FlyBase Allele Report: Dmel\lz[77a7]

General Information

Symbol

Dmel\lz^77a7

Species

D. melanogaster

Name

FlyBase ID

FBal0035197

Feature type

allele

Associated gene

Dmel\lz

Associated Insertion(s)

Carried in Construct

Also Known As

lz^mr1

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

male recombination induced by dysgenesis

Nature of the Allele

Allele class

Mutagen

male recombination induced by dysgenesis

(Crew et al., 1997, Batterham et al., 1996)

Progenitor genotype

Cytology

Description

Deletion of 1398bp in the intronic region between exons II and III.

(Jackson Behan et al., 2005)

Deletion of the eye-specific enhancer in lz intron 2, between nucleotides 9585 and 10983 of accession number AJ217651.

(Siddall et al., 2003)

1398bp deletion within intron II (the lesion is identical to that in lz^50e).

(Flores et al., 1998)

Mutation of cistron A.

(Crew et al., 1997)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:9,286,839..9,288,236 [+]

Linked to:

mr15-mr13 restriction fragment

Comment:

A deletion which includes the eye-specific enhancer. 1398bp deletion within intron II.

(Siddall et al., 2003)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death

(Siddall et al., 2003)

visible

(Siddall et al., 2003, Yan et al., 2003, Behan et al., 2002, Stark and Carlson, 2000, Flores et al., 1998, Crew et al., 1997)

visible (with lz^gal4)

(Crew et al., 1997)

visible | recessive

(Batterham et al., 1996)

Phenotype Manifest In

Detailed Description

Statement

Reference

In lz^77a7 mutant third instar eye discs, R7 cells are not recruited to the ommatidia.

(Siddall et al., 2009)

lz^77a7 adults have a severe mutant eye phenotype. Ommatidia have too few cells or extra cells. Ectopic cell death is seen in third larval instar eye discs, between rows 7 and 12 posterior to the morphogenetic furrow.

(Siddall et al., 2003)

R7 development is incomplete.

(Behan et al., 2002)

Eye colour: red. Eyes of mutant flies are shiny compared to controls. The ocelli appear reasonably normal under low power SEM. The eyes have corneal nipples which look much like those of control flies under high power SEM except with more irregularities.

(Stark and Carlson, 2000)

Mutant flies show disruption of the organised ommatidial lattice, resulting in smooth eyes.

(Flores et al., 1998)

Rough eye phenotype: facets with multiple R7-like cells. 10% ommatidia have abnormal numbers of cells. The fenestrated membrane at the base of the retina is faulty; the holes through which the photoreceptor axons pass are enlarged and irregularly spaced. The sheer size of these holes allows entire clusters of photoreceptor cells to form an abnormal layer that displaces the first optic ganglion of the brain. Transheterozygotes with lz^gal4 exhibit severely roughened eyes.

(Crew et al., 1997)

Homozygotes have a severe rough eye phenotype. Lenses are fused or missing, and some lenses are ruptured. Bristles of the hair nerve group are missing. There is a total lack of ommatidial structure. The eyes have mottled pigmentation and black pock marks are visible on the surface of the eye. Defects in the structure of pigment cells are seen and the number of photoreceptor cells per ommatidium is abnormal. Failure of the fenestrated membrane is apparent, with holes allowing photoreceptor neurons to intermingle with interneurons of the lamina. The retina is smaller than normal. lz¹/lz^77a7 and lz^77a7/lz^g females show disruption of the ommatidia and black pock marking confined to the anterior portion of the eye.

(Batterham et al., 1996)

The number of large and small basiconic sensilla on the antennal funiculus is greatly reduced in hemizygous males, and the number of trichoid sensilla on the antennal funiculus is increased. The number of coeloconic sensilla on the antennal funiculus is normal. The density of the coeloconic and trichoid sensilla on the antennal funiculus is increased and the density of the basiconic sensilla on the antennal funiculus is decreased compared to wild-type.

(Stocker et al., 1993)

female fertile

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

lz^77a7 has increased cell death phenotype, suppressible by BacA\p35^GMR.PH

(Siddall et al., 2003)

NOT suppressed by

Statement

Reference

lz^77a7 has visible phenotype, non-suppressible by BacA\p35^GMR.PH

(Siddall et al., 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

lz^77a7 has phenotype, enhanceable by z^v77h

(Stocker et al., 1993)

Suppressed by

Statement

Reference

lz^77a7 has eye disc phenotype, suppressible by BacA\p35^GMR.PH

(Siddall et al., 2003)

NOT suppressed by

Statement

Reference

lz^77a7 has eye phenotype, non-suppressible by BacA\p35^GMR.PH

(Siddall et al., 2003)

Suppressor of

Statement

Reference

lz^77a7 is a suppressor of photoreceptor cell R7 | increased number | somatic clone | third instar larval stage phenotype of ttk^1e11

(Siddall et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

No recruitment of R7 precursor cells is observed when ttk^1e11 mutant cells are generated in a lz^77a7 background.

(Siddall et al., 2009)

Cell death is blocked in lz^77a7 eye discs that are also expressing BacA\p35^GMR.PH, but the lz^77a7 mutant eye phenotype persists in these double mutant animals.

(Siddall et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

Partially complements

lz³⁷

(Stocker et al., 1993)

Fails to complement

lz^r1

(Flores et al., 1998)

lz^50e

(Batterham et al., 1996)

lz^L

(Batterham et al., 1996)

lz^38.71

(Batterham et al., 1996)

lz^spm2a

(Batterham et al., 1996)

lz^ts1

(Stocker et al., 1993)

lz^K

(Stocker et al., 1993)

lz^g

(Stocker et al., 1993)

lz^50e

(Stocker et al., 1993)

lz³

(Stocker et al., 1993)

lz¹

(Stocker et al., 1993)

lz^b

(Stocker et al., 1993)

lz^L

(Stocker et al., 1993)

lz^38.71

(Stocker et al., 1993)

lz^spm2a

(Stocker et al., 1993)

Rescued by

lz^77a7 is rescued by lz^280.cYa

(Yan et al., 2003)

Comments

The smooth eye phenotype of lz^r7 and lz^r8 is fully complemented by lz^77a7. The smooth eye phenotype of lz^r1 is not complemented by lz^77a7.

(Flores et al., 1998)

Images (1)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type

Stocks (2)

3609

107125

Notes on Origin

Discoverer

M.M. Green.

Comments

Does not revert to wild-type under dysgenic conditions. lz^77a7 maps to the spectacle sublocus of lz.

(Batterham et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

lz^77a7(a)

(Stocker et al., 1993)

lz^77a7

(Mavromatakis and Tomlinson, 2013, Popodi et al., 2010-, Christensen et al., 2008.6.11, Christensen et al., 2008.6.11)

lz^mr1

(Siddall et al., 2009, Jackson Behan et al., 2005, Siddall et al., 2003, Behan et al., 2002, Batterham et al., 1996, Stocker et al., 1993)

Name Synonyms

Secondary FlyBase IDs

References (16)

Report Sections

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