FlyBase Allele Report: Dmel\e(y)2[1]

General Information

Symbol

Dmel\e(y)2¹

Species

D. melanogaster

Name

FlyBase ID

FBal0003368

Feature type

allele

Associated gene

Dmel\e(y)2

Associated Insertion(s)

Stalker{}e(y)2¹

Carried in Construct

Also Known As

e(y)2^u1

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

Stalker-hybrid dysgenesis

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Gause et al., 1996)

Mutagen

Stalker-hybrid dysgenesis

(Georgiev and Gerasimova, 1989)

Progenitor genotype

Associated Insertion(s)

Stalker{}e(y)2¹

Cytology

Description

Insertion of a Stalker element 167bp upstream of the 5' end of the largest e(y)2 cDNA.

(Georgieva et al., 2001)

Insertion of Stalker element.

(Georgiev and Gerasimova, 1989)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Georgieva et al., 2001)

visible | recessive

(Georgiev and Gerasimova, 1989)

Phenotype Manifest In

eye

(Georgiev and Gerasimova, 1989)

macrochaeta

(Georgiev and Gerasimova, 1989)

wing

(Georgiev and Gerasimova, 1989)

Detailed Description

Statement

Reference

The pigmentation of y² e(y)2¹ flies is not altered by Su(mg)1-6^1-6, Su(mg)1-7^1-7 or Su(mg)1-8^1-8.

(Bezborodova et al., 1997)

No mutant phenotype in the wing.

(Melnikova et al., 1996)

Stable mutation. Homozygotes have a shortened, wider body than normal, the wings are separated, the eyes are small, with altered facets, and the bristles are shortened. Has no effect on the y⁺ phenotype.

(Georgiev and Gerasimova, 1989)

head and thorax bristles yellow; microchaetae yellow; short stocky body; wings separated; eyes small; facets altered; bristles shortened.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

e(y)2¹, y² has abnormal body color phenotype, non-suppressible by e(y)2b^su(Hw).PK

(Krasnov et al., 2005)

e(y)2¹, y² has partially lethal | male phenotype, non-suppressible by e(y)2b^su(Hw).PK

(Krasnov et al., 2005)

Enhancer of

Statement

Reference

e(y)2¹ is an enhancer of abnormal eye color phenotype of w^sp2, z^v77h

(Georgiev, 1994)

e(y)2¹ is an enhancer of abnormal eye color phenotype of w^sp1, z^v77h

(Georgiev, 1994)

e(y)2¹ is an enhancer of abnormal eye color phenotype of w^sp4, z^v77h

(Georgiev, 1994)

NOT Enhancer of

Statement

Reference

e(y)2¹ is a non-enhancer of abnormal eye color phenotype of w^sp1, z¹

(Georgiev, 1994)

e(y)2¹ is a non-enhancer of abnormal eye color phenotype of w^sp2, z¹

(Georgiev, 1994)

e(y)2¹ is a non-enhancer of abnormal eye color phenotype of w^sp4, z¹

(Georgiev, 1994)

Other

Statement

Reference

e(y)2¹, y² has abnormal body color phenotype

(Krasnov et al., 2005)

e(y)2¹, y² has partially lethal | male phenotype

(Krasnov et al., 2005)

Taf9¹, e(y)2¹ has lethal phenotype

(Georgieva et al., 2001)

Taf9¹, e(y)2¹ has male sterile phenotype

(Georgiev, 1994)

Taf9¹, e(y)2¹ has partially lethal | male phenotype

(Georgiev, 1994)

e(y)2¹, e(y)3⁴ has lethal phenotype

(Georgiev, 1994)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

e(y)2¹, y² has adult head bristle phenotype, non-suppressible by e(y)2b^su(Hw).PK

(Krasnov et al., 2005)

e(y)2¹, y² has chaeta & adult thorax phenotype, non-suppressible by e(y)2b^su(Hw).PK

(Krasnov et al., 2005)

e(y)2¹, y² has tergite phenotype, non-suppressible by e(y)2b^su(Hw).PK

(Krasnov et al., 2005)

Enhancer of

Statement

Reference

e(y)2¹ is an enhancer of pigment cell phenotype of w^sp2, z^v77h

(Georgiev, 1994)

e(y)2¹ is an enhancer of phenotype of z^v77h

(Georgiev, 1994)

e(y)2¹ is an enhancer of pigment cell phenotype of w^sp4, z^v77h

(Georgiev, 1994)

e(y)2¹ is an enhancer of pigment cell phenotype of w^sp1, z^v77h

(Georgiev, 1994)

e(y)2¹ is an enhancer of phenotype of y²

(Georgiev and Gerasimova, 1989)

NOT Enhancer of

Statement

Reference

e(y)2¹ is a non-enhancer of pigment cell phenotype of w^sp1, z¹

(Georgiev, 1994)

e(y)2¹ is a non-enhancer of pigment cell phenotype of w^sp2, z¹

(Georgiev, 1994)

e(y)2¹ is a non-enhancer of pigment cell phenotype of w^sp4, z¹

(Georgiev, 1994)

Suppressor of

Statement

Reference

e(y)2¹ is a suppressor | partially of anterior notopleural bristle phenotype of sc^+2MC, y^+2MC

(Gause et al., 1996)

e(y)2¹ is a suppressor | partially of anterior notopleural bristle phenotype of sc^2#+9, y^2#+9

(Gause et al., 1996)

e(y)2¹ is a suppressor of phenotype of ct^pN30

(Melnikova et al., 1996)

e(y)2¹ is a suppressor of phenotype of ct^pN2s

(Melnikova et al., 1996)

e(y)2¹ is a suppressor of phenotype of ct^pN1

(Melnikova et al., 1996)

e(y)2¹ is a suppressor of phenotype of ct^n2s

(Melnikova et al., 1996)

Other

Statement

Reference

e(y)2¹, y² has adult head bristle phenotype

(Krasnov et al., 2005, Georgiev and Gerasimova, 1989)

e(y)2¹, y² has tergite phenotype

(Krasnov et al., 2005)

e(y)2¹, y² has chaeta & adult thorax phenotype

(Krasnov et al., 2005)

e(y)2¹, y² has microchaeta phenotype

(Georgiev and Gerasimova, 1989)

e(y)2¹, y² has adult thorax & chaeta phenotype

(Georgiev and Gerasimova, 1989)

Additional Comments

Genetic Interactions

Statement

Reference

e(y)2¹ y² males show reduced viability compared to wild type. 14% of the mutant males have distorted tergites.

Body colour: e(y)2¹ y² males have reduced pigmentation of head and thorax bristles compared to wild type.

The reduced viability, reduced pigmentation of head and thorax bristles and distorted tergite phenotype that is seen in e(y)2¹ y² males is not rescued by e(y)2b^su(Hw).PK.

(Krasnov et al., 2005)

The lethality of e(y)2¹ e(y)1¹ double mutants is rescued by e(y)2^+tGa or by e(y)1^+tSa.

The lethality of e(y)2¹ e(y)1¹ double mutants is not rescued by e(y)1^1.tSa.

(Georgieva et al., 2001)

Partially inhibits ANP bristle formation caused by y^+2MC, sc^+2MC and y^2#+9, sc^2#+9. ANP bristles appear in 70%-90% of flies. Has no effect on the sc phenotype of y², sc^D1, y^+1MC, sc^D1 or y^+3MC, sc^D1 mutants, nor Df(1)ase-1 nor sc⁶.

(Gause et al., 1996)

Partially suppresses the cut wing phenotype of ct^pN2s and ct^n2s, ct^pN1 and ct^pN30. Acts additively in this suppression with z^op6. In combination with e(y)2¹ and z^op6, mod(mdg4)^ul almost completely suppresses the mutant phenotype of ct⁶. No effect on mutant wing phenotype of ct⁶, ct^2s or ct^4s.

(Melnikova et al., 1996)

Heterozygotes with e(y)3⁴ are lethal. Heterozygous males with e(y)1¹ have very low viability and are completely sterile. In z¹ w^zm strain e(y)2¹ causes a slight reduction in eye pigmentation.

(Georgiev, 1994)

Enhances the y² phenotype; head and thorax bristles, and hairs are yellow. This enhancer effect is not suppressed by su(Hw)².

(Georgiev and Gerasimova, 1989)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

e(y)2¹ is rescued by e(y)2^su(Hw).PK

(Krasnov et al., 2005)

e(y)2¹ is rescued by e(y)2^+tGa

(Georgieva et al., 2001)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Mutation is unable to enhance the negative effect of z¹ on w expression but has a synergistic effect with z^v77h on the expression of w (males have brown eyes).

(Georgiev, 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

e(y)2¹

(Georgieva et al., 2001)

e(y)2^u1

(Erokhin et al., 2010, Krasnov et al., 2005, Soldatov and Vasilev, 1998, Bezborodova et al., 1997, Gause et al., 1996, Melnikova et al., 1996, Georgiev, 1994)

e(y)2u1

(Belen'kaia and Georgiev, 1999)

e(y)^2u

(Georgiev and Gerasimova, 1989)

Name Synonyms

Secondary FlyBase IDs

FBal0039309

References (10)

Report Sections

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