FB2024_04 , released June 25, 2024
Aberration: Dmel\Df(3R)Ubx109
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General Information
Symbol
Df(3R)Ubx109
Species
D. melanogaster
Name
Deficiency (3R) Ultrabithorax
FlyBase ID
FBab0002687
Feature type
chromosomal_deletion
Also Known As
Df(3R)Ubx109, Df(3R)109, Df109, Ubx109, Df(3R)P109, Df(Ubx)109, DfUbx109
Computed Breakpoints include

89E1;89E2

Features within 89E1--89E2
Genomic Maps
Sequence coordinates
3R:16,576,189..16,639,771 (Df(3R)Ubx109:bk1)
(Cook, 2016.2.8)
3R:16,831,116..16,923,231 (Df(3R)Ubx109:bk2)
(Cook, 2016.2.8)
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
X ray
(Lewis, 1980)
Class of aberration (relative to wild type)
chromosomal_deletion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Elkins et al., 1990, Kerridge and Dura, 1982, Babu and Bhat, 1981, Lewis, 1980)
Breakpoints

89D1-89D2;89E1-89E2

(Lewis, 1980)

89C;89E

(Babu and Bhat, 1981)

89D2-89D3;89E2-89E3

(Kerridge and Dura, 1982)

89D9-89E1;89E2-89E3

(Elkins et al., 1990)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

l(3)89Da << bk1 << l(3)89Df << bk2 hits abd-A

Genetic mapping information
Comments

The 3R:16576189..16639771 release 6 coordinates of the left breakpoint are estimates. The left extent corresponds to the estimated position of the left end of polytene band 89D2, because published cytologies indicate the Df(3R)Ubx109 breakpoint lies right of 89D1. The right extent corresponds to the right end of Fas1, which published results say is deleted.

(Cook, 2016.2.8)

The 3R:16831116..16923231 release 6 coordinates of the right breakpoint are estimates corresponding to the left and right ends of iab-8. FBrf0042053 mapped the right breakpoint of Df(3R)Ubx109 within iab-8.

(Cook, 2016.2.8)

Breakpoint(s) molecularly mapped

(Karch et al., 1985)

Right breakpoint 86 to 93 kb distal to the right breakpoint of In(3R)Cbxrv1 (Karch et al., 1985)

Comments on Cytology

Ref: FBrf0032262.

(Sato and Denell, 1985)

Left limit of break 1 from non-inclusion of l(3)89Da (FBrf0043252) Right limit of break 1 from inclusion of Fas1 (FBrf0047653) Left limit of break 2 from inclusion of abd-A (FBrf0043252) Right limit of break 2 from polytene analysis (FBrf0034411)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Genes NOT Deleted / Disrupted
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location
Phenotypic Data
In combination with other aberrations

The early stages of cardiac tube morphogenesis occur normally in Df(3R)Ubx109/Dp(3;3)P5 embryos, but later differentiation of the cardiomyocytes is impaired; the cardiac tube shows no heterogeneity along the anterior-posterior axis (in contrast to wild type) and the aorta and heart do not differentiate normally. The cells are not conspicuously polarised along the whole length of the cardiac tube and appear most similar to the cells that are normally found in the anterior-most segments (T3 and A1). Other cells, which may be lymph gland cells, are found in ectopic locations along the cardiac tube.

(Ponzielli et al., 2002)

Does not show a dose-sensitive interaction with Df(3R)by10, Df(3R)by416 or Df(3L)AC1.

(Boube et al., 1997)

Germ line clonal analysis shows that the combination Df(3R)P9/Df(3R)Ubx109 lacks germ line functions necessary for normal egg production. The combination Dp(3;3)bxd100 Df(3R)Ubx109/Df(3R)P9 is viable in germ line clones.

(Kerridge and Dura, 1982)

Viable in heterozygous combination with In(3LR)P88. Viable in heterozygous combination with Tp(3;3)sbd104. Viable in heterozygous combination with Df(3R)sbd104. Viable in heterozygous combination with Tp(3;1)P115. Viable in heterozygous combination with Df(3R)P115 Dp(3;3)S462. Lethal in heterozygous combination with Tp(3;3)bxd100. Lethal in heterozygous combination with Df(3R)bxd100. Lethal in heterozygous combination with Df(3R)P115. Lethal in heterozygous combination with Tp(3;2)iab2P10. Lethal in heterozygous combination with Df(3R)P10. Lethal in heterozygous combination with Df(3R)P10 Dp(3;3)sbd104.

(Struhl, 1982)
NOT in combination with other aberrations

Df(3R)Ubx109 mutant embryos show a significant increase in the proportion of mitotic neuroblasts only in A9-10 ventral nerve cord segments, and a significant increase in the proportion of mitotic neuroblast daughter cells in A1, A7, A8 and A9-10 ventral nerve cord segments, as compared to controls.

(Monedero Cobeta et al., 2017)

Df(3R)Ubx109/Df(3R)Ubx109 mutant embryos exhibit transformation of abdominal segments A2-A8 into T3 identity, and show severe defects in Malpighian tubule migration and organization, with tubules failing to migrate anteriorly beyond the A3 or A4 segment and often being thicker than normal, but tubules do maintain their ability to form loops, as compared to wild type.

(Zohar-Stoopel et al., 2014)

Ubx6.28 Df(3R)Ubx109 heterozygous larvae exhibit mild transformations of the A1 denticle belts towards an intermediate T3/A1 identity. UbxΔQA/Ubx6.28 Df(3R)Ubx109 larvae form ectopic A1 Keilin's Organs with up to three bristles. UbxΔQA/Ubx6.28 Df(3R)Ubx109 embryos generate small but robust ectopic limb primordia of up to half the size of thoracic limb primordia. Df(3R)Ubx109 homozygous larvae form full three-bristle ectopic Keilin's Organs on A1-A7 larval segments. These mutants also exhibit ectopic limb primordia in the A1 embryonic segment. Df(3R)Ubx109 homozygous larvae exhibit mild transformations of the A1 denticle belts towards an intermediate T3/A1 identity.

(Hittinger et al., 2005)

In stage 16 Df(3R)Ubx109 homozygous embryos there is a significant reduction in the total number of cells in the embryonic dorsal vessel from 104 to around 80.

(Ryan et al., 2005)

In mutant embryos, the heart and the posterior aorta are transformed into anterior aorta, with the exception of segment A1.

(Perrin et al., 2004)

BrdU incorporation appears normal in the suboesophageal ganglion and in the thorax of homozygous stage 16/17 embryos. However, in the abdominal neuromeres (except for the terminal region) lateral cells incorporate BrdU in patterns reminiscent of the thoracic region. Heterozygous larvae have additional large clusters of BrdU labelled cells in segments A3, A4 and sometimes A5.

(Prokop et al., 1998)

Heterozygotes show a partial transformation of haltere to wing, characterised by the appearance of bristles and an apparent anterior wing margin. This phenotype is enhanced if the flies are also homozygous for RasGAP1sxt-BJ61. The enhancement of the Df(3R)Ubx109/+ phenotype by RasGAP1sxt-BJ61 is partially reversed if the flies also carry Ras85De1B.

(Boube et al., 1997)

Does not support transvection effects.

(Laney and Biggin, 1996)

Homozygotes fail to form gonads.

(Greig and Akam, 1995)

Ectopic Scr expression causes T1 beard formation in thoracic segments 1 to 3 and abdominal segments 1 to 7 and ectopic salivary glands formation in parasegments 0 and 1.

(Andrew et al., 1994)

In embryos, denticle belts of T3-A7 resemble those of T2. Anterior spiracles form in each segment from T1 to A6. All dorsal Poxn expressing cells in the abdomen migrate ventrally and differentiate as kolbchen.

(Castelli-Gair et al., 1994)

Embryos have no A- and B- cells in A1-7, where instead thorax-speciifc A/B-like glial cells could be detected, which do not derive from NB1-1.

(Prokop and Technau, 1994)

Transformation of parasegment 5 to 12 into copies of parasegment 4. Heat induction of UbxIb.hs in these homozygotes causes transformation of parasegments 1 to 12 into copies of parasegment 6.

(Mann and Hogness, 1990)

When in combination with salm mutations embryos exhibit the Df(3R)Ubx109 phenotype in parasegments 5 to 13 and the salm mutant phenotype in the tail region.

(Jurgens, 1988)

In homozygotes all abdominal segments except the last segment are transformed into thorax.

(Lehmann and Nusslein-Volhard, 1987)

Heterozygotes have halteres that are 2-3 times their normal size, never have hypopleural bristles or metanotal tissue and a weak transformation of anterior third leg to anterior second leg.

(Peifer and Bender, 1986)

Deficiency of Ubx, lethal when heterozygous with Df(3R)P9.

(Karch et al., 1985)

Homozygous lethal.

(Struhl, 1982)

Homozygous embryos have 10 segments with mesothoracic characteristics, followed by a small eighth abdominal segment. The ventral cord of central nervous system is longer and thicker than wild-type, and has 10 clearly defined intracortical cell bands, one at the anterior margin of the first 10 neuromeres.

(Jimenez and Campos-Ortega, 1981)
Stocks (3)
Notes on Origin
Discoverer

Lewis, 1956.

(Lewis, 1980)

Lewis.

 
Balancer / Genotype Variants of the Aberration
 
Separable Components
 
Other Comments
 
Synonyms and Secondary IDs (17)
Reported As
Symbol Synonym
Df Ubx109
(Capdevila and Garcia-Bellido, 1981)
Df(3)Ubx109
(Ponzielli et al., 2002)
Df(3L)Ubx109
(Rowe and Akam, 1988)
Df(3R)109
(Moris-Sanz et al., 2015, Chauvet et al., 2000, Capovilla and Botas, 1998, Macias and Morata, 1996, Graba et al., 1995, Hoppler and Bienz, 1995, Andrew et al., 1994, Graba et al., 1992, Elkins et al., 1990, Gonzalez-Reyes and Morata, 1990, Mann and Hogness, 1990, Jurgens, 1988)
Df(3R)P109
(Garaulet et al., 2014, Bilder and Scott, 1998)
Df(3R)Ubx-109
(Monier et al., 2005)
Df(3R)Ubx109
(Rubio-Ferrera et al., 2023, Pan et al., 2022, Li et al., 2020, Sawyer et al., 2020, Bahrampour et al., 2019, Monedero Cobeta et al., 2017, Lacin and Truman, 2016, Karlsson et al., 2010, Makhijani et al., 2007)
Df(3R)Ubx109
(Hermann et al., 2022, Zohar-Stoopel et al., 2014, Estacio-Gómez et al., 2013, Hittinger et al., 2005, Ryan et al., 2005, Perrin et al., 2004, Alexandre and Vincent, 2003, Castelli-Gair, 1998, Kurant et al., 1998, Burke et al., 1996, Laney and Biggin, 1996, Cimbora and Sakonju, 1995, Feinstein et al., 1995, Greig and Akam, 1995, Heuer et al., 1995, Eldon et al., 1994, Appel and Sakonju, 1993, Jijakli and Ghysen, 1992, Mathog, 1990, Reuter et al., 1990, Botas et al., 1988, Boulet and Scott, 1988, Lehmann and Nusslein-Volhard, 1987, Tiong et al., 1987, Sato and Denell, 1985, Teugels and Ghysen, 1985, Tiong et al., 1985, Struhl, 1983, Kerridge and Dura, 1982, Struhl, 1982, Jimenez and Campos-Ortega, 1981, Lewis, 1980)
Df(Ubx)109
(Peifer and Bender, 1986)
Df(Ubx)109
(Little et al., 1990, Babu and Bhat, 1981)
Df-Ubx109
(Kuhn and Woods, 1982)
Df109
(Sánchez-Higueras et al., 2019, de Navas et al., 2006, Foronda et al., 2006, Prokop et al., 1998, Szuts et al., 1997, Sanchez-Herrero, 1996.3.7, Macias et al., 1990, Bienz and Tremml, 1988, Casanova et al., 1988, Sanchez-Herrero et al., 1985, Struhl and White, 1985)
DfUbx109
(Foronda et al., 2006)
DfUbx109
(Frayne and Sato, 1991, Weinzierl et al., 1987)
Ubx109
(LaBeau et al., 2009, Boube et al., 1998, Boube et al., 1997, Zinn et al., 1988, Frohnhofer and Nusslein-Volhard, 1987, Bender et al., 1983)
Name Synonyms
Deficiency (3R) Ultrabithorax
Ultrabithorax-109
(Lewis, 1980)
Secondary FlyBase IDs
  • FBab0002467
  • FBal0017397
References (99)