FlyBase Allele Report: Dmel\z[v77h]

General Information

Symbol

Dmel\z^v77h

Species

D. melanogaster

Name

FlyBase ID

FBal0018848

Feature type

allele

Associated gene

Dmel\z

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Judd, 1995, Georgiev, 1994, Chen and Pirrotta, 1993)

Mutagen

PM hybrid dysgenesis

male recombination induced by dysgenesis

(Mariani et al., 1985, Green, 1984)

Progenitor genotype

Cytology

Description

Deletion of the z leader sequences.

(Georgiev, 1994)

314bp deletion that removes RNA leader sequences and the AUG initiation codon.

(Laney and Biggin, 1992)

Deletion of approximately 300bp centered around position 0 (the site of P-element insertion in z^π1).

(Mariani et al., 1985)

no P-element Carries deletion of about 320 nucleotides and addition of seven nucleotides in the first exon; P element was probably inserted, followed by excision of the P and the flanking deletion (Pirrotta, Manet, Hardon, Bickel and Benson, 1987), the deletion removing the AUG start codon.

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:2,448,018..2,448,331 [+]

Comment:

Approximate location of a small deletion of 314 nucleotides that takes out the AUG initiation codon and a large portion of the 5' UTR. The exact boundaries were not reported.

(Laney and Biggin, 1992, Goldberg et al., 1989, Pirrotta et al., 1987)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color

(Green, 1984)

visible

(Judd, 1995)

Phenotype Manifest In

pigment cell

(Chen and Pirrotta, 1993, Chen and Pirrotta, 1993, Green, 1984)

Detailed Description

Statement

Reference

Eye colour: yellow, when heterozygous with z¹. Eye colour: essentially wild type, having a slightly diluted red, as hemizygous male or homzygous female.

(Judd, 1995)

Eye colour: near wild-type in males; brown in females.

(Georgiev, 1994)

Eye colour: dull brown, in male.

(Chen and Pirrotta, 1993)

Eye colour: variegated brown.

(Mariani et al., 1985)

Eye colour is slightly lighter in homozygous females than hemizygous males: eye colour is light in colour at the anterior margin and continuously darkens to the posterior eye margin.

(Green, 1984)

Eye colour: diluted, turning brownish with age in hemizygous males and hemi- and homozygous females with a normal complement of w⁺ genes. Eye colour: wild-type, in z^a/z^v77h females. Eye colour: zeste, in z¹/z^v77h females. Eye colour: wild-type, in z^v77h hemizygous males and homozygous females with w⁺ duplication in each X. Eye colour: brown variegated, darkening toward posterior in z^v77h w⁺/Y males and z^v77h w⁺/z^v77h w⁺ females; lighter at 28^oC.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

w^E.BR, z^v77h has abnormal eye color phenotype, enhanceable by Taf9¹

(Soldatov et al., 1999)

w^BR.E.BR, z^v77h has abnormal eye color phenotype, enhanceable by Taf9¹

(Soldatov et al., 1999)

su(Hw)^V/su(Hw)², w^BR.E.BR, z^v77h has abnormal eye color phenotype, enhanceable by Taf9¹

(Soldatov et al., 1999)

Taf9¹, w^BR.E.BR, z^v77h has abnormal eye color phenotype, enhanceable by su(Hw)^V/su(Hw)²

(Soldatov et al., 1999)

w^sp2, z^v77h has abnormal eye color phenotype, enhanceable by Taf9¹

(Georgiev, 1994)

w^sp2, z^v77h has abnormal eye color phenotype, enhanceable by e(y)2¹

(Georgiev, 1994)

w^sp2, z^v77h has abnormal eye color phenotype, enhanceable by e(y)3⁴

(Georgiev, 1994)

w^sp4, z^v77h has abnormal eye color phenotype, enhanceable by Taf9¹

(Georgiev, 1994)

w^sp4, z^v77h has abnormal eye color phenotype, enhanceable by e(y)2¹

(Georgiev, 1994)

w^sp4, z^v77h has abnormal eye color phenotype, enhanceable by e(y)3⁴

(Georgiev, 1994)

w^sp1, z^v77h has abnormal eye color phenotype, enhanceable by Taf9¹

(Georgiev, 1994)

w^sp1, z^v77h has abnormal eye color phenotype, enhanceable by e(y)2¹

(Georgiev, 1994)

w^sp1, z^v77h has abnormal eye color phenotype, enhanceable by e(y)3⁴

(Georgiev, 1994)

Enhancer of

Statement

Reference

z^v77h is an enhancer of abnormal eye color phenotype of w^{+mC.Scer\FRT-Ee.S-500.P1\loxP-su(Hw)BR}, w^unspecified

(Kostyuchenko et al., 2009)

z^v77h is an enhancer of abnormal eye color phenotype of w^sp2

(Georgiev, 1994)

z^v77h is an enhancer of abnormal eye color phenotype of w^sp4

(Georgiev, 1994)

z^v77h is an enhancer of abnormal eye color phenotype of w^sp1

(Georgiev, 1994)

NOT Enhancer of

Statement

Reference

z^v77h is a non-enhancer of abnormal eye color phenotype of su(Hw)^V/su(Hw)², w^{+mC.Scer\FRT-Ee.S-500.P1\loxP-su(Hw)BR}, w^unspecified

(Kostyuchenko et al., 2009)

NOT Suppressor of

Statement

Reference

z^v77h is a non-suppressor of abnormal eye color phenotype of su(Hw)^V/su(Hw)², w^{+mC.Scer\FRT-Ee.S-500.P1\loxP-su(Hw)BR}, w^unspecified

(Kostyuchenko et al., 2009)

Other

Statement

Reference

w^BR.E.BR, z^v77h has abnormal eye color phenotype

(Soldatov et al., 1999)

su(Hw)^V/su(Hw)², w^BR.E.BR, z^v77h has abnormal eye color phenotype

(Soldatov et al., 1999)

w^E.BR, z^v77h has abnormal eye color phenotype

(Soldatov et al., 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

w^E.BR, z^v77h has pigment cell phenotype, enhanceable by Taf9¹

(Soldatov et al., 1999)

w^BR.E.BR, z^v77h has pigment cell phenotype, enhanceable by Taf9¹

(Soldatov et al., 1999)

su(Hw)^V/su(Hw)², w^BR.E.BR, z^v77h has pigment cell phenotype, enhanceable by Taf9¹

(Soldatov et al., 1999)

Taf9¹, w^BR.E.BR, z^v77h has pigment cell phenotype, enhanceable by su(Hw)^V/su(Hw)²

(Soldatov et al., 1999)

w^sp2, z^v77h has pigment cell phenotype, enhanceable by Taf9¹

(Georgiev, 1994)

w^sp2, z^v77h has pigment cell phenotype, enhanceable by e(y)2¹

(Georgiev, 1994)

w^sp2, z^v77h has pigment cell phenotype, enhanceable by e(y)3⁴

(Georgiev, 1994)

w^sp4, z^v77h has pigment cell phenotype, enhanceable by Taf9¹

(Georgiev, 1994)

w^sp4, z^v77h has pigment cell phenotype, enhanceable by e(y)2¹

(Georgiev, 1994)

w^sp4, z^v77h has pigment cell phenotype, enhanceable by e(y)3⁴

(Georgiev, 1994)

w^sp1, z^v77h has pigment cell phenotype, enhanceable by Taf9¹

(Georgiev, 1994)

w^sp1, z^v77h has pigment cell phenotype, enhanceable by e(y)2¹

(Georgiev, 1994)

w^sp1, z^v77h has pigment cell phenotype, enhanceable by e(y)3⁴

(Georgiev, 1994)

z^v77h has phenotype, enhanceable by e(y)3⁴

(Georgiev, 1994)

z^v77h has phenotype, enhanceable by Taf9¹

(Georgiev, 1994)

z^v77h has phenotype, enhanceable by e(y)2¹

(Georgiev, 1994)

Suppressed by

Statement

Reference

z^v77h has phenotype, suppressible by Su(var)205^unspecified

(Judd, 1995)

Enhancer of

Statement

Reference

z^v77h is an enhancer of phenotype of ct^pN1

(Melnikova et al., 1996)

z^v77h is an enhancer of phenotype of ct^n2s

(Melnikova et al., 1996)

z^v77h is an enhancer of phenotype of ct^pN30

(Melnikova et al., 1996)

z^v77h is an enhancer of phenotype of ct^pN2s

(Melnikova et al., 1996)

z^v77h is an enhancer of pigment cell phenotype of w^sp2

(Georgiev, 1994)

z^v77h is an enhancer of pigment cell phenotype of w^sp4

(Georgiev, 1994)

z^v77h is an enhancer of pigment cell phenotype of w^sp1

(Georgiev, 1994)

z^v77h is an enhancer of phenotype of lz^77a7

(Stocker et al., 1993)

Suppressor of

Statement

Reference

z^v77h is a suppressor of anterior notopleural bristle phenotype of sc^D1

(Gause et al., 1996)

z^v77h is a suppressor of ocellar bristle phenotype of sc^D1

(Gause et al., 1996)

z^v77h is a suppressor of postocellar bristle phenotype of sc^D1

(Gause et al., 1996)

z^v77h is a suppressor of scutellar bristle phenotype of sc^D1

(Gause et al., 1996)

z^v77h is a suppressor of macrochaeta & scutum phenotype of sc^D1

(Gause et al., 1996)

Other

Statement

Reference

Kr^If-1, z[+]/z^v77h has eye phenotype

(Sollars et al., 2003)

Kr^If-1, z^v77h has eye phenotype

(Sollars et al., 2003)

w^BR.E.BR, z^v77h has pigment cell phenotype

(Soldatov et al., 1999)

su(Hw)^V/su(Hw)², w^BR.E.BR, z^v77h has pigment cell phenotype

(Soldatov et al., 1999)

w^E.BR, z^v77h has pigment cell phenotype

(Soldatov et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

z^v77h significantly decreases eye pigmentation in flies carrying w^{Scer\FRT.Ee.λWS} in a w¹¹¹⁸ background in half of the transgenic insertion lines examined.

z^v77h has no effect on the eye pigmentation of flies carrying w^λWS in a w¹¹¹⁸ background.

z^v77h significantly decreases eye pigmentation in flies carrying w^{Scer\FRT.Ee.λΔRWS} in a w¹¹¹⁸ background, with the double mutant flies having either yellow or orange eyes.

z^v77h has no effect on the eye pigmentation of flies carrying w^λΔRWS in a w¹¹¹⁸ background.

z^v77h has no effect on the eye pigmentation of flies carrying w^{Scer\FRT.Ee.λ4BWS} in a w¹¹¹⁸ background.

z^v77h has no effect on the eye pigmentation of flies carrying w^λ4BWS in a w¹¹¹⁸ background.

z^v77h has no effect on the eye pigmentation of flies carrying w^{Scer\FRT.Ee.λ.loxP.4B.WS} in a w¹¹¹⁸ background.

z^v77h has no effect on the eye pigmentation of flies carrying w^{λ.loxP.4B.WS} in a w¹¹¹⁸ background.

(Kostyuchenko et al., 2005)

5+/-2% of Kr^If-1/+ flies born to z^v77h/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of Kr^If-1/+ flies born to isogenised wild-type mothers.

(Sollars et al., 2003)

Eye colour: flies carrying w^BR.E.BR have red eyes. The eye colour is not affected if the flies are also carrying e(y)1¹ and z^v77h. Flies that are also carrying e(y)1¹, z^v77h and su(Hw)²/su(Hw)^V have reduced eye pigmentation. Eye colour: flies carrying w^E.BR have brown eyes. The eye pigmentation is reduced if these flies are also carrying e(y)1¹ and z^v77h.

(Soldatov et al., 1999)

Enhancement of the cut wing phenotype of ct^pN2s and ct^n2s, ct^pN1 and ct^pN30 acts additively with e(y)3⁴; in combination with e(y)3⁴ and z^v77h, mod(mdg4)^ul enhances the mutant phenotype of ct⁶, though the gaps in the wing margin are still randomly distributed. No mutant phenotype in the wing, no effect on mutant wing phenotype of ct⁶, ct^2s or ct^4s.

(Melnikova et al., 1996)

Eye colour: lighter zeste background than comparable z¹ genotypes, as z^v77h w^zm male. Eye colour: lighter zeste background than comparable z¹ genotypes, as z^v77h w^zl male. Eye colour: darker than comparable z¹ genotypes, as z^v77h w^zm homozygous female. Eye colour: almost bleached white with a few scattered red facets, as z^v77h In(1)w^m4 female or male. Eye colour: red, as z^v77h In(1)rst³ males and homozygous females. Eye colour: zeste, as z^v77h In(1)rst³/z¹ In(1)rst³ females.

(Judd, 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (3)

1385

101276

106297

Notes on Origin

Discoverer

Green.

Arose as: Single exceptional male offspring.

(Green, 1984)

Comments

Behaves like a z^a mutant in combination with z¹.

(Mariani et al., 1985)

Effects interallelic complementation at the y locus.

(Geyer et al., 1990)

No alteration in vg^U or vg^W dominance is seen in combination with z^v77h, suggesting that the dominance is not produced by z- dependent transvection effects.

(Williams et al., 1990)

Does not alter the effect of mod(mdg4)^ul mutation on y²/y⁺ flies.

(Georgiev and Corces, 1995)

z^v77h In(1)rst³ exhibits more extreme variegation for rst than seen in z⁺ In(1)rst³. Recessive enhancer of PEV in a fashion clearly distinguishable from standard transvection effects.

(Judd, 1995)

Partially restores ocellar, post-vertical and scutellar bristles as well as the ANPs to sc^D1 Shows a mild "Hairy wing" type phenotype: one to three additional bristles appear on the notum. Has no effect on the Df(1)ase-1, sc⁵ or sc⁶ phenotype.

(Gause et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

lz^77h

(Stocker et al., 1993)

z^v778

(Sollars et al., 2003)

z^v77h3

(Williams et al., 1990)

z^v77h

(Liaw, 2022, Bengani et al., 2013, Erokhin et al., 2011, Kostyuchenko et al., 2009, Krivega et al., 2008, Kostyuchenko et al., 2005, Zobacheva et al., 2003)

Name Synonyms

Secondary FlyBase IDs

References (34)

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