FlyBase Allele Report: Dmel\lz[r1]

General Information

Symbol

Dmel\lz^r1

Species

D. melanogaster

Name

FlyBase ID

FBal0050119

Feature type

allele

Associated gene

Dmel\lz

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Daga et al., 1996)

Mutagen

Delta2-3 transposase

(Daga et al., 1996)

Progenitor genotype

lz^Sprite

(Daga et al., 1996)

Cytology

Description

Deletion of 22716bp covering exons II, III, IV, V, VI and some 3'UTR of lz.

(Jackson Behan et al., 2005)

Deletion corresponding to nucleotides 8291-31006 of accession number AJ217651.

(Siddall et al., 2003)

Deletion of the entire coding region.

(Flores et al., 1998)

Imprecise excision of the P-element of lz^Sprite.

(Daga et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:9,285,544..9,307,637 [+]

Comment:

Position of mutation on reference sequence inferred by FlyBase curator based on author statement: Deletion corresponding to nucleotides 8291-31006 of GB:AJ217651.

(Siddall et al., 2003)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell number | third instar larval stage (with lz^gal4)

(Miller et al., 2017)

increased cell size | third instar larval stage (with lz^gal4), with Scer\GAL4^lz-gal4

(Miller et al., 2017)

viable

(Daga et al., 1996)

visible

(Behan et al., 2002, Kaminker et al., 2001)

visible | recessive

(Flores et al., 1998, Gupta et al., 1998)

Phenotype Manifest In

Detailed Description

Statement

Reference

lz^r1/lz^gal4 transheterozygous third instar larvae present a significant increase in both the number and size of circulating crystal cells (identified as Lozenge-positive), as compared to lz^gal4 heterozygous controls.

(Miller et al., 2017)

Mutants have smaller eyes than wild type and show a dramatic loss of ommatidial structure and loss of pigmentation.

(Behan et al., 2002)

Homozygotes have smooth eyes.

(Flores et al., 1998)

The number of sense organ founder cells seen in the antennal disc 10 hours after pupariation is reduced compared to wild-type. The number of trichoid and basiconic sensilla on the antenna is drastically reduced compared to wild-type, while the number of coeloconic sensilla is largely unaffected.

(Gupta et al., 1998)

Adult eye has a smooth surface lacking lenses and the ommatidial array.Partial or complete loss of tarsal claws in the leg, a reduction of the third antennal segment and partial loss of female fertility. Mosaic clones are generated in the eye, lz^- cells lack pigment granules and cells along the clone border are phenotypically normal and abnormal. Aberrant ommatidia along the border contain seven rather than six outer photoreceptor cells.

(Daga et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Other

Statement

Reference

Ras85D^N17.hs.2sev, lz^r1/lz[+] has eye phenotype

(Behan et al., 2002)

Ras85D^N17.hs.2sev, lz^r1/lz[+] has ommatidium phenotype

(Behan et al., 2002)

Ras85D^N17.hs.2sev, lz^r1 has eye phenotype

(Behan et al., 2002)

Ras85D^N17.hs.2sev, lz^r1 has ommatidium phenotype

(Behan et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

The rescue of the lz^r1 mutant eye phenotype by lz^mF4 does not occur if the flies also carry aop^ACT.GMR; most ommatidial structure is lost in these flies. lz^r1/+ ; Ras85D^N17.hs.2sev/+ flies have a rough eye phenotype.

(Behan et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

lz^77a7

(Flores et al., 1998)

Rescued by

lz^r1 is rescued by lz^GMR.PD

(Daga et al., 1996)

Partially rescued by

lz^r1 is partially rescued by lz^mF4

(Behan et al., 2002)

lz^r1 is partially rescued by lz^mF3

(Flores et al., 1998)

lz^r1 is partially rescued by lz^mF4

(Flores et al., 1998)

lz^r1 is partially rescued by lz^mF2

(Flores et al., 1998)

lz^r1 is partially rescued by lz^hs.PD

(Gupta et al., 1998)

Not rescued by

lz^r1 is not rescued by lz^mF1

(Flores et al., 1998)

Comments

The smooth eye phenotype of lz^r1 is not complemented by lz^77a7.

(Flores et al., 1998)

Expression of lz^hs.PD using heat shock during the third larval instar or early pupal stage in a lz^r1 background rescues the number of sensilla trichoidea on the antenna to wild-type. Sensilla basiconica on the antenna are not specified in these animals.

(Gupta et al., 1998)

lz^GMR.PD rescues the external eye phenotype of lz^r1, the ommatidial lattice is restored. Photoreceptor cell defect is also rescued.

(Daga et al., 1996)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

33834

w^* lz^r1/FM6

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Lz^r1

(Ferjoux et al., 2007)

lz^R1

(Bataille et al., 2005, Kaminker et al., 2001, Xu et al., 2000)

lz^r1

(Jang et al., 2017, Miller et al., 2017)

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections

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