FB2024_03 , released June 25, 2024
Allele: Dmel\mod(mdg4)+t7.5
Open Close
General Information
Symbol
Dmel\mod(mdg4)+t7.5
Species
D. melanogaster
Name
FlyBase ID
FBal0117438
Feature type
allele
Associated gene
Dmel\mod(mdg4)
Associated Insertion(s)
Carried in Construct
P{mod(mdg4).7.5}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Buchner et al., 2000)
Progenitor genotype
Carried in construct
P{mod(mdg4).7.5}
Cytology
Description

Included within a 7.5kb BamHI fragment which encompasses the 5' region of mod(mdg4), including exons 1-4 which encode the common 402 amino acids.

(Buchner et al., 2000)
Allele components
Component
Use(s)
Regulatory region(s)
mod(mdg4)
Encoded product / tool
mod(mdg4)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      mod(mdg4)+t7.5 partially rescues mod(mdg4)neo129

      (Soltani-Bejnood et al., 2007)

      mod(mdg4)+t7.5 partially rescues mod(mdg4)Z3-3401

      (Soltani-Bejnood et al., 2007)

      mod(mdg4)+t7.5 partially rescues mod(mdg4)Z3-3401/mod(mdg4)T16

      (Soltani-Bejnood et al., 2007)

      mod(mdg4)+t7.5 partially rescues mod(mdg4)02

      (Buchner et al., 2000)

      mod(mdg4)+t7.5 partially rescues mod(mdg4)neo129

      (Buchner et al., 2000)
      Fails to rescue

      mod(mdg4)+t7.5 fails to rescue mod(mdg4)06

      (Buchner et al., 2000)

      mod(mdg4)+t7.5 fails to rescue mod(mdg4)07

      (Buchner et al., 2000)
      Comments

      mod(mdg4)+t7.5 is able to partially rescue the X-Y nondisjunction defects seen in mod(mdg4)Z3-3401/mod(mdg4)Z3-3401, mod(mdg4)neo129/mod(mdg4)neo129 and mod(mdg4)Z3-3401/mod(mdg4)T16 males, presumably due to trans-splicing.

      (Soltani-Bejnood et al., 2007)

      Lethality of mod(mdg4)02 and mod(mdg4)neo129 is partially rescued, though rescued males show homeotic transformation of A5 to A4. Rescued mod(mdg4)neo129 females are partially fertile - eggs arrest at differing stages of embryogenesis and occasional first instar larvae hatch.

      (Buchner et al., 2000)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      mod(mdg4)+t7.5
      Name Synonyms
      Secondary FlyBase IDs
        References (2)