FlyBase Allele Report: Dmel\lncRNA:roX1[t4.9]

General Information

Symbol

Dmel\lncRNA:roX1^t4.9

Species

D. melanogaster

Name

FlyBase ID

FBal0099839

Feature type

allele

Associated gene

Dmel\lncRNA:roX1

Associated Insertion(s)

Carried in Construct

P{GMroX1}

P{roX1.4.9.arm-lacZ}

Also Known As

GMroX1

Key Links

Genomic Maps

JBrowse

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Kelley et al., 1999)

Progenitor genotype

Carried in construct

P{GMroX1}

P{roX1.4.9.arm-lacZ}

Cytology

Description

Construct: Included within 4.9kb genomic EcoRI fragment containing the roX1 transcription unit. A small amount of yin 3' end is included.

(Kelley et al., 1999)

Allele components

Component

Use(s)

Encoded product / tool

lncRNA:roX1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

rescue_region

X:3,858,505..3,863,458 [-]

Linked to:

EcoRI-EcoRI restriction fragment

Comment:

Position of restriction fragment on reference sequence inferred by FlyBase curator.

(Kelley et al., 1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Df(1)52, P{w⁺4Δ4.3}, lncRNA:roX1^ex6, lncRNA:roX1^t4.9 has partially lethal | male phenotype, enhanceable by Spt5^Q314X/Spt5[+]

(Prabhakaran and Kelley, 2012)

Df(1)52, P{w⁺4Δ4.3}, lncRNA:roX1^ex6, lncRNA:roX1^t4.9 has partially lethal | male phenotype, enhanceable by Spt5[+]/Spt5^E471Z

(Prabhakaran and Kelley, 2012)

Df(1)52, P{w⁺4Δ4.3}, lncRNA:roX1^ex6, lncRNA:roX1^t4.9 has partially lethal | male phenotype, enhanceable by Spt5[+]/Spt5^A680Z

(Prabhakaran and Kelley, 2012)

Df(1)52, P{w⁺4Δ4.3}, lncRNA:roX1^ex6, lncRNA:roX1^t4.9 has partially lethal | male phenotype, enhanceable by Spt5^S14F/Spt5[+]

(Prabhakaran and Kelley, 2012)

Df(1)52, P{w⁺4Δ4.3}, lncRNA:roX1^ex6, lncRNA:roX1^t4.9 has partially lethal | male phenotype, enhanceable by Su(Tpl)[+]/Su(Tpl)^S-192

(Prabhakaran and Kelley, 2012)

Df(1)52, P{w⁺4Δ4.3}, lncRNA:roX1^ex6, lncRNA:roX1^t4.9 has partially lethal | male phenotype, enhanceable by msl-1^L60/msl-1[+]

(Prabhakaran and Kelley, 2012)

NOT Enhanced by

Statement

Reference

Df(1)52, P{w⁺4Δ4.3}, lncRNA:roX1^ex6, lncRNA:roX1^t4.9 has partially lethal | male phenotype, non-enhanceable by JIL-1[+]/JIL-1^z2

(Prabhakaran and Kelley, 2012)

Df(1)52, P{w⁺4Δ4.3}, lncRNA:roX1^ex6, lncRNA:roX1^t4.9 has partially lethal | male phenotype, non-enhanceable by Elongin-C[+]/EloC^G6035

(Prabhakaran and Kelley, 2012)

Suppressed by

Statement

Reference

Df(1)52, P{w⁺4Δ4.3}, lncRNA:roX1^ex6, lncRNA:roX1^t4.9, msl-1^L60 has lethal | male phenotype, suppressible | partially by ocm^Q1297X/ocm[+]

(Lim and Kelley, 2013)

Df(1)52, P{w⁺4Δ4.3}, lncRNA:roX1^ex6, lncRNA:roX1^t4.9, msl-1^L60 has lethal | male phenotype, suppressible | partially by ocm[+]/ocm^G1646E

(Lim and Kelley, 2013)

Df(1)52, P{w⁺4Δ4.3}, lncRNA:roX1^ex6, lncRNA:roX1^t4.9, msl-1^L60 has lethal | male phenotype, suppressible | partially by ocm^S1590F/ocm[+]

(Lim and Kelley, 2013)

NOT suppressed by

Statement

Reference

Df(1)52, P{w⁺4Δ4.3}, lncRNA:roX1^ex6, lncRNA:roX1^t4.9 has partially lethal | male phenotype, non-suppressible by JIL-1[+]/JIL-1^z2

(Prabhakaran and Kelley, 2012)

Df(1)52, P{w⁺4Δ4.3}, lncRNA:roX1^ex6, lncRNA:roX1^t4.9 has partially lethal | male phenotype, non-suppressible by Elongin-C[+]/EloC^G6035

(Prabhakaran and Kelley, 2012)

Other

Statement

Reference

Df(1)52, P{w⁺4Δ4.3}, lncRNA:roX1^ex6, lncRNA:roX1^t4.9, msl-1^L60 has lethal | male phenotype

(Lim and Kelley, 2013)

Df(1)52, P{w⁺4Δ4.3}, lncRNA:roX1^ex6, lncRNA:roX1^t4.9, msl-1^L60, ocm^Q1297X/ocm[+] has partially lethal | male phenotype

(Lim and Kelley, 2013)

Df(1)52, P{w⁺4Δ4.3}, lncRNA:roX1^ex6, lncRNA:roX1^t4.9, msl-1^L60, ocm[+]/ocm^G1646E has partially lethal | male phenotype

(Lim and Kelley, 2013)

Df(1)52, P{w⁺4Δ4.3}, lncRNA:roX1^ex6, lncRNA:roX1^t4.9, msl-1^L60, ocm^S1590F/ocm[+] has partially lethal | male phenotype

(Lim and Kelley, 2013)

Df(1)52, P{w⁺4Δ4.3}, lncRNA:roX1^ex6, lncRNA:roX1^t4.9 has partially lethal | male phenotype

(Lim and Kelley, 2013, Prabhakaran and Kelley, 2012)

Df(1)52, P{w⁺4Δ4.3}, lncRNA:roX1^ex6, lncRNA:roX1^t4.9, msl-1^L60/msl-1[+] has lethal | male phenotype

(Prabhakaran and Kelley, 2012)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The ability of P{GMroX1}75C (which carries roX1^t4.9) to partially rescue the lethality of roX1^ex6/Df(1)52 males is suppressed if the males are also heterozygous for msl-1^L60, msl-1^AFG or msl-1^K1009X.

P{GMroX1}75C (which carries roX1^t4.9) is still able to partially rescue the lethality of roX1^ex6/Df(1)52 males if the males are also heterozygous for msl-1^P864L, msl-1^S943F or msl-1^F979Z.

(Prabhakaran and Kelley, 2010)

The male lethality caused by the roX1^ex6 Df(1)52 P{w⁺4Δ4.3} combination is rescued with an average frequency of 86% by roX1^t4.9.

(Bai et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

lncRNA:roX1^t4.9 partially rescues Df(1)52/lncRNA:roX1^ex6

(Prabhakaran and Kelley, 2010)

Comments

P{GMroX1}75C (which carries roX1^t4.9) partially rescues the lethality of roX1^ex6/Df(1)52 males.

(Prabhakaran and Kelley, 2010)

roX1^t4.9 shows intermediate rescue of the lethality of roX1^ex6 Df(1)52, P{w⁺4Δ4.3} males.

roX1^t4.9 shows intermediate rescue of the lethality of roX1^SMC40A Df(1)52, P{w⁺4Δ4.3} males.

roX1^t4.9 shows intermediate rescue of the lethality of roX1^ex84A Df(1)52, P{w⁺4Δ4.3} males.

roX1^t4.9 shows intermediate rescue of the lethality of roX1^SMC17A Df(1)52, P{w⁺4Δ4.3} males.

(Deng and Meller, 2009)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

lncRNA:roX1^t4.9

roX1^t4.9

Name Synonyms

Secondary FlyBase IDs

References (14)

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