FB2024_03 , released June 25, 2024
Allele: Dmel\mod(mdg4)T16
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General Information
Symbol
Dmel\mod(mdg4)T16
Species
D. melanogaster
Name
FlyBase ID
FBal0086404
Feature type
allele
Associated gene
Dmel\mod(mdg4)
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        mod(mdg4)Z3-3401/mod(mdg4)T16 males show a low frequency of 4th chromosome loss in meiosis (7.9%).

        Homologous pairing in pre-meiotic spermatogonia and in early prophase I spermatocytes appears normal in mod(mdg4)Z3-3401/mod(mdg4)T16 males.

        (Soltani-Bejnood et al., 2007)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhanced by
        Statement
        Reference

        ash117, mod(mdg4)T16/mod(mdg4)[+] has visible | dominant | homeotic phenotype, enhanceable by trxB11/trx[+]

        (Gerasimova and Corces, 1998)
        Enhancer of
        Statement
        Reference

        mod(mdg4)T16/mod(mdg4)[+] is an enhancer of visible | dominant | homeotic phenotype of brm2, trx[+]/trxE2

        (Gerasimova and Corces, 1998)

        mod(mdg4)T16/mod(mdg4)[+] is an enhancer of visible | dominant | homeotic phenotype of brm[+]/brm2, trxE2

        (Gerasimova and Corces, 1998)

        mod(mdg4)T16 is an enhancer of visible | homeotic phenotype of Trl62

        (Gerasimova and Corces, 1998)

        mod(mdg4)T16/mod(mdg4)[+] is an enhancer of visible | dominant | homeotic phenotype of ash1[+]/ash117, trxB11

        (Gerasimova and Corces, 1998)
        NOT Enhancer of
        Statement
        Reference

        mod(mdg4)Z3-5578/mod(mdg4)T16 is a non-enhancer of abnormal body color phenotype of y2

        (Soltani-Bejnood et al., 2007)
        NOT Suppressor of
        Statement
        Reference

        mod(mdg4)Z3-5578/mod(mdg4)T16 is a non-suppressor of abnormal body color phenotype of y2

        (Soltani-Bejnood et al., 2007)
        Other
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Body colour: y2 ; mod(mdg4)T6/mod(mdg4)T16 and y2 ; mod(mdg4)Z3-3401/mod(mdg4)T16 flies have a y- phenotype (yellow bristles, wings and bodies).

        Body colour: the y2 phenotype (black bristles, yellow body and wings) is not altered by mod(mdg4)Z3-5578/mod(mdg4)T16.

        (Soltani-Bejnood et al., 2007)

        mod(mdg4)T16 trxB11 double heterozygotes show a transformation of haltere to wing in 1.4% of cases. mod(mdg4)T16/+ or trxB11/+ single heterozygotes do not show this homeotic transformation. Increases the frequency of homeotic transformations seen in Trl62 heterozygotes. Increases the frequency of homeotic transformations seen in trxB11 ash117 double heterozygotes. Increases the frequency of homeotic transformations seen in trxE2 brm2 double heterozygotes. Dominantly suppresses the frequency and severity of homeotic transformations seen in Df(3L)Pc heterozygotes.

        (Gerasimova and Corces, 1998)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Partially complements

        mod(mdg4)Z3-3401

        (Soltani-Bejnood et al., 2007)

        mod(mdg4)Z3-5578

        (Soltani-Bejnood et al., 2007)

        mod(mdg4)Z3-3298

        (Soltani-Bejnood et al., 2007)
        Rescued by

        mod(mdg4)Z3-3401/mod(mdg4)T16 is rescued by mod(mdg4)MNM.hs.EGFP

        (Soltani-Bejnood et al., 2007)
        Partially rescued by

        mod(mdg4)Z3-3401/mod(mdg4)T16 is partially rescued by mod(mdg4)+t7.5

        (Soltani-Bejnood et al., 2007)
        Comments

        The lethal phenotype of mod(mdg4)T16 is fully complemented by mod(mdg4)Z3-3401, mod(mdg4)Z3-5578 and mod(mdg4)Z3-3298, but mod(mdg4)T16 fails to complement these alleles with respect to X-Y chromosome nondisjunction in male meiosis - the transheterozygotes show a high level of X-Y nondisjunction (frequency is indicated in parentheses after each allele); mod(mdg4)Z3-3401 (39.6%), mod(mdg4)Z3-5578 (44.3%) and mod(mdg4)Z3-3298 (44.6%).

        (Soltani-Bejnood et al., 2007)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        T16
        (Soltani-Bejnood et al., 2007)
        mod(mdg4)T16
        Name Synonyms
        Secondary FlyBase IDs
          References (3)