FlyBase Allele Report: Dmel\lz[K]

General Information

Symbol

Dmel\lz^K

Species

D. melanogaster

Name

of Krivshenko

FlyBase ID

FBal0011825

Feature type

allele

Associated gene

Dmel\lz

Associated Insertion(s)

?{}lz^K

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Daga et al., 1996)

Mutagen

spontaneous

(Lindsley and Zimm, 1992)

Progenitor genotype

Associated Insertion(s)

?{}lz^K

Cytology

Polytene chromosomes normal.

(Krivshenko, 1956)

Description

Insertion of a copia transposable element duplicates the target site GCAG located between exons III and VI of lz.

(Jackson Behan et al., 2005)

Retrotransposon insertion.

(Crew et al., 1997)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:9,290,848..9,290,848

(Jackson Behan et al., 2005, Crew et al., 1997)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death

(Siddall et al., 2003)

male fertile

(Krivshenko, 1956)

visible

(Siddall et al., 2003, Crew et al., 1997)

visible | recessive

(Batterham et al., 1996, Krivshenko, 1956)

Phenotype Manifest In

Detailed Description

Statement

Reference

lz^K adults have a mild mutant eye phenotype. Ectopic cell death is seen in third larval instar eye discs.

(Siddall et al., 2003)

Mild eye phenotype. Defects in photoreceptor neuron recruitment. Some facets have seven cells with larger, R1 to R6 like rhabdomeres, an R7-like cell is absent. Facets may have a duplicated R7 cells. Other facets have normal looking R7 cells but incorrect numbers of outer photoreceptor cells.

(Crew et al., 1997)

Homozygous females have normal eyes. Hemizygous males have a mild rough eye phenotype, with disruption of the ommatidial array at the posterior rim of the eye. Black pock marks are visible on the surface of the eye.

(Batterham et al., 1996)

Some ommatidia have a supernumerary R7 photoreceptor cell, and some have extra outer photoreceptor cells.

(Daga et al., 1996)

The antennal funiculus is reduced in size in hemizygous males. The number of large and small basiconic sensilla is reduced. The density of the coeloconic sensilla on the antennal funiculus is increased and the density of the large basiconic sensilla on the antennal funiculus is decreased compared to wild-type.

(Stocker et al., 1993)

RK1. Tarsal claws normal. Spermathecae and parovaria present.

(Lindsley and Zimm, 1992)

A weak lz allele. Adult eye slightly rough, irregular facets shapes, eye disc appears normal.

(Renfranz and Benzer, 1989)

Homozygous males have slightly narrow eyes, with uneven fused facets. Males are viable and fertile, homozygous females have not been obtained. Heterozygous females are phenotypically normal.

(Krivshenko, 1956)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Interactions of lz^K with other lz alleles described by Green (FBrf0013894). Unaffected by su(f)⁶ or su(Hw)²; however suppressed by su(pr) and enhanced by su(s) and su(w^a) (Rutledge et al., FBrf0048208).