capa-1, CAP2b, capa-2, capa-3, Drm-PK-1
encodes three neuropeptides, two of the periviscerokinin family (CAPA-1 and CAPA-2) and one pyrokinin (Pyrokinin-1) - CAPA-1 and CAPA-2 activate GPCRs encoded by CapaR - Pyrokinin-1 activates Pyrokinin 1 receptor (PK1-R) - Capa is expressed in neurosecretory cells innervating the corpora cardiaca (part of the ring gland) and the abdomen. CAPA-1 and -2 act as diuretic hormones on the Malpighian tubules
Please see the JBrowse view of Dmel\Capa for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.44
Gene model reviewed during 5.53
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Capa using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Capa colocalizes with ScerGAL4ATP7.PB expressing Va neurons.
Capa is expressed in the peptidergic CC-MS 2 neurons in the larval brain and in the Va neurons of the abdominal ventral nerve cord.
Three pairs of Va neurons in abdominal ganglia are immunoreactive for Capa. The processes of the first two Va neuron pairs do not exit the ventral ganglio,n but run anterior underneath the dorsal neural sheath in an individually varying pattern, and terminate in the thoracic ganglia. The neurites of the most posterior Va pair fasciculate and leave the ganglion posteriorly.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Capa in JBrowse3-99
3-97.2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
The "capa-1" and "capa-2" peptides encoded by capa increase fluid secretion rates, stimulate nitric oxide production and elevate intracellular Ca2+ and cGMP in principal cells in the Malpighian tubule. The actions of capa-1" and "capa-2" are not synergistic.
Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day. Shows alteration in expression in a Clk mutant background.
A peptide with similar properties to CAP2b of M.sexta has been isolated from adult Drosophila. It stimulates fluid secretion by Malpighian tubules.
Source for merge of: capa Cap-2b
Source for identity of: capa CG15520
Source for identity of: Capa capa
The gene is named "capability" because it clearly has the ability to encode two neuropeptides of the CAP[[2b]] family.
