FB2024_03 , released June 25, 2024
Allele: Dmel\fweEY08496
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General Information
Symbol
Dmel\fweEY08496
Species
D. melanogaster
Name
FlyBase ID
FBal0161190
Feature type
allele
Associated gene
Dmel\fwe
Associated Insertion(s)
P{EPgy2}fweEY08496
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{EPgy2}fweEY08496
Cytology
Description

P{EPgy2}flowerEY08496 is integrated into the 5'UTR OF flower.

(Yao et al., 2009)
Allele components
Component
Use(s)
Inserted element
P{EPgy2}
Regulatory region(s)
UASp
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      fweEY08496 homozygotes die as embryos or first instar larvae, most of the embryos display head involution defects and defects in dorsal closure are also occasionally observed. Compared to wild-type the kinetics of dorsal closure is significantly slower - in some cases this does not prevent final closure but leads to failure in others.

      (Nazario-Yepiz and Riesgo-Escovar, 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The embryonic cuticular defects and high embryonic mortality characteristic for both fweEY08496 and prg3 homozygous mutants are further enhanced by combination with either one or two copies of either prg3 or fweEY08496, respectively.

      (Nazario-Yepiz and Riesgo-Escovar, 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      fweDB56

      (Yao et al., 2009)

      fweDB25

      (Yao et al., 2009)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CG6151EY08496
      flowerEY08496
      fweEY08496
      (Nazario-Yepiz and Riesgo-Escovar, 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)