FB2024_03 , released June 25, 2024
Allele: Dmel\lz36
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General Information
Symbol
Dmel\lz36
Species
D. melanogaster
Name
FlyBase ID
FBal0011775
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

lz36 adults have a "spectacle" eye phenotype. Ectopic cell death is seen in third larval instar eye discs.

Homozygotes have a total lack of ommatidial structure in the eye. Pigment is dispersed as a ring around the edge of the eye ("spectacle" phenotype).

Mutants display locomotor activity rhythms with circadian periods, though with reduced penetrance (small sample size).

The antennal funiculus is reduced in size in hemizygous males. The number of large and small basiconic sensilla and coeloconic sensilla on the antennal funiculus is slightly reduced. The density of the trichoid sensilla on the antennal funiculus is increased and the density of the coeloconic and basiconic sensilla on the antennal funiculus is decreased compared to wild-type.

A strong lz allele. Adult eye is smooth with a pink eye surface, eye has no lens or cone cell cups, distorted pigment cell layer. eye disc pattern very irregular.

Eyes are greatly reduced in size and have a smooth surface in homozygous flies. Red eye pigment is sparse and confined primarily to the margin of the eye. Tarsal claws are vestigial. The spermathecae and pars ovariae are absent in homozygous females.

spectacle; spermathecae absent; parovaria absent female-sterile Like lz3 in texture, color of eyes, and color of larval Malpighian tubes. Parovaria and spermathecae tend to be abnormal in lz36/+ females (Anderson, 1945). RK1.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT suppressed by
Statement
Reference

lz36 has phenotype, non-suppressible by su(Hw)2

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

Spencer, March 1936.

Comments
Comments

lz36 maps to the spectacle sublocus of lz.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
lz36
Name Synonyms
Secondary FlyBase IDs
    References (13)