FlyBase Allele Report: Dmel\msl-2[1]

General Information

Symbol

Dmel\msl-2¹

Species

D. melanogaster

Name

FlyBase ID

FBal0012561

Feature type

allele

Associated gene

Dmel\msl-2

Associated Insertion(s)

Carried in Construct

Also Known As

msl2¹, msl-2

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

Progenitor genotype

Cytology

Description

Amino acid replacement: P?L.

(Zhou et al., 1995)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:3,465,488..3,465,488 [-]

Nucleotide change:

C3465488T

Reported nucleotide change:

C628T

Amino acid change:

P51L | msl-2-PA; P51L | msl-2-PB

Reported amino acid change:

P51L

(Zhou et al., 1995)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | male

(Kelley et al., 1995)

lethal - all die before end of larval stage | male

(Bone et al., 1994)

some die during larval stage | male

(Bone et al., 1994)

Phenotype Manifest In

Detailed Description

Statement

Reference

male-lethal

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

msl-2[+]/msl-2¹ is an enhancer | maternal effect of partially lethal - majority die | dominant | female phenotype of sc^sisB-1, sisA[+]/sisA¹

(Gladstein et al., 2010)

msl-2[+]/msl-2¹ is an enhancer of lethal | male phenotype of Trl⁶²/Trl^13C

(Greenberg et al., 2004)

msl-2[+]/msl-2¹ is an enhancer of lethal | male phenotype of Trl^2.3/Trl^13C

(Greenberg et al., 2004)

msl-1¹, msl-1[+], msl-2[+], msl-2¹, mle¹, mle[+] is an enhancer of lethal | male phenotype of Trl⁶²/Trl^13C

(Greenberg et al., 2004)

NOT Enhancer of

Statement

Reference

msl-2[+]/msl-2¹ is a non-enhancer of partially lethal | female phenotype of Trl^2.3/Trl^13C

(Greenberg et al., 2004)

msl-1¹, msl-1[+], msl-2[+], msl-2¹, mle¹, mle[+] is a non-enhancer of partially lethal | female phenotype of Trl⁶²/Trl^13C

(Greenberg et al., 2004)

Suppressor of

Statement

Reference

msl-2[+]/msl-2¹ is a suppressor | partially of lethal | male phenotype of ocm^L1658N/ocm^G1646E

(Lim and Kelley, 2013)

NOT Suppressor of

Statement

Reference

msl-1¹, msl-1[+], msl-2[+], mle¹, msl-2¹, mle[+] is a non-suppressor of partially lethal | female phenotype of Trl^2.3/Trl^13C

(Greenberg et al., 2004)

msl-2[+]/msl-2¹ is a non-suppressor of partially lethal | female phenotype of Trl^2.3/Trl^13C

(Greenberg et al., 2004)

Other

Statement

Reference

Sxl[+]/Sxl^fP7B0, msl-2¹ has partially lethal - majority die | female | maternal effect phenotype

(Gladstein et al., 2010)

Sxl^f1, msl-2¹ has abnormal sex-determination | dominant | female phenotype

(Skripsky and Lucchesi, 1982)

Sxl^f1, msl-2¹ has visible | dominant | female phenotype

(Skripsky and Lucchesi, 1982)

Sxl^f1, msl-2¹ has abnormal sex-determination | female phenotype

(Skripsky and Lucchesi, 1982)

Sxl^f1, msl-2¹ has visible | female phenotype

(Skripsky and Lucchesi, 1982)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

msl-2¹³⁸/msl-2¹ is a non-suppressor of ovary phenotype of ovo^D1rv22

(Oliver and Pauli, 1998)

msl-2¹³⁸/msl-2¹ is a non-suppressor of ovary phenotype of ovo^D1rv23

(Oliver and Pauli, 1998)

Other

Statement

Reference

Sxl^f1, msl-2¹ has prothoracic metatarsus | female phenotype

(Skripsky and Lucchesi, 1982)

Additional Comments

Genetic Interactions

Statement

Reference

The viability of Sxl^fP7B0/+ females is significantly reduced if they also carry one maternally-derived copy of msl-2¹.

One maternally-derived copy of msl-2¹ significantly reduces the viability of sc^sisB-1 sisA¹/+ females so that they show almost complete lethality. One paternally-derived copy of msl-2¹ significantly reduces the viability of sc^sisB-1 sisA¹/+ females, although this zygotic effect is generally weaker than the maternal one.

(Gladstein et al., 2010)

Ovaries of ovo^D1rv23/ovo^D1rv22 females contain germline chambers in less than 20% of cases. The phenotype is not affected if the females are also carrying msl-2¹³⁸/msl-2¹.

(Oliver and Pauli, 1998)

Some females homozygous for msl-2¹ and heterozygous for Sxl^f1 have sex combs on the basitarsi of their forelegs. This phenotype occurs with a higher frequency in females with homozygous msl-2¹ mothers.

(Skripsky and Lucchesi, 1982)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

msl-2¹ is rescued by msl-2^SXB1

(Kelley et al., 1997)

msl-2¹ is rescued by msl-2^SM53

(Kelley et al., 1997)

msl-2¹ is rescued by msl-2^SXB2

(Kelley et al., 1997)

msl-2¹ is rescued by msl-2^+t6

(Kelley et al., 1997)

msl-2¹ is rescued by msl-2^NOPU

(Kelley et al., 1997)

msl-2¹ is rescued by msl-2^SXB1-2

(Kelley et al., 1997)

msl-2¹ is rescued by msl-2^MM2SV

(Kelley et al., 1997)

msl-2¹ is rescued by msl-2^+tKg

(Kelley et al., 1995)

msl-2¹ is rescued by msl-2^+tKa

(Kelley et al., 1995)

msl-2¹ is rescued by msl-2^+tKb

(Kelley et al., 1995)

Partially rescued by

msl-2¹ is partially rescued by msl-2^hs.Venus

(Straub et al., 2005)

Not rescued by

msl-2¹ is not rescued by msl-2^tKf

(Kelley et al., 1995)

msl-2¹ is not rescued by msl-2^tKd

(Kelley et al., 1995)

msl-2¹ is not rescued by msl-2^tKe

(Kelley et al., 1995)

msl-2¹ is not rescued by msl-2^tKc

(Kelley et al., 1995)

Comments

msl-2¹ homozygous males carrying msl-2^{hs.T:Avic\GFP-Venus} show a survival rate of 60% at 25[o]C.

(Straub et al., 2005)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Belote.

Comments

Clonal analysis indicates that msl-2 acts in a cell autonomous manner, and is required in imaginal discs and histoblasts at some time after blastoderm formation in males. The requirement in the imaginal discs is late in development, during mid to late third instar. Clonal analysis also shows that the msl-2 mutation does not affect sexual differentiation.

(Belote, 1983)

H4Ac16, acetylated form of His4, is not localised to the X chromosome in male salivary gland nuclei.

(Bone et al., 1994)

γ ray induced revertants of msl-2¹ are cytologically normal.

(Zhou et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

msl-2

(Belote, 1983, Skripsky and Lucchesi, 1982)

msl-2¹

(Evans and Cline, 2013, Gladstein et al., 2010, Dahlsveen et al., 2006)

msl2¹

(Lim and Kelley, 2013, Straub et al., 2005, Rattner and Meller, 2004, Meller, 2003)

Name Synonyms

Secondary FlyBase IDs

References (18)

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