FB2024_03 , released June 25, 2024
Gene Group: UNPAIRED FAMILY
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General Information
Name
UNPAIRED FAMILY
Species
D. melanogaster
Symbol
UPD
FlyBase ID
FBgg0000527
Date last reviewed
2016-06-28
Number of members
3
Description
Description
The Unpaired (UPD) family encodes the only known cytokines capable of activating the JAK/STAT pathway in D.mel, by binding the receptor dome. This pathway is involved in cell proliferation, embryonic development and stem cell maintenance. (Adapted from FBrf0232479, FBrf0213113 and FBrf0219535).
Notes on Group
Source Material
The UNPAIRED FAMILY Gene Group has been compiled using the following publication(s): Chakrabarti et al., 2016, Osman et al., 2012, Rajan and Perrimon, 2012, Wright et al., 2011, and Hombria et al., 2005 .
Key Gene Ontology (GO) terms
Molecular Function
cytokine activity
Biological Process
positive regulation of receptor signaling pathway via JAK-STAT
Cellular Component
extracellular region
Related Gene Groups
Parent group(s)
RECEPTOR LIGANDS
Other related group(s)
JAK-STAT Signaling Pathway Core Components
Members (3)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
upd1
unpaired 1
upd, unpaired, os, sisC, outstretched
(Chakrabarti et al., 2016, Osman et al., 2012, Rajan and Perrimon, 2012, Wright et al., 2011, Hombria et al., 2005)
upd2
unpaired 2
Upd, upd-2
(Chakrabarti et al., 2016, Osman et al., 2012, Rajan and Perrimon, 2012, Wright et al., 2011, Hombria et al., 2005)
upd3
unpaired 3
os, Upd, upd-3, outstretched, Upd-like
(Chakrabarti et al., 2016, Osman et al., 2012, Rajan and Perrimon, 2012, Wright et al., 2011, Hombria et al., 2005)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
UPD
UNPAIRED FAMILY
Secondary FlyBase ID(s)
References (6)