Deletion of 1398bp in the intronic region between exons II and III.
1398bp deletion within intron II (the lesion is identical to that in lz77a7).
Mutation in cistron A.
1398bp deletion within intron II (the lesion is identical to that in lz77a7
Reported as a deletion of 1,398bp (GB:AF217651 coordinates 9,586–10,982). Mapped to X:9286840..9288236:1 .
lz50e adults have a severe mutant eye phenotype. Ectopic cell death is seen in third larval instar eye discs.
Expression of lzhs.PD using heat shock during the third larval instar or early pupal stage in a lz50e background dramatically increases the number of sensilla basiconica on the antenna, and slightly reduces the number of sensilla trichoidea. Several basiconic sensilla are found in regions of the antenna where sensilla trichoidea are normally found.
Rough eye phenotype: facets with multiple R7-like cells.
Homozygotes have severe eye defects. Lenses are fused and may be ruptured. Bristles are missing. There is a total lack of ommatidial structure. The eyes have mottled pigmentation and black pock marks are visible on the surface of the eye. Defects in cone cells, pigment cells and the fenestrated membrane are seen, and the number of photoreceptor cells per ommatidium is abnormal. The structure of the optic lobes is disorganised. lz1/lz50e, lz50e/lzg and lz50e/lz37 females show disruption of the ommatidia and black pock marking confined to the anterior portion of the eye. lz50e/lz34 females have a thin, vertical, central stripe of black pock marks in an otherwise normal eye.
Ovulation rate is normal.
Displays locomotor activity rhythm with an approximately 24h period.
The antennal funiculus is reduced in size in hemizygous males. The number of large and small basiconic sensilla is reduced. The density of the coeloconic, trichoid and small basiconic sensilla on the antennal funiculus is increased and the density of the large basiconic sensilla on the antennal funiculus is decreased compared to wild-type.
Eyes are greatly reduced in size and have a smooth surface in homozygous flies. Red eye pigment is distributed over the entire eye. The tarsal claws are normal. The spermathecae and pars ovariae are normal in homozygous females.
Like lz49h. Eyes reduced in size and almond shaped; no indication of facets; covered with indentations, giving a pock-marked appearance. Hairs on eye surface sparse or absent; eye surface glossy with many large black or brown flecks. Tarsal claws normal. Females fertile; spermathecae and parovaria present and normal. lz50e/lz has normal eyes except for a few flecks. Complements most other lz alleles except lz49h, lz52c and those associated with rearrangements or deficiencies. Unaffected by su(f)6 (Schalet, 1970). RK1. spectacle; tarsal structures present; spermathecae present; parovaria present female-fertile
R.C. King, 30 May 1950.
lz50e maps to the spectacle sublocus of lz.
Severe lz mutation.