Ast, Ast-A, drostatin-A4, AstA-1, allatostatin
neuropeptide secreted by the corpus cardiacum - a modulator of AKH and DILP signaling and feeding choices between dietary carbohydrates and protein - conveys inhibitory input onto protocerebral dopamine neurons
Please see the JBrowse view of Dmel\AstA for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.49
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.56
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\AstA using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: posterior third of the posterior midgut
Comment: peptides
Comment: peptides
AstA is expressed in two to three interneurons with somata in the posterior lateral protocerebrum. These send a primary neurite dorsally, just anterior of the calyx, which trifurcate and then arborize throughout the whole superior lateral, superior intermediate and superior medial protocerebrum. These arborizations extend from the height of the fan-shaped body to just anterior of the calyx. Expression is seen in a small number of cells in the medulla. In the adult abdominal neuromere, expression is seen in three pairs of cells within the dorsolateral part of the posterior abdominal neuromere, these send neurites via the abdominal nerve trunk to innervate the hindgut and posterior-most midgut, including the adult rectal valve and adult pylorus and send processes to innervate the rectum which also part extend through the muscle layer. Expression is also seen innerves innervating the wings and halteres, and a subset of adult enteroendocrine cells
Ast protein is detected in layer 5 of the fan-shaped body.
AstA peptides were detected in extracts from adult and larval midguts.
Tk protein is expressed in 3 local neurons that innervate most adult antennal lobe glomeruli. These neurons have their cell bodies in one lateral cluster. These neurons co-express ScerGAL4Cha.7.4 and ScerGAL4GH298.
Four pairs of AstA-positive cells were observed in the larval brain hemispheres: anterolateral tritocerebrum (ALT), superior lateral protocerebrum (SLP), posterolateral tritocerebrum (PLT), and small, weakly staining ventromedial subesophageal (VMS) .
JBrowse - Visual display of RNA-Seq signals
View Dmel\AstA in JBrowse
3-85
3-84.5
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Ortholog of B. mori juvenile-hormone-related gene (involved in JH biosynthesis, metabolism or signaling).
The putative Ast gene product was identified and its expression pattern studied using cross-reactivity with a monoclonal antibody raised against Diploptera punctata allatostatin I.
Source for merge of: Ast BcDNA:RE16553
Source for merge of: Ast CG13633
Source for merge of Ast BcDNA:RE16553 was TrEMBL update ( date:020807 ).
Source for merge of Ast CG13633 was sequence comparison ( date:000815 ).
Source for identity of: AstA Ast
Renamed from 'Ast' to 'AstA' to match the nomenclature of the other Allatostatin-encoding genes and thus provide an informative suffix, and to reflect usage in the literature.
