Gene Group: RECEPTOR LIGANDS

General Information

Name

RECEPTOR LIGANDS

Species

D. melanogaster

Symbol

RLIG

FlyBase ID

FBgg0001105

Date last reviewed

2019-05-06

Number of members

114

Description

Receptor ligands are endogenous polypeptides that bind transmembrane cell surface receptors to elicit a cellular response.

Notes on Group

The RECEPTOR LIGANDS gene group is not an fully comprehensive list of ligands, but a collection of ligand families and genes with GO annotations indicating ligand activity.

Source Material

The RECEPTOR LIGANDS Gene Group has been compiled using the following publication(s): Scholz et al., 2023, Li et al., 2022, Boulanger et al., 2021, Mele and Johnson, 2019, Anthoney et al., 2018, Post et al., 2018, Amarnath et al., 2017, Foldi et al., 2017, Lee et al., 2017, Upadhyay et al., 2017, Chakrabarti et al., 2016, Koyama and Mirth, 2016, Lamiable et al., 2016, Lee et al., 2016, Roh et al., 2016, Yoo et al., 2016, Andersen et al., 2015, Reynaud et al., 2015, Jung et al., 2014, Veenstra and Ida, 2014, Yamamoto et al., 2014, Emerson et al., 2013, Manning et al., 2013, Muha and Müller, 2013, Andersen et al., 2012, Herr and Basler, 2012, Matsumoto et al., 2012, Osman et al., 2012, Rajan and Perrimon, 2012, Tsuzuki et al., 2012, Ida et al., 2011, Wright et al., 2011, Kim et al., 2010, Kim et al., 2010, Nässel and Winther, 2010, Veenstra, 2009, Wang and Zhu, 2009, Zlatic et al., 2009, Wegener and Gorbashov, 2008, Zhu et al., 2008, Bates and Whitington, 2007, Yang et al., 2007, Ayoob et al., 2006, Englund et al., 2006, Wu and Brown, 2006, Yazdani and Terman, 2006, Hombria et al., 2005, Itoh and Ornitz, 2004, Hoch and Soriano, 2003, Castellani and Rougon, 2002, Nassel, 2002, Urban et al., 2002, Bahri et al., 2001, Llimargas and Lawrence, 2001, Parker et al., 2001, Fremion et al., 2000, Yu and Kolodkin, 1999, Wolfner et al., 1997, Schnepp et al., 1996, and Hart et al., 1993 .

Key Gene Ontology (GO) terms

Molecular Function

receptor ligand activity

Biological Process

Cellular Component

Related Gene Groups

Component group(s)

EGFR AGONISTS

FIBROBLAST GROWTH FACTORS

GROWTH-BLOCKING PEPTIDES

INSULIN-LIKE PEPTIDES

NEUROPEPTIDES

NOTCH LIGANDS

PDGF- AND VEGF-RELATED FACTORS

SEMAPHORINS

SPATZLES

TRANSFORMING GROWTH FACTOR-BETA FAMILY

UNCLASSIFIED RECEPTOR LIGANDS

UNPAIRED FAMILY

WNTs

Other related group(s)

TRANSMEMBRANE RECEPTORS

Members (114)

For all members:

GO ribbon stack

	molecular function	biological process	cellular component

ACTIVINS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Actβ

Activin-β

dActivin, Activin, dAct, activin-beta, Act-β

(Upadhyay et al., 2017)

daw

dawdle

Alp23B, Alp, Activin Like Protein at 23B

(Upadhyay et al., 2017)

myo

myoglianin

(Upadhyay et al., 2017)

BONE MORPHOGENETIC PROTEINS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

dpp

decapentaplegic

BMP, TGF-β, shv, TGF-beta, shortvein

(Upadhyay et al., 2017)

gbb

glass bottom boat

60A, gbb-60A, BMP, Tgfbeta-60A, tgfb-60A

(Upadhyay et al., 2017)

mav

maverick

(Upadhyay et al., 2017)

scw

screw

l(2)37Ff

(Upadhyay et al., 2017)

EGFR AGONISTS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

grk

gurken

(Urban et al., 2002)

Krn

Keren

gritz

(Urban et al., 2002)

spi

spitz

sSpi, l(2)s3547, s-spi, l(2)01068

(Mele and Johnson, 2019, Urban et al., 2002)

vein

ddd, CT29452

(Mele and Johnson, 2019, Schnepp et al., 1996)

FIBROBLAST GROWTH FACTORS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

bnl

branchless

FGF, l(3)06916, fibroblast growth factor

(Mele and Johnson, 2019, Muha and Müller, 2013, Itoh and Ornitz, 2004)

pyr

pyramus

FGF8-like2

(Mele and Johnson, 2019, Muha and Müller, 2013, Itoh and Ornitz, 2004)

ths

thisbe

Neu4, FGF8-like1

(Mele and Johnson, 2019, Muha and Müller, 2013, Itoh and Ornitz, 2004)

GROWTH-BLOCKING PEPTIDES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG12517

(Matsumoto et al., 2012, Tsuzuki et al., 2012)

CG14069

(Tsuzuki et al., 2012)

Gbp1

Growth-blocking peptide 1

GBP, Growth-blocking peptide

(Koyama and Mirth, 2016, Matsumoto et al., 2012, Tsuzuki et al., 2012)

Gbp2

Growth-blocking peptide 2

GBP

(Koyama and Mirth, 2016, Tsuzuki et al., 2012)

Gbp3

Growth-blocking peptide 3

GBP

(Koyama and Mirth, 2016, Tsuzuki et al., 2012)

INSULIN-LIKE PEPTIDES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Ilp1

Insulin-like peptide 1

dilp1, DILP, insulin-like peptide, Dilp 1, dilp-1

(Mele and Johnson, 2019, Post et al., 2018, Wu and Brown, 2006, Nassel, 2002)

Ilp2

Insulin-like peptide 2

dilp2, DILP, dilp-2, Dilp 2, Ilp-2

(Mele and Johnson, 2019, Post et al., 2018, Wu and Brown, 2006, Nassel, 2002)

Ilp3

Insulin-like peptide 3

dilp3, DILP-3, Ilp-3, Dilp 3, DILPs

(Mele and Johnson, 2019, Post et al., 2018, Wu and Brown, 2006, Nassel, 2002)

Ilp4

Insulin-like peptide 4

dilp4, mes3, DILPs, DILP 4, anon-EST:CLB3

(Mele and Johnson, 2019, Post et al., 2018, Wu and Brown, 2006, Nassel, 2002)

Ilp5

Insulin-like peptide 5

dilp5, DILP-5, Dilp 5, Ilp-5, DILP

(Mele and Johnson, 2019, Post et al., 2018, Wu and Brown, 2006, Nassel, 2002)

Ilp6

Insulin-like peptide 6

dilp6, DILP-6, DILP, Dilp 6, DILPs

(Mele and Johnson, 2019, Post et al., 2018, Wu and Brown, 2006, Nassel, 2002)

Ilp7

Insulin-like peptide 7

dilp7, DILP, DILPs, DILP 7, dilp-7

(Mele and Johnson, 2019, Post et al., 2018, Wu and Brown, 2006, Nassel, 2002)

Ilp8

Insulin-like peptide 8

dilp8, Drosophila insulin-like peptide 8, dILP-8, DILP 8, DILPs

(Post et al., 2018, Andersen et al., 2012)

NEUROPEPTIDES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Akh

Adipokinetic hormone

Drm-AKH, dAkh

(Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

amn

amnesiac

PACAP38, PACAP, Drm-amn, cheapdate, chpd

(Nässel and Winther, 2010, Nassel, 2002)

AstA

Allatostatin A

Ast, Ast-A, drostatin-A4, allatostatin, AstA-1

(Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

AstC

Allatostatin C

Ast-C, drostatin-C, flatline, FLT, Ast2

(Nässel and Winther, 2010, Veenstra, 2009, Wegener and Gorbashov, 2008, Nassel, 2002)

AstCC

Allatostatin double C

Ast-CC

(Veenstra, 2009)

Burs

Bursicon

bursicon α, bursα, burs α, bursicon α-subunit

(Nässel and Winther, 2010)

Capa

Capability

capa-1, CAP_2b, capa-2, capa-3, Drm-PK-1

(Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

CCAP

Crustacean cardioactive peptide

Cardioacceleratory peptide

(Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

CCHa1

CCHamide-1

(Veenstra and Ida, 2014, Nässel and Winther, 2010)

CCHa2

CCHamide-2

CCHamide, CCHamid2

(Veenstra and Ida, 2014, Nässel and Winther, 2010)

CNMa

CNMamide

(Jung et al., 2014)

Crz

Corazonin

Drm-COR, COR, Dm-Crz

(Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

Dh31

Diuretic hormone 31

diuretic hormone, Drm-DH₃₁

(Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

Dh44

Diuretic hormone 44

Dh, DH₄₄, Diuretic hormone, CRF-like peptide, Drm-DH

(Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

Dsk

Drosulfakinin

sulfakinin, Drm-SK-2, sulfakinin-0, DSK II, DSK-1

(Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

Eclosion hormone

DMEHAB, Drm-EH

(Nässel and Winther, 2010, Nassel, 2002)

ETH

Ecdysis triggering hormone

Drm-ETH-1, Drm-ETH-2, ETH1, ETH2, ecdysis-triggering hormone-2

(Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

FMRFa

FMRFamide

Fmrf, dFMRFa, dFMRFamide, DPKQDFMRFamide, FMRFamide-related

(Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

Gpa2

Glycoprotein hormone alpha 2

(Nässel and Winther, 2010)

Gpb5

Glycoprotein hormone beta 5

β-glycoprotein-hormone-related

(Nässel and Winther, 2010)

Hug

Hugin

Drm-PK-2, pyrokinin-2, hug-γ, hugγ, hug γ

(Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

Ilp1

Insulin-like peptide 1

dilp1, DILP, insulin-like peptide, Dilp 1, dilp-1

(Nässel and Winther, 2010, Nassel, 2002)

Ilp2

Insulin-like peptide 2

dilp2, DILP, dilp-2, Dilp 2, Ilp-2

(Nässel and Winther, 2010, Nassel, 2002)

Ilp3

Insulin-like peptide 3

dilp3, DILP-3, Ilp-3, Dilp 3, DILPs

(Nässel and Winther, 2010, Nassel, 2002)

Ilp4

Insulin-like peptide 4

dilp4, mes3, DILPs, DILP 4, anon-EST:CLB3

(Nässel and Winther, 2010, Nassel, 2002)

Ilp5

Insulin-like peptide 5

dilp5, DILP-5, Dilp 5, Ilp-5, DILP

(Nässel and Winther, 2010)

Ilp6

Insulin-like peptide 6

dilp6, DILP-6, DILP, Dilp 6, DILPs

(Nässel and Winther, 2010, Nassel, 2002)

Ilp7

Insulin-like peptide 7

dilp7, DILP, DILPs, DILP 7, dilp-7

(Nässel and Winther, 2010, Nassel, 2002)

Ilp8

Insulin-like peptide 8

dilp8, Drosophila insulin-like peptide 8, dILP-8, DILP 8, DILPs

(Andersen et al., 2012)

ITP

Ion transport peptide

DrmITP, DrmITPL1, DrmITPL2

(Nässel and Winther, 2010, Nassel, 2002)

Leucokinin

DLK, kinin, drosokinin, pp, LCK

(Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

Mip

Myoinhibiting peptide precursor

drostatin-B2, AstB, Allatostatin B, myoinhibitory peptide, AstB-1

(Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

Myosuppressin

DMS, Dromyosuppressin, Drm-MS, Nems, TDVDHVFLRFamide

(Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

NPF

neuropeptide F

dNPF, Drm-NPF, sNPF, Dm-NPF

(Veenstra and Ida, 2014, Ida et al., 2011, Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

Nplp1

Neuropeptide-like precursor 1

IPNa, IPNamide, APK, Neuropeptide like precursor protein 1, VQQ

(Nässel and Winther, 2010, Wegener and Gorbashov, 2008)

Nplp2

Neuropeptide-like precursor 2

(Nässel and Winther, 2010)

Nplp3

Neuropeptide-like precursor 3

(Nässel and Winther, 2010)

Nplp4

Neuropeptide-like precursor 4

(Nässel and Winther, 2010)

Orcokinin

Orcokinin B, OK-B

(Veenstra and Ida, 2014)

Pburs

Partner of Bursicon

bursicon β, bursβ, pu, burs β, bursicon

(Nässel and Winther, 2010)

Pdf

Pigment-dispersing factor

PDH, PAP, cPDH, Drm-PDF, pigment-dispersing hormone

(Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

Proc

Proctolin

Proct

(Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

Ptth

Prothoracicotropic hormone

(Mele and Johnson, 2019, Nässel and Winther, 2010)

RYa

RYamide

(Ida et al., 2011)

SIFa

SIFamide

IFa, Drm-IFa, Neb-LFamide

(Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

sNPF

short neuropeptide F precursor

short neuropeptide F, Drm-sNPF-1, short NPF, sNPF-3, short neuropeptide F-1

(Ida et al., 2011, Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

Sex Peptide

Acp70A, ACP, Accessory gland protein 70A, DrmSP

(Nässel and Winther, 2010)

spab

space blanket

(Nässel and Winther, 2010)

Tachykinin

DTK, tachykinin-3, DTK-3, DTK-4, DTK-6

(Veenstra and Ida, 2014, Nässel and Winther, 2010, Wegener and Gorbashov, 2008, Nassel, 2002)

NOTCH LIGANDS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Delta

Dl, Overflow

(Yamamoto et al., 2014, Kim et al., 2010)

Ser

Serrate

Bd, Beaded, Rpw

(Yamamoto et al., 2014, Kim et al., 2010)

wry

weary

(Kim et al., 2010)

PDGF- AND VEGF-RELATED FACTORS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Pvf1

PDGF- and VEGF-related factor 1

PVF, Pvf-1, DmVEGF-1, VEGF, Vegf17E

(Mele and Johnson, 2019, Hoch and Soriano, 2003)

Pvf2

PDGF- and VEGF-related factor 2

DmVEGF-2, VEGF, Pvf, Vegf27Cb

(Mele and Johnson, 2019, Hoch and Soriano, 2003)

Pvf3

PDGF- and VEGF-related factor 3

Pvf, DmVEGF-3

(Mele and Johnson, 2019, Hoch and Soriano, 2003)

SEMAPHORINS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Sema1a

Semaphorin 1a

Sema-1a, Sema 1a, D-SemaI, Fasciclin-IV, sema-I

(Yoo et al., 2016, Emerson et al., 2013, Zlatic et al., 2009, Bates and Whitington, 2007, Ayoob et al., 2006, Yazdani and Terman, 2006, Castellani and Rougon, 2002, Bahri et al., 2001, Yu and Kolodkin, 1999)

Sema1b

Semaphorin 1b

Sema-1b, sema-III, Sema 1b, semaphorin, semaphorin-like

(Yoo et al., 2016, Yazdani and Terman, 2006, Yu and Kolodkin, 1999)

Sema2a

Semaphorin 2a

Sema-2a, SemaII, D-SemaII, semaphorin, sema-II

(Roh et al., 2016, Yoo et al., 2016, Emerson et al., 2013, Zlatic et al., 2009, Bates and Whitington, 2007, Ayoob et al., 2006, Yazdani and Terman, 2006)

Sema2b

Semaphorin 2b

Sema-2b, semaphorin

(Roh et al., 2016, Yoo et al., 2016, Emerson et al., 2013, Bates and Whitington, 2007, Yazdani and Terman, 2006)

Sema5c

Semaphorin 5c

Sema-5c, Sema-3a, BG01245, Sema 5c, semaphorin

(Yoo et al., 2016, Yazdani and Terman, 2006, Castellani and Rougon, 2002, Bahri et al., 2001)

SPATZLES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

NT1

Neurotrophin 1

DNT1, Spz2, spatzle 2, Spz-2

(Anthoney et al., 2018, Foldi et al., 2017, Wang and Zhu, 2009, Zhu et al., 2008, Parker et al., 2001)

spz

spatzle

Spaetzle, Spz-1

(Anthoney et al., 2018, Wang and Zhu, 2009, Zhu et al., 2008, Parker et al., 2001)

spz3

spatzle 3

(Wang and Zhu, 2009, Zhu et al., 2008, Parker et al., 2001)

spz4

spatzle 4

(Wang and Zhu, 2009, Zhu et al., 2008, Parker et al., 2001)

spz5

spatzle 5

DNT2, Spz-5, NT2

(Anthoney et al., 2018, Foldi et al., 2017, Wang and Zhu, 2009, Zhu et al., 2008, Parker et al., 2001)

spz6

spatzle 6

(Wang and Zhu, 2009, Zhu et al., 2008, Parker et al., 2001)

UNCLASSIFIED RECEPTOR LIGANDS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Acp32CD

Accessory gland protein 32CD

Accessory gland-specific peptide 32CD

(Wolfner et al., 1997)

Acp33A

Accessory gland-specific peptide 33A

(Wolfner et al., 1997)

Acp36DE

Accessory gland protein 36DE

36DE accessory gland protein, Accessory gland peptide 36DE

(Wolfner et al., 1997)

Acp98AB

Accessory gland protein 98AB

Acp98, Acp98B

(Wolfner et al., 1997)

Ama

Amalgam

(Fremion et al., 2000)

boss

bride of sevenless

(Mele and Johnson, 2019, Hart et al., 1993)

Diedel

die

(Lamiable et al., 2016)

Dup99B

Ductus ejaculatorius peptide 99B

anon-SAGE:Wang-013, DUP

(Kim et al., 2010)

egr

eiger

TNF, TNF-α, TNFα, Ect1, Wengen

(Andersen et al., 2015)

fog

folded gastrulation

114, l(1)114, l114, M67

(Manning et al., 2013)

hedgehog

Mrt, l(3)neo56, bar-3

(Lee et al., 2016)

jeb

jelly belly

l(2)k05644

(Mele and Johnson, 2019, Yang et al., 2007)

miple1

midkine and pleiotrophin 1

miple

(Englund et al., 2006)

miple2

midkine and pleiotrophin 2

(Englund et al., 2006)

orion

l(1)G0193, l(1)G0327, lethal (1) G0193

(Boulanger et al., 2021)

Sgsf

Salivary gland-derived secreted factor

(Li et al., 2022)

shv

shriveled

(Lee et al., 2017)

Tollo

Toll-8, Toll8, Tl-8

(Scholz et al., 2023)

trk

trunk

fs(2)trunk

(Mele and Johnson, 2019, Amarnath et al., 2017)

UNPAIRED FAMILY

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

upd1

unpaired 1

upd, unpaired, os, sisC, outstretched

(Chakrabarti et al., 2016, Osman et al., 2012, Rajan and Perrimon, 2012, Wright et al., 2011, Hombria et al., 2005)

upd2

unpaired 2

Upd, upd-2

(Chakrabarti et al., 2016, Osman et al., 2012, Rajan and Perrimon, 2012, Wright et al., 2011, Hombria et al., 2005)

upd3

unpaired 3

os, Upd, upd-3, Upd-like, outstretched

(Chakrabarti et al., 2016, Osman et al., 2012, Rajan and Perrimon, 2012, Wright et al., 2011, Hombria et al., 2005)

WNTs

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

wingless

Wnt, Sp, Wnt-1, Gla, Br

(Herr and Basler, 2012, Llimargas and Lawrence, 2001)

Wnt2

Wnt oncogene analog 2

DWnt-2, DWnt2, Wnt-2

(Herr and Basler, 2012, Llimargas and Lawrence, 2001)

Wnt4

Wnt oncogene analog 4

DWnt4, DWnt-4, Wnt-4

(Mele and Johnson, 2019, Herr and Basler, 2012, Llimargas and Lawrence, 2001)

Wnt5

Wnt oncogene analog 5

DWnt5, DWnt-3, Dwnt-5, DWnt3, Wnt3

(Mele and Johnson, 2019, Reynaud et al., 2015, Herr and Basler, 2012, Llimargas and Lawrence, 2001)

Wnt6

Wnt oncogene analog 6

DWnt6

(Herr and Basler, 2012, Llimargas and Lawrence, 2001)

Wnt10

Wnt oncogene analog 10

DWnt10

(Herr and Basler, 2012, Llimargas and Lawrence, 2001)

wntD

wnt inhibitor of Dorsal

Wnt8, DWnt8, DWnt-8

(Herr and Basler, 2012, Llimargas and Lawrence, 2001)

External Data

Equivalent Group(s)

Human Endogenous Ligands (HGNC)

Other resource(s)

Synonyms and Secondary IDs

Synonym(s)

RLIG

RECEPTOR LIGANDS

Secondary FlyBase ID(s)

References (61)

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