FB2024_03 , released June 25, 2024
Allele: Dmel\bskDN.UAS
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General Information
Symbol
Dmel\bskDN.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0097043
Feature type
allele
Associated gene
Dmel\bsk
Associated Insertion(s)
Carried in Construct
P{UAS-bsk.DN}
Also Known As
UAS-bskDN, UAS-bskDN, bskDN, UAS-Bsk-DN, UAS-JNKDN, bsk DN, UAS-bsk DN, Bsk-DN, UAS-DJNKDN, UAS-bsk.DN
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Adachi-Yamada et al., 1999)
Progenitor genotype
Carried in construct
P{UAS-bsk.DN}
Cytology
Description

A nonactivatable mutant form of bsk is expressed under the control of UAS regulatory sequences.

(Adachi-Yamada et al., 1999)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
bsk
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  cancer
      CEA with DeltaUAS.cDa
      (Bossuyt et al., 2009)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  gastrointestinal adenoma
      modeled by ApcQ8, Apc2g10
      (Suijkerbuijk et al., 2016)
      ameliorates  cancer
      modeled by Ras85DV12.UAS, fmt1
      (Ma et al., 2017)
      modeled by Ras85DV12.UAS, PpVΔ1
      (Ma et al., 2017)
      modeled by l(2)glGD4047, RpL27A1
      (Grifoni et al., 2015)
      modeled by dor8, Ras85DV12.UAS
      (Chi et al., 2010)
      modeled by Ras85DV12.UAS, scrib1
      (Wu et al., 2010)
      modeled by Hsap\S100A4wt.UAS, Ras85DV12.UAS
      (Ismail et al., 2017)
      ameliorates  carcinoma
      modeled by EgfrUAS.cBa, Socs36EGD8929
      (Xu et al., 2022)
      modeled by Ras85DV12.UAS, l(2)gl4
      (Srivastava et al., 2007, Igaki et al., 2006)
      modeled by Ras85DV12.UAS, scrib1
      (Igaki et al., 2006, Uhlirova and Bohmann, 2006)
      modeled by Ras85DV12.UAS, dlg114
      (Igaki et al., 2006)
      modeled by Ras85DV12.UAS, egrUAS.cIa
      (Igaki et al., 2006)
      modeled by scribHMJ21977, ykiS111A.S168A.S250A.UAS.Tag:V5
      (Snigdha et al., 2021)
      exacerbates  cancer
      modeled by DeltaUAS.cDa, lolaGS88A8, psqGS88A8
      (Bossuyt et al., 2009)
      modeled by pnutGD1512, ykiUAS.cHa
      (Gerlach et al., 2018)
      ameliorates  neurodegenerative disease
      modeled by Hsap\APPAβ42.UAS.cUa
      (Tare et al., 2011)
      ameliorates  colorectal cancer
      modeled by Ras85DV12.UAS
      (Bangi et al., 2012)
      ameliorates  Alzheimer's disease 1
      modeled by Hsap\APPAβ42.UAS.cUa
      (Irwin et al., 2020)
      DOES NOT ameliorate  cancer
      modeled by HipkUAS.Tag:HA
      (Blaquiere et al., 2018)
      ameliorates  intestinal cancer
      modeled by Sox21a6
      (Zhai et al., 2015)
      ameliorates  tauopathy
      modeled by shot3, tauMR22
      (Voelzmann et al., 2016)
      ameliorates  juvenile polyposis syndrome
      modeled by shnKK101278
      (Zhou and Boutros, 2020)
      modeled by MedKK108412
      (Zhou and Boutros, 2020)
      ameliorates  nephrolithiasis
      modeled by Pvrλ.UASp.Tag:MYC
      (Xu et al., 2024)
      exacerbates  carcinoma
      modeled by scrib1
      (Zheng et al., 2023)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of bskDN.UAS under the control of Scer\GAL4dome-PG14 (in combination with tub-Gal80[ts]) leads to a decline in the cortical zone of lymph gland primary lobe of larvae.

      (Tiwari et al., 2020)

      Somatic clones expressing bskDN.UAS under the control of Scer\GAL4Tub.PU contain a smaller overall number of cells and intestinal stem cells in adult flies compared to controls, but maintain a wild-type ratio of stem cells/clone.

      (Gervais et al., 2019)

      Expression of bskDN.Scer\UAS under the control of Scer\GAL4Dll-md23 in MARCM clones in type II neuroblast lineages does not affect the clone size as compared to wild-type control clones in third instar larvae.

      (Rives-Quinto et al., 2017)

      Expression of dominant-negative bskDN.Scer\UAS results in a robust enhancement of the regenerative response. The nerve growth response is similar, whether bskDN.Scer\UAS is expressed ubiquitously with Scer\GAL4αTub84B.Switch.PK or neuronally through Scer\GAL4elav.Switch.PO, indicating that the enhanced growth is dependent on altering neuronal signaling and not the environment.

      Expression of bskDN.Scer\UAS under the control of Scer\GAL4elav.Switch.PO results in a marked decrease in the size of pigmented scar after injury.

      (Soares et al., 2014)

      Expression of bskDN.Scer\UAS under the control of Scer\GAL4ato.3.6 results in a decrease in the number of medulla axons compared to wild type.

      (Langen et al., 2013)

      Healthy egg chambers from starved flies expressing bskDN.Scer\UAS under the control of Scer\GAL4GR1 appear wild type, and dying egg chambers begin the normal process of follicle cell (FC) engulfment, including the enlargement of the FCs and uptake of the germline debris. However engulfment defects are seen later in the process. The FCs fails to enlarge and the FC nuclei become pycnotic. Nurse cell nuclei are not taken up by the FCs. The nurse cell nuclei also failed to fragment properly, making it difficult to assess the specific phases of degeneration. Very few degenerating egg chambers are seen in unstarved flies.

      (Etchegaray et al., 2012)

      Males expressing bskDN.Scer\UAS under the control of Scer\GAL4en.PU display mis-oriented adult genitalia, and the acceleration of genitalia rotation is significantly impaired in these flies compared to controls.

      (Kuranaga et al., 2011)

      Expression of bskDN.Scer\UAS under the control of Scer\GAL4GMR.PU has no effect on the size of the eye imaginal disc or adult eye.

      (Tare et al., 2011)

      Expression of bskDN.Scer\UAS under the control of Scer\GAL4opa results in thorax closure defects in the adult.

      Expression of bskDN.Scer\UAS under the control of Scer\GAL4opa results in transformation of the medial edge peripodial membrane cells of the wing disc into a more broad hexagonal shape (they are elongated in wild-type discs).

      (Tripura et al., 2011)

      Embryos expressing bskDN.Scer\UAS under the control of Scer\GAL4ptc-559.1 completely lack cell intercalation and mixer cell shifting at the segment boundary during dorsal closure (in the abdominal segments of wild-type embryos at the end of dorsal closure, a mixer cell moves across the segment boundary from the anterior compartment to the posterior compartment and two cells from the ventral ectoderm intercalate into the leading edge, posterior to the mixer cell).

      Most embryos expressing bskDN.Scer\UAS under the control of Scer\GAL4ptc-559.1 are able to complete dorsal closure, but 92% of them show a high degree of segment mismatching at the dorsal midline (53% of abdominal segments A1-6 show defects).

      Embryos expressing bskDN.Scer\UAS under the control of Scer\GAL4en-e16E show normal cell intercalation and mixer cell shifting at the segment boundary during dorsal closure.

      (Gettings et al., 2010)

      Expression of bskDN.Scer\UAS using Scer\GAL4ey-OK107 results in axon defasciculation, axon degeneration and axon overextension phenotypes.

      (Rallis et al., 2010)

      Expression of bskDN.Scer\UAS in the developing retina under the control of Scer\GAL4GMR.PF results in a few mild R axon misrouting defects.

      (Sato et al., 2006)

      Expression of bskDN.Scer\UAS under the control of Scer\GAL4ey.PH does not affect eye size.

      (Singh et al., 2006)

      Expression of one copy of bskDN.Scer\UAS, driven by Scer\GAL4ato.3.6, results in the reduction of the number of dorsal cluster neuron axons crossing toward the medulla from an average of 11.7 axons in wild-type flies to an average of 4.4 axons. Expression of two copies of the transgene results in an average of only 1.1 axons with 30% showing no axon at all. By examining axon extension at 20-30% pupal development, it is clear that extension of the axons is affected, as opposed to excessive axon retraction.

      Single cell dorsal cluster neuron clones expressing bskDN.Scer\UAS under the control of Scer\GAL4ato.3.6 fail to extend axons to the medulla, but show no obvious guidance defects within the lobula.

      (Srahna et al., 2006)

      Expression of bskDN.Scer\UAS in the posterior compartment of the wing disc, driven by Scer\GAL4en-e16E, prevents wound healing in the posterior compartment of the disc. The formation of actin-rich cables around the wound is an essential part of wound healing; in the affected posterior wing disc compartment expressing bskDN.Scer\UAS, there is an actin-rich area only at the vertex of the wound and not in the rest of the wound. Wound healing in the anterior compartment of the disc, that does not express bskDN.Scer\UAS, is unaffected.

      (Bosch et al., 2005)

      Expression of bskDN.Scer\UAS, under the control of Scer\GAL4P2.4.Pdf, has no effect on the normal development of the terminal axonal arbour of the sLNv.

      (Leyssen et al., 2005)

      Expression of bskDN.Scer\UAS under the control of Scer\GAL4GMR.PF results in flies with small eyes.

      (Müller et al., 2005)

      When bskDN.Scer\UAS is driven by Scer\GAL4e22c or Scer\GAL469B a strong dorsal closure defect is observed. When bskDN.Scer\UAS is driven by Scer\GAL4A58 larvae are viable, active and do not display any morphological abnormalities. However the wound healing process is affected. No defects are seen in the early steps in wound healing, including scab formation, epidermal cell orientation toward the wound, and epidermal cell fusion to form a syncytium. However, reepithithelialization is blocked or defective, with no cytoplasmic processes or extremely fine or distorted processes and no cuticle synthesis beneath the scab 16h after wounding.

      (Galko and Krasnow, 2004)

      Flies that express bskDN.Scer\UAS under the control of Scer\GAL4ap-md544 show a cleft at the dorsal midline of the thorax.

      (Cha et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      NOT Enhanced by
      Suppressed by
      NOT suppressed by
      Enhancer of
      NOT Enhancer of
      Suppressor of
      Statement
      Reference

      bskDN.UAS/Scer\GAL4αTub84B.PL is a suppressor of decreased size | somatic clone | larval stage phenotype of Rer1KO

      (Paul et al., 2024)

      bskDN.UAS, Scer\GAL4GMR.long is a suppressor | partially of visible | adult stage phenotype of Hsap\APP2xAPP.SP.UAS, Scer\GAL4GMR.long

      (Deshpande et al., 2023)

      bskDN.UAS, Scer\GAL4GMR.long is a suppressor | partially of decreased size | adult stage phenotype of Hsap\APP2xAPP.SP.UAS, Scer\GAL4GMR.long

      (Deshpande et al., 2023)

      bskDN.UAS, Scer\GAL4GMR.long is a suppressor | partially of visible | adult stage phenotype of Hsap\APP2xAPP.SP.UAS, Mnat9KK109382, Scer\GAL4GMR.long

      (Deshpande et al., 2023)

      bskDN.UAS, Scer\GAL4GMR.long is a suppressor | partially of decreased size | adult stage phenotype of Hsap\APP2xAPP.SP.UAS, Mnat9KK109382, Scer\GAL4GMR.long

      (Deshpande et al., 2023)

      bskDN.UAS, Scer\GAL4GMR.long is a suppressor | partially of increased cell death | larval stage phenotype of Hsap\APP2xAPP.SP.UAS, Scer\GAL4GMR.long

      (Deshpande et al., 2023)

      bskDN.UAS, Scer\GAL4GMR.long is a suppressor | partially of increased cell death | larval stage phenotype of Hsap\APP2xAPP.SP.UAS, Mnat9KK109382, Scer\GAL4GMR.long

      (Deshpande et al., 2023)

      bskDN.UAS, Scer\GAL4hh.PU is a suppressor | partially of increased cell death | larval stage phenotype of Paip1GD13792, Scer\GAL4hh.PU

      (Xue et al., 2023)

      bskDN.UAS/Scer\GAL4Act.PU is a suppressor | partially of decreased cell number | somatic clone | larval stage phenotype of Scer\GAL4Act.PU, Xbp1UAS.s.Tag:V5, scrib1

      (Zheng et al., 2023)

      bskDN.UAS, Scer\GAL4Act.PU is a suppressor | partially of decreased cell number | somatic clone | larval stage phenotype of Ire1UAS.Tag:V5, Scer\GAL4Act.PU, scrib1

      (Zheng et al., 2023)

      bskDN.UAS, Atg13G6421/Atg13G6421 is a suppressor of decreased cell number | somatic clone | larval stage phenotype of Ire1UAS.Tag:V5, Scer\GAL4Act.PU, scrib1

      (Zheng et al., 2023)

      bskDN.UAS, Atg600096/Atg600096 is a suppressor of decreased cell number | somatic clone | larval stage phenotype of Ire1UAS.Tag:V5, Scer\GAL4Act.PU, scrib1

      (Zheng et al., 2023)

      bskDN.UAS/Scer\GAL4Act.PU is a suppressor of decreased cell number | somatic clone | larval stage phenotype of scrib1

      (Zheng et al., 2023)

      bskDN.UAS/Scer\GAL4ptc-559.1 is a suppressor | partially of increased size | third instar larval stage phenotype of Scer\GAL4ptc-559.1, Toll-7C993Y.UAS.Tag:FLAG

      (Ding et al., 2022)

      bskDN.UAS/Scer\GAL4ptc-559.1 is a suppressor of abnormal cell migration | third instar larval stage phenotype of Scer\GAL4ptc-559.1, Toll-7C993Y.UAS.Tag:FLAG

      (Ding et al., 2022)

      bskDN.UAS/ZnT86DKK101698, Scer\GAL4Act.PU is a suppressor of increased mortality during development | somatic clone - tissue specific phenotype of RafUAS.F179, Scer\GAL4Act.PU, scrib1

      (Wei et al., 2021)

      bskDN.UAS, Scer\GAL4Act.PU is a suppressor of increased mortality during development | somatic clone - tissue specific phenotype of RafUAS.F179, Scer\GAL4Act.PU, scrib1

      (Wei et al., 2021)

      bskDN.UAS, Scer\GAL4Act.PU is a suppressor of neoplasia | larval stage | somatic clone - tissue specific phenotype of RafUAS.F179, Scer\GAL4Act.PU, scrib1

      (Wei et al., 2021)

      bskDN.UAS/ZnT86DKK101698, Scer\GAL4Act.PU is a suppressor of neoplasia | larval stage | somatic clone - tissue specific phenotype of RafUAS.F179, Scer\GAL4Act.PU, scrib1

      (Wei et al., 2021)

      bskDN.UAS/Scer\GAL4Tub.PU is a suppressor of increased cell number | recessive | somatic clone | adult stage phenotype of kis10D26

      (Gervais et al., 2019)

      bskDN.UAS/Scer\GAL4ptc-559.1 is a suppressor | partially of abnormal cell migration | third instar larval stage phenotype of Scer\GAL4ptc-559.1, armUAS.Exel

      (Zhang et al., 2019)

      bskDN.UAS/Scer\GAL4ptc-559.1 is a suppressor | partially of abnormal cell migration | third instar larval stage phenotype of Scer\GAL4ptc-559.1, scribGD11666

      (Zhang et al., 2019)

      ykiHMS00041/bskDN.UAS, Scer\GAL4dpp.blk1 is a suppressor of neoplasia phenotype of HipkUAS.Tag:HA, Scer\GAL4dpp.blk1

      (Blaquiere et al., 2018)

      ykiHMS00041/bskDN.UAS, Scer\GAL4dpp.blk1 is a suppressor of abnormal cell migration | larval stage phenotype of HipkUAS.Tag:HA, Scer\GAL4dpp.blk1

      (Blaquiere et al., 2018)

      bskDN.UAS/Scer\GAL4ap-md544 is a suppressor | partially of increased cell death | third instar larval stage phenotype of Scer\GAL4ap-md544, pnutGD1512

      (Gerlach et al., 2018)

      bskDN.UAS, Scer\GAL4Act5C.PI is a suppressor of neoplasia | somatic clone | larval stage phenotype of Hsap\S100A4wt.UAS, Ras85DV12.UAS, Scer\GAL4Act5C.PI

      (Ismail et al., 2017)

      bskDN.UAS, Scer\GAL4FRT.Act5C is a suppressor | somatic clone of neoplasia | somatic clone | third instar larval stage phenotype of Ras85DV12.UAS, Scer\GAL4FRT.Act5C, fmt1

      (Ma et al., 2017)

      bskDN.UAS, Scer\GAL4FRT.Act5C is a suppressor | somatic clone of neoplasia | somatic clone | third instar larval stage phenotype of PpVΔ1, Ras85DV12.UAS, Scer\GAL4FRT.Act5C

      (Ma et al., 2017)

      bskDN.UAS, Scer\GAL4FRT.Act5C is a suppressor | somatic clone of increased occurrence of cell division | somatic clone | third instar larval stage phenotype of PpVΔ1, Ras85DV12.UAS, Scer\GAL4FRT.Act5C

      (Ma et al., 2017)

      bskDN.UAS/Scer\GAL4ptc.PU is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4ptc.PU, fmtGD6928

      (Ma et al., 2017)

      bskDN.UAS/Scer\GAL4Dll-md23 is a suppressor of abnormal size | somatic clone | third instar larval stage phenotype of scrib1

      (Rives-Quinto et al., 2017)

      bskDN.UAS/Scer\GAL4Dll-md23 is a suppressor of decreased cell number | somatic clone | third instar larval stage phenotype of scrib1

      (Rives-Quinto et al., 2017)

      bskDN.UAS/Scer\GAL4Dll-md23 is a suppressor of abnormal neuroanatomy | somatic clone | third instar larval stage phenotype of scrib1

      (Rives-Quinto et al., 2017)

      bskDN.UAS/Scer\GAL4Act.PU is a suppressor of abnormal size | somatic clone | wandering third instar larval stage phenotype of Scer\GAL4Act.PU, wupAJF02172

      (Casas-Tintó et al., 2016)

      bskDN.UAS, Scer\GAL4bun-GSG5961, Scer\GAL4GSG5966 is a suppressor | RU486 conditional of increased cell number | somatic clone phenotype of Apc2g10, ApcQ8

      (Suijkerbuijk et al., 2016)

      bskDN.UAS, Scer\GAL4bun-GSG5961, Scer\GAL4GSG5966 is a suppressor | RU486 conditional of decreased cell number | somatic clone | cell non-autonomous phenotype of Apc2g10, ApcQ8

      (Suijkerbuijk et al., 2016)

      bskDN.UAS/Scer\GAL4Tub.PU is a suppressor | somatic clone of increased cell number | somatic clone phenotype of Apc2g10, ApcQ8

      (Suijkerbuijk et al., 2016)

      bskDN.UAS/Scer\GAL4GSG2326 is a suppressor | cell non-autonomous of increased cell number | somatic clone phenotype of Apc2g10, ApcQ8

      (Suijkerbuijk et al., 2016)

      bskDN.UAS, Scer\GAL4en.PU is a suppressor of neoplasia phenotype of RpL27A1, Scer\GAL4en.PU, l(2)glGD4047

      (Grifoni et al., 2015)

      bskDN.UAS/Scer\GAL4Su(H).GBE is a suppressor | partially of neoplasia phenotype of Sox21a6

      (Zhai et al., 2015)

      bskDN.UAS/Scer\GAL4NP0001 is a suppressor | partially of neoplasia phenotype of Sox21a6

      (Zhai et al., 2015)

      bskDN.UAS/Scer\GAL4GMR.PF is a suppressor of abnormal size phenotype of Scer\GAL4GMR.PF, egrUAS.cIa

      (Zhang et al., 2015)

      bskDN.UAS/Scer\GAL4GMR.PF is a suppressor of visible phenotype of Scer\GAL4GMR.PF, egrUAS.cIa

      (Zhang et al., 2015)

      bskDN.UAS, Scer\GAL4Act.PU is a suppressor of increased cell death | somatic clone | cell autonomous | third instar larval stage phenotype of Ras85DV12.UAS, Scer\GAL4Act.PU, Sec151

      (Chabu and Xu, 2014)

      bskDN.UAS/Scer\GAL4sd-SG29.1 is a suppressor of increased cell death | heat sensitive phenotype of Scer\GAL4sd-SG29.1, Src64BUY1332

      (Fernández et al., 2014)

      bskDN.UAS, Scer\GAL4sd-SG29.1 is a suppressor of increased cell growth rate phenotype of BacA\p35GMR.PH, Scer\GAL4sd-SG29.1, Src64BUY1332

      (Fernández et al., 2014)

      bskDN.UAS, Scer\GAL4ato.3.6 is a suppressor of abnormal neuroanatomy | adult stage phenotype of NECN.UAS, Scer\GAL4ato.3.6

      (Langen et al., 2013)

      bskDN.UAS, Scer\GAL4ato.3.6 is a suppressor of abnormal neuroanatomy | adult stage phenotype of PakUAS.Tag:Myr(Src64B), Scer\GAL4ato.3.6

      (Langen et al., 2013)

      bskDN.UAS/Scer\GAL4Act5C.PP is a suppressor of increased cell death | somatic clone phenotype of Pten117

      (Nowak et al., 2013)

      bskDN.UAS/Scer\GAL4Act5C.PP is a suppressor of increased cell death | somatic clone | nutrition conditional phenotype of Pten117

      (Nowak et al., 2013)

      bskDN.UAS/Scer\GAL4Act5C.PP is a suppressor of increased cell growth rate | somatic clone | nutrition conditional phenotype of Pten117

      (Nowak et al., 2013)

      bskDN.UAS, Scer\GAL4byn-Gal4 is a suppressor | partially of abnormal cell migration | adult stage | progressive phenotype of Ras85DV12.UAS, Scer\GAL4byn-Gal4

      (Bangi et al., 2012)

      bskDN.UAS/Scer\GAL4NP4132 is a suppressor of abnormal memory phenotype of Scer\GAL4NP4132, hiwΔRING.UAS

      (Huang et al., 2012)

      bskDN.UAS/Scer\GAL4GMR.PF is a suppressor of increased cell death phenotype of Scer\GAL4GMR.PF, egrUAS.cIa

      (Ma et al., 2012)

      bskDN.UAS/Scer\GAL4ey.PU is a suppressor | partially of increased cell death phenotype of Scer\GAL4ey.PU, vitoGD10890

      (Marinho et al., 2011)

      bskDN.UAS, Scer\GAL4GMR.PU is a suppressor of increased cell death phenotype of Hsap\APPAβ42.UAS.cUa, Scer\GAL4GMR.PU

      (Tare et al., 2011)

      bskDN.UAS, Scer\GAL4GMR.PU is a suppressor of visible phenotype of Hsap\APPAβ42.UAS.cUa, Scer\GAL4GMR.PU

      (Tare et al., 2011)

      bskDN.UAS, Scer\GAL4FRT.Act5C is a suppressor of hyperplasia phenotype of Ras85DV12.UAS, Scer\GAL4FRT.Act5C, dorC107

      (Chi et al., 2010)

      bskDN.UAS/Scer\GAL4e22c is a suppressor of increased cell death phenotype of Scer\GAL4e22c, hppyUAS.cLa

      (Lam et al., 2010)

      bskDN.UAS, Scer\GAL4dpp.blk1 is a suppressor of increased cell death phenotype of Rho1UAS.cMa, Scer\GAL4dpp.blk1

      (Neisch et al., 2010)

      bskDN.UAS, Scer\GAL4ap-md544 is a suppressor of increased cell death phenotype of GliUAS.cPa, Scer\GAL4ap-md544

      (Padash-Barmchi et al., 2010)

      bskDN.UAS, Scer\GAL4Act.PU is a suppressor of neoplasia | somatic clone phenotype of Ras85DV12.UAS, Scer\GAL4Act.PU, scrib1

      (Wu et al., 2010)

      bskDN.UAS, Scer\GAL4elav.PLu is a suppressor of abnormal neuroanatomy phenotype of Atg1UAS.cSa, Scer\GAL4elav.PLu

      (Shen and Ganetzky, 2009)

      bskDN.UAS, Scer\GAL4elav.PLu is a suppressor of increased cell growth rate phenotype of Atg1UAS.cSa, Scer\GAL4elav.PLu

      (Shen and Ganetzky, 2009)

      bskDN.UAS/Scer\GAL4GMR.PF is a suppressor | partially of visible phenotype of Ras85DKP

      (Wu et al., 2009)

      bskDN.UAS, Scer\GAL4Act5C.PU is a suppressor of neoplasia | somatic clone phenotype of Ras85DV12.UAS, Scer\GAL4Act5C.PU, scrib1

      (Srivastava et al., 2007)

      bskDN.UAS/Scer\GAL4Act5C.PI is a suppressor of neoplasia | somatic clone phenotype of Ras85DV12.UAS, scrib1

      (Igaki et al., 2006)

      bskDN.UAS, Scer\GAL4Act5C.PI is a suppressor of neoplasia | somatic clone phenotype of Ras85DV12.UAS, Scer\GAL4Act5C.PI, scrib1

      (Igaki et al., 2006)

      bskDN.UAS, Scer\GAL4ato.3.6 is a suppressor of abnormal neuroanatomy phenotype of Rac1N17.UAS, Scer\GAL4ato.3.6

      (Srahna et al., 2006)

      bskDN.UAS, Scer\GAL4Act5C.PI is a suppressor | partially of neoplasia | somatic clone phenotype of Ras85DV12.UAS, Scer\GAL4Act5C.PI, scrib1

      (Uhlirova and Bohmann, 2006)

      bskDN.UAS, Scer\GAL4Act5C.PI is a suppressor of lethal | somatic clone | third instar larval stage phenotype of Ras85DV12.UAS, Scer\GAL4Act5C.PI, scrib1

      (Uhlirova and Bohmann, 2006)

      bskDN.UAS is a suppressor of abnormal neuroanatomy phenotype of Hsap\APPUAS.Tag:MYC, Scer\GAL4P2.4.Pdf

      (Leyssen et al., 2005)

      bskDN.UAS, Scer\GAL4GMR.PF is a suppressor of visible phenotype of HUAS.cMa, Scer\GAL4GMR.PF

      (Müller et al., 2005)
      NOT Suppressor of
      Statement
      Reference

      bskDN.UAS/Scer\GAL4αTub84B.PL is a non-suppressor of increased cell death | somatic clone | larval stage phenotype of Rer1KO

      (Paul et al., 2024)

      bskDN.UAS, Scer\GAL4GMR.long is a non-suppressor | partially of visible | adult stage phenotype of Hsap\APP2xAPP.SP.UAS, Mnat9KK109382, Scer\GAL4GMR.long

      (Deshpande et al., 2023)

      bskDN.UAS, Scer\GAL4GMR.long is a non-suppressor | partially of decreased size | adult stage phenotype of Hsap\APP2xAPP.SP.UAS, Mnat9KK109382, Scer\GAL4GMR.long

      (Deshpande et al., 2023)

      bskDN.UAS, Scer\GAL4dpp.blk1 is a non-suppressor of abnormal cell migration | larval stage phenotype of HipkUAS.Tag:HA, Scer\GAL4dpp.blk1

      (Blaquiere et al., 2018)

      bskDN.UAS/Scer\GAL4GMR.PU is a non-suppressor of visible | adult stage phenotype of Scer\GAL4GMR.PU, mir-285UAS.DsRed(Unk)

      (Li et al., 2017)

      bskDN.UAS/Scer\GAL4en.PU is a non-suppressor of visible | adult stage phenotype of Scer\GAL4en.PU, mir-285UAS.DsRed(Unk)

      (Li et al., 2017)

      bskDN.UAS/Scer\GAL4en.PU is a non-suppressor of increased cell death | larval stage phenotype of Scer\GAL4en.PU, mir-285UAS.DsRed(Unk)

      (Li et al., 2017)

      bskDN.UAS/Scer\GAL4e22c is a non-suppressor of decreased size | adult stage phenotype of Scer\GAL4e22c, Tcs3KK101323

      (Rojas-Benítez et al., 2017)

      bskDN.UAS/Scer\GAL4e22c is a non-suppressor of visible | adult stage phenotype of Scer\GAL4e22c, Tcs3KK101323

      (Rojas-Benítez et al., 2017)

      bskDN.UAS, Scer\GAL4ap.PU is a non-suppressor of increased cell death | third instar larval stage phenotype of HPV18\E6UAS.Tag:MYC, Hsap\UBE3AUAS.cRa, Scer\GAL4ap.PU

      (Padash Barmchi et al., 2016)

      bskDN.UAS, Scer\GAL4hs.2sev is a non-suppressor of increased cell death phenotype of Mmus\Gria1Lc.UAS, Scer\GAL4hs.2sev

      (Yang et al., 2013)

      bskDN.UAS/Scer\GAL4GMR.PF is a non-suppressor of increased cell death phenotype of Scer\GAL4GMR.PF, nopoUAS.cUa

      (Ma et al., 2012)

      bskDN.UAS/Scer\GAL4ey.PU is a non-suppressor of abnormal size | third instar larval stage phenotype of Scer\GAL4ey.PU, vitoGD10890

      (Marinho et al., 2011)

      bskDN.UAS, Scer\GAL4Antp-10 is a non-suppressor of increased cell number | third instar larval stage phenotype of ND-75KK108222, Scer\GAL4Antp-10

      (Sinenko et al., 2011)

      bskDN.UAS, Scer\GAL4Act.PU is a non-suppressor of neoplasia | somatic clone phenotype of Ras85DV12.UAS, Scer\GAL4Act.PU, upd1UAS.cUa

      (Wu et al., 2010)

      bskDN.UAS is a non-suppressor of abnormal neuroanatomy phenotype of AblUAS.cFa, Scer\GAL4P2.4.Pdf

      (Leyssen et al., 2005)
      Other
      Statement
      Reference

      Hsap\APP2xAPP.SP.UAS, Mnat9UAS.ORF.GW.Tag:HA, Scer\GAL4GMR.long, bskDN.UAS has increased cell death | larval stage phenotype

      (Deshpande et al., 2023)

      RpL27A1, Scer\GAL4en.PU, bskDN.UAS, l(2)glGD4047 has partially lethal - majority die phenotype

      (Grifoni et al., 2015)

      Scer\GAL4GMR.PU, bskDN.UAS, egrUAS.cIa has visible phenotype

      (Chabu and Xu, 2014)

      Scer\GAL4GMR.PU, TaceGD572, bskDN.UAS, egrUAS.cIa has increased cell death phenotype

      (Chabu and Xu, 2014)

      Scer\GAL4GMR.PU, TaceGD572, bskDN.UAS, egrUAS.cIa has majority die during pupal stage phenotype

      (Chabu and Xu, 2014)

      Scer\GAL4GMR.PU, TaceRNAi.UAS.cSa, bskDN.UAS, egrUAS.cIa has increased cell death phenotype

      (Chabu and Xu, 2014)

      Scer\GAL4GMR.PU, TaceRNAi.UAS.cSa, bskDN.UAS, egrUAS.cIa has majority die during pupal stage phenotype

      (Chabu and Xu, 2014)

      Scer\GAL4GR1, bskDN.UAS, drprI.UAS has lethal phenotype

      (Etchegaray et al., 2012)

      Scer\GAL4Tub.PU, bskDN.UAS, l(2)gl4 has increased cell number | somatic clone phenotype

      (Froldi et al., 2010)

      Scer\GAL4Tub.PU, bskDN.UAS, l(2)gl4 has abnormal cell polarity | somatic clone phenotype

      (Froldi et al., 2010)

      Scer\GAL4Tub.PU, bskDN.UAS, l(2)gl4 has decreased cell number | somatic clone phenotype

      (Froldi et al., 2010)

      Dcp-1UAS.cKa, Scer\GAL4GMR.PF, bskDN.UAS has lethal phenotype

      (Kim et al., 2010)

      DeltaUAS.cDa, Scer\GAL4ey.PH, bskDN.UAS has neoplasia phenotype

      (Bossuyt et al., 2009)

      DeltaUAS.cDa, Scer\GAL4ey.PH, atoUAS.cJa, bskDN.UAS, lolaGS88A8, psqGS88A8 has neoplasia phenotype

      (Bossuyt et al., 2009)

      Ras85DV12.UAS, Scer\GAL4Act5C.PI, bskDN.UAS, egrUAS.cIa, shgk03401 has neoplasia | somatic clone phenotype

      (Igaki et al., 2006)

      Ras85DV12.UAS, Scer\GAL4Act5C.PI, bskDN.UAS, scrib1 has lethal | somatic clone | pharate adult stage phenotype

      (Uhlirova and Bohmann, 2006)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Scer\GAL4GMR.PU, bskDN.UAS, egrUAS.cIa has eye phenotype, enhanceable by TaceGD572/Scer\GAL4GMR.PU

      (Chabu and Xu, 2014)

      Scer\GAL4GMR.PU, bskDN.UAS, egrUAS.cIa has eye phenotype, enhanceable by TaceRNAi.UAS.cSa/Scer\GAL4GMR.PU

      (Chabu and Xu, 2014)

      Scer\GAL4ato.3.6, bskDN.UAS has axon & dorsal cluster neuron phenotype, enhanceable by dsh1

      (Srahna et al., 2006)

      Scer\GAL4ap-md544, bskDN.UAS has thorax phenotype, enhanceable by Traf1[+]/Traf4ex1

      (Cha et al., 2003)
      NOT Enhanced by
      Statement
      Reference

      Hsap\APP2xAPP.SP.UAS, Scer\GAL4GMR.long, bskDN.UAS has eye phenotype, non-enhanceable by Mnat9KK109382, Scer\GAL4GMR.long

      (Deshpande et al., 2023)

      Scer\GAL4ato.3.6, bskDN.UAS has axon & dorsal cluster neuron phenotype, non-enhanceable by Rac1N17.UAS, Scer\GAL4ato.3.6

      (Srahna et al., 2006)
      Suppressed by
      NOT suppressed by
      Statement
      Reference

      Hsap\APP2xAPP.SP.UAS, Scer\GAL4GMR.long, bskDN.UAS has eye phenotype, non-suppressible by Mnat9KK109382, Scer\GAL4GMR.long

      (Deshpande et al., 2023)

      Scer\GAL4ato.3.6, bskDN.UAS has medulla phenotype, non-suppressible by PakUAS.Tag:Myr(Src64B), Scer\GAL4ato.3.6

      (Langen et al., 2013)

      Scer\GAL4ato.3.6, bskDN.UAS has medulla phenotype, non-suppressible by NECN.UAS, Scer\GAL4ato.3.6

      (Langen et al., 2013)

      Scer\GAL4ato.3.6, bskDN.UAS has axon & dorsal cluster neuron phenotype, non-suppressible by Rac1N17.UAS, Scer\GAL4ato.3.6

      (Srahna et al., 2006)
      Enhancer of
      NOT Enhancer of
      Suppressor of
      Statement
      Reference

      bskDN.UAS, Scer\GAL4GMR.long is a suppressor | partially of eye phenotype of Hsap\APP2xAPP.SP.UAS, Scer\GAL4GMR.long

      (Deshpande et al., 2023)

      bskDN.UAS, Scer\GAL4GMR.long is a suppressor | partially of eye phenotype of Hsap\APP2xAPP.SP.UAS, Mnat9KK109382, Scer\GAL4GMR.long

      (Deshpande et al., 2023)

      bskDN.UAS, Scer\GAL4GMR.long is a suppressor | partially of eye disc | larval stage phenotype of Hsap\APP2xAPP.SP.UAS, Scer\GAL4GMR.long

      (Deshpande et al., 2023)

      bskDN.UAS, Scer\GAL4GMR.long is a suppressor | partially of eye disc | larval stage phenotype of Hsap\APP2xAPP.SP.UAS, Mnat9KK109382, Scer\GAL4GMR.long

      (Deshpande et al., 2023)

      bskDN.UAS, Scer\GAL4hh.PU is a suppressor | partially of wing disc posterior compartment | larval stage phenotype of Paip1GD13792, Scer\GAL4hh.PU

      (Xue et al., 2023)

      bskDN.UAS/Scer\GAL4Act.PU is a suppressor | partially of eye-antennal disc | somatic clone phenotype of Scer\GAL4Act.PU, Xbp1UAS.s.Tag:V5, scrib1

      (Zheng et al., 2023)

      bskDN.UAS, Scer\GAL4Act.PU is a suppressor | partially of eye-antennal disc | somatic clone phenotype of Ire1UAS.Tag:V5, Scer\GAL4Act.PU, scrib1

      (Zheng et al., 2023)

      bskDN.UAS, Atg13G6421/Atg13G6421 is a suppressor of eye-antennal disc | somatic clone phenotype of Ire1UAS.Tag:V5, Scer\GAL4Act.PU, scrib1

      (Zheng et al., 2023)

      bskDN.UAS, Atg600096/Atg600096 is a suppressor of eye-antennal disc | somatic clone phenotype of Ire1UAS.Tag:V5, Scer\GAL4Act.PU, scrib1

      (Zheng et al., 2023)

      bskDN.UAS/Scer\GAL4Act.PU is a suppressor of eye-antennal disc | somatic clone phenotype of scrib1

      (Zheng et al., 2023)

      bskDN.UAS/Scer\GAL4Act.PU is a suppressor | partially of autophagosome | increased number | somatic clone | larval stage phenotype of scrib1

      (Zheng et al., 2023)

      bskDN.UAS/Scer\GAL4ptc-559.1 is a suppressor | partially of anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype of Scer\GAL4ptc-559.1, Toll-7C993Y.UAS.Tag:FLAG

      (Ding et al., 2022)

      bskDN.UAS/ZnT86DKK101698, Scer\GAL4Act.PU is a suppressor of eye-antennal disc | larval stage | somatic clone - tissue specific phenotype of RafUAS.F179, Scer\GAL4Act.PU, scrib1

      (Wei et al., 2021)

      bskDN.UAS, Scer\GAL4Act.PU is a suppressor of eye-antennal disc | larval stage | somatic clone - tissue specific phenotype of RafUAS.F179, Scer\GAL4Act.PU, scrib1

      (Wei et al., 2021)

      bskDN.UAS/ZnT86DKK101698, Scer\GAL4Act.PU is a suppressor of gonad | larval stage | somatic clone - tissue specific phenotype of RafUAS.F179, Scer\GAL4Act.PU, scrib1

      (Wei et al., 2021)

      bskDN.UAS, Scer\GAL4Act.PU is a suppressor of gonad | larval stage | somatic clone - tissue specific phenotype of RafUAS.F179, Scer\GAL4Act.PU, scrib1

      (Wei et al., 2021)

      bskDN.UAS/ZnT86DKK101698, Scer\GAL4Act.PU is a suppressor of embryonic/larval brain | larval stage | somatic clone - tissue specific phenotype of RafUAS.F179, Scer\GAL4Act.PU, scrib1

      (Wei et al., 2021)

      bskDN.UAS, Scer\GAL4Act.PU is a suppressor of embryonic/larval brain | larval stage | somatic clone - tissue specific phenotype of RafUAS.F179, Scer\GAL4Act.PU, scrib1

      (Wei et al., 2021)

      bskDN.UAS/ZnT86DKK101698, Scer\GAL4Act.PU is a suppressor of larval ventral nerve cord | larval stage | somatic clone - tissue specific phenotype of RafUAS.F179, Scer\GAL4Act.PU, scrib1

      (Wei et al., 2021)

      bskDN.UAS, Scer\GAL4Act.PU is a suppressor of larval ventral nerve cord | larval stage | somatic clone - tissue specific phenotype of RafUAS.F179, Scer\GAL4Act.PU, scrib1

      (Wei et al., 2021)

      bskDN.UAS, Scer\GAL4Act.PU is a suppressor | partially of eye disc | larval stage phenotype of RafUAS.F179, Scer\GAL4Act.PU, scrib1

      (Wei et al., 2021)

      bskDN.UAS, Scer\GAL4Act.PU is a suppressor | partially of autophagosome | larval stage phenotype of RafUAS.F179, Scer\GAL4Act.PU, scrib1

      (Wei et al., 2021)

      bskDN.UAS/ZnT86DKK101698, Scer\GAL4Act.PU is a suppressor | partially of eye disc | larval stage phenotype of RafUAS.F179, Scer\GAL4Act.PU, scrib1

      (Wei et al., 2021)

      bskDN.UAS/ZnT86DKK101698, Scer\GAL4Act.PU is a suppressor | partially of autophagosome | larval stage phenotype of RafUAS.F179, Scer\GAL4Act.PU, scrib1

      (Wei et al., 2021)

      bskDN.UAS/Scer\GAL4ey.PU is a suppressor of eye disc | larval stage phenotype of Scer\GAL4ey.PU, ZnT86DHMS02884

      (Wei et al., 2021)

      bskDN.UAS/Scer\GAL4ey.PU is a suppressor of autophagosome | larval stage phenotype of Scer\GAL4ey.PU, ZnT86DHMS02884

      (Wei et al., 2021)

      bskDN.UAS/Scer\GAL4Tub.PU is a suppressor of adult midgut epithelium | somatic clone phenotype of kis10D26

      (Gervais et al., 2019)

      bskDN.UAS/Scer\GAL4Tub.PU is a suppressor of intestinal stem cell | somatic clone | adult stage phenotype of kis10D26

      (Gervais et al., 2019)

      bskDN.UAS/Scer\GAL4ptc-559.1 is a suppressor | partially of anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype of Scer\GAL4ptc-559.1, armUAS.Exel

      (Zhang et al., 2019)

      bskDN.UAS/Scer\GAL4ptc-559.1 is a suppressor | partially of anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype of Scer\GAL4ptc-559.1, scribGD11666

      (Zhang et al., 2019)

      ykiHMS00041/bskDN.UAS, Scer\GAL4dpp.blk1 is a suppressor of wing disc phenotype of HipkUAS.Tag:HA, Scer\GAL4dpp.blk1

      (Blaquiere et al., 2018)

      bskDN.UAS/Scer\GAL4ap-md544 is a suppressor | partially of wing disc dorsal compartment | third instar larval stage phenotype of Scer\GAL4ap-md544, pnutGD1512

      (Gerlach et al., 2018)

      bskDN.UAS, Scer\GAL4Act5C.PI is a suppressor of eye-antennal disc | somatic clone phenotype of Hsap\S100A4wt.UAS, Ras85DV12.UAS, Scer\GAL4Act5C.PI

      (Ismail et al., 2017)

      bskDN.UAS, Scer\GAL4Act5C.PI is a suppressor of larval ventral nerve cord | somatic clone | larval stage phenotype of Hsap\S100A4wt.UAS, Ras85DV12.UAS, Scer\GAL4Act5C.PI

      (Ismail et al., 2017)

      bskDN.UAS, Scer\GAL4FRT.Act5C is a suppressor | somatic clone of eye-antennal disc | somatic clone | third instar larval stage phenotype of Ras85DV12.UAS, Scer\GAL4FRT.Act5C, fmt1

      (Ma et al., 2017)

      bskDN.UAS, Scer\GAL4FRT.Act5C is a suppressor | somatic clone of eye-antennal disc | somatic clone | third instar larval stage phenotype of PpVΔ1, Ras85DV12.UAS, Scer\GAL4FRT.Act5C

      (Ma et al., 2017)

      bskDN.UAS/Scer\GAL4ptc.PU is a suppressor | partially of anterior crossvein phenotype of Scer\GAL4ptc.PU, fmtGD6928

      (Ma et al., 2017)

      bskDN.UAS/Scer\GAL4Dll-md23 is a suppressor of embryonic/larval brain | somatic clone | third instar larval stage phenotype of scrib1

      (Rives-Quinto et al., 2017)

      bskDN.UAS/Scer\GAL4Act.PU is a suppressor of wing disc | somatic clone | wandering third instar larval stage phenotype of Scer\GAL4Act.PU, wupAJF02172

      (Casas-Tintó et al., 2016)

      bskDN.UAS/Scer\GAL4Tub.PU is a suppressor | somatic clone of intestinal stem cell of posterior adult midgut epithelium | somatic clone phenotype of Apc2g10, ApcQ8

      (Suijkerbuijk et al., 2016)

      bskDN.UAS, Scer\GAL4bun-GSG5961, Scer\GAL4GSG5966 is a suppressor | RU486 conditional of intestinal stem cell of posterior adult midgut epithelium | somatic clone phenotype of Apc2g10, ApcQ8

      (Suijkerbuijk et al., 2016)

      bskDN.UAS, Scer\GAL4bun-GSG5961, Scer\GAL4GSG5966 is a suppressor | RU486 conditional of intestinal stem cell of posterior adult midgut epithelium | somatic clone | cell non-autonomous phenotype of Apc2g10, ApcQ8

      (Suijkerbuijk et al., 2016)

      bskDN.UAS/Scer\GAL4GSG2326 is a suppressor | cell non-autonomous of intestinal stem cell of posterior adult midgut epithelium | somatic clone phenotype of Apc2g10, ApcQ8

      (Suijkerbuijk et al., 2016)

      bskDN.UAS, Scer\GAL4en.PU is a suppressor of tracheal section | ectopic phenotype of RpL27A1, Scer\GAL4en.PU, l(2)glGD4047

      (Grifoni et al., 2015)

      bskDN.UAS, Scer\GAL4en.PU is a suppressor of wing disc phenotype of RpL27A1, Scer\GAL4en.PU, l(2)glGD4047

      (Grifoni et al., 2015)

      bskDN.UAS/Scer\GAL4GMR.PF is a suppressor of eye phenotype of Scer\GAL4GMR.PF, egrUAS.cIa

      (Zhang et al., 2015, Ma et al., 2012)

      bskDN.UAS/Scer\GAL4Su(H).GBE is a suppressor | partially of adult anterior midgut epithelium phenotype of Sox21a6

      (Zhai et al., 2015)

      bskDN.UAS/Scer\GAL4NP0001 is a suppressor | partially of adult anterior midgut epithelium phenotype of Sox21a6

      (Zhai et al., 2015)

      bskDN.UAS, Scer\GAL4ato.3.6 is a suppressor of medulla phenotype of NECN.UAS, Scer\GAL4ato.3.6

      (Langen et al., 2013)

      bskDN.UAS, Scer\GAL4ato.3.6 is a suppressor of medulla phenotype of PakUAS.Tag:Myr(Src64B), Scer\GAL4ato.3.6

      (Langen et al., 2013)

      bskDN.UAS/Scer\GAL4Act5C.PP is a suppressor of eye | somatic clone phenotype of Pten117

      (Nowak et al., 2013)

      bskDN.UAS/Scer\GAL4Act5C.PP is a suppressor of eye | somatic clone | nutrition conditional phenotype of Pten117

      (Nowak et al., 2013)

      bskDN.UAS/Scer\GAL4ap-md544 is a suppressor of wing disc phenotype of Scer\GAL4ap-md544, Vha44UAS.Tag:HA

      (Petzoldt et al., 2013)

      bskDN.UAS, Scer\GAL4byn-Gal4 is a suppressor | partially of adult hindgut phenotype of Ras85DV12.UAS, Scer\GAL4byn-Gal4

      (Bangi et al., 2012)

      bskDN.UAS, Scer\GAL4byn-Gal4 is a suppressor | partially of adult abdomen phenotype of Ras85DV12.UAS, Scer\GAL4byn-Gal4

      (Bangi et al., 2012)

      bskDN.UAS/Scer\GAL4αTub84B.PL is a suppressor of germline cell | embryonic stage 15 phenotype of raw155.27/raw134.47

      (Jemc et al., 2012)

      bskDN.UAS/Scer\GAL4ey.PU is a suppressor | partially of eye disc phenotype of Scer\GAL4ey.PU, vitoGD10890

      (Marinho et al., 2011)

      bskDN.UAS, Scer\GAL4GMR.PU is a suppressor of eye disc phenotype of Hsap\APPAβ42.UAS.cUa, Scer\GAL4GMR.PU

      (Tare et al., 2011)

      bskDN.UAS, Scer\GAL4GMR.PU is a suppressor of eye phenotype of Hsap\APPAβ42.UAS.cUa, Scer\GAL4GMR.PU

      (Tare et al., 2011)

      bskDN.UAS, Scer\GAL4dpp.blk1 is a suppressor of wing disc | third instar larval stage phenotype of Rho1UAS.cMa, Scer\GAL4dpp.blk1

      (Neisch et al., 2010)

      bskDN.UAS, Scer\GAL4ap-md544 is a suppressor of wing disc phenotype of GliUAS.cPa, Scer\GAL4ap-md544

      (Padash-Barmchi et al., 2010)

      bskDN.UAS, Scer\GAL4Act.PU is a suppressor of eye disc | somatic clone phenotype of Ras85DV12.UAS, Scer\GAL4Act.PU, scrib1

      (Wu et al., 2010)

      bskDN.UAS, Scer\GAL4elav.PLu is a suppressor of NMJ bouton phenotype of Atg1UAS.cSa, Scer\GAL4elav.PLu

      (Shen and Ganetzky, 2009)

      bskDN.UAS, Scer\GAL4elav.PLu is a suppressor of neuromuscular junction phenotype of Atg1UAS.cSa, Scer\GAL4elav.PLu

      (Shen and Ganetzky, 2009)

      bskDN.UAS/Scer\GAL4GMR.PF is a suppressor | partially of eye phenotype of Ras85DKP

      (Wu et al., 2009)

      bskDN.UAS, Scer\GAL4Act5C.PU is a suppressor of eye-antennal disc | somatic clone phenotype of Ras85DV12.UAS, Scer\GAL4Act5C.PU, scrib1

      (Srivastava et al., 2007)

      bskDN.UAS/Scer\GAL448Y is a suppressor | partially of embryonic/larval anterior midgut phenotype of pucGS16811

      (Taniguchi et al., 2007)

      bskDN.UAS/Scer\GAL4NP3392 is a suppressor | partially of embryonic/larval anterior midgut phenotype of pucGS16811

      (Taniguchi et al., 2007)

      bskDN.UAS, bsk1, bsk[+], Scer\GAL4NP3392 is a suppressor of embryonic/larval anterior midgut phenotype of pucGS16811

      (Taniguchi et al., 2007)

      bskDN.UAS/Scer\GAL4ey.PH is a suppressor of eye disc | ventral phenotype of L2

      (Singh et al., 2006)

      bskDN.UAS/Scer\GAL4ey.PH is a suppressor of eye | ventral phenotype of L2

      (Singh et al., 2006)

      bskDN.UAS, Scer\GAL4ato.3.6 is a suppressor of axon & dorsal cluster neuron phenotype of Rac1N17.UAS, Scer\GAL4ato.3.6

      (Srahna et al., 2006)

      bskDN.UAS/Scer\GAL4Act5C.PI is a suppressor of eye-antennal disc | somatic clone phenotype of Ras85DV12.UAS

      (Uhlirova and Bohmann, 2006)

      bskDN.UAS, Scer\GAL4Act5C.PI is a suppressor of larval ventral nerve cord | somatic clone phenotype of Ras85DV12.UAS, Scer\GAL4Act5C.PI, scrib1

      (Igaki et al., 2006, Uhlirova and Bohmann, 2006)

      bskDN.UAS, Scer\GAL4Act5C.PI is a suppressor of embryonic/larval brain | somatic clone phenotype of Ras85DV12.UAS, Scer\GAL4Act5C.PI, scrib1

      (Uhlirova and Bohmann, 2006)

      bskDN.UAS is a suppressor of ventral adult lateral neuron & axon phenotype of Hsap\APPUAS.Tag:MYC, Scer\GAL4P2.4.Pdf

      (Leyssen et al., 2005)

      bskDN.UAS, Scer\GAL4GMR.PF is a suppressor of eye phenotype of HUAS.cMa, Scer\GAL4GMR.PF

      (Müller et al., 2005)

      bskDN.UAS/Scer\GAL4GMR.PF is a suppressor of eye phenotype of Scer\GAL4GMR.PF, egrGS9830

      (Igaki et al., 2002)

      bskDN.UAS/Scer\GAL4GMR.PF is a suppressor | partially of eye phenotype of Scer\GAL4GMR.PF, rprUAS.cIa

      (Kuranaga et al., 2002)
      NOT Suppressor of
      Statement
      Reference

      bskDN.UAS, Scer\GAL4GMR.long is a non-suppressor | partially of eye phenotype of Hsap\APP2xAPP.SP.UAS, Mnat9KK109382, Scer\GAL4GMR.long

      (Deshpande et al., 2023)

      bskDN.UAS, Scer\GAL4Act.PU is a non-suppressor of eye disc | somatic clone | larval stage phenotype of BacA\p35UAS.cUa, Scer\GAL4Act.PU, hidUAS.cUa

      (Farrell et al., 2022)

      bskDN.UAS, Scer\GAL4Act.PU is a non-suppressor of filamentous actin | somatic clone | larval stage phenotype of BacA\p35UAS.cUa, Scer\GAL4Act.PU, hidUAS.cUa

      (Farrell et al., 2022)

      bskDN.UAS/Scer\GAL4GMR.PU is a non-suppressor of eye phenotype of Scer\GAL4GMR.PU, mir-285UAS.DsRed(Unk)

      (Li et al., 2017)

      bskDN.UAS/Scer\GAL4en.PU is a non-suppressor of wing phenotype of Scer\GAL4en.PU, mir-285UAS.DsRed(Unk)

      (Li et al., 2017)

      bskDN.UAS/Scer\GAL4en.PU is a non-suppressor of wing disc phenotype of Scer\GAL4en.PU, mir-285UAS.DsRed(Unk)

      (Li et al., 2017)

      bskDN.UAS/Scer\GAL4e22c is a non-suppressor of wing phenotype of Scer\GAL4e22c, Tcs3KK101323

      (Rojas-Benítez et al., 2017)

      bskDN.UAS, Scer\GAL4ap.PU is a non-suppressor of wing disc dorsal compartment | third instar larval stage phenotype of HPV18\E6UAS.Tag:MYC, Hsap\UBE3AUAS.cRa, Scer\GAL4ap.PU

      (Padash Barmchi et al., 2016)

      bskDN.UAS/Scer\GAL4sd-SG29.1 is a non-suppressor of epithelial cell phenotype of Scer\GAL4sd-SG29.1, Src64BUY1332

      (Fernández et al., 2014)

      bskDN.UAS, Scer\GAL4hs.2sev is a non-suppressor of eye phenotype of Mmus\Gria1Lc.UAS, Scer\GAL4hs.2sev

      (Yang et al., 2013)

      bskDN.UAS/Scer\GAL4GMR.PF is a non-suppressor of eye phenotype of Scer\GAL4GMR.PF, nopoUAS.cUa

      (Ma et al., 2012)

      bskDN.UAS, Scer\GAL4Antp-10 is a non-suppressor of lamellocyte | third instar larval stage phenotype of ND-75KK108222, Scer\GAL4Antp-10

      (Sinenko et al., 2011)

      bskDN.UAS, Scer\GAL4GMR.PU is a non-suppressor of eye phenotype of MsrAUAS.cCa, Scer\GAL4GMR.PU

      (Chung et al., 2010)

      bskDN.UAS, Scer\GAL4Act.PU is a non-suppressor of eye disc | somatic clone phenotype of Ras85DV12.UAS, Scer\GAL4Act.PU, upd1UAS.cUa

      (Wu et al., 2010)

      bskDN.UAS is a non-suppressor of ventral adult lateral neuron & axon phenotype of AblUAS.cFa, Scer\GAL4P2.4.Pdf

      (Leyssen et al., 2005)

      bskDN.UAS/Scer\GAL471B is a non-suppressor of wing phenotype of Scer\GAL471B, tkvCA.UAS

      (Adachi-Yamada et al., 1999)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expressing ykiHMS00041 and bskDN.UAS under the control of Scer\GAL4dpp.blk1 does not have a major effect in the wing disc.

      (Blaquiere et al., 2018)

      The co-expression of bskDN.UAS partially suppresses the third instar larval wing disc dorsal compartment apoptosis induced by the expression of pnutGD1512 from the second instar larval stage under the combined control of Scer\GAL4ap-md544 and Gal80[ts].

      The co-expression of bskDN.UAS enhances the third instar larval wing disc tumors induced by the co-expression of pnutGD1512 and ykiUAS.cHa from the second instar larval stage under the combined control of Scer\GAL4ap-md544 and Gal80[ts].

      (Gerlach et al., 2018)

      The strong tumorigenic activity of Scer\GAL4Scer\FRT.Act5C>Ras85DV12.Scer\UAS;fmt1/fmt1 MARCM clones in third instar larval eye-antennal discs is strongly impeded and their invasive capacity abolished by co-expression of bskDN.Scer\UAS in the clones.

      Similarly, the tumorigenicity of Ras85DV12.Scer\UAS-expressing clones is also enhanced if the clones are mutant for PpVΔ1, they display invasive behavior and increased mitotic activity; these characteristics are suppressed by co-expression of bskDN.Scer\UAS.

      The partial or complete loss of the wing anterior crossvein in flies expressing fmtGD6928 under the control of Scer\GAL4ptc.PU is partially suppressed by co-expression of bskDN.Scer\UAS.

      (Ma et al., 2017)

      The small size of Type II neuroblast lineage MARCM clones mutant for scrib1 in third instar larvae can be rescued by expression of bskDN.Scer\UAS under the control of Scer\GAL4Dll-md23 in the mutant clones, these clones are also recovered more frequently than scrib1-only mutant clones.

      (Rives-Quinto et al., 2017)

      The shortening of the dendritic arbor in class IV ddaC neurons in third instar larvae expressing prelScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4109(2)80 is slightly enhanced by co-expression of bskDN.Scer\UAS.

      (Tsuyama et al., 2017)

      The co-expression of bskDN.Scer\UAS suppresses the decreased relative clonal area of somatic clones expressing wupAJF02172 under the control of Scer\GAL4Act.PU in wandering third instar larval wing discs.

      (Casas-Tintó et al., 2016)

      Expression of bskDN.Scer\UAS under the control of Scer\GAL4bun-GSG5961 and Scer\GAL4GSG5966 (along with RU486 to induce expression via the GeneSwitch system) in the gut fully restores growth of wild type clones in the presence of ApcQ8/ApcQ8, Apc2g10/Apc2g10 mutant clones in the posterior midgut, and suppresses the growth of ApcQ8/ApcQ8, Apc2g10/Apc2g10 mutant clones. ApcQ8/ApcQ8, Apc2g10/Apc2g10 mutant clones expressing bskDN.Scer\UAS under the control of Scer\GAL4tub.PU also show suppressed growth. Expression of bskDN.Scer\UAS in host tissue only, under the control of Scer\GAL4GSG2326, severely suppresses growth of ApcQ8/ApcQ8, Apc2g10/Apc2g10 mutant clones.

      (Suijkerbuijk et al., 2016)

      Expression of bskDN.Scer\UAS suppresses the tumor growth seen when l(2)glGD4047 is expressed under the control of Scer\GAL4en.PU in a minute background (RpL27A1). Individuals differentiate into adult pharates and a small proportion of the pupae eclose into adults with no evident phenotypic alterations.

      (Grifoni et al., 2015)

      Expression of bskDN.Scer\UAS in enteroblasts under the control of Scer\GAL4Su(H).GBE reduces tumor formation in the anterior midgut of Sox21a6 mutant flies. Expression of bskDN.Scer\UAS in enterocytes under the control of Scer\GAL4Myo31DF-NP0001 also suppresses tumor formation and the presence of delaminating enterocytes.

      (Zhai et al., 2015)

      Co-expression of egrScer\UAS.cIa and bskDN.Scer\UAS under the control of Scer\GAL4GMR.PU results in a moderate hanging eye phenotype.

      Expression of TaceGD572 enhances the hanging eye phenotype seen when egrScer\UAS.cIa and bskDN.Scer\UAS are co-expressed under the control of Scer\GAL4GMR.PU. The majority of these triple mutant animals die in late pupal stages and show a ring of necrotic tissue around the eyes.

      Expression of TacedsRNA.Scer\UAS enhances the hanging eye phenotype seen when egrScer\UAS.cIa and bskDN.Scer\UAS are co-expressed under the control of Scer\GAL4GMR.PU. The majority of these triple mutant animals die in late pupal stages and show a ring of necrotic tissue around the eyes.

      Expression of bskDN.Scer\UAS suppresses the increased cell death seen in eye-antennal disc clones expressing Ras85DV12.Scer\UAS under the control of Scer\GAL4Act.PU in a Sec151 mutant background. Tumor growth is not restored to that seen in clones expressing Ras85DV12.Scer\UAS alone.

      (Chabu and Xu, 2014)

      The number of medulla axons in animals co-expressing both bskDN.Scer\UAS and NECN.Scer\UAS under the control of Scer\GAL4ato.3.6 is similar to that seen in animals expressing bskDN.Scer\UAS alone under the control of Scer\GAL4ato.3.6.

      The number of medulla axons in animals co-expressing both bskDN.Scer\UAS and PakScer\UAS.T:Myr-Src64B under the control of Scer\GAL4ato.3.6 is similar to that seen in animals expressing bskDN.Scer\UAS alone under the control of Scer\GAL4ato.3.6.

      (Langen et al., 2013)

      Expression of bskDN.Scer\UAS in Pten117 eye clones (using the MARCM system) efficiently blocks apoptosis and enhanced the overgrowth phenotype.

      (Nowak et al., 2013)

      Co-expression of bskDN.Scer\UAS suppresses the wing disc overgrowth caused by expression of Vha44Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4ap-md544.

      (Petzoldt et al., 2013)

      Co-expression of bskDN.Scer\UAS partially suppresses the dissemination of hindgut cells seen in flies expressing Ras85DV12.Scer\UAS under the control of Scer\GAL4byn-Gal4.

      (Bangi et al., 2012)

      Expression of bskDN.Scer\UAS suppresses the enhancement of aversive long term memory seen when hiwΔRING.Scer\UAS is expressed under the control of Scer\GAL4NP4132. Learning is unaffected.

      (Huang et al., 2012)

      Expression of bskDN.Scer\UAS using Scer\GAL4αTub84B.PL suppresses the frequency of ensheathment defects in raw134.47/raw155.27 mutants.

      (Jemc et al., 2012)

      Co-expression of bskDN.Scer\UAS does not suppress the small, rough eye phenotype found upon expression of nopoScer\UAS.cUa under the control of Scer\GAL4GMR.PF.

      egrScer\UAS.cIa-induced cell death is partially suppressed by co-expression of bskDN.Scer\UAS under the control of Scer\GAL4GMR.PF.

      (Ma et al., 2012)

      Co-expression of bskDN.Scer\UAS in the Scer\GAL4ey.PU, vitoGD10890 background partially suppresses the increased apoptosis phenotype, but eye disc size is not rescued.

      (Marinho et al., 2011)

      Expression of bskDN.Scer\UAS under the control of Scer\GAL4Act.PU in the cells surrounding scrib1 clones in the eye-antennal disc significantly suppresses the elimination of the mutant scrib1 clones compared to that seen when the cells surrounding the clone are wild type.

      (Ohsawa et al., 2011)

      Expression of bskDN.Scer\UAS does not suppress the increase in circulating lamellocytes seen when ND75KK108222 is expressed under the control of Scer\GAL4Antp-10.

      (Sinenko et al., 2011)

      Co-expression of bskDN.Scer\UAS dramatically rescues the increase in cell death seen in the third larval instar eye disc of animals expressing Hsap\APPAβ42.Scer\UAS.cUa under the control of Scer\GAL4GMR.PU and also strongly rescues the reduced size of the adult eye.

      (Tare et al., 2011)

      Expression of bskDN.Scer\UAS in Ras85DV12.Scer\UAS, Scer\GAL4Scer\FRT.Act5C /dorC107 clones suppresses the enhanced tumour overgrowth and metastasis.

      (Chi et al., 2010)

      Wing pouch clones expressing bskDN.Scer\UAS under the control of Scer\GAL4tub.PU in a l(2)gl4 mutant background do not show increased apoptosis, but are smaller in size than wild type controls. In contrast, clones in the proximal regions of the wing disc lose polarity and overgrow.

      (Froldi et al., 2010)

      Co-expression of bskDN.Scer\UAS and Dcp-1Scer\UAS.cKa (insertion line P{UAS-Dcp-1.K}19-2) under the control of Scer\GAL4GMR.PF is lethal.

      (Kim et al., 2010)

      Inhibition of the JNK pathway through expression of bskDN.Scer\UAS under the control of Scer\GAL4e22c suppresses the cell death induced by ectopic hppyScer\UAS.cLa expression.

      (Lam et al., 2010)

      Co-expression of bskDN.Scer\UAS suppresses the ectopic apoptosis in cells expressing Rho1Scer\UAS.cMa under the control of Scer\GAL4dpp.blk1.

      (Neisch et al., 2010)

      Co-expression of bskDN.Scer\UAS in wing discs expressing GliScer\UAS.cPa under the control of Scer\GAL4ap-md544 completely suppresses cell migration and apoptosis.

      (Padash-Barmchi et al., 2010)

      Expression of bskDN.Scer\UAS suppresses the tumors seen in scrib1 mutant eye-antennal disc clones that simultaneously express Ras85DV12.Scer\UAS under the control of Scer\GAL4Act.PU.

      Expression of bskDN.Scer\UAS does not suppress the tumors seen in eye-antennal disc clones that simultaneously express Ras85DV12.Scer\UAS and upd1Scer\UAS.cUa under the control of Scer\GAL4Act.PU.

      Expression of bskDN.Scer\UAS in eye-antennal disc clones that express Ras85DV12.Scer\UAS under the control of Scer\GAL4Act.PU, and in which adjacent cells are mutant for scrib1, partially suppresses the tumor phenotype. Few scrib1 cells remain in the tissue at late stages.

      (Wu et al., 2010)

      Co-expression of bskDN.Scer\UAS in the 'eyeful' (Scer\GAL4ey.PH, DlScer\UAS.cDa, psqGS88A8, lolaGS88A8) background leads to tumors in 61% of eyes and an approximately 7-fold increase in metastasis.

      Co-expression of bskDN.Scer\UAS in a Scer\GAL4ey.PH DlScer\UAS.cDa background leads to the induction of tumors and metastasis.

      Co-expression of bskDN.Scer\UAS in a atoScer\UAS.cJa 'eyeful' (Scer\GAL4ey.PH, DlScer\UAS.cDa, psqGS88A8, lolaGS88A8) background leads to a suppression of the inhibitory effects of atoScer\UAS.cJa on the 'eyeful' tumor phenotype, restoring tumor formation and enhancing metastasis.

      (Bossuyt et al., 2009)

      Expression of bskDN.Scer\UAS under the control of Scer\GAL4elav.PLu partially suppresses the high levels of autophagy and bouton number found upon expression of Atg1Scer\UAS.cSa under the control of Scer\GAL4elav.PLu.

      (Shen and Ganetzky, 2009)

      The eye phenotype in Ras85DKP mutant flies is partially suppressed by ectopic expression of bskDN.Scer\UAS in the eye under the control of Scer\GAL4GMR.PF.

      (Wu et al., 2009)

      Co-expression of bskDN.Scer\UAS suppresses the invasive behaviour of clones in the eye antennal disc which are expressing Ras85DV12.Scer\UAS under the control of Scer\GAL4Act5C and are also homozygous for scrib1.

      (Srivastava et al., 2007)

      Expression of bskDN.Scer\UAS under the control of Scer\GAL448Y significantly suppresses the defects in left-right asymmetry of the anterior midgut that are seen in homozygous pucGS16811 embryos.

      Expression of bskDN.Scer\UAS under the control of Scer\GAL4Gap1-NP3392 significantly suppresses the defects in left-right asymmetry of the anterior midgut that are seen in homozygous pucGS16811 embryos. This suppression is stronger if the embryos are also carrying bsk1/+.

      (Taniguchi et al., 2007)

      Co-expression of bskDN.Scer\UAS and Ras85DV12.Scer\UAS in scrib1 mutant clones completely blocks the invasion of the ventral nerve cord as well as secondary tumour foci formation.

      Expression of Ras85DV12.Scer\UAS, egrScer\UAS.cIa and bskDN.Scer\UAS, under the control of Scer\GAL4Act5C.PI in shgk03401 mutant larval cephalic complexes (brain, eye and antennal discs) induces tumor invasion of the ventral nerve cord.

      (Igaki et al., 2006)

      Expression of bskDN.Scer\UAS under the control of Scer\GAL4ey.PH results in rescue of the ventral eye loss of L2/+ mutants in 36% of cases.

      (Singh et al., 2006)

      Coexpression of bskDN.Scer\UAS and Rac1N17.Scer\UAS under the control of Scer\GAL4ato.3.6 results in the few dorsal cluster neuron axons crossing the optic chiasm, which is the same phenotype seen as single bskDN.Scer\UAS expression and is opposite to that seen when only Rac1N17.Scer\UAS is expressed.

      Expression of one copy of bskDN.Scer\UAS, under the control of Scer\GAL4ato.3.6, in dsh1 mutant animals results in a synergistic reduction of extension of dorsal cluster neuron axons, with 60% showing no axons crossing the optic chiasm.

      (Srahna et al., 2006)

      Expression of bskDN.Scer\UAS clones blocks the cell invasive phenotype of Scer\GAL4Act5C.PI>Ras85DV12.Scer\UAS, scrib1 eye/antennal imaginal disc clones. These clones still overgrow in the discs but never leave this structure. bskDN.Scer\UAS expression also rescues the larval lethality of Scer\GAL4Act5C.PI>Ras85DV12.Scer\UAS, scrib1 clone-bearing animals, with rescued animals progressing through most of metamorphosis and dying as pharate adults.

      (Uhlirova and Bohmann, 2006)

      Expression of bskDN.Scer\UAS, has no effect on Scer\GAL4P2.4.Pdf>AblScer\UAS.cFa-induced axonal arborization of the sLNv.

      (Leyssen et al., 2005)

      Expression of bskDN.Scer\UAS, under the control of Scer\GAL4ap-md544, in a Traf1ex1/+ background results in an enhancement of the thorax closure defect seen in Scer\GAL4ap-md544>bskDN.Scer\UAS flies. The Scer\GAL4ap-md544>bskDN.Scer\UAS, Traf1ex1 flies have a larger cleft and the notum structure is disruoted.

      (Cha et al., 2003)

      The addition of bskDN.Scer\UAS to egrGS9830, Scer\GAL4GMR.PF animals leads to a strong suppression of the eye phenotype.

      (Igaki et al., 2002)

      Does not suppress the phenotype caused by tkvCA.Scer\UAS expressed under the control of Scer\GAL471B.

      (Adachi-Yamada et al., 1999)
      Xenogenetic Interactions
      Statement
      Reference

      The additional co-expression of bskDN.Scer\UAS does not modify the adult wing defects and the rough eye phenotype observed upon the co-expression of HPV18\E6Scer\UAS.T:Hsap\MYC and Hsap\UBE3AScer\UAS.cRa under the control of Scer\GAL4ap.PU and Scer\GAL4GMR.PU, respectively.

      (Padash Barmchi et al., 2016)

      Expression of bskDN.Scer\UAS under the control of Scer\GAL4hs.2sev has no effect on the reduced adult eye size phenotype found in Scer\GAL4hs.2sev->Mmus\Gria1Lc.Scer\UAS flies.

      (Yang et al., 2013)

      Expression of bskDN.Scer\UAS suppresses the Scer\GAL4P2.4.Pdf>Hsap\APPScer\UAS.T:Hsap\MYC-dependent arborization of the sLNv.

      (Leyssen et al., 2005)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      BskDN
      (Uhlirova and Bohmann, 2006)
      JNKDN
      (Cha et al., 2003)
      bskDN.Scer\UAS
      bskDN.UAS
      bskDN
      (Cai et al., 2019, Pfleger et al., 2007)
      bsk[DN]
      (Tsuyama et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (140)