FlyBase Allele Report: Dmel\mod(mdg4)[07]

General Information

Symbol

Dmel\mod(mdg4)⁰⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0117432

Feature type

allele

Associated gene

Dmel\mod(mdg4)

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Buchner et al., 2000)

Mutagen

ethyl methanesulfonate

(Buchner et al., 2000)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Enhances the variegation in, i.e. reduces the eye pigmentation of, In(1)w^m4h, Su(var)2-1¹ males.

(Buchner et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

mod(mdg4)⁰⁷/mod(mdg4)⁰² has lethal phenotype, suppressible | partially by Dvir\mod(mdg4)^t11.5

(Gabler et al., 2005)

NOT suppressed by

Statement

Reference

mod(mdg4)⁰⁷/mod(mdg4)^neo129 has lethal phenotype, non-suppressible by Dvir\mod(mdg4)^t11.5

(Gabler et al., 2005)

mod(mdg4)⁰⁷/mod(mdg4)⁰² has lethal phenotype, non-suppressible by Dvir\mod(mdg4)^t6.8

(Gabler et al., 2005)

Enhancer of

Statement

Reference

mod(mdg4)⁰⁷/mod(mdg4)[+] is an enhancer of visible | homeotic phenotype of trx^red-P6

(Buchner et al., 2000)

Suppressor of

Statement

Reference

mod(mdg4)⁰⁷/mod(mdg4)[+] is a suppressor of suppressor of variegation phenotype of In(1)w^m4h, Su(var)2-1¹

(Buchner et al., 2000)

Phenotype Manifest In

Enhancer of

Statement

Reference

mod(mdg4)⁰⁷/mod(mdg4)[+] is an enhancer of adult abdominal segment 5 phenotype of trx^red-P6

(Buchner et al., 2000)

Other

Statement

Reference

In(1)w^m4h, Su(var)2-1¹, mod(mdg4)⁰⁷/mod(mdg4)[+] has pigment cell phenotype

(Buchner et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Enhances the homeotic transformation of A5 to A4 of trx^red-P6.

(Buchner et al., 2000)

Xenogenetic Interactions

Statement

Reference

One copy of Dvir\mod(mdg4)^t11.5 does not suppresses the lethality of mod(mdg4)⁰⁷/mod(mdg4)^neo129 transheterozygotes. The lethality of mod(mdg4)⁰⁷/mod(mdg4)⁰² transheterozygotes is only slightly suppressed by one copy of Dvir\mod(mdg4)^t11.5 (12.5% or 5.4% viability has been seen). One copy of Dvir\mod(mdg4)^t6.8 does not suppresses the lethality of mod(mdg4)⁰⁷/mod(mdg4)⁰² transheterozygotes.