FB2024_03 , released June 25, 2024
Allele: Dmel\zop6
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General Information
Symbol
Dmel\zop6
Species
D. melanogaster
Name
FlyBase ID
FBal0018842
Feature type
allele
Associated gene
Dmel\z
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypermorphic allele - genetic evidence

neomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypermorphic allele - genetic evidence

(Mariani et al., 1985)

neomorphic allele - genetic evidence

(Muller et al., 1999)
Mutagen
ethyl methanesulfonate
Progenitor genotype
z1
(Bickel and Pirrotta, 1990, Mariani et al., 1985)
Cytology
Description

Point mutation.

(Georgiev, 1994)

Amino acid replacement: K425M. Amino acid replacement: S496A. Amino acid replacement: P454L.

(Chen and Pirrotta, 1993)

Amino acid replacement: P454L.

(Chen et al., 1992)

Amino acid replacement: K425M. Amino acid replacement: P450L.

(Bickel and Pirrotta, 1990)

Insertion in a presumptive control region.

(Lifschytz and Green, 1984)

Carries all the polymorphisms in the z1 sequence as well as the change from Lys to Met; also a C to T mutation causing a proline to leucine change in the middle region of the protein, increasing its hydrophobic nature (Pirrotta, Manet, Hardon, Bickel and Benson, 1987).

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:2,449,828..2,449,828 [+]
Nucleotide change:

C2449828T

Amino acid change:

P450L | z-PA; P450L | z-PB; P450L | z-PC

Reported amino acid change:

P450L

Comment:

Induced on z1 chromosome so also carries a K425M amino acid change. Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Bickel and Pirrotta, 1990, Pirrotta et al., 1987)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Eye colour: yellow in males, at 25oC.

      (Georgiev, 1994)

      Eye colour: yellow in males and females.

      (Chen and Pirrotta, 1993)

      Do not require two w+ genes for expression unless the z+ gene is present.

      (Lifschytz and Green, 1984)

      Eye colour: zeste in hemizygous males and homozygous females with one or two copies of w+; heterozygous z+/zop6 females wild type if one copy of w+, but zeste if two copies.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      wsp2, zop6 has abnormal eye color phenotype, enhanceable by e(y)34

      (Georgiev, 1994)

      wsp4, zop6 has abnormal eye color phenotype, enhanceable by e(y)34

      (Georgiev, 1994)

      wsp1, zop6 has abnormal eye color phenotype, enhanceable by e(y)34

      (Georgiev, 1994)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      wsp2, zop6 has pigment cell phenotype, enhanceable by e(y)34

      (Georgiev, 1994)

      wsp4, zop6 has pigment cell phenotype, enhanceable by e(y)34

      (Georgiev, 1994)

      zop6 has phenotype, enhanceable by Taf91

      (Georgiev, 1994)

      zop6 has phenotype, enhanceable by e(y)34

      (Georgiev, 1994)

      wsp1, zop6 has pigment cell phenotype, enhanceable by e(y)34

      (Georgiev, 1994)
      Suppressor of
      Statement
      Reference

      zop6 is a suppressor | partially of anterior notopleural bristle phenotype of sc+2MC, y+2MC

      (Gause et al., 1996)

      zop6 is a suppressor | partially of anterior notopleural bristle phenotype of sc2#+9, y2#+9

      (Gause et al., 1996)

      zop6 is a suppressor of phenotype of ctpN2s

      (Melnikova et al., 1996)

      zop6 is a suppressor of phenotype of ctpN1

      (Melnikova et al., 1996)

      zop6 is a suppressor of phenotype of ctn2s

      (Melnikova et al., 1996)

      zop6 is a suppressor of phenotype of ctpN30

      (Melnikova et al., 1996)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      zop6 decreases the eye pigmentation of wP1\loxP.Z.Scer\FRT.Z flies.

      (Zobacheva et al., 2003)

      Enhances the eye colour phenotype by suppressing the transactivation of the mini-w gene seen when wMcp.y.scs'.1 and ywe.Mcp.2 are combined and when wMcp.scs'.21 and ywe.Mcp.1 are combined leading to lighter eyes.

      (Muller et al., 1999)

      Partially suppresses the cut wing phenotype of ctpN2s and ctn2s, ctpN1 and ctpN30; acts additively in this suppression with e(y)21. In combination with e(y)21 and zop6, mod(mdg4)ul almost completely suppresses the mutant phenotype of ct6.

      (Melnikova et al., 1996)

      Enhancement by e(y)11 and e(y)34 at 18oC; enhancement by e(y)34 shows dominance.

      (Georgiev, 1994)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      zop6 is rescued by zCZ

      (Chen and Pirrotta, 1993)
      Comments

      Rescue is dosage-dependent.

      (Chen and Pirrotta, 1993)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Lifschytz.

      Comments
      Comments

      Reverts to weaker alleles after EMS or X rays. Strong antagonist of z+ gene product. Allelic series: zop6 > zop11 > zRN4 > z1 > zRN1 > wild type.

      (Lifschytz and Green, 1984)

      Causes a specific underexpression of w in the eye even when a single, unpaired copy of w is present. Behaves like z+ in promoting transvection effects at Ubx but fails to permit transvection at the dpp locus.

      (Bickel and Pirrotta, 1990)

      The zop6 mutation causes a new hydrophobic nucleus in the region of the protein preceding the C-terminal domain, resulting in a further stage of multimerization. Alone the S496A and P454L changes have no effect, see z+op6.

      (Chen and Pirrotta, 1993)

      Does not alter the effect of mod(mdg4)ul mutation on y2/y+.

      (Georgiev and Corces, 1995)

      Partially inhibits ANP bristle formation caused by y+2MC, sc+2MC and y2#+9, sc2#+9. ANP bristles appear in 70%-90% of flies. Has no effect on the sc phenotype of y2 scD1, y+1MC scD1 or y+3MC scD1 mutants, nor Df(1)ase-1 nor sc6.

      (Gause et al., 1996)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      zOp6
      (Zobacheva et al., 2003, Gause et al., 1996, Melnikova et al., 1996, Georgiev and Corces, 1995, Georgiev, 1994)
      zop6
      Name Synonyms
      Secondary FlyBase IDs
        References (19)