FlyBase Aberration Report: Dmel\Df(2R)Px2

General Information

Symbol

Df(2R)Px2

Species

D. melanogaster

Name

Deficiency (2R) Plexate

FlyBase ID

FBab0002027

Feature type

chromosomal_deletion

Also Known As

Df(2R)Px²

Computed Breakpoints include

60C6;60D9-60D10

Features within 60C6--60D9 (Estimated cytology)

Genomic Maps

JBrowse

Sequence coordinates

2R:24,268,358..24,306,028 (Df(2R)Px2:bk1)

(Cook et al., 2010.2.12)

2R:24,605,302..24,612,892 (Df(2R)Px2:bk2)

(Cook et al., 2010.2.12)

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

Progenitor

Mutagen

X ray

(Gotwals and Fristrom, 1991)

Class of aberration (relative to wild type)

chromosomal_deletion

(Cook et al., 2010.2.12, FlyBase, 2007)

Class of aberration (relative to progenitor)

chromosomal_deletion

(Prout et al., 1997, Dettman et al., 1996, Duffy et al., 1996, Harbecke and Lengyel, 1995, Pauli et al., 1995, Montell et al., 1992, Sunkel and Whittle, 1987)

Breakpoints

60C6;60D11

(Sunkel and Whittle, 1987)

60C5-60C6;60D9-60D10

(Prout et al., 1997, Dettman et al., 1996, Duffy et al., 1996, Harbecke and Lengyel, 1995, Pauli et al., 1995, Montell et al., 1992, Schupbach and Wieschaus, 1989)

Causes alleles

Carries alleles

Transposon Insertions

Formalized genetic data

sp Nop60B << bk1 << βTub60D << God << bk2 << Dll

Genetic mapping information

Comments

Comments on Cytology

The left Df(2R)Px2 breakpoint lies within CG13577 or βTub60D or in the region between them, and lies in the range 2R:20155881..20193551 (R5) (predicted cytology: 60C4-60C6).

(Cook et al., 2010.2.12)

The right Df(2R)Px2 breakpoint lies within CG4707 or CG42360 and CG42361 or in the region between them, and lies in the range 2R:20492825..20500415 (R5) (predicted cytology: 60D9).

(Cook et al., 2010.2.12)

Left limit of break 1 from polytene analysis (FBrf0047276) Right limit of break 1 from inclusion of slbo (FBrf0055567) Limits of break 2 from polytene analysis (FBrf0049878)

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

(LaJeunesse et al., 2001, Spradling et al., 1999, Walsh and Brown, 1998, Guillemin et al., 1996, Montagne et al., 1996, Affolter et al., 1994, BDGP Project Members, 1994-1999, Fristrom et al., 1994, Gotwals and Fristrom, 1991, Diaz-Benjumea and Garcia-Bellido, 1990, Kimble et al., 1990, Bridges, 1937)

CG3511

(Edgar et al., 2005)

God60D

(Ruden and Jäckle, 1995)

kis

(BDGP Project Members, 1994-1999)

l(2)60Ca

(Kimble et al., 1990)

l(2)60Cb

(Kimble et al., 1990)

l(2)60Cc

(Kimble et al., 1990)

l(2)60Cd

(Kimble et al., 1990)

l(2)60Da

(Kimble et al., 1990)

l(2)60Db

(Kimble et al., 1990)

l(2)60Dc

(Kimble et al., 1990)

l(2)60Dd

(Kimble et al., 1990)

l(2)60De

(Kimble et al., 1990)

l(2)60Df

(Kimble et al., 1990)

l(2)60Dg

(Kimble et al., 1990)

milou

(Galloni and Edgar, 1999)

Mod(Prat:bw)2-5

(Malmanche and Clark, 2003)

Nurf-38

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

pio

(Jazwinska et al., 2003, Prout et al., 1997)

slbo

(Montell et al., 1992, Rorth and Montell, 1992)

βTub60D

(Dettman et al., 2001, Dettman et al., 1996, Kimble et al., 1990)

Partially deleted / disrupted

Molecular Data

Completely deleted

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

Molecular Data

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Affected Genes Inferred by Location

Related Comments

Phenotypic Data

In combination with other aberrations

No effect on In(1)w^m4h position-effect variegation.

(Wustmann et al., 1989)

Lethal in combination with Df(2R)Px5.

(Thompson, 1963)

Df(2R)Px1/Df(2R)Px2 lethal Df(2R)Px2/Df(2R)Px5 lethal

NOT in combination with other aberrations

Homozygotes show lethality at late stages of embryogenesis. The body wall muscles develop correctly in the mutant embryos and attach to the epidermis as in wild type.

(Rudolf et al., 2012)

The Df(2R)Px2 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion).

(Mason et al., 2004)

Heterozygosity for Df(2R)Px2 results in 0.8% X chromosome nondisjunction and 0.6% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females.

(Harris et al., 2003)

Heterozygotes show an extra wing vein phenotype.

(LaJeunesse et al., 2001)

Heterozygotes have a blistered wing and ectopic vein phenotype.

(Firth et al., 2000)

No defects in targeting are seen in individual axons in Df(2R)Px2 heterozygotes. However the R7,8 axon array is mispositioned in 13% of optic lobes in pupal brains.

(Hoyle et al., 2000)

Heterozygotes have ectopic wing veins.

(Palsson and Gibson, 2000)

Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome.

(Coyne et al., 1998)

No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1.

(Halsell and Kiehart, 1998)

Shows no maternal enhancement of dpp^hr4.

(Nicholls and Gelbart, 1998)

Transheterozygotes with βTub60D^P126 are semi-lethal and survivors are sterile, remaining combinations with βTub60D alleles are lethal. Myogenesis and sarcomere integrity are normal in mutant larvae and embryos.

(Dettman et al., 1996)

Dominantly causes tergite defects in less than 50% of run³ heterozygotes.

(Duffy et al., 1996)

The tracheal phenotypes previously reported for this deficiency in FBrf0051997 and FBrf0072461, where the primary branches are disrupted and discontinuous, are due to the deletion of a gene other than bs, or more than one gene in the region.

(Guillemin et al., 1996)

Shows a haploinsufficient ectopic wing vein phenotype.

(Montagne et al., 1996)

Deficient embryos show a variably penetrant mutant midgut phenotype: central constriction forms posterior to normal site.

(Bilder and Scott, 1995)

Homozygous embryos have a defective tracheal system.

(Harbecke and Lengyel, 1995)

Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2.

(Pauli et al., 1995)

Heterozygotes with T(2;3)God¹ are inviable.

(Ruden and Jäckle, 1995)

Progeny of the genotype zip/Df(zip) exhibit the mlf phenotype (malformed syndrome), wing malformations and leg defects, at a penetrance of 14--35%.

(Gotwals and Fristrom, 1991)

Heterozygotes have smaller and narrower wings, slight plexates between all longitudinal veins. Veins are thickened at irregular intervals

(Diaz-Benjumea and Garcia-Bellido, 1990)

cell lethal (Ripoll and Garcia-Bellido, 1979). Wing veins of heterozygote with plexuslike or δlike thickenings, most often near posterior crossvein and free fragments of vein, most often in third posterior cell; L4 vein bent near margin. Wings smaller and narrower than wild type and dusky textured. Closely resembles bs. Expression more extreme in female; enhanced by cold (19^o). embryonic lethal as homozygote

Stocks (3)

Bloomington

2604

Df(2R)Px2/CyO, P{sevRas1.V12}FK1

Kyoto

107424

Df(2R)Px2/SM5

103283

Df(2R)Px2, bw¹ speck¹ / SM1, al² Duox^Cy cn² speck²

Notes on Origin

Discoverer

Schultz, 1st Dec. 1932.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Complementation tests reported for Df(2R)Px1 may have used a Df(2R)Px2 stock. The Mid-America Stock Center stock 1779 and the Bloomington Stock Center stock 750, which were labeled Df(2R)Px1, were in fact Df(2R)Px2 stocks. The mix-up predates 1991.

(Bloomington Drosophila Stock Center, 2003.8.1)

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

BL-2604

(Edgar et al., 2005)

Def (2R) Px2

(Giang et al., 2011)

Def-(2R) Px2

(Giang et al., 2011)

Df(2L)Px²

(Terriente-Félix and de Celis, 2009)

Df(2R)PX2

(Halsell and Kiehart, 1998)

Df(2R)Px2

(Clough et al., 2014, Galindo et al., 2014, Cook et al., 2010.2.12, Kirchner et al., 2008, Barbash and Lorigan, 2007, Crest et al., 2007, Matsuo et al., 2007)

Df(2R)Px²

(Rudolf et al., 2012, Dettman et al., 2001, Abrell et al., 2000, Hoyle et al., 2000, Galloni and Edgar, 1999, Dettman et al., 1996, Montagne et al., 1996, Affolter et al., 1994, Germeraad et al., 1992, Montell et al., 1992, Rorth and Montell, 1992, Ludwig et al., 1991, Schupbach and Wieschaus, 1991, Schupbach and Wieschaus, 1989, Wustmann et al., 1989, Sunkel and Whittle, 1987)

Df(2R)px²

(Bokel et al., 2005)

Px²

(Thompson, 1963)

Name Synonyms

Deficiency (2R) Plexate

Secondary FlyBase IDs

References (74)

Report Sections

Open Close