dilp1, DILP, insulin-like peptide, Dilp 1, dilp-1
ligand of the insulin/IGF-signaling pathway - expressed in brain neurosecretory cells of larvae, pupae, and adults - Mutation diminishes organismal weight during pupal development, whereas overexpression increases it - survival during starvation is strongly diminished in mutants - overexpression decreases survival during starvation in female flies and increases egg laying and decreases egg to pupal viability - mutants extend lifespan and increase Akh mRNA and protein in a dilp1-dependent manner - expressed in non-feeding stages and in diapausing flies - is under feedback regulation and appears to play sex-specific functional roles
Please see the JBrowse view of Dmel\Ilp1 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.43
Gene model reviewed during 5.45
Gene model reviewed during 6.04
There is only one protein coding transcript and one polypeptide associated with this gene
Heterodimer of a B chain and an A chain linked by two disulfide bonds.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ilp1 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Ilp1 protein is expressed in dorsomedial neurosecretory cells during pupal stages and in newly eclosed adults. After one week the expression is decreased and not detectable in two week old adults.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Ilp1 in JBrowse3-31
3-24.1
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
May be a pseudogene.
Source for merge of: Ilp1 CG14173