FlyBase Allele Report: Dmel\Trl[62]

General Information

Symbol

Dmel\Trl⁶²

Species

D. melanogaster

Name

FlyBase ID

FBal0029713

Feature type

allele

Associated gene

Dmel\Trl

Associated Insertion(s)

P{hsneo.ry⁺}Trl⁶²

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Dorn et al., 1993)

Progenitor genotype

Associated Insertion(s)

P{hsneo.ry⁺}Trl⁶²

Cytology

Description

Transposable element inserted 5' of the transcription start site.

(Granok et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:14,757,932..14,757,932 [-]

(Greenberg et al., 2004, Dorn et al., 1993)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Trl^13C/Trl⁶² females have a similar viability to homozygotes, males show a significantly reduced viability.

(Greenberg et al., 2004)

Most homozygotes die as third instar larvae.

(Granok et al., 2001)

Lethality occurs at metamorphosis.

(Katokhin et al., 2001)

brm² shows little if any interaction in double heterozygous combination with Trl⁶²; less than 3% of flies have held-out wings.

(Vazquez et al., 1999)

Enhances the position effect variegation at the w locus caused by In(1)w^m4 and enhances the position effect variegation at the bw locus caused by In(2R)bw^VDe2. Does not enhance position effect variegation at the bw locus caused by Byron or the position effect variegation of w seen in the P{wA^R}41A insertion.

(Sass and Henikoff, 1998)

Transheterozygotes with Trl^13C are even less viable than Trl^13C homozygotes.

(Bhat et al., 1996)

Moderate enhancer of position effect variegation. Heterozygotes with Trl^13C eclose late, are poorly viable and exhibit the same phenotypes as Trl^13C homozygotes.

(Farkas et al., 1994)

Enhances variegation of In(1)w^m4h.

(Dorn et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Trl⁶²/Trl^13C has lethal | male phenotype, enhanceable by msl-2[+]/msl-2¹

(Greenberg et al., 2004)

Trl⁶²/Trl^13C has lethal | male phenotype, enhanceable by msl-1¹/msl-1[+]/msl-2[+]/msl-2¹/mle¹/mle[+]

(Greenberg et al., 2004)

Trl⁶²/Trl^13C has lethal | male phenotype, enhanceable by msl-1¹/msl-1[+]

(Greenberg et al., 2004)

Trl⁶² has visible | homeotic phenotype, enhanceable by mod(mdg4)^ul

(Gerasimova and Corces, 1998)

Trl⁶² has visible | homeotic phenotype, enhanceable by mod(mdg4)^T16

(Gerasimova and Corces, 1998)

NOT Enhanced by

Statement

Reference

Trl⁶²/Trl^13C has partially lethal | female phenotype, non-enhanceable by msl-1¹/msl-1[+]/msl-2[+]/msl-2¹/mle¹/mle[+]

(Greenberg et al., 2004)

Trl⁶²/Trl^13C has partially lethal | female phenotype, non-enhanceable by msl-1¹/msl-1[+]

(Greenberg et al., 2004)

Suppressed by

Statement

Reference

Trl⁶²/Trl^13C has lethal | male phenotype, suppressible | partially by msl-2^Hsp83.PK

(Greenberg et al., 2004)

NOT suppressed by

Statement

Reference

Trl⁶²/Trl^13C has partially lethal | female phenotype, non-suppressible by mle¹/mle[+]

(Greenberg et al., 2004)

Trl⁶²/Trl^13C has partially lethal | female phenotype, non-suppressible by msl-1¹/msl-1[+]

(Greenberg et al., 2004)

Enhancer of

Statement

Reference

Trl⁶² is an enhancer of abnormal body color phenotype of mod(mdg4)^ul, y²

(Gerasimova and Corces, 1998)

Suppressor of

Statement

Reference

Trl⁶² is a suppressor of lethal phenotype of Ras85D^V12.sev, sev^S11.Tag:MYC

(Maixner et al., 1998)

Other

Statement

Reference

Trl⁶²/Trl^13C, msl-2^Hsp83.PK has partially lethal phenotype

(Greenberg et al., 2004)

Ras85D^V12.sev, Trl⁶², sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Phenotype Manifest In

Enhancer of

Statement

Reference

Trl⁶² is an enhancer of adult cuticle | male phenotype of mod(mdg4)^ul, y²

(Gerasimova and Corces, 1998)

Trl[+]/Trl⁶² is an enhancer of sex comb | ectopic & mesothoracic leg phenotype of Pc³

(Strutt et al., 1997)

Trl⁶² is an enhancer of mesothoracic leg phenotype of Pc³

(Strutt et al., 1997)

Trl[+]/Trl⁶² is an enhancer of sex comb | ectopic & mesothoracic leg phenotype of Pc¹⁵

(Strutt et al., 1997)

Trl⁶² is an enhancer of mesothoracic leg phenotype of Pc¹⁵

(Strutt et al., 1997)

Suppressor of

Statement

Reference

Trl⁶² is a suppressor of eye phenotype of CycE^JP

(Brumby et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Mutant weakly suppresses the CycE^JP rough eye phenotype.

(Brumby et al., 2002)

Mutant heterozygotes show a weak enhancement of the eye phenotype see in P{UAS-lacZ.Abd-B.5F24} leading to lighter eyes.

(Cavalli, 1999)

The frequency of homeotic transformations seen in heterozygotes is increased in double heterozygous combination with mod(mdg4)^ul or mod(mdg4)^T16. Dominantly enhances the effect of mod(mdg4)^ul on the y² phenotype.

(Gerasimova and Corces, 1998)

The formation of extra sex combs on the second and third legs in Pc⁴/+ flies is not enhanced by Trl⁶².

(Kehle et al., 1998)

The lethality caused by sev^{S11.T:Hsap\MYC} in combination with Ras85D^V12.sev is suppressed by Trl⁶².

(Maixner et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Not rescued by

Trl⁶²/Trl^13C is not rescued by Trl^hs.PG

(Granok et al., 2001)

Trl⁶²/Trl^R67 is not rescued by Trl^hs.PG

(Granok et al., 2001)

Trl^R85/Trl⁶² is not rescued by Trl^hs.PG

(Granok et al., 2001)

Trl⁶² is not rescued by Trl^hs.PG

(Granok et al., 2001)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

58474

w^*; P{hsneo.ry⁺}Trl⁶²/TM6B, Tb⁺

Notes on Origin

Discoverer

Comments

Weak enhancer. High spontaneous background rate of E(var) mutations in these experiments allows for the possibility that the P insertion is not the cause of the E(var) phenotype.

(Dorn et al., 1993)

Attempts to make germ-line clones with this allele failed.

(Liaw et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

E(var)62

(Dorn et al., 1993)

E(var)62¹

GAGA^Trl62

(Laney and Biggin, 1996)

Trl62

(Katokhin et al., 2001)

Trl⁶²

(Vázquez et al., 2008, Hodgson et al., 2001)

trl⁶²

(Maixner et al., 1998)

Name Synonyms

Secondary FlyBase IDs

References (20)

Report Sections

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