FlyBase Allele Report: Dmel\lz[mr2]

General Information

Symbol

Dmel\lz^mr2

Species

D. melanogaster

Name

FlyBase ID

FBal0063890

Feature type

allele

Associated gene

Dmel\lz

Associated Insertion(s)

P{}lz^mr2

Carried in Construct

Also Known As

lz^s90f

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

male recombination induced by dysgenesis

Nature of the Allele

Allele class

Mutagen

male recombination induced by dysgenesis

(Batterham et al., 1996)

Progenitor genotype

Associated Insertion(s)

P{}lz^mr2

Cytology

Description

Insertion of an internally deleted P-element.

(Batterham et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:9,284,552..9,284,552

(Jackson Behan et al., 2005, Batterham et al., 1996)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death

(Siddall et al., 2003)

visible

(Siddall et al., 2009, Siddall et al., 2003)

visible | recessive

(Batterham et al., 1996)

Phenotype Manifest In

basiconic sensillum of antennal segment 3

(Stocker et al., 1993)

eye

(Siddall et al., 2003)

eye | posterior

(Batterham et al., 1996)

eye disc

(Siddall et al., 2003)

ommatidium

(Siddall et al., 2009, Batterham et al., 1996)

third segment of antenna

(Stocker et al., 1993)

trichoid sensillum of antennal segment 3

(Stocker et al., 1993)

Detailed Description

Statement

Reference

Adult lz^mr2 males exhibit minor ommatidial defects at the posterior rim of the eye.

(Siddall et al., 2009)

lz^mr2 adults have a mild mutant eye phenotype. Ectopic cell death is seen in third larval instar eye discs.

(Siddall et al., 2003)

Homozygotes show disruption of the ommatidial array at the posterior rim of the eye.

(Batterham et al., 1996)

The antennal funiculus is reduced in size in hemizygous males. The number of large and small basiconic sensilla on the antennal funiculus is greatly reduced, and the number of trichoid sensilla on the antennal funiculus is increased. The number of coeloconic sensilla on the antennal funiculus is normal. The density of the coeloconic and trichoid sensilla on the antennal funiculus is increased and the density of the basiconic sensilla on the antennal funiculus is decreased compared to wild-type.

(Stocker et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

lz^mr2 is a suppressor of visible | somatic clone phenotype of ttk^1e11

(Siddall et al., 2009)

lz^mr2 is a suppressor of visible | somatic clone phenotype of ttk^rM730

(Siddall et al., 2009)

Phenotype Manifest In

Suppressor of

Statement

Reference

lz^mr2 is a suppressor of eye | somatic clone phenotype of ttk^1e11

(Siddall et al., 2009)

lz^mr2 is a suppressor of ommatidium | somatic clone phenotype of ttk^1e11

(Siddall et al., 2009)

lz^mr2 is a suppressor of interommatidial bristle | somatic clone phenotype of ttk^1e11

(Siddall et al., 2009)

lz^mr2 is a suppressor of eye | somatic clone phenotype of ttk^rM730

(Siddall et al., 2009)

lz^mr2 is a suppressor of ommatidium | somatic clone phenotype of ttk^rM730

(Siddall et al., 2009)

lz^mr2 is a suppressor of interommatidial bristle | somatic clone phenotype of ttk^rM730

(Siddall et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

The eye phenotype observed in ttk^1e11 clones is partially suppressed in a lz^mr2 mutant background. Ommatidial structures and sensory bristles are present, and the eye appears less scarred.

The eye phenotype observed in ttk^rM730 clones is partially suppressed in a lz^mr2 mutant background. Ommatidial structures and sensory bristles are present, and the eye appears less scarred.

(Siddall et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

lz^50e

(Batterham et al., 1996)

lz^77a7

(Batterham et al., 1996)

lz^38.71

(Batterham et al., 1996)

Fails to complement

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Unstable allele; can revert to wild-type under dysgenic conditions. lz^mr2 maps to the spectacle sublocus of lz.

(Batterham et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

lz^mr2

(Siddall et al., 2009)

lz^s90f

(Batterham et al., 1996, Stocker et al., 1993)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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