FlyBase Allele Report: Dmel\lz[37]

General Information

Symbol

Dmel\lz³⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0011778

Feature type

allele

Associated gene

Dmel\lz

Associated Insertion(s)

Carried in Construct

Also Known As

lz^37h

Key Links

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

(Batterham et al., 1996, Fitch et al., 1992, Green and Green, 1956)

Progenitor genotype

Cytology

Description

Insertion of tourist transposable element in the intronic region between exons III and VI of lz.

(Jackson Behan et al., 2005)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death

(Siddall et al., 2003)

visible

(Siddall et al., 2003)

visible | recessive

(Batterham et al., 1996, Green and Green, 1956)

Phenotype Manifest In

Detailed Description

Statement

Reference

lz³⁷ adults have a mild mutant eye phenotype. Ectopic cell death is seen in third larval instar eye discs.

(Siddall et al., 2003)

Homozygous females have normal eyes. Hemizygous males have a mild rough eye phenotype, with disruption of the ommatidial array at the posterior rim of the eye. Black pock marks are visible on the surface of the eye. lz^50e/lz³⁷ females show disruption of the ommatidia and black pock marking confined to the anterior portion of the eye.

(Batterham et al., 1996)

The antennal funiculus is reduced in size in hemizygous males. The number of large and small basiconic sensilla, trichoid sensilla and coeloconic sensilla on the antennal funiculus is slightly reduced. The density of the large basiconic sensilla on the antennal funiculus is decreased compared to wild-type.

(Stocker et al., 1993)

A low frequency of individuals homozygous for Bpt¹ and lz³⁷ have small eye spots, the frequency is enhanced in the presence of su(f)¹.

(Duus et al., 1992)

Hemizygotes have ovoid eyes, with a slightly roughened surface and a glossy appearance.

(Fitch et al., 1992)

Moderate sensilla phenotype: bears 70% of normal basiconic sensilla complement. lz³⁷ females show a drastically reduced receptivity despite the presence of basiconic sensilla and despite their higher activity than lz³ females, comparisons with lz³⁷ females demonstrate this is not due to an olfactory defect.

(Stocker and Gendre, 1989)

The number of basiconic sensilla on the funiculus is reduced by approximately 30% in lz³⁷ flies.

(Stocker and Gendre, 1988)

Homozygotes have rough eyes which are reduced in size. Red eye pigment is distributed over the entire eye. The tarsal claws are reduced. The spermathecae and pars ovariae are absent in homozygous females.

(Green and Green, 1956)

Eye size reduced. Areas of irregular facets in posterior region of eye; eye color normal. Enhanced by su(f)⁶ (Schalet, 1970); also enhanced by su(Hw)² and su(s) (Rutledge, Mortin, Schwarz, Thierry-Mieg, and Meselson, 1988). Phenol oxidase level decreased from 94% to 58% of normal (Snyder and Smith, 1976). RK1. glossy; tarsal structures reduced or absent; spermathecae absent; parovaria absent

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

lz³⁷ has increased cell death phenotype, enhanceable by su(f)^unspecified

(Siddall et al., 2003)

lz³⁷ has visible phenotype, enhanceable by su(f)^unspecified

(Siddall et al., 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

lz³⁷ has eye disc phenotype, enhanceable by su(f)^unspecified

(Siddall et al., 2003)

lz³⁷ has eye phenotype, enhanceable by su(f)^unspecified

(Siddall et al., 2003)

lz³⁷ has phenotype, enhanceable by su(f)¹

(Fitch et al., 1992)

lz³⁷ has phenotype, enhanceable by su(f)⁸

(Fitch et al., 1992)

lz³⁷ has phenotype, enhanceable by su(f)¹²

(Fitch et al., 1992)

lz³⁷ has phenotype, enhanceable by su(f)⁴

(Schalet, 1972)

Additional Comments

Genetic Interactions

Statement

Reference

The severity of the mutant eye phenotype and amount of ectopic cell death seen in third larval instar eye discs in lz³⁷ animals is enhanced by su(f)^unspecified.

(Siddall et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially complements

lz^ts1

(Stocker et al., 1993)

lz^K

(Stocker et al., 1993)

lz^g

(Stocker et al., 1993)