FlyBase Allele Report: Dmel\mod(mdg4)[03]

General Information

Symbol

Dmel\mod(mdg4)⁰³

Species

D. melanogaster

Name

FlyBase ID

FBal0117436

Feature type

allele

Associated gene

Dmel\mod(mdg4)

Associated Insertion(s)

P{}mod(mdg4)⁰³

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Buchner et al., 2000)

Mutagen

P-element activity

(Buchner et al., 2000)

Progenitor genotype

Associated Insertion(s)

P{}mod(mdg4)⁰³

Cytology

Description

Insertion into the first 5' non-coding exon of the mod(mdg4) transcription unit.

(Buchner et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal meiotic cell cycle | male (with mod(mdg4)^Z3-3401)

(Soltani-Bejnood et al., 2007)

female sterile (with mod(mdg4)⁰²)

(Buchner et al., 2000)

female sterile (with mod(mdg4)⁰⁵)

(Buchner et al., 2000)

female sterile (with mod(mdg4)⁰⁶)

(Buchner et al., 2000)

female sterile (with mod(mdg4)⁰⁷)

(Buchner et al., 2000)

female sterile (with mod(mdg4)^neo129)

(Buchner et al., 2000)

female sterile (with mod(mdg4)^R32)

(Buchner et al., 2000)

lethal

(Soltani-Bejnood et al., 2007)

lethal | recessive

(Buchner et al., 2000)

partially lethal - majority die (with mod(mdg4)⁰²)

(Buchner et al., 2000)

partially lethal - majority die (with mod(mdg4)⁰⁶)

(Buchner et al., 2000)

partially lethal - majority die (with mod(mdg4)⁰⁷)

(Buchner et al., 2000)

partially lethal - majority die (with mod(mdg4)^neo129)

(Buchner et al., 2000)

partially lethal - majority die (with mod(mdg4)^R32)

(Buchner et al., 2000)

Phenotype Manifest In

Detailed Description

Statement

Reference

Enhances the variegation in, i.e. reduces the eye pigmentation of, In(1)w^m4h, Su(var)2-1¹ males.

(Buchner et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

mod(mdg4)⁰³/mod(mdg4)[+] is an enhancer of visible | homeotic phenotype of trx^red-P6

(Buchner et al., 2000)

Suppressor of

Statement

Reference

mod(mdg4)⁰³/mod(mdg4)[+] is a suppressor of suppressor of variegation phenotype of In(1)w^m4h, Su(var)2-1¹

(Buchner et al., 2000)

Phenotype Manifest In

Enhancer of

Statement

Reference

mod(mdg4)⁰³/mod(mdg4)[+] is an enhancer of adult abdominal segment 5 phenotype of trx^red-P6

(Buchner et al., 2000)

Other

Statement

Reference

In(1)w^m4h, Su(var)2-1¹, mod(mdg4)⁰³/mod(mdg4)[+] has pigment cell phenotype

(Buchner et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Enhances the homeotic transformation of A5 to A4 of trx^red-P6.

(Buchner et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially complements

mod(mdg4)^Z3-3401

(Soltani-Bejnood et al., 2007)

mod(mdg4)⁰²

(Buchner et al., 2000)

mod(mdg4)⁰⁵

(Buchner et al., 2000)

mod(mdg4)⁰⁶

(Buchner et al., 2000)

mod(mdg4)⁰⁷

(Buchner et al., 2000)

mod(mdg4)^R32

(Buchner et al., 2000)

mod(mdg4)^neo129

(Buchner et al., 2000)

Fails to complement

mod(mdg4)⁰⁴

(Buchner et al., 2000)

Comments

The lethal phenotype of mod(mdg4)⁰³ is fully complemented by mod(mdg4)^Z3-3401, but mod(mdg4)⁰³ fails to complement mod(mdg4)^Z3-3401 with respect to X-Y chromosome nondisjunction in male meiosis - transheterozygotes show a high level of X-Y nondisjunction (34.9%).

The lethal phenotype of mod(mdg4)⁰³ is fully complemented by mod(mdg4)^Z3-5578 and mod(mdg4)^Z3-3298, and mod(mdg4)⁰³ partially or fully complements these alleles with respect to X-Y chromosome nondisjunction in male meiosis - the transheterozygotes show only a low level of X-Y nondisjunction (frequency is indicated in parentheses after each allele); mod(mdg4)^Z3-5578 (0.07%) and mod(mdg4)^Z3-3298 (0.12%).

(Soltani-Bejnood et al., 2007)

Complementation statements based on viability. Semilethal, and female sterile, over Df(3R)GC14.

(Buchner et al., 2000)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Alleles of mod(mdg4) show an allelic series for their effect on In(1)w^m4h variegation. From strongest to weakest: mod(mdg4)^R32 = mod(mdg4)⁰⁴ = mod(mdg4)⁰⁶ = mod(mdg4)⁰⁷ = mod(mdg4)^142Δ32 > mod(mdg4)^neo129 = mod(mdg4)⁰² = mod(mdg4)⁰³ > mod(mdg4)⁰⁵.

(Buchner et al., 2000)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

(Soltani-Bejnood et al., 2007)

mod(mdg4)⁰³

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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