FB2024_03 , released April 23, 2024
Aberration: Dmel\Df(3L)AC1
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General Information
Symbol
Df(3L)AC1
Species
D. melanogaster
Name
Deficiency (3L) Adelaide Carpenter
FlyBase ID
FBab0002292
Feature type
chromosomal_deletion
Also Known As
Df(dronc)
Computed Breakpoints include

67A2;67D11-67D13

Features within 67A2--67D13
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
X ray
Class of aberration (relative to wild type)
chromosomal_deletion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Boube et al., 1997, Deak et al., 1997, Hernandez et al., 1997, Salzberg et al., 1997, Duffy et al., 1996, Harbecke and Lengyel, 1995, Komma and Endow, 1995, Lai et al., 1995, Pauli et al., 1995, Landecker et al., 1994)
Breakpoints

67A2;67D11-67D13

(Boube et al., 1997, Hernandez et al., 1997, Salzberg et al., 1997, Duffy et al., 1996, Harbecke and Lengyel, 1995, Lai et al., 1995, Landecker et al., 1994)

67A;67D

(Pauli et al., 1995)

67A;67D11-67D13

(Komma and Endow, 1995)

67A2;67D13

(Deak et al., 1997)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

Rdl << bk1 << eIF-4E << l(3)67BDa << bk2 << can

Genetic mapping information
Comments

This deletion removes multiple ribosomal protein-coding genes (in addition to other genes).

(Marygold et al., 2007)
Comments on Cytology

Ref: FBrf0058107.

(Komma and Endow, 1995)

Limits of break 1 from polytene analysis (FBrf0076124) Left limit of break 2 from polytene analysis (FBrf0099762) Right limit of break 2 from polytene analysis (FBrf0076124)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
aay
(Szeged Stock Center, 1998-, Salzberg et al., 1997)
Abd-B
(Ghabrial et al., 2011)
Cdk8
(Loncle et al., 2007)
cfo
(Wakefield et al., 2000)
CG32052
(Brogiolo et al., 2001)
Dronc
(Xu et al., 2005, Tenev et al., 2002)
E(ftz)20
(Kankel et al., 2004)
eIF4E1
(Spradling et al., 1999, Szeged Stock Center, 1998-, Hernandez et al., 1997, BDGP Project Members, 1994-1999)
fry
(Cong et al., 2001, Spradling et al., 1999, Neufeld et al., 1998, BDGP Project Members, 1994-1999)
ghi
(Giansanti et al., 2004)
Ilp1
(Brogiolo et al., 2001)
Ilp2
(Brogiolo et al., 2001)
Ilp3
(Brogiolo et al., 2001)
Ilp4
(Brogiolo et al., 2001)
Ilp5
(Brogiolo et al., 2001)
l(3)67BDn
(Kirchner et al., 2007)
l(3)01859
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
l(3)C10
(Slack et al., 2006)
l(3)j2B9
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
l(3)OL61
(Slack et al., 2006)
l(3)rK145
(BDGP Project Members, 1994-1999)
l(3)S002302
(Deak et al., 1997)
l(3)S010102a
(Szeged Stock Center, 1998-, Deak et al., 1997)
l(3)S023809
(Deak et al., 1997)
l(3)S036912
(Szeged Stock Center, 1998-)
l(3)S089004
(Szeged Stock Center, 1998-)
LanB2
(Yarnitzky and Volk, 1995)
MTF-1
(Egli et al., 2003)
RpS17
(Leicht and Bonner, 1988)
scramb1
(Acharya et al., 2006)
Shc
(Luschnig et al., 2000)
Uch-L5
(Spradling et al., 1999)
vnc
(Wang et al., 2010, Rees, 1990.8.1)
αTub67C
(Komma and Endow, 1995)
Partially deleted / disrupted
Molecular Data
Completely deleted
Jarid2
(Silva et al., 2007)
pall
(Silva et al., 2007)
RpS9
(Marygold et al., 2007)
RpS17
(Marygold et al., 2007)
Uch-L5
(Silva et al., 2007)
Partially deleted
Genes NOT Deleted / Disrupted
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location
    Phenotypic Data
    In combination with other aberrations

    Fails to complement Df(3L)BSC282.

    (Christensen et al., 2007.5.8)

    Inferred to overlap with: Df(3L)BSC282.

    (Christensen et al., 2007.5.8)

    Inferred to overlap with: Df(3L)BSC283.

    (Christensen et al., 2007.5.8)

    Df(3L)AC1 suppresses the position effect variegation of the mutant Sb phenotype which is seen in the T(2;3)SbV chromosome.

    (Sasai et al., 2007)

    Does not show a dose-sensitive interaction with Df(3R)Ubx109.

    (Boube et al., 1997)
    NOT in combination with other aberrations

    The salivary gland distal tip does not initiate turning and migration in embryos homozygous for Df(3L)AC1 by stage 14.

    (Jattani et al., 2009)

    Flies heterozygous for the deletion show a Minute bristle phenotype.

    (Marygold et al., 2007)

    In Df(3L)AC1 homozygous embryos, the macrophages migrate throughout the embryo, cluster in the vicinity of apoptotic cells and perform endocytosis of diI-AcLDLs as in controls.

    (Silva et al., 2007)

    Df(3L)AC1 embryos show defects in tracheal cell migration.

    (Myat et al., 2005)

    Heterozygotes have a suppressed eye phenotype compared to wild-type flies that have been exposed to UV irradiation.

    (Jassim et al., 2003)

    Heterozygosity for this deletion has no effects on achiasmate chromosome segregation.

    (Matthies et al., 1999)

    Dominantly suppresses the KrIf-1/+ eye phenotype.

    (Carrera et al., 1998)

    Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome.

    (Coyne et al., 1998)

    Weak second site non-complementing phenotype with zipEbr and zipmhc-c6.1 : malformed phenotype penetrance 10-24%.

    (Halsell and Kiehart, 1998)

    Shows no maternal enhancement of dpphr4.

    (Nicholls and Gelbart, 1998)

    Shows a dose-sensitive interaction with pbhs.PB.

    (Boube et al., 1997)

    Acts as a dosage sensitive maternal modifier of run : causes tergite defects in greater than 50% of run3 heterozygotes.

    (Duffy et al., 1996)

    Deficient embryos show a mutant midgut phenotype: central constriction absent.

    (Bilder and Scott, 1995)

    Homozygous embryos show abnormal head involution and tracheal formation. Formation and differentiation of the gut is variable.

    (Harbecke and Lengyel, 1995)

    Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovoD2.

    (Pauli et al., 1995)

    Fertile when heterozygous with haync2.

    (Regan and Fuller, 1988)
    Stocks (2)
    Notes on Origin
    Discoverer

    Carpenter.

     

    Uncovered among progeny of males

    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     

    The Df(3L)AC1 chromosome may act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion), but the eye colour phenotype in the presence of Df(3L)AC1 overlaps the eye colour phenotype in a wild-type background so it cannot be unequivocally demonstrated that the deficiency chromosome uncovers a suppressor of telomeric silencing.

    (Mason et al., 2004)
    Synonyms and Secondary IDs (8)
    References (111)