FlyBase Allele Report: Dmel\Tip60[UAS.cPa]

General Information

Symbol

Dmel\Tip60^UAS.cPa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Pirooznia

FlyBase ID

FBal0294223

Feature type

allele

Associated gene

Dmel\Tip60

Associated Insertion(s)

Carried in Construct

P{UAS-Tip60.P}

Key Links

Transgenic product class

wild_type

(Pirooznia et al., 2012)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Pirooznia et al., 2012)

Mutagen

in vitro construct

(Pirooznia et al., 2012)

Progenitor genotype

Carried in construct

P{UAS-Tip60.P}

Cytology

Description

UAS regulatory sequences drive expression of wild-type Tip60.

(Pirooznia et al., 2012)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Tip60

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Alzheimer's disease

modeled by Hsap\APP^{695.UAS.Tag:MYC}

(Panikker et al., 2018, Pirooznia et al., 2012)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

partially lethal - majority die, with Scer\GAL4^179Y

(Pirooznia et al., 2012)

partially lethal - majority die, with Scer\GAL4^337Y

(Pirooznia et al., 2012)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Scer\GAL4^337Y, Tip60^UAS.cPa has partially lethal - majority die phenotype, non-suppressible by Hsap\APP^{695.UAS.Tag:MYC}, Scer\GAL4^337Y

(Pirooznia et al., 2012)

Scer\GAL4^179Y, Tip60^UAS.cPa has partially lethal - majority die phenotype, non-suppressible by Hsap\APP^{695.UAS.Tag:MYC}, Scer\GAL4^179Y

(Pirooznia et al., 2012)

Scer\GAL4^337Y, Tip60^UAS.cPa has partially lethal - majority die phenotype, non-suppressible by Hsap\APP^{695ΔCT.UAS.Tag:MYC}, Scer\GAL4^337Y

(Pirooznia et al., 2012)

Scer\GAL4^179Y, Tip60^UAS.cPa has partially lethal - majority die phenotype, non-suppressible by Hsap\APP^{695ΔCT.UAS.Tag:MYC}, Scer\GAL4^179Y

(Pirooznia et al., 2012)

Suppressor of

Statement

Reference

Tip60^UAS.cPa, Scer\GAL4^ey-OK107 is a suppressor of abnormal size | third instar larval stage phenotype of Hsap\APP^{695.UAS.Tag:MYC}, Scer\GAL4^ey-OK107

(Panikker et al., 2018)

Tip60^UAS.cPa, Scer\GAL4^elav-C155 is a suppressor of abnormal memory | third instar larval stage phenotype of Hsap\APP^{695.UAS.Tag:MYC}, Scer\GAL4^elav-C155

(Panikker et al., 2018)

Tip60^UAS.cPa, Scer\GAL4^elav-C155 is a suppressor of abnormal learning | third instar larval stage phenotype of Hsap\APP^{695.UAS.Tag:MYC}, Scer\GAL4^elav-C155

(Panikker et al., 2018)

Tip60^UAS.cPa, Scer\GAL4^337Y is a suppressor | partially of majority die during P-stage phenotype of Hsap\APP^{695.UAS.Tag:MYC}, Scer\GAL4^337Y

(Pirooznia et al., 2012)

Tip60^UAS.cPa, Scer\GAL4^179Y is a suppressor | partially of majority die during P-stage phenotype of Hsap\APP^{695.UAS.Tag:MYC}, Scer\GAL4^179Y

(Pirooznia et al., 2012)

Tip60^UAS.cPa, Scer\GAL4^179Y is a suppressor | partially of increased cell death | third instar larval stage phenotype of Hsap\APP^{695.UAS.Tag:MYC}, Scer\GAL4^179Y

(Pirooznia et al., 2012)

Phenotype Manifest In

Suppressor of

Statement

Reference

Tip60^UAS.cPa, Scer\GAL4^ey-OK107 is a suppressor of embryonic/larval mushroom body | third instar larval stage phenotype of Hsap\APP^{695.UAS.Tag:MYC}, Scer\GAL4^ey-OK107

(Panikker et al., 2018)

Tip60^UAS.cPa, Scer\GAL4^179Y is a suppressor | partially of embryonic/larval brain | third instar larval stage phenotype of Hsap\APP^{695.UAS.Tag:MYC}, Scer\GAL4^179Y

(Pirooznia et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

The co-expression of Tip60^UAS.cPa partially suppresses the decreased olfactory learning and memory exhibited by third instar larvae upon the expression of Hsap\APP^{695.UAS.Tag:MYC} under the control of Scer\GAL4^elav-C155. The co-expression of Tip60^UAS.cPa also partially suppresses the smaller larval mushroom body induced by the expression of Hsap\APP^{695.UAS.Tag:MYC} under the control of Scer\GAL4^ey-OK107.

(Panikker et al., 2018)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Tip60^Scer\UAS.cPa

Tip60^UAS.cPa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Pirooznia

Secondary FlyBase IDs

References (2)

Report Sections

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