FB2024_03 , released June 25, 2024
Allele: Dvir\mod(mdg4)t11.5
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General Information
Symbol
Dvir\mod(mdg4)t11.5
Species
D. virilis
Name
FlyBase ID
FBal0184035
Feature type
allele
Associated gene
Dvir\mod(mdg4)
Associated Insertion(s)
Carried in Construct
P{Dvir\mod(mdg4)t11.5}
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Gabler et al., 2005)
Progenitor genotype
Carried in construct
P{Dvir\mod(mdg4)t11.5}
Cytology
Description

Construct: 11.5kb genomic NotI fragment which encodes the Dvir\mod(mdg4) common exons, five specific exons from isoforms 64.2, 60.1, 53.5, 55.1 and 53.1 and a partial specific exon from isoform 62.3. This fragment is not expected to produce the 62.3 isoform, because both the trans-splice site and a putative promoter driving its expression are not included.

(Gabler et al., 2005)
Allele components
Component
Use(s)
Encoded product / tool
Dvir\mod(mdg4)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      Dvir\mod(mdg4)t11.5 is a non-suppressor of lethal phenotype of mod(mdg4)07/mod(mdg4)neo129

      (Gabler et al., 2005)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      One copy of Dvir\mod(mdg4)t11.5 can rescue the lethality of mod(mdg4)02 homozygotes, with the degree of rescue depending on the P{Dvir\mod(mdg4)t11.5} line used (26.6% and 79.0% viability has been seen). Two copies of Dvir\mod(mdg4)t11.5 completely suppress the lethality of mod(mdg4)02 homozygotes. One copy of Dvir\mod(mdg4)t11.5 can rescue the lethality of mod(mdg4)neo129 homozygotes (92% of the expected progeny survive). One copy of Dvir\mod(mdg4)t11.5 can rescue the lethality of mod(mdg4)02/mod(mdg4)neo129 transheterozygotes, with the degree of rescue depending on the P{Dvir\mod(mdg4)t11.5} line used (95.1% and full viability has been seen). One copy of Dvir\mod(mdg4)t11.5 can rescue the lethality of mod(mdg4)R32/mod(mdg4)02 transheterozygotes. Rescued males show greater viability (91.8% or 95.9% depending on the P{Dvir\mod(mdg4)t11.5} line used) compared to rescued females (26.2% or 37.8% depending on the P{Dvir\mod(mdg4)t11.5} line used). One copy of Dvir\mod(mdg4)t11.5 can rescue the lethality of mod(mdg4)R32/mod(mdg4)neo129 transheterozygotes. Rescued males show greater viability (63.2%) compared to rescued females (40.5%). One copy of Dvir\mod(mdg4)t11.5 does not suppresses the lethality of mod(mdg4)07/mod(mdg4)neo129 transheterozygotes. The lethality of mod(mdg4)07/mod(mdg4)02 transheterozygotes is only slightly suppressed by one copy of Dvir\mod(mdg4)t11.5 (12.5% or 5.4% viability has been seen).

      (Gabler et al., 2005)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Assayed in D.melanogaster.

      (Gabler et al., 2005)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Dvir\mod(mdg4)t11.5
      Name Synonyms
      Secondary FlyBase IDs
        References (1)