FB2024_03 , released June 25, 2024
Allele: Dmel\lz12-4669
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General Information
Symbol
Dmel\lz12-4669
Species
D. melanogaster
Name
FlyBase ID
FBal0035196
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
lzts3
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Homozygotes show disruption of the ommatidial array at the posterior rim of the eye when raised at 18oC. When raised at 29oC there is a general lack of ommatidial structure. The eyes may have mottled pigmentation with black pock marks visible on the surface of the eye, or pigment may be dispersed as a ring around the edge of the eye ("spectacle" phenotype).

    The antennal funiculus is reduced in size in hemizygous males raised at 29oC. All large and small basiconic sensilla on the antennal funiculus are missing, and the number of trichoid sensilla on the antennal funiculus is reduced. The number of coeloconic sensilla on the antennal funiculus is normal. The density of the coeloconic and trichoid sensilla on the antennal funiculus is increased compared to wild-type. The number of large and small basiconic sensilla on the antennal funiculus is greatly reduced in hemizygous males raised at 18oC, and the number of trichoid sensilla on the antennal funiculus is increased. The number of coeloconic sensilla on the antennal funiculus is normal. The density of the trichoid sensilla on the antennal funiculus is increased and the density of the basiconic sensilla on the antennal funiculus is decreased compared to wild-type.

    No eggs are laid.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Enhanced by
    Statement
    Reference

    lz12-4669 has visible | recessive | heat sensitive phenotype, enhanceable by E(lz)151

    lz12-4669 has visible | recessive | heat sensitive phenotype, enhanceable by E(lz)531

    lz12-4669 has visible | recessive | heat sensitive phenotype, enhanceable by E(lz)1741

    lz12-4669 has visible | recessive | heat sensitive phenotype, enhanceable by E(lz)1781

    lz12-4669 has visible | recessive | heat sensitive phenotype, enhanceable by E(lz)2051

    Phenotype Manifest In
    Enhanced by
    Statement
    Reference

    lz12-4669 has eye phenotype, enhanceable by E(lz)151

    lz12-4669 has eye phenotype, enhanceable by E(lz)531

    lz12-4669 has eye phenotype, enhanceable by E(lz)1741

    lz12-4669 has eye phenotype, enhanceable by E(lz)1781

    lz12-4669 has eye phenotype, enhanceable by E(lz)2051

    Additional Comments
    Genetic Interactions
    Statement
    Reference

    The eye phenotype but not the antennal or maxillary palp sensilla phenotype of lz12-4669 flies is dominantly enhanced by E(lz)151, E(lz)531, E(lz)1741, E(lz)1781 and E(lz)2051.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (5)
    Reported As
    Name Synonyms
    Secondary FlyBase IDs
      References (4)