FB2024_03 , released June 25, 2024
Allele: Dmel\fwee202
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General Information
Symbol
Dmel\fwee202
Species
D. melanogaster
Name
FlyBase ID
FBal0247696
Feature type
allele
Associated gene
Dmel\fwe
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Rhiner et al., 2010)
Mutagen
Delta2-3 transposase
(Rhiner et al., 2010)
Progenitor genotype
P{EPgy2}fweEY08496
(Rhiner et al., 2010)
Cytology
Description

Imprecise excision of P{EPgy2}fweEY08496 resulting in the deletion of the 5' UTR and the first two exons of fwe, including the start ATG in exon 1.

(Rhiner et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:15,815,399..15,816,355 [-]
Comment:

Imprecise excision of P{EPgy2}fwe[EY08496], deleting 1.0 kb of DNA that spans the 5' UTR and first 2 coding exons of fwe.

(Rhiner et al., 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous fwee202 mutant cell clones survive initially in the wing imaginal disc epithelium, but they are gradually eliminated due to apoptosis.

      Posterior compartments of wing imaginal discs that are formed entirely by homozygous fwee202 mutant cell clones reach their final size before the neighbouring anterior compartment composed of RpL19unspecified/+ cells. The fwee202 mutant cell clones exhibit massive signs of apoptosis.

      (Rhiner et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      fwee202 is rescued by fweUASp.ubi

      (Rhiner et al., 2010)
      Not rescued by

      fwee202 is not rescued by fweUASp.Lose-A

      (Rhiner et al., 2010)

      fwee202 is not rescued by fweUASp.Lose-B

      (Rhiner et al., 2010)
      Comments

      Expression of fweScer\UAS.cRa under the control of Scer\GAL4αTub84B.PL in homozygous fwee202 mutant cell clones restores the survival of fwee202 mutant cells.

      Expression of fweScer\UAS.cRb under the control of Scer\GAL4αTub84B.PL in homozygous fwee202 mutant cell clones does not restore the survival of fwee202 mutant cells.

      Expression of fweScer\UAS.cRc under the control of Scer\GAL4αTub84B.PL in homozygous fwee202 mutant cell clones does not restore the survival of fwee202 mutant cells.

      (Rhiner et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      fwe202
      (Portela et al., 2010)
      fwee202
      (Rhiner et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)