FB2024_03 , released June 25, 2024
Allele: Dmel\ocmG1646E
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General Information
Symbol
Dmel\ocmG1646E
Species
D. melanogaster
Name
FlyBase ID
FBal0284226
Feature type
allele
Associated gene
Dmel\ocm
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Lim and Kelley, 2012)
Progenitor genotype
Cytology
Description

Amino acid replacement: G1646E.

(Lim and Kelley, 2012)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:24,193,473..24,193,473 [+]
Nucleotide change:

G24193473A

Amino acid change:

G1645E | ocm-PA; G1645E | ocm-PB; G1645E | ocm-PC

Reported amino acid change:

G1646E

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Lim and Kelley, 2012)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      ocmG1646E/+ has no effect on the position effect variegation of the w locus caused by In(1)wm4 in males or in females.

      ocmL1658N/ocmG1646E males reach the third instar larval stage, but die before adulthood.

      (Lim and Kelley, 2013)

      ocmG1646E increases eye pigmentation in males homozygous for the P{GMroX1}75C insertion, but has no effect on the eye pigmentation in females homozygous for this insertion.

      (Lim and Kelley, 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      ocmL1658N/ocmG1646E has lethal | male phenotype, suppressible | partially by msl-1L60/msl-1[+]

      (Lim and Kelley, 2013)

      ocmL1658N/ocmG1646E has lethal | male phenotype, suppressible | partially by msl-2[+]/msl-21

      (Lim and Kelley, 2013)

      ocmL1658N/ocmG1646E has lethal | male phenotype, suppressible | partially by mle1/mle[+]

      (Lim and Kelley, 2013)
      Suppressor of
      Statement
      Reference

      ocm[+]/ocmG1646E is a suppressor | partially of lethal | male phenotype of Df(1)52, P{w+4Δ4.3}, lncRNA:roX1ex6, lncRNA:roX1t4.9, msl-1L60

      (Lim and Kelley, 2013)
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      610A
      (Lim and Kelley, 2012)
      ocmG1646E
      (Lim and Kelley, 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)