dTip60, EG:EG0007.7 , Dmel/TIP60, EG0007.7
histone acetyltransferase that regulates general metabolism, axon growth and dendritic targeting and sleep-wake cycle - regulates acetylation of histone H2A and promotes the generation of silent chromatin
Please see the JBrowse view of Dmel\Tip60 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Stop Codon spans the intron.
Gene model reviewed during 5.46
Component of the Tip60 chromatin-remodeling complex which contains the catalytic subunit Tip60 and the subunits Domino, Tra1, Brd8, E(Pc), DMAP1, Pontin, Reptin, Ing3, Act87E, BAP55, Mrg15, MrgBP, Gas41 and YL-1.
Autoacetylation at Lys-355 is required for proper function.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tip60 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Tip60 is localized at both the pre and postsynaptic sides of the neuromuscular junction and in presynaptic boutons.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Tip60 in JBrowse1-7
1-6.0
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
monoclonal
polyclonal
Tip60 controls neuronal specific gene expression profiles that are required for appropriate development and function of the nervous system.
DNA-protein interactions: genome-wide binding profile assayed for Tip60 protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069).
Identified in an RNAi screen for host factors that alter infection of SL2 cells by L.monocytogenes.
Source for identity of: EG:EG0007.7 CG6121
Source for identity of: Tip60 CG6121