FlyBase Allele Report: Dmel\Taf9[1]

General Information

Symbol

Dmel\Taf9¹

Species

D. melanogaster

Name

FlyBase ID

FBal0003366

Feature type

allele

Associated gene

Dmel\Taf9

Associated Insertion(s)

Stalker{}Taf9¹

Carried in Construct

Also Known As

e(y)^u1, e(y)1^u1, Stalker{}e(y)1¹

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Stalker-hybrid dysgenesis

Nature of the Allele

Allele class

Mutagen

Stalker-hybrid dysgenesis

(Georgiev and Gerasimova, 1989)

Progenitor genotype

Associated Insertion(s)

Stalker{}Taf9¹

Cytology

Description

Insertion of a Stalker element in the second exon, in the opposite direction to that of e(y)1 transcription. This results in a chimeric protein in which the 25 carboxyl amino acids of e(y)1 are replaced with 17 amino acids encoded by Stalker sequence.

(Soldatov et al., 1999)

Insertion of Stalker element.

(Georgiev and Gerasimova, 1989)

Stalker insertion

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:17,843,082..17,843,084 [-]

(Soldatov et al., 1999, Soldatov and Nabirochkina, 1996, Georgiev and Gerasimova, 1989)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile | recessive

(Soldatov et al., 1999, Georgiev and Gerasimova, 1989)

viable

(Georgieva et al., 2001, Soldatov et al., 1999)

Phenotype Manifest In

oocyte

(Soldatov et al., 1999)

ovary

(Soldatov et al., 1999)

Detailed Description

Statement

Reference

Homozygous adults show no visible morphological changes compared to wild type. Homozygous females are sterile; the ovaries are dramatically underdeveloped and do not contain mature oocytes.

(Soldatov et al., 1999)

The pigmentation of y² e(y)2¹ flies is not altered by Su(mg)1-6^1-6, Su(mg)1-7^1-7 or Su(mg)1-8^1-8.

(Bezborodova et al., 1997)

No mutant phenotype in the wing.

(Melnikova et al., 1996)

Stable mutation. Has no effect on the y⁺ phenotype.

(Georgiev and Gerasimova, 1989)

head and thorax bristles yellow; microchaetae yellow; female-sterile

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Taf9¹, w^BR.E.BR, z^v77h has abnormal eye color phenotype, enhanceable by su(Hw)^V/su(Hw)²

(Soldatov et al., 1999)

Enhancer of

Statement

Reference

Taf9¹ is an enhancer of abnormal eye color phenotype of w^+mC

(Soldatov et al., 1999)

Taf9¹ is an enhancer of abnormal eye color phenotype of w^BR.E.BR, z^v77h

(Soldatov et al., 1999)

Taf9¹ is an enhancer of abnormal eye color phenotype of su(Hw)^V/su(Hw)², w^BR.E.BR, z^v77h

(Soldatov et al., 1999)

Taf9¹ is an enhancer of abnormal body color phenotype of y^2PR1

(Soldatov et al., 1999)

Taf9¹ is an enhancer of abnormal body color phenotype of y^2PR2

(Soldatov et al., 1999)

Taf9¹ is an enhancer of abnormal eye color phenotype of w^E.BR, z^v77h

(Soldatov et al., 1999)

Taf9¹ is an enhancer of abnormal body color phenotype of y^76d28

(Soldatov et al., 1999)

Taf9¹ is an enhancer of abnormal eye color phenotype of w^sp2, z^v77h

(Georgiev, 1994)

Taf9¹ is an enhancer of abnormal eye color phenotype of w^sp2, z¹

(Georgiev, 1994)

Taf9¹ is an enhancer of abnormal eye color phenotype of w^sp4, z^v77h

(Georgiev, 1994)

Taf9¹ is an enhancer of abnormal eye color phenotype of w^sp4, z¹

(Georgiev, 1994)

Taf9¹ is an enhancer of abnormal eye color phenotype of w^sp1, z^v77h

(Georgiev, 1994)

Taf9¹ is an enhancer of abnormal eye color phenotype of w^sp1, z¹

(Georgiev, 1994)

Other

Statement

Reference

Taf9¹, e(y)2¹ has lethal phenotype

(Georgieva et al., 2001)

Taf9¹, e(y)3⁴ has lethal phenotype

(Soldatov et al., 1999, Georgiev, 1994)

Taf9¹, y^+2MC has abnormal body color phenotype

(Soldatov et al., 1999)

Taf9¹, y² has abnormal body color phenotype

(Soldatov et al., 1999)

Taf9¹, e(y)2¹ has male sterile phenotype

(Georgiev, 1994)

Taf9¹, e(y)2¹ has partially lethal | male phenotype

(Georgiev, 1994)

Phenotype Manifest In

Enhanced by

Statement

Reference

Taf9¹, w^BR.E.BR, z^v77h has pigment cell phenotype, enhanceable by su(Hw)^V/su(Hw)²

(Soldatov et al., 1999)

Enhancer of

Statement

Reference

Taf9¹ is an enhancer of pigment cell phenotype of w^+mC

(Soldatov et al., 1999)

Taf9¹ is an enhancer of pigment cell phenotype of w^BR.E.BR, z^v77h

(Soldatov et al., 1999)

Taf9¹ is an enhancer of pigment cell phenotype of su(Hw)^V/su(Hw)², w^BR.E.BR, z^v77h

(Soldatov et al., 1999)

Taf9¹ is an enhancer of pigment cell phenotype of w^E.BR, z^v77h

(Soldatov et al., 1999)

Taf9¹ is an enhancer of leg & external sensory organ phenotype of y^76d28

(Soldatov et al., 1999)

Taf9¹ is an enhancer of adult thorax & macrochaeta phenotype of y^76d28

(Soldatov et al., 1999)

Taf9¹ is an enhancer of adult abdomen & macrochaeta phenotype of y^76d28

(Soldatov et al., 1999)

Taf9¹ is an enhancer of phenotype of w^sp2

(Georgiev, 1994)

Taf9¹ is an enhancer of pigment cell phenotype of w^sp2, z^v77h

(Georgiev, 1994)

Taf9¹ is an enhancer of pigment cell phenotype of w^sp2, z¹

(Georgiev, 1994)

Taf9¹ is an enhancer of phenotype of w^sp4

(Georgiev, 1994)

Taf9¹ is an enhancer of pigment cell phenotype of w^sp4, z^v77h

(Georgiev, 1994)

Taf9¹ is an enhancer of pigment cell phenotype of w^sp4, z¹

(Georgiev, 1994)

Taf9¹ is an enhancer of phenotype of z^op6

(Georgiev, 1994)

Taf9¹ is an enhancer of phenotype of w^sp1

(Georgiev, 1994)

Taf9¹ is an enhancer of pigment cell phenotype of w^sp1, z^v77h

(Georgiev, 1994)

Taf9¹ is an enhancer of pigment cell phenotype of w^sp1, z¹

(Georgiev, 1994)

Taf9¹ is an enhancer of phenotype of z^v77h

(Georgiev, 1994)

NOT Enhancer of

Statement

Reference

Taf9¹ is a non-enhancer of phenotype of y^+1MC

(Soldatov et al., 1999)

Taf9¹ is a non-enhancer of phenotype of y^+3MC

(Soldatov et al., 1999)

Suppressor of

Statement

Reference

Taf9¹ is a suppressor of phenotype of sc^D1

(Gause et al., 1996)

NOT Suppressor of

Statement

Reference

Taf9¹/Su(mg)1-6^1-6 is a non-suppressor of phenotype of y²

(Bezborodova et al., 1997)

Taf9¹/Su(mg)1-7^1-7 is a non-suppressor of phenotype of y²

(Bezborodova et al., 1997)

Taf9¹/Su(mg)1-8^1-8 is a non-suppressor of phenotype of y²

(Bezborodova et al., 1997)

Taf9¹ is a non-suppressor of anterior notopleural bristle phenotype of sc^+2MC, y^+2MC

(Gause et al., 1996)

Taf9¹ is a non-suppressor of anterior notopleural bristle phenotype of sc^2#+9, y^2#+9

(Gause et al., 1996)

Other

Statement

Reference

Taf9¹, y^+2MC has adult thorax & macrochaeta phenotype

(Soldatov et al., 1999)

Taf9¹, y^+2MC has adult abdomen & macrochaeta phenotype

(Soldatov et al., 1999)

Taf9¹, y^+2MC has leg & external sensory organ phenotype

(Soldatov et al., 1999)

Taf9¹, y² has adult thorax & macrochaeta phenotype

(Soldatov et al., 1999)

Taf9¹, y² has leg & external sensory organ phenotype

(Soldatov et al., 1999)

Taf9¹, y^2PR1 has adult thorax & macrochaeta phenotype

(Soldatov et al., 1999)

Taf9¹, y^2PR1 has leg & external sensory organ phenotype

(Soldatov et al., 1999)

Taf9¹, y^2PR2 has adult thorax & macrochaeta phenotype

(Soldatov et al., 1999)

Taf9¹, y^2PR2 has leg & external sensory organ phenotype

(Soldatov et al., 1999)

Taf9¹, y² has macrochaeta phenotype

(Georgiev and Gerasimova, 1989)

Taf9¹, y² has microchaeta phenotype

(Georgiev and Gerasimova, 1989)

Taf9¹, y² has adult head bristle phenotype

(Georgiev and Gerasimova, 1989)

Additional Comments

Genetic Interactions

Statement

Reference

The lethality of e(y)2¹ e(y)1¹ double mutants is rescued by e(y)2^+tGa or by e(y)1^+tSa.

The lethality of e(y)2¹ e(y)1¹ double mutants is not rescued by e(y)1^1.tSa.

(Georgieva et al., 2001)

Does not affect the y^+1MC or y^+3MC phenotypes. Enhances the y², y^+2MC, y^2PR1, y^2PR2 and y^76d28 phenotypes; reducing the levels of pigmentation in adult bristles, but not in the body or wings. The enhancing effect of e(y)1¹ on the y² phenotype is partially suppressed by e(y)1^1.tSa and completely suppressed by e(y)1^+tSa. Lethal in combination with e(y)3⁴. Viability is rescued by e(y)1^+tSa and partially rescued by e(y)1^1.tSa. Eye colour: the eye pigmentation of flies carrying w^+mC in a w¹¹¹⁸ background is reduced by e(y)1¹ in a number of different P{CaSpeR-3} insertion strains. Eye colour: flies carrying w^BR.E.BR have red eyes. The eye colour is not affected if the flies are also carrying e(y)1¹ and z^v77h. Flies that are also carrying e(y)1¹, z^v77h and su(Hw)²/su(Hw)^V have reduced eye pigmentation. Eye colour: flies carrying w^E.BR have brown eyes. The eye pigmentation is reduced if these flies are also carrying e(y)1¹ and z^v77h.

(Soldatov et al., 1999)

Suppresses the sc^D1 phenotype slightly in males and strongly in females. Has no effect on ANP bristle formation caused by y^+2MC, sc^+2MC and y^2#+9, sc^2#+9. Has no effect on the Df(1)ase-1, sc⁵ or sc⁶ phenotype.

(Gause et al., 1996)

No effect on mutant wing phenotype of ct⁶, ct^pN2s, ct^n2s, ct^2s or ct^4s. z¹ and e(y)1¹ have no effect on the mod(mdg4)^ul effect on ct⁶.

(Melnikova et al., 1996)

Heterozygotes with e(y)3⁴ are lethal. Heterozygous males with e(y)2¹ have very low viability and are completely sterile. In z¹ w^zm strain e(y)1¹ causes a significant reduction in eye pigmentation.

(Georgiev, 1994)

Enhances the y² phenotype; head and thorax bristles, and hairs are yellow. This enhancer effect is not suppressed by su(Hw)².

(Georgiev and Gerasimova, 1989)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Taf9¹ is rescued by Taf9^+tSa

(Soldatov et al., 1999)

Partially rescued by

Taf9¹ is partially rescued by Taf9^1.tSa

(Soldatov et al., 1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Mutation enhances the negative effect of z point mutations, z^v77h or z¹, on w expression. w expression levels of w^sp1, w^sp2 and w^sp4 are strongly reduced, exhibited by a reduced level of eye pigmentation, by e(y)1¹.

(Georgiev, 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Taf9¹

e(y)1¹

(Georgieva et al., 2001)

e(y)1^u1

(Bezborodova et al., 1997, Zoldatov et al., 1997, Gause et al., 1996, Melnikova et al., 1996)

e(y)1u1

(Belen'kaia and Georgiev, 1999)

e(y)^1u1

(Georgiev and Gerasimova, 1989)

e(y)^u1

(Albright and Tjian, 2000, Soldatov et al., 1999, Soldatov and Vasilev, 1998, Georgiev, 1994, Kozitsina et al., 1992)

Name Synonyms

Secondary FlyBase IDs

FBal0034449

References (13)

Report Sections

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