sulfakinin, Drm-SK-2, sulfakinin-0, DSK II, DSK-1
neuropeptide - neuromodulator - modulates aggression - controls fighting - regulates sexual arousal - regulates aspects of gut function, satiety and food ingestion - escape-related locomotion - regulates neuromuscular junction growth through the CREB pathway - nsDSK II, a non-sulfated version of the hormone, signals through DSK-R2 to influence gut motility and locomotion
Please see the JBrowse view of Dmel\Dsk for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.48
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.40
Gene model reviewed during 5.54
0.8 (northern blot, sequence analysis)
There is only one protein coding transcript and one polypeptide associated with this gene
128 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dsk using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Dsk protein is detected in adults in MP1 and MP3 cells, and in a number of interneurons in both the brain and ventral nerve cord.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Dsk in JBrowse3-47.1
3-44.1
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Sulfated Dsk isoforms 1 and 2 activate the CCKLR-17D1 receptor in a cell culture assay. Dsk/CCKLR-17D1 signaling appears to promote larval body wall muscle contraction and is necessary for mediating locomotor behaviour in the stress-induced escape response.
Spatial and temporal expression patterns of Dsk peptides in the central nervous system is examined using antisera to distinguish between the three peptides. Peptides are present throughout development in several cell bodies in the brain lobe, optic lobe, subesophageal ganglion, thoracic ganglion and an abdominal ganglion.
Encodes a Drosophila homologue of the vertebrate neuropeptide, cholecystokinin (CKK), which the authors dub drosulfakinin (DSK). In situ hybridization of antisense probes detects Dsk transcripts in regions of the adult brain, specifically the protocerebrum.
Source for merge of: Dsk CG18090
Source for merge of: Dsk BcDNA:RH46857
Source for merge of Dsk BcDNA:RH46857 was a shared cDNA ( date:030728 ).
