FB2024_03 , released June 25, 2024
Allele: Dmel\y+2MC
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General Information
Symbol
Dmel\y+2MC
Species
D. melanogaster
Name
FlyBase ID
FBal0036025
Feature type
allele
Associated gene
Dmel\y
Associated Insertion(s)
gypsy{}y-2
jockey{}y+2MC
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
mitomycin C
(Georgiev et al., 1990)
Progenitor genotype
y2
(Gause et al., 1996, Georgiev and Corces, 1995, Gerasimova et al., 1995, Georgiev et al., 1990)
Associated Insertion(s)
gypsy{}y-2
jockey{}y+2MC
Cytology
Description

Transposition of jockey and 1.8kb of the sc gene (which contains an enhancer responsible for the development of anterior notopleural bristles) from scD1 into the gypsy element present at the y locus in y2. A small fragment of the gypsy sequence, including the su(Hw) binding region, has been deleted and replaced with the inserted sequence. Insertion into y is in opposite orientation to that of y2#+9.

(Gause et al., 1996)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Body colour: mutant flies have wild-type pigmentation in the body and wings and in the thoracic, leg and abdominal bristles.

      (Soldatov et al., 1999)

      Pigmentation of homozygotes is normal.

      (Gerasimova et al., 1995)

      Revertant.

      (Georgiev et al., 1990)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      Taf91, y+2MC has abnormal body color phenotype

      (Soldatov et al., 1999)
      Phenotype Manifest In
      NOT Enhanced by
      Statement
      Reference

      y+2MC has phenotype, non-enhanceable by mod(mdg4)ul

      (Georgiev and Corces, 1995)
      Suppressed by
      Statement
      Reference

      sc+2MC, y+2MC has anterior notopleural bristle phenotype, suppressible | partially by zop6

      (Gause et al., 1996)

      sc+2MC, y+2MC has anterior notopleural bristle phenotype, suppressible | partially by e(y)21

      (Gause et al., 1996)
      NOT suppressed by
      Statement
      Reference

      sc+2MC, y+2MC has anterior notopleural bristle phenotype, non-suppressible by Taf91

      (Gause et al., 1996)

      sc+2MC, y+2MC has anterior notopleural bristle phenotype, non-suppressible by e(y)34

      (Gause et al., 1996)
      Other
      Statement
      Reference

      Taf91, y+2MC has adult thorax & macrochaeta phenotype

      (Soldatov et al., 1999)

      Taf91, y+2MC has adult abdomen & macrochaeta phenotype

      (Soldatov et al., 1999)

      Taf91, y+2MC has leg & external sensory organ phenotype

      (Soldatov et al., 1999)

      sc+2MC, y+2MC has anterior notopleural bristle phenotype

      (Gause et al., 1996)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Pigmentation of the thoracic, leg and abdominal bristles is reduced in combination with e(y)11.

      (Soldatov et al., 1999)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Trans-inactivation by mod(mdg4)ul.

      (Georgiev and Kozitsina, 1992)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      y+2MC
      Name Synonyms
      Secondary FlyBase IDs
        References (6)