FlyBase Allele Report: Scer\GAL4[Switch1.106]

General Information

Symbol

Scer\GAL4^Switch1.106

Species

S. cerevisiae

Name

FlyBase ID

FBal0286168

Feature type

allele

Associated gene

Scer\GAL4

Associated Insertion(s)

P{Switch1}106

Carried in Construct

Also Known As

S₁106, S106-GS-Gal4, S106, S1-106, S106-GS, S106-Gal4, S₁106-GAL4

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

P{Switch1}106

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{Switch1}

enhancer trap

Encoded product / tool

GAL4::GS

binary expression system - small molecule-regulated driver

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

distribution deduced from reporter (Gal4 UAS)

Stage

Tissue/Position (including subcellular localization)

Reference

pupal stage -- adult stage

pupal/adult digestive system

(Rera et al., 2011)

adult fat body

(Rera et al., 2011)

adult stage

fat body

(Roman et al., 2001)

abdomen | restricted

(Hwangbo et al., 2004)

thorax | restricted

(Hwangbo et al., 2004)

fat body of thorax

(Hwangbo et al., 2004)

fat body of abdomen

(Hwangbo et al., 2004)

fat body | subset

(Hwangbo et al., 2004)

microinjection

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

fat body

(Giannakou et al., 2004)

Additional Information

Statement

Reference

Drives mifepristone-inducible expression in pupal and adult thoracic and abdominal fat bodies.

(FlyBase Curators, 2017)

ScerGAL4^Switch1.106 drives mifepristone-inducible expression in the digestive tract and in the abdominal fat body.

(Rera et al., 2011)

Adult expression is observed in the abdominal and thoracic fat bodies, and occasionally in the cavity surround the mouthparts.

(Hwangbo et al., 2004)

Marker for

adult fat body

(Rera et al., 2011, Hwangbo et al., 2004)

fat body

(Giannakou et al., 2004, Roman et al., 2001)

pupal/adult digestive system

(Rera et al., 2011)

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal adult locomotory behavior, with foxo^UAS.cFa

(Martínez Corrales et al., 2022)

abnormal circadian rhythm, with InR^UAS.cHa

(Zheng et al., 2007)

abnormal heat stress response | RU486 conditional, with Men^UAS.cKa

(Kim et al., 2015)

abnormal immune response, with PGRP-LE^UAS.Tag:FLAG

(Libert et al., 2006)

abnormal locomotor behavior | adult stage, with Lam^UAS.cGa

(Brandt et al., 2008)

abnormal oxidative stress response, with InR^UAS.cHa

(Zheng et al., 2007)

abnormal oxidative stress response | adult stage | RU486 conditional, with Mrp4^EP3177

(Huang et al., 2014)

abnormal oxidative stress response | RU486 conditional, with Men^UAS.cKa

(Kim et al., 2015)

abnormal starvation stress response, with Lpin^GD14004

(Ugrankar et al., 2011)

abnormal starvation stress response | adult stage | RU486 conditional, with Bcat^HMS01832

(Kim et al., 2023)

abnormal starvation stress response | adult stage | RU486 conditional, with Sirt1^GD11580

(Banerjee et al., 2012)

abnormal stress response | adult stage | RU486 conditional, with Nmdmc^UAS.cYa

(Yu et al., 2015)

chemical resistant, with foxo^UAS.cFa

(Martínez Corrales et al., 2022)

chemical resistant | RU486 conditional, with foxo^UAS.cFa

(Giannakou et al., 2004)

chemical sensitive, with mor^HMS01267

(Martínez Corrales et al., 2022)

decreased fecundity | female, with foxo^UAS.cFa

(Giannakou et al., 2004)

female sterile | RU486 conditional, with Cbeta\DT^A-I.UAS

(Roman et al., 2001)

increased mortality | chemical conditional, with mor^HMS01267

(Martínez Corrales et al., 2022)

lethal | RU486 conditional, with Cbeta\DT^A-I.UAS

(Roman et al., 2001)

long lived, with CG15812^{UAS.ORF.GW.Tag:HA}

(Martínez Corrales et al., 2022)

long lived, with foxo^Δ94, foxo^UAS.cFa

(Martínez Corrales et al., 2022)

long lived, with ImpL2^GX4499

(Paik et al., 2012)

long lived, with Naglu^UAS.Tag:HA

(Xue et al., 2022)

long lived, with Xbp1^UAS.RA

(Martínez Corrales et al., 2022)

long lived, with Xbp1^UAS.RB

(Martínez Corrales et al., 2022)

long lived | female, with foxo^UAS.cFa

(Martínez Corrales et al., 2022)

long lived | female | RU486 conditional, with foxo^UAS.cFa

(Giannakou et al., 2005, Giannakou et al., 2004)

long lived | female limited | RU486 conditional, with ImpL2^UAS.cHa

(Alic et al., 2011)

long lived | male | RU486 conditional, with EcR^RNAi.UAS.cCa

(Tricoire et al., 2009)

long lived | RU486 conditional, with AMPKα^WT.UAS

(Stenesen et al., 2013)

long lived | RU486 conditional, with aop^ACT.UAS

(Slack et al., 2015, Alic et al., 2014)

long lived | RU486 conditional, with aop^UAS.Tag:FLAG

(Alic et al., 2014)

long lived | RU486 conditional, with Atg1^UAS.cSa

(Bjedov et al., 2020)

long lived | RU486 conditional, with chinmo^RNAi.UAS.cCa

(Pandey et al., 2021)

long lived | RU486 conditional, with Fatp1^UAS.Tag:FLAG

(Pandey et al., 2021)

long lived | RU486 conditional, with foxo^UAS.cFa

(Alic et al., 2014)

long lived | RU486 conditional, with foxo^Δ94, foxo^UAS.cFa

(Alic et al., 2014)

long lived | RU486 conditional, with Hsap\MIR125B1^UAS.cPa

(Pandey et al., 2021)

long lived | RU486 conditional, with InR^K1409A.UAS

(Ikeya et al., 2009)

long lived | RU486 conditional, with Men^UAS.cKa

(Kim et al., 2015)

long lived | RU486 conditional, with Nmdmc^UAS.cYa

(Yu et al., 2015)

long lived | RU486 conditional, with Ras85D^HMS01294

(Slack et al., 2015)

long lived | RU486 conditional, with Ras85D^N17.UAS

(Slack et al., 2015)

long lived | RU486 conditional, with rl^HMS00173

(Slack et al., 2015)

long lived | RU486 conditional, with Sirt6^UAS.cTa

(Taylor et al., 2022)

long lived | RU486 conditional, with srl^UAS.cRa

(Rera et al., 2011)

short lived, with aop^ACT.UAS

(Martínez Corrales et al., 2022)

short lived, with dom^HMS00142

(Martínez Corrales et al., 2022)

short lived, with Lam^UAS.cGa

(Brandt et al., 2008)

short lived, with Mi-2^HMS00301

(Martínez Corrales et al., 2022)

short lived, with Naglu^HMC03368

(Xue et al., 2022)

short lived, with PGRP-LE^UAS.Tag:FLAG

(Libert et al., 2006)

short lived, with pnt^P1.UAS

(Alic et al., 2014)

short lived, with Tip60^HM05049

(Martínez Corrales et al., 2022)

short lived | :RU486 conditional | nutrition conditional, with Fatp1^HMC04206

(Pandey et al., 2021)

short lived | RU486 conditional, with AMPKα^KK102684

(Stenesen et al., 2013)

short lived | RU486 conditional, with chinmo^UAS.Tag:FLAG

(Pandey et al., 2021)

short lived | RU486 conditional, with chinmo^{UAS.Tag:NLS(SV40-largeT)}

(Pandey et al., 2021)

short lived | RU486 conditional, with FASN1^HMS01524

(Pandey et al., 2021)

short lived | RU486 conditional, with Nmdmc^RNAi.UAS.cUa

(Yu et al., 2015)

short lived | RU486 conditional, with Scer\NDI1^UAS.cBa

(Bahadorani et al., 2010)

viable, with Cbeta\DT^A-I.UAS

(Roman et al., 2001)

wild-type | RU486 conditional, with foxo^TM.UAS

(Hwangbo et al., 2004)

wild-type | RU486 conditional, with foxo^UAS.cFa

(Hwangbo et al., 2004)

wild-type | RU486 conditional, with Pten^UAS.cGb

(Hwangbo et al., 2004)

Phenotype Manifest In

adult fat body, with Lam^UAS.cGa

(Brandt et al., 2008)

adult fat body | :RU486 conditional | nutrition conditional, with Hsap\MIR125B1^UAS.cPa

(Pandey et al., 2021)

adult fat body | adult stage | RU486 conditional, with Lsd-1^RNAi.UAS.cUa

(Wang et al., 2021)

adult fat body | adult stage | RU486 conditional, with Lsd-1^UAS.mCherry

(Wang et al., 2021)

adult fat body | RU486 conditional, with Cbeta\DT^A-I.UAS

(Roman et al., 2001)

adult fat body | RU486 conditional, with chinmo^RNAi.UAS.cCa

(Pandey et al., 2021)

adult fat body | RU486 conditional, with chinmo^UAS.Tag:FLAG

(Pandey et al., 2021)

adult fat body | RU486 conditional, with chinmo^{UAS.Tag:NLS(SV40-largeT)}

(Pandey et al., 2021)

lipid droplet | adult stage | :RU486 conditional | nutrition conditional, with Hsap\MIR125B1^UAS.cPa

(Pandey et al., 2021)

lipid droplet | adult stage | RU486 conditional, with chinmo^RNAi.UAS.cCa

(Pandey et al., 2021)

lipid droplet | adult stage | RU486 conditional, with chinmo^UAS.Tag:FLAG

(Pandey et al., 2021)

lipid droplet | adult stage | RU486 conditional, with chinmo^{UAS.Tag:NLS(SV40-largeT)}

(Pandey et al., 2021)

lipid droplet | adult stage | RU486 conditional, with Lsd-1^RNAi.UAS.cUa

(Wang et al., 2021)

lipid droplet | adult stage | RU486 conditional, with Lsd-1^UAS.mCherry

(Wang et al., 2021)

nucleus | adult stage, with Lam^UAS.cGa

(Brandt et al., 2008)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^Switch1.106, pnt^P1.UAS has short lived phenotype, enhanceable by foxo^UAS.cFa/Scer\GAL4^Switch1.106

(Alic et al., 2014)

NOT Enhanced by

Statement

Reference

Scer\GAL4^Switch1.106, foxo^UAS.cFa has long lived | female phenotype, non-enhanceable by Su(var)205^HMS00278/Scer\GAL4^Switch1.106

(Martínez Corrales et al., 2022)

Mi-2^HMS00301, Scer\GAL4^Switch1.106 has short lived phenotype, non-enhanceable by foxo^UAS.cFa, Scer\GAL4^Switch1.106

(Martínez Corrales et al., 2022)

Scer\GAL4^Switch1.106, aop^ACT.UAS has long lived | RU486 conditional phenotype, non-enhanceable by Ras85D^N17.UAS, Scer\GAL4^Switch1.106

(Slack et al., 2015)

Scer\GAL4^Switch1.106, aop^ACT.UAS has long lived | RU486 conditional phenotype, non-enhanceable by chico¹/chico[+]

(Slack et al., 2015)

Suppressed by

Statement

Reference

Scer\GAL4^Switch1.106, dom^HMS00142 has short lived phenotype, suppressible by foxo^UAS.cFa/Scer\GAL4^Switch1.106

(Martínez Corrales et al., 2022)

Scer\GAL4^Switch1.106, Tip60^HM05049 has short lived phenotype, suppressible by foxo^UAS.cFa/Scer\GAL4^Switch1.106

(Martínez Corrales et al., 2022)

Scer\GAL4^Switch1.106, foxo^UAS.cFa has long lived | female phenotype, suppressible by mor^HMS01267/Scer\GAL4^Switch1.106

(Martínez Corrales et al., 2022)

Scer\GAL4^Switch1.106, foxo^UAS.cFa has long lived | female phenotype, suppressible by osa^HMS01738/Scer\GAL4^Switch1.106

(Martínez Corrales et al., 2022)

Scer\GAL4^Switch1.106, foxo^UAS.cFa has long lived | female phenotype, suppressible by Iswi^HMS00628, Scer\GAL4^Switch1.106

(Martínez Corrales et al., 2022)

Scer\GAL4^Switch1.106, foxo^UAS.cFa has abnormal adult locomotory behavior phenotype, suppressible by Iswi^HMS00628, Scer\GAL4^Switch1.106

(Martínez Corrales et al., 2022)

Scer\GAL4^Switch1.106, foxo^UAS.cFa has long lived | female phenotype, suppressible by Etl1^HMS00829, Scer\GAL4^Switch1.106

(Martínez Corrales et al., 2022)

Scer\GAL4^Switch1.106, foxo^UAS.cFa has chemical resistant phenotype, suppressible by mor^HMS01267/Scer\GAL4^Switch1.106

(Martínez Corrales et al., 2022)

Scer\GAL4^Switch1.106, foxo^UAS.cFa has chemical resistant phenotype, suppressible by Iswi^HMS00628, Scer\GAL4^Switch1.106

(Martínez Corrales et al., 2022)

Scer\GAL4^Switch1.106, foxo^UAS.cFa has long lived | female phenotype, suppressible by dom^HMS00142/Scer\GAL4^Switch1.106

(Martínez Corrales et al., 2022)

Scer\GAL4^Switch1.106, foxo^UAS.cFa has long lived | female phenotype, suppressible by Tip60^HM05049/Scer\GAL4^Switch1.106

(Martínez Corrales et al., 2022)

Scer\GAL4^Switch1.106, foxo^UAS.cFa has abnormal adult locomotory behavior phenotype, suppressible by mor^HMS01267/Scer\GAL4^Switch1.106

(Martínez Corrales et al., 2022)

Ras85D^N17.UAS, Scer\GAL4^Switch1.106 has long lived | RU486 conditional phenotype, suppressible by aop^HMS01256, Scer\GAL4^Switch1.106

(Slack et al., 2015)

Scer\GAL4^Switch1.106, foxo^UAS.cFa, pnt^P1.UAS has short lived phenotype, suppressible by aop^ACT.UAS/Scer\GAL4^Switch1.106

(Alic et al., 2014)

PGRP-LE^UAS.Tag:FLAG, Scer\GAL4^Switch1.106 has abnormal immune response phenotype, suppressible by Tak1^K46R.M.UAS, Scer\GAL4^Switch1.106

(Libert et al., 2006)

PGRP-LE^UAS.Tag:FLAG, Scer\GAL4^Switch1.106 has abnormal immune response phenotype, suppressible by Fadd^RNAi.UAS, Scer\GAL4^Switch1.106

(Libert et al., 2006)

PGRP-LE^UAS.Tag:FLAG, Scer\GAL4^Switch1.106 has abnormal immune response phenotype, suppressible by Rel^E20, Scer\GAL4^Switch1.106

(Libert et al., 2006)

NOT suppressed by

Statement

Reference

Scer\GAL4^Switch1.106, foxo^UAS.cFa has long lived | female phenotype, non-suppressible by Su(var)205^HMS00278/Scer\GAL4^Switch1.106

(Martínez Corrales et al., 2022)

Mi-2^HMS00301, Scer\GAL4^Switch1.106 has short lived phenotype, non-suppressible by foxo^UAS.cFa, Scer\GAL4^Switch1.106

(Martínez Corrales et al., 2022)

Scer\GAL4^Switch1.106, aop^ACT.UAS has long lived | RU486 conditional phenotype, non-suppressible by Ras85D^N17.UAS, Scer\GAL4^Switch1.106

(Slack et al., 2015)

Scer\GAL4^Switch1.106, aop^ACT.UAS has long lived | RU486 conditional phenotype, non-suppressible by foxo^unspecified/foxo^unspecified

(Alic et al., 2014)

Scer\GAL4^Switch1.106, Sirt1^GD11580 has abnormal starvation stress response | adult stage | RU486 conditional phenotype, non-suppressible by chico¹/chico[+]

(Banerjee et al., 2012)

PGRP-LE^UAS.Tag:FLAG, Scer\GAL4^Switch1.106 has abnormal immune response phenotype, non-suppressible by Rel^E23, Scer\GAL4^Switch1.106

(Libert et al., 2006)

Enhancer of

Statement

Reference

foxo^UAS.cFa/Scer\GAL4^Switch1.106 is an enhancer of short lived phenotype of Scer\GAL4^Switch1.106, pnt^P1.UAS

(Alic et al., 2014)

NOT Enhancer of

Statement

Reference

Su(var)205^HMS00278/Scer\GAL4^Switch1.106 is a non-enhancer of long lived | female phenotype of Scer\GAL4^Switch1.106, foxo^UAS.cFa

(Martínez Corrales et al., 2022)

foxo^UAS.cFa, Scer\GAL4^Switch1.106 is a non-enhancer of short lived phenotype of Mi-2^HMS00301, Scer\GAL4^Switch1.106

(Martínez Corrales et al., 2022)

aop^ACT.UAS/Scer\GAL4^Switch1.106 is a non-enhancer of long lived | dominant phenotype of chico¹

(Slack et al., 2015)

Ras85D^N17.UAS, Scer\GAL4^Switch1.106 is a non-enhancer of long lived | RU486 conditional phenotype of Scer\GAL4^Switch1.106, aop^ACT.UAS

(Slack et al., 2015)

Suppressor of

Statement

Reference

foxo^UAS.cFa/Scer\GAL4^Switch1.106 is a suppressor of short lived phenotype of Scer\GAL4^Switch1.106, dom^HMS00142

(Martínez Corrales et al., 2022)

foxo^UAS.cFa/Scer\GAL4^Switch1.106 is a suppressor of short lived phenotype of Scer\GAL4^Switch1.106, Tip60^HM05049

(Martínez Corrales et al., 2022)

mor^HMS01267/Scer\GAL4^Switch1.106 is a suppressor of long lived | female phenotype of Scer\GAL4^Switch1.106, foxo^UAS.cFa

(Martínez Corrales et al., 2022)

osa^HMS01738/Scer\GAL4^Switch1.106 is a suppressor of long lived | female phenotype of Scer\GAL4^Switch1.106, foxo^UAS.cFa

(Martínez Corrales et al., 2022)

Iswi^HMS00628, Scer\GAL4^Switch1.106 is a suppressor of long lived | female phenotype of Scer\GAL4^Switch1.106, foxo^UAS.cFa

(Martínez Corrales et al., 2022)

Iswi^HMS00628, Scer\GAL4^Switch1.106 is a suppressor of abnormal adult locomotory behavior phenotype of Scer\GAL4^Switch1.106, foxo^UAS.cFa

(Martínez Corrales et al., 2022)

Etl1^HMS00829, Scer\GAL4^Switch1.106 is a suppressor of long lived | female phenotype of Scer\GAL4^Switch1.106, foxo^UAS.cFa

(Martínez Corrales et al., 2022)

mor^HMS01267/Scer\GAL4^Switch1.106 is a suppressor of chemical resistant phenotype of Scer\GAL4^Switch1.106, foxo^UAS.cFa

(Martínez Corrales et al., 2022)

Iswi^HMS00628, Scer\GAL4^Switch1.106 is a suppressor of chemical resistant phenotype of Scer\GAL4^Switch1.106, foxo^UAS.cFa

(Martínez Corrales et al., 2022)

dom^HMS00142/Scer\GAL4^Switch1.106 is a suppressor of long lived | female phenotype of Scer\GAL4^Switch1.106, foxo^UAS.cFa

(Martínez Corrales et al., 2022)

Tip60^HM05049/Scer\GAL4^Switch1.106 is a suppressor of long lived | female phenotype of Scer\GAL4^Switch1.106, foxo^UAS.cFa

(Martínez Corrales et al., 2022)

mor^HMS01267/Scer\GAL4^Switch1.106 is a suppressor of abnormal adult locomotory behavior phenotype of Scer\GAL4^Switch1.106, foxo^UAS.cFa

(Martínez Corrales et al., 2022)

aop^HMS01256, Scer\GAL4^Switch1.106 is a suppressor of long lived | RU486 conditional phenotype of Ras85D^N17.UAS, Scer\GAL4^Switch1.106

(Slack et al., 2015)

aop^ACT.UAS/Scer\GAL4^Switch1.106 is a suppressor of short lived phenotype of Scer\GAL4^Switch1.106, foxo^UAS.cFa, pnt^P1.UAS

(Alic et al., 2014)

Tak1^K46R.M.UAS, Scer\GAL4^Switch1.106 is a suppressor of abnormal immune response phenotype of PGRP-LE^UAS.Tag:FLAG, Scer\GAL4^Switch1.106

(Libert et al., 2006)

Fadd^RNAi.UAS, Scer\GAL4^Switch1.106 is a suppressor of abnormal immune response phenotype of PGRP-LE^UAS.Tag:FLAG, Scer\GAL4^Switch1.106

(Libert et al., 2006)

Rel^E20, Scer\GAL4^Switch1.106 is a suppressor of abnormal immune response phenotype of PGRP-LE^UAS.Tag:FLAG, Scer\GAL4^Switch1.106

(Libert et al., 2006)

NOT Suppressor of

Statement

Reference

Su(var)205^HMS00278/Scer\GAL4^Switch1.106 is a non-suppressor of long lived | female phenotype of Scer\GAL4^Switch1.106, foxo^UAS.cFa

(Martínez Corrales et al., 2022)

foxo^UAS.cFa, Scer\GAL4^Switch1.106 is a non-suppressor of short lived phenotype of Mi-2^HMS00301, Scer\GAL4^Switch1.106

(Martínez Corrales et al., 2022)

Ras85D^N17.UAS, Scer\GAL4^Switch1.106 is a non-suppressor of long lived | RU486 conditional phenotype of Scer\GAL4^Switch1.106, aop^ACT.UAS

(Slack et al., 2015)

Rel^E23, Scer\GAL4^Switch1.106 is a non-suppressor of abnormal immune response phenotype of PGRP-LE^UAS.Tag:FLAG, Scer\GAL4^Switch1.106

(Libert et al., 2006)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

SREBP^UAS.cKa/Scer\GAL4^Switch1.106 rescues SREBP¹⁸⁹

(Kunte et al., 2006)

Partially rescues

foxo^UAS.cFa/Scer\GAL4^Switch1.106 partially rescues foxo^Δ94

(Alic et al., 2014)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

8151

w¹¹¹⁸; P{Switch1}106

80948

w^*; P{Switch1}106; foxo²⁵/TM3, Sb¹

Notes on Origin

Discoverer

Comments

The Scer\GAL4^Switch1.106 driver is leaky during the larval stages (driving expression of a UAS transgene in the absence of RU486).

(Poirier et al., 2008)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

S₁106

(Roman et al., 2001)

Scer\GAL4^S106-GS

Scer\GAL4^Switch1.106

Name Synonyms

Secondary FlyBase IDs

FBal0128072
FBal0241183

References (71)

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