FlyBase Allele Report: Dmel\mod(mdg4)[R32]

General Information

Symbol

Dmel\mod(mdg4)^R32

Species

D. melanogaster

Name

FlyBase ID

FBal0117430

Feature type

allele

Associated gene

Dmel\mod(mdg4)

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

loss of function allele

(Buchner et al., 2000)

Mutagen

P-element activity

(Buchner et al., 2000)

Progenitor genotype

mod(mdg4)^neo129

(Buchner et al., 2000)

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile (with mod(mdg4)⁰³)

(Buchner et al., 2000)

lethal (with mod(mdg4)⁰²)

(Gabler et al., 2005)

lethal | recessive

(Gabler et al., 2005, Buchner et al., 2000)

partially lethal - majority die (with mod(mdg4)⁰³)

(Buchner et al., 2000)

Phenotype Manifest In

Detailed Description

Statement

Reference

Enhances the variegation in, i.e. reduces the eye pigmentation of, In(1)w^m4h, Su(var)2-1¹ males.

(Buchner et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

mod(mdg4)^neo129/mod(mdg4)^R32 has lethal phenotype, suppressible | partially by Dvir\mod(mdg4)^t11.5

(Gabler et al., 2005)

mod(mdg4)⁰²/mod(mdg4)^R32 has lethal | male phenotype, suppressible | partially by Dvir\mod(mdg4)^t6.8

(Gabler et al., 2005)

mod(mdg4)⁰²/mod(mdg4)^R32 has lethal phenotype, suppressible | partially by Dvir\mod(mdg4)^t11.5

(Gabler et al., 2005)

NOT suppressed by

Statement

Reference

mod(mdg4)⁰²/mod(mdg4)^R32 has lethal | female phenotype, non-suppressible by Dvir\mod(mdg4)^t6.8

(Gabler et al., 2005)

Enhancer of

Statement

Reference

mod(mdg4)[+]/mod(mdg4)^R32 is an enhancer of visible | homeotic phenotype of trx^red-P6

(Buchner et al., 2000)

Suppressor of

Statement

Reference

mod(mdg4)[+]/mod(mdg4)^R32 is a suppressor of suppressor of variegation phenotype of In(1)w^m4h, Su(var)2-1¹

(Buchner et al., 2000)

Phenotype Manifest In

Enhancer of

Statement

Reference

mod(mdg4)[+]/mod(mdg4)^R32 is an enhancer of adult abdominal segment 5 phenotype of trx^red-P6

(Buchner et al., 2000)

Other

Statement

Reference

In(1)w^m4h, Su(var)2-1¹, mod(mdg4)[+]/mod(mdg4)^R32 has pigment cell phenotype

(Buchner et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Enhances the homeotic transformation of A5 to A4 of trx^red-P6.

(Buchner et al., 2000)

Xenogenetic Interactions

Statement

Reference

One copy of Dvir\mod(mdg4)^t11.5 can rescue the lethality of mod(mdg4)^R32/mod(mdg4)⁰² transheterozygotes. Rescued males show greater viability (91.8% or 95.9% depending on the P{Dvir\mod(mdg4)^t11.5} line used) compared to rescued females (26.2% or 37.8% depending on the P{Dvir\mod(mdg4)^t11.5} line used). One copy of Dvir\mod(mdg4)^t11.5 can rescue the lethality of mod(mdg4)^R32/mod(mdg4)^neo129 transheterozygotes. Rescued males show greater viability (63.2%) compared to rescued females (40.5%). One copy of Dvir\mod(mdg4)^t6.8 partially rescues the lethality of mod(mdg4)^R32/mod(mdg4)⁰² transheterozygous males (52.3% viability is seen), but the lethality of mod(mdg4)^R32/mod(mdg4)⁰² females is not rescued.