IFa, Neb-LFamide, Drm-IFa
hormone, regulation of feeding behavior and sexual behavior, brain
Please see the JBrowse view of Dmel\SIFa for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.52
There is only one protein coding transcript and one polypeptide associated with this gene
Small SIFa-derived neuropeptides identified by 2D capillary LC/ESI-MS/MS: AYRKPPFNGSIF-amide.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\SIFa using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Expression of SIFa was established via single cell RNA sequencing of ScerGAL4Kurs58 or ScerGAL4c767 positive pars intercerebralis neurons. Expression was found in two out of five tested cells.
Expression of SIFa protein is found in a subset of four ScerGAL4Kurs58 positive pars intercerebralis neurons.
SIFa colocalizes with larval dorsomedial ScerGAL4ATP7.PB expressing larval dorsomedial neurosecretory cells.
SIFa protein is detected in layer 5 of the fan-shaped body, as well as faintly in the central and ventral layers.
SIFa protein is expressed in 4 cells in the pars intercerebralis that extend processes throughout most of the brain neuropils, except for the mushroom body stalks, lobes and calyces. The processes that innervate the antennal lobe arborise in most glomeruli. In addition, 3 pairs of cell bodies are detected in the dorsolateral protocerebrum. The cells labelled in the pars intercerebralis by SIFa also express ScerGAL4IFa.PT.
JBrowse - Visual display of RNA-Seq signals
View Dmel\SIFa in JBrowse2-107
2-111.0
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Release 4.1 annotation CG33527 corresponds to the 3' part of release 2 annotation CG4681 (which was deleted in the release 3 version of CG4681). Release 4.1 annotation CG33527 corresponds to IFa.
The 3' part of release 2 annotation CG4681 (which was deleted in the release 3 version of CG4681) corresponds to part of a separate gene - IFa.
Source for identity of: SIFa IFa
Changed from 'IFa' to 'SIFa' to reflect usage in the literature and match nomenclature of the receptor ('SIFaR').
