Deshpande et al., 2023)

visible | adult stage, with Scer\GAL4^GMR.PF

(Coelho et al., 2018)

visible | adult stage, with Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

visible | adult stage, with Scer\GAL4^GMR.PU

(Kim et al., 2023, Kizil et al., 2022, Fernandez-Funez et al., 2016, Minjarez et al., 2016)

visible | adult stage, with Scer\GAL4^Toll-6-D42

(Arnés et al., 2017)

visible | adult stage | progressive, with Scer\GAL4^elav-C155

(Arnés et al., 2017)

visible | adult stage | progressive, with Scer\GAL4^Lk.2.2

(Arnés et al., 2017)

Phenotype Manifest In

adult abdomen | progressive, with Scer\GAL4^elav-C155

(Arnés et al., 2017)

adult abdomen | progressive, with Scer\GAL4^Lk.2.2

(Arnés et al., 2017)

adult brain | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

(Coelho et al., 2018)

adult optic lobe, with Scer\GAL4^GMR.PF

(Coelho et al., 2018)

adult optic lobe | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

(Coelho et al., 2018)

axon, with Scer\GAL4^ey-OK107

(Fernandez-Funez et al., 2016)

axon | larval stage, with Scer\GAL4^GMR.long

(Deshpande et al., 2023)

calyx of adult mushroom body, with Scer\GAL4^ey-OK107

(Fernandez-Funez et al., 2015)

calyx of adult mushroom body | progressive, with Scer\GAL4^ey-OK107

(Fernandez-Funez et al., 2016)

eye, with Scer\GAL4^elav-C155

(Casas-Tinto et al., 2011)

eye, with Scer\GAL4^GMR.long

(Deshpande et al., 2023)

eye, with Scer\GAL4^GMR.PF

(Coelho et al., 2018, Casas-Tinto et al., 2011)

eye, with Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

eye, with Scer\GAL4^GMR.PU

(Kim et al., 2023, Kizil et al., 2022, Fernandez-Funez et al., 2016)

eye | adult stage, with Scer\GAL4^GMR.PU

(Minjarez et al., 2016)

eye | progressive, with Scer\GAL4^GMR.PF

(Casas-Tinto et al., 2011)

eye disc, with Scer\GAL4^GMR.PF

(Coelho et al., 2018)

eye disc | larval stage, with Scer\GAL4^GMR.long

(Deshpande et al., 2023)

eye disc | somatic clone, with Scer\GAL4^GMR.PF

(Coelho et al., 2018)

eye disc posterior compartment | larval stage, with Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

eye photoreceptor cell | larval stage, with Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Kenyon cell, with Scer\GAL4^ey-OK107

(Fernandez-Funez et al., 2016)

Kenyon cell | progressive, with Scer\GAL4^ey-OK107

(Fernandez-Funez et al., 2015)

lens, with Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016, Fernandez-Funez et al., 2015)

mushroom body, with Scer\GAL4^ey-OK107

(Fernandez-Funez et al., 2015)

ommatidium, with Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2015)

ommatidium | adult stage, with Scer\GAL4^GMR.long

(Deshpande et al., 2023)

ommatidium | adult stage, with Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

photoreceptor neuron, with Scer\GAL4^elav-C155

(Casas-Tinto et al., 2011)

photoreceptor neuron, with Scer\GAL4^GMR.PF

(Casas-Tinto et al., 2011)

proboscis | progressive, with Scer\GAL4^elav-C155

(Arnés et al., 2017)

proboscis | progressive, with Scer\GAL4^Lk.2.2

(Arnés et al., 2017)

retina, with Scer\GAL4^elav-C155

(Casas-Tinto et al., 2011)

retina, with Scer\GAL4^GMR.PF

(Casas-Tinto et al., 2011)

wing, with Scer\GAL4^Toll-6-D42

(Arnés et al., 2017)

wing disc | third instar larval stage, with Scer\GAL4^e22c

(Arnés et al., 2017)

Detailed Description

Statement

Reference

Adulthood-only expression of Hsap\APP^2xAPP.SP.UAS under the control of Scer\GAL4^{elav.Switch.PO} (RU486-induced) leads to decreased climbing activity.

(Yu et al., 2020)

Eye disc clones expressing Hsap\APP^2xAPP.SP.UAS under the control of Scer\GAL4^Act5C.PI occupy a smaller area than control clones.

Expressing Hsap\APP^2xAPP.SP.UAS under the control of Scer\GAL4^GMR.PF induces a rough eye phenotype and induces significant apoptosis (cleaved DCP1 labelling or TUNEL assay) in the eye disc and in the adult optic lobe, as compared to controls.

Adulthood-only expression of Hsap\APP^2xAPP.SP.UAS under the combined control of Scer\GAL4^{elav.Switch.PO} and RU486 feeding results in increased apoptosis (TUNEL assay) and decreased mitotic index (phospho-H3 staining) in the optic lobe, as well as increased necrosis (propidium iodine staining) and increased vacuolization of the brain. These adults are short-lived and show behavioral defects (decreased activity time, shorter walks, and ataxia), and impaired long-term memory (in courtship suppression assays).

(Coelho et al., 2018)

Adult flies expressing Hsap\APP^{2xAPP.SP.Scer\UAS} under the control of either Scer\GAL4^elav-C155 or Scer\GAL4^Lk.2.2 combined with Tub-Gal80[ts] to limit the expression to adulthood exhibit inflated, liquid-filled abdomen and proboscis, the phenotype grows more severe until death. Continuous expression under Scer\GAL4^Toll-6-D42 results in severe wing defects (deformed, unfurled wings) in adult flies but no evidence of increase in cell death is seen in the developing wing discs from third instar larvae. However, when driven by Scer\GAL4^e22c, excessive apoptotic activity (detected by Casp3 immunolabelling) is observed.

(Arnés et al., 2017)

Flies expressing Hsap\APP^{2xAPP.SP.Scer\UAS} under the control of Scer\GAL4^GMR.PU exhibit a dramatic reduction in the size of the eye, disorganization of the ommatidia, depigmentation and accumulation of necrotic spots in the eye, as well as fusion and rupture of lenses, as compared to controls. Larval eye discs in these flies exhibit increased apoptosis throughout the posterior eye disc, as compared to controls.

Adult mushroom bodies in flies expressing Hsap\APP^{2xAPP.SP.Scer\UAS} under the control of Scer\GAL4^ey-OK107 show increased cell death in the Kenyon cell clusters, thinner Kenyon cell axonal lobes, and larger calyces at 1 day old but smaller calyces at 20 or 40 days old, as compared to controls.

Flies expressing Hsap\APP^{2xAPP.SP.Scer\UAS} under the control of Scer\GAL4^elav.PU exhibit progressive climbing defects and reduced lifespan.

(Fernandez-Funez et al., 2016)

Expression of Hsap\APP^{2xAPP.SP.Scer\UAS} under the control of Scer\GAL4^GMR.PU results in a disruption of the ommatidial lattice and glassy eye phenotype in adults.

(Minjarez et al., 2016)

Flies expressing Scer\GAL4^GMR.PU>Hsap\APP^{2xAPP.SP.Scer\UAS} display small, glassy, depigmented eyes compared with wild-type. At higher magnification, the eye lattice is highly disorganized, ommatidia are fused, and the lenses show holes owing to late cell death.

Expression of Hsap\APP^{2xAPP.SP.Scer\UAS} under the control of Scer\GAL4^ey-OK107 results in thinner axonal projections from the mushroom bodies and a progressive loss of calyx volume compared with wild-type.

Flies expressing Hsap\APP^{2xAPP.SP.Scer\UAS} pan-neurally under the control of Scer\GAL4^elav.PU show progressive locomotor dysfunction.

Kenyon cell clusters of 20 day old wild-type flies do not show apoptosis. In contrast, age-matched flies expressing Hsap\APP^{2xAPP.SP.Scer\UAS} under the control of Scer\GAL4^ey-OK107 display more than 20 apoptotic cells per Kenyon cell cluster.

(Fernandez-Funez et al., 2015)

Expression of bi-cistronic Hsap\APP^{2xAPP.SP.Scer\UAS} in the developing eye under the control of Scer\GAL4^GMR.PF results in small and disorganised eyes containing black, necrotic spots. The retinae of young flies (day 1 post-eclosion) are also thin and disorganised, with poorly differentiated photoreceptors and lenses. The same phenotype is seen upon expression of Hsap\APP^{2xAPP.SP.Scer\UAS} in photoreceptors, under the control of Scer\GAL4^elav-C155.

Flies expressing Hsap\APP^{2xAPP.SP.Scer\UAS} in the developing eye (under the control of Scer\GAL4^GMR.PF) for 20 days develop increased disorganisation and vacuolation of the retina.

Expression of Hsap\APP^{2xAPP.SP.Scer\UAS} in the CNS (under the control of Scer\GAL4^elav-C155) results in 20% eclosion of adult flies (i.e. 80% lethality).

(Casas-Tinto et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa has visible | adult stage phenotype, enhanceable by Xbp1^KK102632, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa has decreased size | adult stage phenotype, enhanceable by Xbp1^KK102632, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa has visible | adult stage phenotype, enhanceable by Avic\GFP^{UAS.Tag:SS(wg)}, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa has decreased size | adult stage phenotype, enhanceable by Avic\GFP^{UAS.Tag:SS(wg)}, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has visible | adult stage phenotype, enhanceable by Jra^Asp.B.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has increased cell death | larval stage phenotype, enhanceable by Jra^Asp.B.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has visible | adult stage phenotype, enhanceable by hep^Act.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has decreased size | adult stage phenotype, enhanceable by hep^Act.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has increased cell death | larval stage phenotype, enhanceable by hep^Act.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has visible | adult stage phenotype, enhanceable by Mnat9^KK109382, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has increased cell death | larval stage phenotype, enhanceable by Mnat9^KK109382, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^elav-C155 has increased mortality during development phenotype, enhanceable by Mnat9^KK109382, Scer\GAL4^elav-C155

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long has visible | adult stage phenotype, enhanceable by Jra^Asp.B.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Jra^Asp.B.UAS, Scer\GAL4^GMR.long has visible | adult stage phenotype, enhanceable by Mnat9^KK109382, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Jra^Asp.B.UAS, Scer\GAL4^GMR.long has decreased size | adult stage phenotype, enhanceable by Mnat9^KK109382, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Mnat9^KK109382, Scer\GAL4^GMR.long has visible | adult stage phenotype, enhanceable by Jra^Asp.B.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Mnat9^KK109382, Scer\GAL4^GMR.long has decreased size | adult stage phenotype, enhanceable by Jra^Asp.B.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Mnat9^KK109382, Scer\GAL4^GMR.long has increased cell death | larval stage phenotype, enhanceable by Jra^Asp.B.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long has visible | adult stage phenotype, enhanceable by hep^Act.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, enhanceable by Gcat^HMC02902, Scer\GAL4^GMR.PU

(Kizil et al., 2022)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has short lived | RU486 conditional phenotype, enhanceable by Clc^UAS.EGFP, Scer\GAL4^{elav.Switch.PO}

(Yu et al., 2020)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has short lived | RU486 conditional phenotype, enhanceable by EndoA^UAS.cVa, Scer\GAL4^{elav.Switch.PO}

(Yu et al., 2020)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has abnormal locomotor behavior | RU486 conditional phenotype, enhanceable by EndoA^UAS.cVa, Scer\GAL4^{elav.Switch.PO}

(Yu et al., 2020)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has short lived | RU486 conditional phenotype, enhanceable by Eps-15^UAS.cKa, Scer\GAL4^{elav.Switch.PO}

(Yu et al., 2020)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has short lived | RU486 conditional phenotype, enhanceable by lqf^{UASp.Tag:FLAG}, Scer\GAL4^{elav.Switch.PO}

(Yu et al., 2020)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has short lived | RU486 conditional phenotype, enhanceable by Rab4^UASp.YFP, Scer\GAL4^{elav.Switch.PO}

(Yu et al., 2020)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has short lived | RU486 conditional phenotype, enhanceable by Rab7^UAS.GFP, Scer\GAL4^{elav.Switch.PO}

(Yu et al., 2020)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has short lived | RU486 conditional phenotype, enhanceable by Rab10^UASp.YFP, Scer\GAL4^{elav.Switch.PO}

(Yu et al., 2020)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has short lived | RU486 conditional phenotype, enhanceable by lap^HMS01939, Scer\GAL4^{elav.Switch.PO}

(Yu et al., 2020)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has short lived | RU486 conditional phenotype, enhanceable by Rab5^UAS.EGFP, Scer\GAL4^{elav.Switch.PO}

(Yu et al., 2020)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has short lived | RU486 conditional phenotype, enhanceable by cindr^UAS.cUa, Scer\GAL4^{elav.Switch.PO}

(Yu et al., 2020)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has short lived | RU486 conditional phenotype, enhanceable by Rab11^{UAS.ORF.Tag:HA}, Scer\GAL4^{elav.Switch.PO}

(Yu et al., 2020)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has short lived | RU486 conditional phenotype, enhanceable by Rab8^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^{elav.Switch.PO}

(Yu et al., 2020)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has abnormal neuroanatomy | adult stage | RU486 conditional phenotype, enhanceable by azot^DsRed(T4), Scer\GAL4^{elav.Switch.PO}

(Coelho et al., 2018)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has short lived | RU486 conditional phenotype, enhanceable by azot^DsRed(T4), Scer\GAL4^{elav.Switch.PO}

(Coelho et al., 2018)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has abnormal behavior | RU486 conditional phenotype, enhanceable by azot^DsRed(T4), Scer\GAL4^{elav.Switch.PO}

(Coelho et al., 2018)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has abnormal neuroanatomy | adult stage | RU486 conditional phenotype, enhanceable by Diap1^UAS.cHa, Scer\GAL4^{elav.Switch.PO}

(Coelho et al., 2018)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has abnormal neuroanatomy | adult stage | RU486 conditional phenotype, enhanceable by azot^KO/azot^KO

(Coelho et al., 2018)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has abnormal memory | adult stage | RU486 conditional phenotype, enhanceable by azot^KO/azot^KO

(Coelho et al., 2018)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, enhanceable by Rho1^RNAi.UAS.cBa, Scer\GAL4^GMR.PU

(Minjarez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, enhanceable by Pgm1^HMS01333, Scer\GAL4^GMR.PU

(Minjarez et al., 2016)

NOT Enhanced by

Statement

Reference

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has decreased size | adult stage phenotype, non-enhanceable by Mnat9^KK109382, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has abnormal neuroanatomy | larval stage phenotype, non-enhanceable by Mnat9^KK109382, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Mnat9^KK109382, Scer\GAL4^GMR.long has visible | adult stage phenotype, non-enhanceable by bsk^DN.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Mnat9^KK109382, Scer\GAL4^GMR.long has decreased size | adult stage phenotype, non-enhanceable by bsk^DN.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long, bsk^DN.UAS has visible | adult stage phenotype, non-enhanceable by Mnat9^KK109382, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long, bsk^DN.UAS has decreased size | adult stage phenotype, non-enhanceable by Mnat9^KK109382, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long has visible | adult stage phenotype, non-enhanceable by puc^UAS.cMa, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has short lived | RU486 conditional phenotype, non-enhanceable by shi^1.UAS, Scer\GAL4^{elav.Switch.PO}

(Yu et al., 2020)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has short lived | RU486 conditional phenotype, non-enhanceable by Rab14^UASp.YFP, Scer\GAL4^{elav.Switch.PO}

(Yu et al., 2020)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has short lived | RU486 conditional phenotype, non-enhanceable by Snap25^UAS.cLa, Scer\GAL4^{elav.Switch.PO}

(Yu et al., 2020)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has short lived | RU486 conditional phenotype, non-enhanceable by nSyb^UAS.EGFP, Scer\GAL4^{elav.Switch.PO}

(Yu et al., 2020)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has abnormal memory | adult stage | RU486 conditional phenotype, non-enhanceable by Diap1^UAS.cHa, Scer\GAL4^{elav.Switch.PO}

(Coelho et al., 2018)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has abnormal neuroanatomy | adult stage | RU486 conditional phenotype, non-enhanceable by azot^KO.hid/azot^KO.hid

(Coelho et al., 2018)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, non-enhanceable by Sfxn1-3^d06383, Scer\GAL4^GMR.PU

(Minjarez et al., 2016)

Suppressed by

Statement

Reference

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has short lived | RU486 conditional phenotype, suppressible by LanB1^EP-600, Scer\GAL4^{elav.Switch.PO}

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has short lived | RU486 conditional phenotype, suppressible by LanB1^UAS.mRFP1, Scer\GAL4^{elav.Switch.PO}

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa has visible | adult stage phenotype, suppressible by LanB1^UAS.mRFP1, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa has decreased size | adult stage phenotype, suppressible by LanB1^UAS.mRFP1, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa has visible | adult stage phenotype, suppressible by LanB1^EP-600, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa has decreased size | adult stage phenotype, suppressible by LanB1^EP-600, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has short lived | RU486 conditional phenotype, suppressible by Col4a1^UAS.mRFP1, Scer\GAL4^{elav.Switch.PO}

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa has visible | adult stage phenotype, suppressible by Col4a1^UAS.mRFP1, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa has decreased size | adult stage phenotype, suppressible by Col4a1^UAS.mRFP1, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa has visible | adult stage phenotype, suppressible | partially by LanA^EY02207, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa has decreased size | adult stage phenotype, suppressible | partially by LanA^EY02207, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GS.nSyb.PB has short lived | RU486 conditional phenotype, suppressible by LanB2^UAS.GFP, Scer\GAL4^GS.nSyb.PB

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa has visible | adult stage phenotype, suppressible by LanB2^UAS.GFP, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa has decreased size | adult stage phenotype, suppressible by LanB2^UAS.GFP, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa has visible | adult stage phenotype, suppressible by Avic\GFP^{UAS.Tag:ER(KDEL)}, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa has decreased size | adult stage phenotype, suppressible by Avic\GFP^{UAS.Tag:ER(KDEL)}, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has decreased size | adult stage phenotype, suppressible | partially by Hsap\NAT9^UAS.cMa, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has abnormal neuroanatomy | larval stage phenotype, suppressible | partially by Hsap\NAT9^UAS.cMa, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has decreased size | adult stage phenotype, suppressible | partially by Hsap\NAT9^AAA.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has visible | adult stage phenotype, suppressible | partially by Hsap\NAT9^AAA.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has visible | adult stage phenotype, suppressible | partially by Hsap\NAT9^UAS.cMa, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has visible | adult stage phenotype, suppressible by Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has decreased size | adult stage phenotype, suppressible by Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has abnormal neuroanatomy | larval stage phenotype, suppressible | partially by Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has increased cell death | larval stage phenotype, suppressible by Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^elav-C155 has increased mortality during development phenotype, suppressible | partially by Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^elav-C155

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has visible | adult stage phenotype, suppressible | partially by Mnat9^AcDel.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has decreased size | adult stage phenotype, suppressible | partially by Mnat9^AcDel.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has abnormal neuroanatomy | larval stage phenotype, suppressible | partially by Mnat9^AcDel.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has visible | adult stage phenotype, suppressible | partially by Mnat9^AAA.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has decreased size | adult stage phenotype, suppressible | partially by Mnat9^AAA.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has abnormal neuroanatomy | larval stage phenotype, suppressible | partially by Mnat9^AAA.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Jra^Asp.B.UAS, Scer\GAL4^GMR.long has visible | adult stage phenotype, suppressible | partially by Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Jra^Asp.B.UAS, Scer\GAL4^GMR.long has decreased size | adult stage phenotype, suppressible | partially by Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has visible | adult stage phenotype, suppressible | partially by bsk^DN.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has decreased size | adult stage phenotype, suppressible | partially by bsk^DN.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has visible | adult stage phenotype, suppressible | partially by puc^UAS.cMa, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has decreased size | adult stage phenotype, suppressible | partially by puc^UAS.cMa, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Mnat9^KK109382, Scer\GAL4^GMR.long has visible | adult stage phenotype, suppressible | partially by bsk^DN.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Mnat9^KK109382, Scer\GAL4^GMR.long has decreased size | adult stage phenotype, suppressible | partially by bsk^DN.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Mnat9^KK109382, Scer\GAL4^GMR.long has visible | adult stage phenotype, suppressible | partially by puc^UAS.cMa, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Mnat9^KK109382, Scer\GAL4^GMR.long has decreased size | adult stage phenotype, suppressible | partially by puc^UAS.cMa, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has increased cell death | larval stage phenotype, suppressible | partially by bsk^DN.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Mnat9^KK109382, Scer\GAL4^GMR.long has increased cell death | larval stage phenotype, suppressible | partially by bsk^DN.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has increased cell death | larval stage phenotype, suppressible | partially by puc^UAS.cMa, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Mnat9^KK109382, Scer\GAL4^GMR.long has increased cell death | larval stage phenotype, suppressible | partially by puc^UAS.cMa, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long, bsk^DN.UAS has visible | adult stage phenotype, suppressible | partially by Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long, bsk^DN.UAS has decreased size | adult stage phenotype, suppressible | partially by Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long, hep^Act.UAS has visible | adult stage phenotype, suppressible | partially by Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long, hep^Act.UAS has decreased size | adult stage phenotype, suppressible | partially by Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible | partially by Nsun2^UAS.cAa, Scer\GAL4^GMR.PU

(Kim et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has short lived | RU486 conditional phenotype, suppressible by bumpel^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^{elav.Switch.PO}

(Xu et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has decreased rate of adult locomotory behavior | progressive | RU486 conditional phenotype, suppressible by bumpel^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^{elav.Switch.PO}

(Xu et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has short lived | RU486 conditional phenotype, suppressible | partially by lap^A.UAS, Scer\GAL4^{elav.Switch.PO}

(Yu et al., 2020)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has abnormal locomotor behavior | RU486 conditional phenotype, suppressible | partially by lap^A.UAS, Scer\GAL4^{elav.Switch.PO}

(Yu et al., 2020)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has abnormal locomotor behavior | RU486 conditional phenotype, suppressible | partially by Amph^A.UAS, Scer\GAL4^{elav.Switch.PO}

(Yu et al., 2020)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has short lived | RU486 conditional phenotype, suppressible | partially by Amph^A.UAS, Scer\GAL4^{elav.Switch.PO}

(Yu et al., 2020)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has abnormal neuroanatomy | adult stage | RU486 conditional phenotype, suppressible by azot^DsRed(T4)

(Coelho et al., 2018)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has increased cell death | adult stage | RU486 conditional phenotype, suppressible by Diap1^UAS.cHa, Scer\GAL4^{elav.Switch.PO}

(Coelho et al., 2018)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has increased cell death | adult stage | RU486 conditional phenotype, suppressible by azot^KO/azot^KO

(Coelho et al., 2018)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has abnormal behavior | RU486 conditional phenotype, suppressible by azot^DsRed(T4)

(Coelho et al., 2018)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has abnormal memory | adult stage | RU486 conditional phenotype, suppressible by azot^DsRed(T4)

(Coelho et al., 2018)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF has increased cell death | larval stage phenotype, suppressible by Diap1^UAS.cHa, Scer\GAL4^GMR.PF

(Coelho et al., 2018)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF has increased cell death | larval stage phenotype, suppressible by fwe^{RNAi.UASp.Lhp}, Scer\GAL4^GMR.PF

(Coelho et al., 2018)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF has increased cell death | larval stage phenotype, suppressible by azot^DsRed(T4), Scer\GAL4^GMR.PF

(Coelho et al., 2018)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF has increased cell death | larval stage phenotype, suppressible by fwe^UASp.Lose-B, Scer\GAL4^GMR.PF

(Coelho et al., 2018)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF has increased cell death | adult stage phenotype, suppressible by fwe^{RNAi.UASp.Lhp}, Scer\GAL4^GMR.PF

(Coelho et al., 2018)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF has increased cell death | adult stage phenotype, suppressible by azot^DsRed(T4), Scer\GAL4^GMR.PF

(Coelho et al., 2018)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF has increased cell death | adult stage phenotype, suppressible by fwe^UASp.Lose-B, Scer\GAL4^GMR.PF

(Coelho et al., 2018)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^Lk.2.2 has visible | adult stage | progressive phenotype, suppressible by Pi3K92E^CAAX.UAS, Scer\GAL4^Lk.2.2

(Arnés et al., 2017)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^e22c has increased cell death | third instar larval stage phenotype, suppressible | partially by Pi3K92E^CAAX.UAS, Scer\GAL4^e22c

(Arnés et al., 2017)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has increased cell death | adult stage phenotype, suppressible by Hsap\HSPA1L^UAS.sec, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^ey-OK107 has increased cell death | adult stage phenotype, suppressible | partially by Hsap\HSPA1L^UAS.sec, Scer\GAL4^ey-OK107

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has abnormal size | adult stage phenotype, suppressible by Hsap\HSPA1L^UAS.sec, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^ey-OK107 has increased cell death | adult stage phenotype, suppressible | partially by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^ey-OK107

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has increased cell death | larval stage phenotype, suppressible | partially by Hsap\HSPA1L^UAS.sec, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^elav.PU has abnormal locomotor behavior | progressive phenotype, suppressible | partially by Hsap\HSPA1L^UAS.sec, Scer\GAL4^elav.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^elav.PU has short lived phenotype, suppressible | partially by Hsap\HSPA1L^UAS.sec, Scer\GAL4^elav.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Hsap\HSPA1L^K71E.UAS.sec, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has increased cell death | adult stage phenotype, suppressible by Hsap\HSPA1L^K71E.UAS.sec, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has abnormal size | adult stage phenotype, suppressible by Hsap\HSPA1L^K71E.UAS.sec, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Hsap\HSPA1L^UAS.sec, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^ey-OK107 has abnormal neuroanatomy phenotype, suppressible | partially by Zzzz\scFv^{42.2.UAS.Tag:MYC,Tag:polyHis}, Scer\GAL4^ey-OK107

(Fernandez-Funez et al., 2015)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^elav.PU has abnormal locomotor behavior | progressive phenotype, suppressible | partially by Scer\GAL4^ey-OK107/Zzzz\scFv^{42.2.UAS.Tag:MYC,Tag:polyHis}

(Fernandez-Funez et al., 2015)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^elav.PU has abnormal locomotor behavior | progressive phenotype, suppressible | partially by Scer\GAL4^ey-OK107/Zzzz\scFv^{9.UAS.Tag:MYC,Tag:polyHis}

(Fernandez-Funez et al., 2015)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^elav.PU has abnormal locomotor behavior | progressive phenotype, suppressible | partially by Scer\GAL4^ey-OK107/Zzzz\scFv^{42.2.UAS.Tag:MYC,Tag:polyHis}/Zzzz\scFv^{9.UAS.Tag:MYC,Tag:polyHis}

(Fernandez-Funez et al., 2015)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^elav.PU has increased cell death | progressive phenotype, suppressible | partially by Scer\GAL4^ey-OK107/Zzzz\scFv^{42.2.UAS.Tag:MYC,Tag:polyHis}

(Fernandez-Funez et al., 2015)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^elav.PU has increased cell death | progressive phenotype, suppressible | partially by Scer\GAL4^ey-OK107/Zzzz\scFv^{9.UAS.Tag:MYC,Tag:polyHis}

(Fernandez-Funez et al., 2015)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^elav.PU has increased cell death | progressive phenotype, suppressible | partially by Scer\GAL4^ey-OK107/Zzzz\scFv^{42.2.UAS.Tag:MYC,Tag:polyHis}/Zzzz\scFv^{9.UAS.Tag:MYC,Tag:polyHis}

(Fernandez-Funez et al., 2015)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PS has visible phenotype, suppressible | partially by ksr^j5E2/ksr[+]

(Ambegaokar and Jackson, 2011)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PS has visible phenotype, suppressible by sgg^G0335/sgg[+]

(Ambegaokar and Jackson, 2011)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF has abnormal eye color phenotype, suppressible by Scer\GAL4^elav-C155/Xbp1^d08698

(Casas-Tinto et al., 2011)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF has abnormal eye color phenotype, suppressible by Scer\GAL4^elav-C155/Mmus\Xbp1^UAS.cCTa

(Casas-Tinto et al., 2011)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^elav-C155 has increased mortality during development phenotype, suppressible by RyR¹⁶/RyR[+]

(Casas-Tinto et al., 2011)

NOT suppressed by

Statement

Reference

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa has visible | adult stage phenotype, non-suppressible by Cdc14^EY10303, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa has decreased size | adult stage phenotype, non-suppressible by Cdc14^EY10303, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa has visible | adult stage phenotype, non-suppressible by LanA^JF02908, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa has decreased size | adult stage phenotype, non-suppressible by LanA^JF02908, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa has visible | adult stage phenotype, non-suppressible by wb^JF03238, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa has decreased size | adult stage phenotype, non-suppressible by wb^JF03238, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has decreased size | adult stage phenotype, non-suppressible by Mnat9^KK109382, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has abnormal neuroanatomy | larval stage phenotype, non-suppressible by Mnat9^KK109382, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Mnat9^KK109382, Scer\GAL4^GMR.long has visible | adult stage phenotype, non-suppressible | partially by bsk^DN.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Mnat9^KK109382, Scer\GAL4^GMR.long has decreased size | adult stage phenotype, non-suppressible | partially by bsk^DN.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long has visible | adult stage phenotype, non-suppressible by puc^UAS.cMa, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long, bsk^DN.UAS has visible | adult stage phenotype, non-suppressible by Mnat9^KK109382, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long, bsk^DN.UAS has decreased size | adult stage phenotype, non-suppressible by Mnat9^KK109382, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has abnormal locomotor behavior | RU486 conditional phenotype, non-suppressible by Rab5^UAS.EGFP, Scer\GAL4^{elav.Switch.PO}

(Yu et al., 2020)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has short lived | RU486 conditional phenotype, non-suppressible by shi^1.UAS, Scer\GAL4^{elav.Switch.PO}

(Yu et al., 2020)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has short lived | RU486 conditional phenotype, non-suppressible by Rab14^UASp.YFP, Scer\GAL4^{elav.Switch.PO}

(Yu et al., 2020)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has short lived | RU486 conditional phenotype, non-suppressible by Snap25^UAS.cLa, Scer\GAL4^{elav.Switch.PO}

(Yu et al., 2020)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has short lived | RU486 conditional phenotype, non-suppressible by nSyb^UAS.EGFP, Scer\GAL4^{elav.Switch.PO}

(Yu et al., 2020)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has abnormal behavior | RU486 conditional phenotype, non-suppressible by Diap1^UAS.cHa, Scer\GAL4^{elav.Switch.PO}

(Coelho et al., 2018)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, non-suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has increased cell death | adult stage phenotype, non-suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has abnormal size | adult stage phenotype, non-suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, non-suppressible by Hsc70-3^UAS.cEa, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has increased cell death | adult stage phenotype, non-suppressible by Hsc70-3^UAS.cEa, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has abnormal size | adult stage phenotype, non-suppressible by Hsc70-3^UAS.cEa, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has increased cell death | larval stage phenotype, non-suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^elav.PU has abnormal locomotor behavior | progressive phenotype, non-suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^elav.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^elav.PU has short lived phenotype, non-suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^elav.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, non-suppressible by Hsap\HSPA1L^{SBD-GG.UAS.sec}, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has increased cell death | adult stage phenotype, non-suppressible by Hsap\HSPA1L^{SBD-GG.UAS.sec}, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has abnormal size | adult stage phenotype, non-suppressible by Hsap\HSPA1L^{SBD-GG.UAS.sec}, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, non-suppressible by Hsap\HSPA1L^{SBD-GY.UAS.sec}, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has increased cell death | adult stage phenotype, non-suppressible by Hsap\HSPA1L^{SBD-GY.UAS.sec}, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has abnormal size | adult stage phenotype, non-suppressible by Hsap\HSPA1L^{SBD-GY.UAS.sec}, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^ey-OK107 has abnormal neuroanatomy phenotype, non-suppressible by Zzzz\scFv^{9.UAS.Tag:MYC,Tag:polyHis}, Scer\GAL4^ey-OK107

(Fernandez-Funez et al., 2015)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PS has visible phenotype, non-suppressible | partially by ksr^j5E2/ksr[+]

(Ambegaokar and Jackson, 2011)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PS has visible phenotype, non-suppressible by NC2α^EY18723/NC2alpha[+]

(Ambegaokar and Jackson, 2011)

Enhancer of

Statement

Reference

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa is an enhancer of visible | adult stage phenotype of LanB1^UAS.mRFP1, Scer\GAL4^GMR.PFa, Xbp1^KK102632

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long is an enhancer of visible | adult stage phenotype of Jra^Asp.B.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long is an enhancer of decreased size | adult stage phenotype of Jra^Asp.B.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

NOT Enhancer of

Statement

Reference

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long is a non-enhancer of decreased size | adult stage phenotype of Scer\GAL4^GMR.long, hep^Act.UAS

(Deshpande et al., 2023)

NOT Suppressor of

Statement

Reference

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long is a non-suppressor of decreased size | adult stage phenotype of Scer\GAL4^GMR.long, hep^Act.UAS

(Deshpande et al., 2023)

Other

Statement

Reference

Hsap\APP^2xAPP.SP.UAS, Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long, hep^Act.UAS has increased cell death | larval stage phenotype

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Mnat9^KK109382, Scer\GAL4^GMR.long has melanotic necrosis | adult stage phenotype

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Jra^Asp.B.UAS, Mnat9^KK109382, Scer\GAL4^GMR.long has melanotic necrosis | adult stage phenotype

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Jra^Asp.B.UAS, Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long has increased cell death | larval stage phenotype

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long, puc^UAS.cMa has increased cell death | larval stage phenotype

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long, bsk^DN.UAS has increased cell death | larval stage phenotype

(Deshpande et al., 2023)

Diap1^UAS.cHa, Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF has increased cell death | larval stage phenotype

(Coelho et al., 2018)

BacA\p35^UAS.cUa, Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^Toll-6-D42 has lethal phenotype

(Arnés et al., 2017)

BacA\p35^UAS.cUa, Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^e22c has lethal phenotype

(Arnés et al., 2017)

Hsap\APP^2xAPP.SP.UAS, Hsap\HSPA1L^UAS.sec, Scer\GAL4^ey-OK107 has abnormal neuroanatomy | adult stage phenotype

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Hsap\HSPA1L^UAS.sec, Scer\GAL4^ey-OK107 has abnormal size | adult stage phenotype

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Hsap\HSPA1L^UAS.cWa, Scer\GAL4^ey-OK107 has abnormal neuroanatomy | adult stage phenotype

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Hsap\HSPA1L^UAS.cWa, Scer\GAL4^ey-OK107 has abnormal size | adult stage phenotype

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^ey-OK107, Zzzz\scFv^{42.2.UAS.Tag:MYC,Tag:polyHis}, Zzzz\scFv^{9.UAS.Tag:MYC,Tag:polyHis} has abnormal neuroanatomy phenotype

(Fernandez-Funez et al., 2015)

Phenotype Manifest In

Enhanced by

Statement

Reference

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa has eye phenotype, enhanceable by Xbp1^KK102632, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa has eye phenotype, enhanceable by Avic\GFP^{UAS.Tag:SS(wg)}, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has eye phenotype, enhanceable by Jra^Asp.B.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has eye disc | larval stage phenotype, enhanceable by Jra^Asp.B.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has eye phenotype, enhanceable by hep^Act.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has eye disc | larval stage phenotype, enhanceable by hep^Act.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has eye phenotype, enhanceable by Mnat9^KK109382, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has eye disc | larval stage phenotype, enhanceable by Mnat9^KK109382, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has eye photoreceptor cell | larval stage phenotype, enhanceable by Mnat9^KK109382, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, enhanceable by Jra^Asp.B.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Jra^Asp.B.UAS, Scer\GAL4^GMR.long has eye phenotype, enhanceable by Mnat9^KK109382, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Mnat9^KK109382, Scer\GAL4^GMR.long has eye phenotype, enhanceable by Jra^Asp.B.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Mnat9^KK109382, Scer\GAL4^GMR.long has eye disc | larval stage phenotype, enhanceable by Jra^Asp.B.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, enhanceable by hep^Act.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Gcat^HMC02902, Scer\GAL4^GMR.PU

(Kizil et al., 2022)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has adult brain | RU486 conditional phenotype, enhanceable by azot^DsRed(T4), Scer\GAL4^{elav.Switch.PO}

(Coelho et al., 2018)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has adult brain | RU486 conditional phenotype, enhanceable by Diap1^UAS.cHa, Scer\GAL4^{elav.Switch.PO}

(Coelho et al., 2018)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has adult brain | RU486 conditional phenotype, enhanceable by azot^KO/azot^KO

(Coelho et al., 2018)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has eye | adult stage phenotype, enhanceable by Rho1^RNAi.UAS.cBa, Scer\GAL4^GMR.PU

(Minjarez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has eye | adult stage phenotype, enhanceable by Pgm1^HMS01333, Scer\GAL4^GMR.PU

(Minjarez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF has eye | progressive phenotype, enhanceable by Xbp1^GD4745, Scer\GAL4^GMR.PF

(Casas-Tinto et al., 2011)

NOT Enhanced by

Statement

Reference

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has axon | larval stage phenotype, non-enhanceable by Mnat9^KK109382, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Mnat9^KK109382, Scer\GAL4^GMR.long has eye phenotype, non-enhanceable by bsk^DN.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long, bsk^DN.UAS has eye phenotype, non-enhanceable by Mnat9^KK109382, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, non-enhanceable by puc^UAS.cMa, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has adult brain | RU486 conditional phenotype, non-enhanceable by azot^KO.hid/azot^KO.hid

(Coelho et al., 2018)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has eye | adult stage phenotype, non-enhanceable by Sfxn1-3^d06383, Scer\GAL4^GMR.PU

(Minjarez et al., 2016)

Suppressed by

Statement

Reference

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa has eye phenotype, suppressible by LanB1^UAS.mRFP1, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa has eye phenotype, suppressible by LanB1^EP-600, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa has eye phenotype, suppressible by LanB2^UAS.GFP, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa has eye phenotype, suppressible | partially by LanA^EY02207, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa has eye phenotype, suppressible by Col4a1^UAS.mRFP1, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa has eye phenotype, suppressible by Avic\GFP^{UAS.Tag:ER(KDEL)}, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible by Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has eye disc | larval stage phenotype, suppressible by Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has axon | larval stage phenotype, suppressible | partially by Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has eye photoreceptor cell | larval stage phenotype, suppressible | partially by Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible | partially by Mnat9^AcDel.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has eye disc | larval stage phenotype, suppressible | partially by Mnat9^AcDel.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible | partially by Mnat9^AAA.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has eye disc | larval stage phenotype, suppressible | partially by Mnat9^AAA.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Jra^Asp.B.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible | partially by Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible | partially by bsk^DN.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible | partially by puc^UAS.cMa, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Mnat9^KK109382, Scer\GAL4^GMR.long has eye phenotype, suppressible | partially by bsk^DN.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Mnat9^KK109382, Scer\GAL4^GMR.long has eye phenotype, suppressible | partially by puc^UAS.cMa, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has eye disc | larval stage phenotype, suppressible | partially by bsk^DN.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Mnat9^KK109382, Scer\GAL4^GMR.long has eye disc | larval stage phenotype, suppressible | partially by bsk^DN.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has eye disc | larval stage phenotype, suppressible | partially by puc^UAS.cMa, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Mnat9^KK109382, Scer\GAL4^GMR.long has eye disc | larval stage phenotype, suppressible | partially by puc^UAS.cMa, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long, bsk^DN.UAS has eye phenotype, suppressible | partially by Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long, hep^Act.UAS has eye phenotype, suppressible | partially by Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible | partially by Hsap\NAT9^UAS.cMa, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has eye disc | larval stage phenotype, suppressible | partially by Hsap\NAT9^UAS.cMa, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has eye phenotype, suppressible | partially by Hsap\NAT9^AAA.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible | partially by Nsun2^UAS.cAa, Scer\GAL4^GMR.PU

(Kim et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has adult brain | RU486 conditional phenotype, suppressible by azot^DsRed(T4)

(Coelho et al., 2018)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has adult brain | RU486 conditional phenotype, suppressible by Diap1^UAS.cHa, Scer\GAL4^{elav.Switch.PO}

(Coelho et al., 2018)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO} has adult brain | RU486 conditional phenotype, suppressible by azot^KO/azot^KO

(Coelho et al., 2018)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF has eye disc phenotype, suppressible by Diap1^UAS.cHa, Scer\GAL4^GMR.PF

(Coelho et al., 2018)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF has eye disc phenotype, suppressible by fwe^{RNAi.UASp.Lhp}, Scer\GAL4^GMR.PF

(Coelho et al., 2018)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF has eye disc phenotype, suppressible by azot^DsRed(T4), Scer\GAL4^GMR.PF

(Coelho et al., 2018)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF has eye disc phenotype, suppressible by fwe^UASp.Lose-B, Scer\GAL4^GMR.PF

(Coelho et al., 2018)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF has adult optic lobe phenotype, suppressible by fwe^{RNAi.UASp.Lhp}, Scer\GAL4^GMR.PF

(Coelho et al., 2018)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF has adult optic lobe phenotype, suppressible by azot^DsRed(T4), Scer\GAL4^GMR.PF

(Coelho et al., 2018)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF has adult optic lobe phenotype, suppressible by fwe^UASp.Lose-B, Scer\GAL4^GMR.PF

(Coelho et al., 2018)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^Lk.2.2 has proboscis | progressive phenotype, suppressible by Pi3K92E^CAAX.UAS, Scer\GAL4^Lk.2.2

(Arnés et al., 2017)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^Lk.2.2 has adult abdomen | progressive phenotype, suppressible by Pi3K92E^CAAX.UAS, Scer\GAL4^Lk.2.2

(Arnés et al., 2017)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Hsap\HSPA1L^UAS.sec, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has ommatidium | adult stage phenotype, suppressible by Hsap\HSPA1L^UAS.sec, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has lens phenotype, suppressible by Hsap\HSPA1L^UAS.sec, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has eye disc posterior compartment | larval stage phenotype, suppressible | partially by Hsap\HSPA1L^UAS.sec, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^ey-OK107 has Kenyon cell phenotype, suppressible | partially by Hsap\HSPA1L^UAS.sec, Scer\GAL4^ey-OK107

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^ey-OK107 has Kenyon cell phenotype, suppressible | partially by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^ey-OK107

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^ey-OK107 has axon phenotype, suppressible | partially by Hsap\HSPA1L^UAS.sec, Scer\GAL4^ey-OK107

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Hsap\HSPA1L^K71E.UAS.sec, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has ommatidium | adult stage phenotype, suppressible by Hsap\HSPA1L^K71E.UAS.sec, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has lens phenotype, suppressible by Hsap\HSPA1L^K71E.UAS.sec, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has ommatidium phenotype, suppressible | partially by Zzzz\scFv^{9.UAS.Tag:MYC,Tag:polyHis}, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2015)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has lens phenotype, suppressible | partially by Zzzz\scFv^{9.UAS.Tag:MYC,Tag:polyHis}, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2015)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has ommatidium phenotype, suppressible | partially by Zzzz\scFv^{42.2.UAS.Tag:MYC,Tag:polyHis}, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2015)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has lens phenotype, suppressible | partially by Zzzz\scFv^{42.2.UAS.Tag:MYC,Tag:polyHis}, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2015)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU, Zzzz\scFv^{9.UAS.Tag:MYC,Tag:polyHis} has ommatidium phenotype, suppressible | partially by Zzzz\scFv^{42.2.UAS.Tag:MYC,Tag:polyHis}, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2015)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU, Zzzz\scFv^{9.UAS.Tag:MYC,Tag:polyHis} has lens phenotype, suppressible | partially by Zzzz\scFv^{42.2.UAS.Tag:MYC,Tag:polyHis}, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2015)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^ey-OK107 has mushroom body phenotype, suppressible | partially by Zzzz\scFv^{42.2.UAS.Tag:MYC,Tag:polyHis}, Scer\GAL4^ey-OK107

(Fernandez-Funez et al., 2015)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^ey-OK107 has calyx of adult mushroom body phenotype, suppressible | partially by Zzzz\scFv^{42.2.UAS.Tag:MYC,Tag:polyHis}, Scer\GAL4^ey-OK107

(Fernandez-Funez et al., 2015)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^ey-OK107, Zzzz\scFv^{9.UAS.Tag:MYC,Tag:polyHis} has calyx of adult mushroom body phenotype, suppressible | partially by Zzzz\scFv^{42.2.UAS.Tag:MYC,Tag:polyHis}, Scer\GAL4^ey-OK107

(Fernandez-Funez et al., 2015)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^elav.PU has Kenyon cell | progressive phenotype, suppressible | partially by Scer\GAL4^ey-OK107/Zzzz\scFv^{42.2.UAS.Tag:MYC,Tag:polyHis}

(Fernandez-Funez et al., 2015)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^elav.PU has Kenyon cell | progressive phenotype, suppressible | partially by Scer\GAL4^ey-OK107/Zzzz\scFv^{9.UAS.Tag:MYC,Tag:polyHis}

(Fernandez-Funez et al., 2015)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^elav.PU has Kenyon cell | progressive phenotype, suppressible | partially by Scer\GAL4^ey-OK107/Zzzz\scFv^{42.2.UAS.Tag:MYC,Tag:polyHis}/Zzzz\scFv^{9.UAS.Tag:MYC,Tag:polyHis}

(Fernandez-Funez et al., 2015)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PS has eye phenotype, suppressible | partially by ksr^j5E2/ksr[+]

(Ambegaokar and Jackson, 2011)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PS has eye phenotype, suppressible by sgg^G0335/sgg[+]

(Ambegaokar and Jackson, 2011)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Xbp1^d08698, Scer\GAL4^GMR.PF

(Casas-Tinto et al., 2011)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF has retina phenotype, suppressible by Xbp1^d08698, Scer\GAL4^GMR.PF

(Casas-Tinto et al., 2011)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF has photoreceptor neuron phenotype, suppressible by Xbp1^d08698, Scer\GAL4^GMR.PF

(Casas-Tinto et al., 2011)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Mmus\Xbp1^UAS.cCTa, Scer\GAL4^GMR.PF

(Casas-Tinto et al., 2011)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF has retina phenotype, suppressible by Mmus\Xbp1^UAS.cCTa, Scer\GAL4^GMR.PF

(Casas-Tinto et al., 2011)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF has photoreceptor neuron phenotype, suppressible by Mmus\Xbp1^UAS.cCTa, Scer\GAL4^GMR.PF

(Casas-Tinto et al., 2011)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF has eye | progressive phenotype, suppressible by Mmus\Xbp1^UAS.cCTa, Scer\GAL4^GMR.PF

(Casas-Tinto et al., 2011)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF has eye | progressive phenotype, suppressible by Xbp1^d08698, Scer\GAL4^GMR.PF

(Casas-Tinto et al., 2011)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by RyR¹⁶/RyR[+]

(Casas-Tinto et al., 2011)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF has retina phenotype, suppressible by RyR¹⁶/RyR[+]

(Casas-Tinto et al., 2011)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF has photoreceptor neuron phenotype, suppressible by RyR¹⁶/RyR[+]

(Casas-Tinto et al., 2011)

NOT suppressed by

Statement

Reference

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa has eye phenotype, non-suppressible by Cdc14^EY10303, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa has eye phenotype, non-suppressible by LanA^JF02908, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa has eye phenotype, non-suppressible by wb^JF03238, Scer\GAL4^GMR.PFa

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long has axon | larval stage phenotype, non-suppressible by Mnat9^KK109382, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Mnat9^KK109382, Scer\GAL4^GMR.long has eye phenotype, non-suppressible | partially by bsk^DN.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, non-suppressible by puc^UAS.cMa, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long, bsk^DN.UAS has eye phenotype, non-suppressible by Mnat9^KK109382, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has lens phenotype, non-suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by Hsc70-3^UAS.cEa, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has ommatidium | adult stage phenotype, non-suppressible by Hsc70-3^UAS.cEa, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has lens phenotype, non-suppressible by Hsc70-3^UAS.cEa, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has eye disc posterior compartment | larval stage phenotype, non-suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^ey-OK107 has axon phenotype, non-suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^ey-OK107

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by Hsap\HSPA1L^{SBD-GG.UAS.sec}, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has ommatidium | adult stage phenotype, non-suppressible by Hsap\HSPA1L^{SBD-GG.UAS.sec}, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has lens phenotype, non-suppressible by Hsap\HSPA1L^{SBD-GG.UAS.sec}, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by Hsap\HSPA1L^{SBD-GY.UAS.sec}, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has ommatidium | adult stage phenotype, non-suppressible by Hsap\HSPA1L^{SBD-GY.UAS.sec}, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has lens phenotype, non-suppressible by Hsap\HSPA1L^{SBD-GY.UAS.sec}, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has ommatidium | adult stage phenotype, non-suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has ommatidium phenotype, non-suppressible by Zzzz\scFv^{40.UAS.Tag:MYC,Tag:polyHis}, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2015)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU has lens phenotype, non-suppressible by Zzzz\scFv^{40.UAS.Tag:MYC,Tag:polyHis}, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2015)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^ey-OK107 has mushroom body phenotype, non-suppressible by Zzzz\scFv^{9.UAS.Tag:MYC,Tag:polyHis}, Scer\GAL4^ey-OK107

(Fernandez-Funez et al., 2015)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PS has eye phenotype, non-suppressible | partially by ksr^j5E2/ksr[+]

(Ambegaokar and Jackson, 2011)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PS has eye phenotype, non-suppressible by NC2α^EY18723/NC2alpha[+]

(Ambegaokar and Jackson, 2011)

Enhancer of

Statement

Reference

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PFa is an enhancer of eye phenotype of LanB1^UAS.mRFP1, Scer\GAL4^GMR.PFa, Xbp1^KK102632

(Catterson et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long is an enhancer of eye phenotype of Jra^Asp.B.UAS, Scer\GAL4^GMR.long

(Deshpande et al., 2023)

NOT Enhancer of

Statement

Reference

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long is a non-enhancer of eye phenotype of Scer\GAL4^GMR.long, hep^Act.UAS

(Deshpande et al., 2023)

NOT Suppressor of

Statement

Reference

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.long is a non-suppressor of eye phenotype of Scer\GAL4^GMR.long, hep^Act.UAS

(Deshpande et al., 2023)

Other

Statement

Reference

Hsap\APP^2xAPP.SP.UAS, Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long, hep^Act.UAS has eye disc | larval stage phenotype

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Jra^Asp.B.UAS, Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long has eye disc | larval stage phenotype

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long, puc^UAS.cMa has eye disc | larval stage phenotype

(Deshpande et al., 2023)

Hsap\APP^2xAPP.SP.UAS, Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^GMR.long, bsk^DN.UAS has eye disc | larval stage phenotype

(Deshpande et al., 2023)

Diap1^UAS.cHa, Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PF has eye disc phenotype

(Coelho et al., 2018)

Hsap\APP^2xAPP.SP.UAS, Hsap\HSPA1L^UAS.sec, Scer\GAL4^ey-OK107 has calyx of adult mushroom body phenotype

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Hsap\HSPA1L^UAS.cWa, Scer\GAL4^ey-OK107 has calyx of adult mushroom body phenotype

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^ey-OK107, Zzzz\scFv^{42.2.UAS.Tag:MYC,Tag:polyHis}, Zzzz\scFv^{9.UAS.Tag:MYC,Tag:polyHis} has mushroom body phenotype

(Fernandez-Funez et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The inflated abdomen and proboscis phenotype (that grows progressively more severe until death) induced by adult-onset expression of Hsap\APP^{2xAPP.SP.Scer\UAS} under the control of Scer\GAL4^Lk.2.2 (combined with Tub-Gal4 to limit the expression to adulthood) is completely suppressed in all flies by co-expression of Pi3K92E^{CAAX.Scer\UAS}. Similarly, the increased apoptotic activity (detected by Casp3 immunolabelling) observed in third instar larval wing discs expressing Hsap\APP^{2xAPP.SP.Scer\UAS} under Scer\GAL4^e22c is significantly suppressed by Pi3K92E^{CAAX.Scer\UAS} co-expression. Expresion of Hsap\APP^{2xAPP.SP.Scer\UAS} under Scer\GAL4^Toll-6-D42 either on its own or in combination with Pi3K92E^{CAAX.Scer\UAS} does not induce cell death in larval wing discs.

Flies co-expressing Hsap\APP^{2xAPP.SP.Scer\UAS} and BacA\p35^Scer\UAS.cUa under either Scer\GAL4^Toll-6-D42 or Scer\GAL4^e22c are lethal and do not reach adulthood.

(Arnés et al., 2017)

Co-expression of Hsap\HSPA1L^Scer\UAS.sec or Hsap\HSPA1L^{K71E.Scer\UAS.sec} (but not Hsap\HSPA1L^Scer\UAS.cWa, Hsap\HSPA1L^{SBD-GG.Scer\UAS.sec}, Hsap\HSPA1L^{SBD-GY.Scer\UAS.sec} or Hsc70-3^Scer\UAS.cEa) completely suppresses the eye phenotypes of adult flies expressing Hsap\APP^{2xAPP.SP.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

Co-expression of Hsap\HSPA1L^Scer\UAS.sec (but not Hsap\HSPA1L^Scer\UAS.cWa) partially suppresses the increased cell death observed in larval posterior eye discs in flies expressing Hsap\APP^{2xAPP.SP.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

Co-expression of either Hsap\HSPA1L^Scer\UAS.sec or Hsap\HSPA1L^Scer\UAS.cWa partially suppresses the increased cell death observed in adult Kenyon cells of the mushroom body, and enhances the increased size of the calyx at 1 day old; expression of Hsap\HSPA1L^Scer\UAS.sec (but not Hsap\HSPA1L^Scer\UAS.cWa) suppresses the thin Kenyon cell axons, and suppresses the decreased size of the calyx at 20 and 40 days old in flies expressing Hsap\APP^{2xAPP.SP.Scer\UAS} under the control of Scer\GAL4^ey-OK107.

Co-expression of Hsap\HSPA1L^Scer\UAS.sec (but not Hsap\HSPA1L^Scer\UAS.cWa) partially suppresses the locomotor defects and reduced lifespan of flies expressing Hsap\APP^{2xAPP.SP.Scer\UAS} under the control of Scer\GAL4^elav.PU.

(Fernandez-Funez et al., 2016)

The glassy eye phenotype and disrupted ommatidial lattice observed in adult flies expressing Hsap\APP^{2xAPP.SP.Scer\UAS} under the control of Scer\GAL4^GMR.PU is significantly worsened by co-expression of either Rho1^{dsRNA.Scer\UAS} or Pgm^HMS01333 RNAi with necrotic spots appearing in the posterior eye but is not affected by combination with CG11739^d06383.

(Minjarez et al., 2016)

Co-expression of Hsap\APP^{2xAPP.SP.Scer\UAS} with Mus\scFv^{9.Scer\UAS.T:Hsap\MYC,T:Zzzz\His6} partially suppresses the Hsap\APP^{2xAPP.SP.Scer\UAS} phenotype, with larger eyes and improved pigmentation. The eyes of these flies are better organized, with fewer fused ommatidia, and better differentiation of lenses with fewer broken lenses.

Co-expression of Hsap\APP^{2xAPP.SP.Scer\UAS} with Mus\scFv^{42.2.Scer\UAS.T:Hsap\MYC,T:Zzzz\His6} partially suppresses the Hsap\APP^{2xAPP.SP.Scer\UAS} phenotype, with larger eyes and improved pigmentation. The eyes of these flies are better organized, with fewer fused ommatidia, and better differentiation of lenses with fewer broken lenses.

Co-expression of Mus\scFv^{42.2.Scer\UAS.T:Hsap\MYC,T:Zzzz\His6} partially suppresses the size defects in the mushroom body lobes resulting from the expression of Scer\GAL4^ey-OK107>Hsap\APP^{2xAPP.SP.Scer\UAS}.

Co-expression of the combination of Mus\scFv^{42.2.Scer\UAS.T:Hsap\MYC,T:Zzzz\His6} and Mus\scFv^{9.Scer\UAS.T:Hsap\MYC,T:Zzzz\His6} with Scer\GAL4^ey-OK107>Hsap\APP^{2xAPP.SP.Scer\UAS} produces dorsal and medial mushroom body lobes that are slightly larger than wild-type.

(Fernandez-Funez et al., 2015)

ksr^j5E2 mildly suppresses the eye phenotype seen in flies expressing Hsap\APP^{2xAPP.SP.Scer\UAS} under the control of Scer\GAL4^GMR.PS.

One copy of NC2α^EY18723 does not suppress the eye phenotype seen in flies expressing Hsap\APP^{2xAPP.SP.Scer\UAS} under the control of Scer\GAL4^GMR.PS.

Expression of SdhB^EY12081 does not suppress the eye phenotype seen in flies expressing Hsap\APP^{2xAPP.SP.Scer\UAS} under the control of Scer\GAL4^GMR.PS.

One copy of sgg^G0335 suppresses the eye phenotype seen in flies expressing Hsap\APP^{2xAPP.SP.Scer\UAS} under the control of Scer\GAL4^GMR.PS.

(Ambegaokar and Jackson, 2011)

Co-expression of Hsap\APP^{2xAPP.SP.Scer\UAS} and Xbp1^d08698 in the developing eye under the control of Scer\GAL4^GMR.PF significantly improves both eye organisation and size compared to expression of Hsap\APP^{2xAPP.SP.Scer\UAS} alone.

Co-expression of Mmus\Xbp1^{Scer\UAS.cCTa} with Hsap\APP^{2xAPP.SP.Scer\UAS} (both under the control of Scer\GAL4^GMR.PF) results in bigger, better-organised eyes that lack necrotic spots. Additionally, retinae are thicker and photoreceptors and lenses are better differentiated.

Hsap\APP^{2xAPP.SP.Scer\UAS} flies co-expressing either Mmus\Xbp1^{Scer\UAS.cCTa} or Xbp1^d08698 in the developing eye (under the control of Scer\GAL4^GMR.PF) show milder degenerative changes in the retina compared to flies expressing Hsap\APP^{2xAPP.SP.Scer\UAS}, indicating Mmus\Xbp1 or Xbp1 protects against the progressive degeneration of photoreceptors induced by Hsap\APP.

In flies co-expressing Hsap\APP^{2xAPP.SP.Scer\UAS} and Xbp1^GD4745 in the developing eye (under the control of Scer\GAL4^GMR.PF) aged 20 days, the retinae undergo dramatic degeneration, leaving large holes underneath the cornea.

A heterozygous RyR¹⁶ background significantly suppresses the eye degeneration seen upon expression of Hsap\APP^{2xAPP.SP.Scer\UAS} under the control of Scer\GAL4^GMR.PF. Sixty percent of the flies expressing only Hsap\APP^{2xAPP.SP.Scer\UAS} show a highly disorganised eye surface and short retina with small photoreceptors. On the other hand, 62% of the flies with a heterozygous RyR¹⁶ background exhibit mild eye disorganisation with well-developed retinae and long photoreceptors. There is a significant improvement in eye organisation in flies carrying RyR¹⁶.

Viability of flies expressing Hsap\APP^{2xAPP.SP.Scer\UAS} in the CNS (under the control of Scer\GAL4^elav-C155) is completely restored in a heterozygous RyR¹⁶ background.

(Casas-Tinto et al., 2011)

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Hsap\APP^{2xAPP.SP.Scer\UAS}

Hsap\APP^2xAPP.SP.UAS

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