FlyBase Allele Report: Dmel\foxo[Δ94]

General Information

Symbol

Dmel\foxo^Δ94

Species

D. melanogaster

Name

FlyBase ID

FBal0269838

Feature type

allele

Associated gene

Dmel\foxo

Associated Insertion(s)

Carried in Construct

Also Known As

dfoxo^Δ94, dFOXO⁹⁴, Foxo^D94, Δ94, dfoxo^Δ

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Slack et al., 2011)

Progenitor genotype

foxo^BG01018

(Slack et al., 2011)

Cytology

Description

Imprecise excision of P{GT1}foxo^BG01018 generate a deletion that spans over 20kb of the foxo locus, removing part of the predicted promoter region as well as several coding exons.

(Slack et al., 2011)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Parkinson's disease

CEA

(Tas et al., 2018)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of Parkinson's disease

is ameliorated by Fer2^UAS.Tag:FLAG

(Tas et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate

(Slack et al., 2011)

abnormal developmental rate (with foxo²⁵)

(Slack et al., 2011)

abnormal locomotor behavior | recessive

(Tas et al., 2018)

decreased body size

(Slack et al., 2011)

decreased body size (with foxo²⁵)

(Slack et al., 2011)

decreased cell number | adult stage | progressive | recessive

(Tas et al., 2018)

long lived, with Scer\GAL4^Ilp2.215-55, foxo^UAS.cFa

(Alic et al., 2014)

long lived, with Scer\GAL4^Switch1.106, foxo^UAS.cFa

(Martínez Corrales et al., 2022)

long lived | nutrition conditional

(Slack et al., 2011)

long lived | RU486 conditional, with Scer\GAL4^Switch1.106, foxo^UAS.cFa

(Alic et al., 2014)

majority die during third instar larval stage, with Df(3R)Exel8159, Scer\GAL4^phtm.PO, foxo^UAS.cKc

(Koyama et al., 2014)

short lived

(Slack et al., 2015, Alic et al., 2014, Slack et al., 2011)

short lived | recessive

(Tas et al., 2018)

viable

(Tiebe et al., 2015, Slack et al., 2011)

Phenotype Manifest In

autophagosome | adult stage

(Tas et al., 2018)

dopaminergic PAM neuron | adult stage | progressive

(Tas et al., 2018)

embryonic/larval neuromuscular junction

(Nechipurenko and Broihier, 2012)

microtubule

(Nechipurenko and Broihier, 2012)

wing

(Slack et al., 2011)

wing (with foxo²⁵)

(Slack et al., 2011)

Detailed Description

Statement

Reference

foxo^Δ94 homozygous adults show a significant decrease in lifespan, a significant decrease in locomotor capacity (in a startle-induced climbing assay), a significant and progressive decrease in the number of dopaminergic PAM neurons, but not of PPM1, PPM2, PPM3, PPL1, PPL2a/b, PPL2c or PAL neurons, and a significant and progressive decrease in the number of autophagosomes (i.e. Atg-8-positive puncta) in the PAM neuron region, but not in the PAL neuron region, in the adult brain, as compared to heterozygous and wild-type controls.

(Tas et al., 2018)

foxo^Δ94 mutant flies show a similar reduction in lifespan when fed excess sugar as wild type. foxo^Δ94 mutation causes a slight but significant increase in triacylglycerol (TAG) levels when flies are fed 8x sugar food.

foxo^Δ94 suppresses the extension in lifespan seen in flies fed excess sugar when Scer\GAL4^Ilp3.PB-expressing median neurosecretory cells (mNSCs) have been ablated.

(Al Saud et al., 2015)

foxo^Δ94 homozygous females exhibit short lifespans.

(Alic et al., 2014)

foxo^Δ94/Df(3R)Exel8159 mutant starved larvae that express foxo^NK.Scer\UAS under the control of Scer\GAL4^phm.PO reach the 'critical weight' ecdysone peak later and at larger sizes than controls, but earlier and at smaller sizes than larvae that express foxo^Scer\UAS.cKc.

When foxo^Scer\UAS.cKc is expressed under the control of Scer\GAL4^phm.PO in foxo^Δ94/Df(3R)Exel8159 background most larvae do not survive to the third instar larval stage.

Expression of foxo^Scer\UAS.cKc in a foxo^Δ94/Df(3R)Exel8159 mutant background in the oenocytes under the control of Scer\GAL4^Desat1.PB, or in the corpora allata under the control of Scer\GAL4^Aug21 does not affect the duration of the third instar larval stage (L3) or final body size in starved larvae. Expression in the ring gland, oenocytes and the corpora allata under the control of Scer\GAL4^P0206 delays metamorphosis and increases body size at the 'critical weight' ecdysone peak compared to parental controls. Feeding ecdysone to Scer\GAL4^P0206>foxo^Scer\UAS.cKc foxo^Δ94/Df(3R)Exel8159 starved early third instar larvae eliminates this delay in metamorphosis.

(Koyama et al., 2014)

Homozygous foxo^Δ94 mutants do not exhibit any activity or sleep defects.

Unlike in controls, treating foxo^Δ94 mutant flies with tolbutamide does not increase daytime activity.

(Metaxakis et al., 2014)

foxo^Δ94 mutants do not exhibit defects in locomotory ability.

(Wang et al., 2014)

foxo^Δ94 mutant neuromuscular junctions display enhanced microtubule stability compared to controls.

(Nechipurenko and Broihier, 2012)

foxo^Δ94 homozygotes and foxo^Δ94/foxo²⁵ transheterozygotes are delayed in egg-adult development time and are smaller in size compared to controls, with a significant reduction in both body weight and wing area. Homozygous foxo^Δ94 females are shorter lived than controls and lay fewer eggs.

foxo^Δ94 mutant clones appear normal in size, suggesting that foxo does not act cell-autonomously to restrict cell proliferation or growth.

foxo^Δ94 females display an increase in lifespan under dietary restriction.

(Slack et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

foxo^Δ94 has decreased cell number | adult stage | recessive | progressive phenotype, enhanceable by Fer2^RNAi.UAS.5/Scer\GAL4^Fer2.2359

(Tas et al., 2018)

Suppressed by

Statement

Reference

foxo^Δ94 has decreased cell number | recessive | adult stage | progressive phenotype, suppressible by Fer2^UAS.Tag:FLAG/Scer\GAL4^Fer2.2359

(Tas et al., 2018)

foxo^Δ94 has decreased cell number | recessive | adult stage | progressive phenotype, suppressible by Fer2^UAS.Tag:FLAG/Scer\GAL4^GMR58E02

(Tas et al., 2018)

foxo^Δ94 has abnormal locomotor behavior | recessive phenotype, suppressible | partially by Fer2^UAS.Tag:FLAG/Scer\GAL4^GMR58E02

(Tas et al., 2018)

foxo^Δ94 has short lived | recessive phenotype, suppressible | partially by Fer2^UAS.Tag:FLAG/Scer\GAL4^GMR58E02

(Tas et al., 2018)

chico¹, foxo^Δ94 has lethal phenotype, suppressible by foxo^UASp.cSa/Scer\GAL4^da.G32

(Slack et al., 2011)

NOT suppressed by

Statement

Reference

foxo^Δ94 has short lived phenotype, non-suppressible by chico¹/chico[+]

(Slack et al., 2015)

foxo^Δ94 has viable phenotype, non-suppressible by InR^K1409A.UAS/Scer\GAL4^da.G32

(Slack et al., 2011)

foxo^Δ94 has viable phenotype, non-suppressible by rpr^UAS.C/Scer\GAL4^Ilp3.PB

(Slack et al., 2011)

foxo^Δ94 has viable | RU486 conditional phenotype, non-suppressible by InR^K1409A.UAS/Scer\GAL4^da.Switch.PT

(Slack et al., 2011)

foxo^Δ94 has viable | RU486 conditional phenotype, non-suppressible by Pi3K92E^{D954A.UAS.Tag:MYC}/Scer\GAL4^da.Switch.PT

(Slack et al., 2011)

NOT Enhancer of

Statement

Reference

foxo^Δ94/foxo^Δ94 is a non-enhancer of short lived | RU486 conditional phenotype of Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

nej^GD8975, Scer\GAL4^{repo.Switch.2301}, foxo^Δ94, foxo^Δ94 is a non-enhancer of short lived | RU486 conditional phenotype of Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

Suppressor of

Statement

Reference

nej^GD8975, foxo[+], foxo^Δ94, Scer\GAL4^{repo.Switch.2301} is a suppressor | partially of short lived | RU486 conditional phenotype of Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

foxo^Δ94 is a suppressor of increased cell death | third instar larval stage phenotype of Lsd-2^GD14108, Scer\GAL4^Bx-MS1096-KE

(Binh et al., 2019)

foxo^Δ94 is a suppressor | partially of visible | adult stage phenotype of Lsd-2^GD14108, Scer\GAL4^Bx-MS1096-KE

(Binh et al., 2019)

foxo[+]/foxo^Δ94 is a suppressor of abnormal courtship behavior phenotype of Hsap\APP^{695.UAS.Tag:MYC}, Scer\GAL4^Gr33a-GAL4

(Hu et al., 2015)

foxo[+]/foxo^Δ94 is a suppressor | partially of increased cell death | third instar larval stage phenotype of Hsap\APLP1^UAS.cMa, Scer\GAL4^ptc-559.1

(Wang et al., 2015)

foxo[+]/foxo^Δ94 is a suppressor of visible phenotype of Hsap\APLP1^UAS.cMa, Scer\GAL4^sd-SG29.1

(Wang et al., 2015)

foxo[+]/foxo^Δ94 is a suppressor of visible phenotype of Hsap\APLP1^UAS.cMa, Scer\GAL4^pnr-MD237

(Wang et al., 2015)

foxo[+]/foxo^Δ94 is a suppressor | partially of abnormal sleep phenotype of InR^K1409A.UAS, Scer\GAL4^da.G32

(Metaxakis et al., 2014)

foxo[+]/foxo^Δ94 is a suppressor of abnormal starvation stress response phenotype of Dark^CD4

(Obata et al., 2014)

foxo^Δ94 is a suppressor of increased cell death phenotype of Hsap\APP^695.UAS, Scer\GAL4^ptc-559.1

(Wang et al., 2014)

foxo^Δ94 is a suppressor of increased cell death phenotype of Hsap\APP^695.UAS, Scer\GAL4^pnr-MD237

(Wang et al., 2014)

foxo^Δ94 is a suppressor of abnormal locomotor behavior phenotype of Hsap\APP^695.UAS, Scer\GAL4^Appl.G1a

(Wang et al., 2014)

foxo^Δ94 is a suppressor of increased cell death phenotype of Hsap\APP^695.UAS, Scer\GAL4^sd-SG29.1

(Wang et al., 2014)

foxo^Δ94 is a suppressor | partially of long lived phenotype of InR^K1409A.UAS, Scer\GAL4^da.Switch.PT

(Slack et al., 2011)

foxo^Δ94 is a suppressor of abnormal developmental rate phenotype of InR^K1409A.UAS, Scer\GAL4^da.G32

(Slack et al., 2011)

foxo^Δ94 is a suppressor of long lived | RU486 conditional phenotype of InR^K1409A.UAS, Scer\GAL4^da.Switch.PT

(Slack et al., 2011)

foxo^Δ94 is a suppressor of long lived | RU486 conditional phenotype of Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^da.Switch.PT

(Slack et al., 2011)

foxo^Δ94 is a suppressor of long lived phenotype of Scer\GAL4^Ilp3.PB, rpr^UAS.C

(Slack et al., 2011)

foxo^Δ94 is a suppressor | partially of long lived | drug conditional phenotype of Scer\GAL4^Ilp3.PB, rpr^UAS.C

(Slack et al., 2011)

NOT Suppressor of

Statement

Reference

foxo^Δ94/foxo^Δ94 is a non-suppressor of short lived | RU486 conditional phenotype of Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

nej^GD8975, Scer\GAL4^{repo.Switch.2301}, foxo^Δ94, foxo^Δ94 is a non-suppressor of short lived | RU486 conditional phenotype of Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

foxo^Δ94 is a non-suppressor of viable | RU486 conditional phenotype of Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^da.Switch.PT

(Slack et al., 2011)

foxo^Δ94 is a non-suppressor of decreased body size phenotype of Scer\GAL4^Ilp3.PB, rpr^UAS.C

(Slack et al., 2011)

foxo^Δ94 is a non-suppressor of decreased fecundity | female | RU486 conditional phenotype of Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^da.Switch.PT

(Slack et al., 2011)

Other

Statement

Reference

REPTOR^KO, foxo^Δ94 has lethal - all die during larval stage phenotype

(Tiebe et al., 2015)

InR^K1409A.UAS, Scer\GAL4^da.G32, foxo^Δ94 has viable phenotype

(Metaxakis et al., 2014)

Df(3L)Ilp2-3, Ilp5¹, foxo^Δ94 has lethal phenotype

(Metaxakis et al., 2014)

InR^K1409A.UAS, Scer\GAL4^da.G32, foxo[+]/foxo^Δ94 has abnormal sleep phenotype

(Metaxakis et al., 2014)

Ilp2¹, Ilp3¹, Ilp5¹, foxo^Δ94 has lethal phenotype

(Slack et al., 2011)

chico¹, foxo^Δ94 has lethal phenotype

(Slack et al., 2011)

Lnk^Del29, foxo^Δ94 has lethal phenotype

(Slack et al., 2011)

Phenotype Manifest In

Enhanced by

Statement

Reference

foxo^Δ94 has dopaminergic PAM neuron | adult stage | progressive phenotype, enhanceable by Fer2^RNAi.UAS.5/Scer\GAL4^Fer2.2359

(Tas et al., 2018)

Suppressed by

Statement

Reference

foxo^Δ94 has dopaminergic PAM neuron | adult stage | progressive phenotype, suppressible by Fer2^UAS.Tag:FLAG/Scer\GAL4^Fer2.2359

(Tas et al., 2018)

foxo^Δ94 has dopaminergic PAM neuron | adult stage | progressive phenotype, suppressible by Fer2^UAS.Tag:FLAG/Scer\GAL4^GMR58E02

(Tas et al., 2018)

Suppressor of

Statement

Reference

foxo^Δ94 is a suppressor of wing pouch | third instar larval stage phenotype of Lsd-2^GD14108, Scer\GAL4^Bx-MS1096-KE

(Binh et al., 2019)

foxo^Δ94 is a suppressor | partially of wing phenotype of Lsd-2^GD14108, Scer\GAL4^Bx-MS1096-KE

(Binh et al., 2019)

foxo[+]/foxo^Δ94 is a suppressor | partially of anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype of Hsap\APLP1^UAS.cMa, Scer\GAL4^ptc-559.1

(Wang et al., 2015)

foxo[+]/foxo^Δ94 is a suppressor of wing blade | adult stage phenotype of Hsap\APLP1^UAS.cMa, Scer\GAL4^sd-SG29.1

(Wang et al., 2015)

foxo[+]/foxo^Δ94 is a suppressor of scutellum | adult stage phenotype of Hsap\APLP1^UAS.cMa, Scer\GAL4^pnr-MD237

(Wang et al., 2015)

foxo^Δ94 is a suppressor of anterior crossvein phenotype of Hsap\APP^695.UAS, Scer\GAL4^ptc-559.1

(Wang et al., 2014)

foxo^Δ94 is a suppressor of scutellum phenotype of Hsap\APP^695.UAS, Scer\GAL4^pnr-MD237

(Wang et al., 2014)

foxo^Δ94 is a suppressor of wing phenotype of Hsap\APP^695.UAS, Scer\GAL4^sd-SG29.1

(Wang et al., 2014)

foxo^Δ94 is a suppressor of eye phenotype of InR^K1409A.UAS, Scer\GAL4^ey.PH

(Slack et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

The progressive decrease in the number of adult PAM neurons observed in foxo^Δ94 homozygotes is enhanced by the Scer\GAL4^Fer2.2359-driven expression of Fer2^miRNA.UAS.5 and is suppressed by the Scer\GAL4^Fer2.2359-driven or Scer\GAL4^GMR58E02-driven expression of Fer2^UAS.Tag:FLAG; the expression of Fer2^miRNA.UAS.5 under the control of Scer\GAL4^Fer2.2359, however, does not affect the number of adult PAL cluster neurons observed in foxo^Δ94 homozygotes. The decreased adult locomotion capacity and the decreased lifespan presented by foxo^Δ94 homozygotes are partially suppressed by the expression of Fer2^UAS.Tag:FLAG under the control of Scer\GAL4^GMR58E02.

(Tas et al., 2018)

Expressing foxo^NK.Scer\UAS and usp^Scer\UAS.cUa under the control of Scer\GAL4^phm.PO in foxo^Δ94/Df(3R)Exel8159 mutant larvae does not alter the age and size of the 'critical weight' ecdysone peak, nor does it alter final body size when compared to overexpressing foxo^NK.Scer\UAS alone.

(Koyama et al., 2014)

One copy of foxo^Δ94 partially rescues the sleep defects seen in flies expressing InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^da.G32, specifically affecting day, but not night time phenotypes. Mutants show strongly reduced day activity and increased day sleep duration without changes in wakefulness (average activity per awake minute), and the number of day sleep bouts does not differ significantly from controls.

(Metaxakis et al., 2014)

foxo^Δ94/+ partially rescues the starvation stress phenotype of Ark^CD4 flies.

(Obata et al., 2014)

A foxo^Δ94 mutant background suppresses the Scer\GAL4^ptc-559.1-->Hsap\APP^695.Scer\UAS induced cell death in the larval wing disc and the loss of anterior cross vein found in these mutants.

A foxo^Δ94 mutant background suppresses the induced scutellum phenotype found upon expression of Hsap\APP^695.Scer\UAS under the control of Scer\GAL4^ap-md544 and the Scer\GAL4^sd-SG29.1-->Hsap\APP^695.Scer\UAS-induced small wing phenotype.

A foxo^Δ94 mutant background suppresses the Scer\GAL4^ptc-559.1-->Hsap\APP^695.Scer\UAS induced cell death in the larval wing disc and the loss of anterior cross vein found in these mutants.

(Wang et al., 2014)

Expression of foxo^{Scer\UAS.P\T.cSa} within the median neurosecretary cells (MNCs) under the control of Scer\GAL4^da.G32 rescues the lethality seen in chico¹;foxo^Δ94 mutants.

Expression of InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^da.G32 in foxo^Δ94 mutant flies results in an age-related increase in survival compared to controls, but this is less than in wild-type flies expressing InR^{K1409A.Scer\UAS}.

A foxo^Δ94 mutant background suppresses the extension in lifespan seen upon RU486-induced expression of InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^da.Switch.PT.

Expression of InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^da.G32 does not affect the viability of foxo^Δ94 flies.

Late ablation of the mNSCs through expression of rpr^Scer\UAS.C under the control of Scer\GAL4^Ilp3.PB does not affect the viability of foxo^Δ94 flies.

Adult onset ubiquitous expression of InR^{K1409A.Scer\UAS} or Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC} under the control of the RU486-inducible Scer\GAL4^da.Switch.PT has no effect on the viability of foxo^Δ94 flies.

foxo^Δ94 mutant females expressing InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^da.G32 show reduced egg laying compared with controls.

foxo^Δ94 mutant females expressing InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^da.Switch.PT treated with RU486 lay significantly fewer eggs than their uninduced controls.

foxo^Δ94 mutant flies expressing InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^da.G32 all survive for longer on food supplemented with 20mM paraquat compared to controls (but shorter compared to expression in a wild-type background).

A foxo^Δ94 background suppresses the DTT resistance seen in flies expressing InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^da.G32.

A foxo^Δ94 background fully suppresses the tissue-restricted growth inhibition seen in the eye upon expression of InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^ey.PH.

Removal of foxo through a foxo^Δ94 background does not suppress the developmental delay or reduced body size seen in flies expressing InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^da.G32.

A foxo^Δ94 mutant background suppresses the extension in lifespan seen upon RU486-induced expression of Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^da.Switch.PT.

Adult onset ubiquitous expression of Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC} under the control of the RU486-inducible Scer\GAL4^da.Switch.PT has no effect on the viability of foxo^Δ94 flies.

A foxo^Δ94 mutant background does not affect the decrease in egg-laying found upon adult-specific ubiquitous expression of Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^da.Switch.PT.

foxo^Δ94 mutant flies expressing Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^da.Switch.PT all survive for longer on food supplemented with 20mM paraquat compared to controls (but shorter compared to expression in a wild-type background).

A foxo^Δ94 background suppresses the DTT resistance seen in flies expressing Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^da.Switch.PT.

foxo^Δ94 mutant flies expressing Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^da.G32 all survive for longer on food supplemented with 20mM paraquat compared to controls (but shorter compared to expression in a wild-type background).

A foxo^Δ94 background suppresses the lifespan of female flies expressing rpr^Scer\UAS.C under the control of Scer\GAL4^Ilp3.PB, almost to wild-type levels.

foxo^Δ94 mutant females expressing rpr^Scer\UAS.C under the control of Scer\GAL4^da.G32 show reduced egg laying compared with controls.

In a foxo^Δ94 mutant background, Scer\GAL4^Ilp3.PB driven expression of rpr^Scer\UAS.C leads to significantly fewer eggs being laid than in controls.

(Slack et al., 2011)

Xenogenetic Interactions

Statement

Reference

The younger female preference defect of males expressing Hsap\APP^{695.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^Gr33a-GAL4 is significantly rescued in the presence of foxo^Δ94/+ mutation.

(Hu et al., 2015)

foxo^Δ94/+ significantly partially suppresses the increased cell death induced by expression of Hsap\APLP1^Scer\UAS.cMa driven along the anterior/posterior compartment boundary in third instar larval wing discs by Scer\GAL4^ptc-559.1, suppresses the blistered wing phenotype in flies with expression of Hsap\APLP1^Scer\UAS.cMa driven by Scer\GAL4^sd-SG29.1, and suppresses the small scutellum phenotype seen with expression of Hsap\APLP1^Scer\UAS.cMa driven by Scer\GAL4^pnr-MD237.

(Wang et al., 2015)

Complementation and Rescue Data

Partially rescued by

foxo^Δ94 is partially rescued by foxo^UAS.cFa/Scer\GAL4^GMR58E02

(Tas et al., 2018)

foxo^Δ94 is partially rescued by foxo^UAS.cFa/Scer\GAL4^Switch1.106

(Alic et al., 2014)

foxo^Δ94 is partially rescued by Scer\GAL4^Ilp2.215-55/foxo^UAS.cFa

(Alic et al., 2014)

Comments

The expression of foxo^UAS.cFa under the control of Scer\GAL4^GMR58E02 rescues the decreased number of dopaminergic PAM neurons in the adult brain but enhances the decreased lifespan presented by foxo^Δ94 homozygotes.

(Tas et al., 2018)

The presence of RU486 from day 2 of adulthood extends the median lifespan of foxo^Δ94 female flies expressing foxo^Scer\UAS.cFa under the control of Scer\GAL4^Switch1.106 on average by 10%.

Expressing foxo^Scer\UAS.cFa specifically in the mNSCs in the adult brain, using the Scer\GAL4^Ilp2.215-55 driver, extends the lifespan of female flies in foxo^Δ94 mutants.

Induction of foxo^Scer\UAS.cFa expression in the gut and fat body, under the control of Scer\GAL4^Switch1.106 enhances the climbing ability of female flies throughout their lifespan, observed as an increase in the proportion of high, or combined medium and high, climbers. This enhancement is seen in a foxo^Δ94 background.

Induction of foxo^Scer\UAS.cFa expression in adulthood, under the control of Scer\GAL4^Switch1.106 (and RU486) has no effect on fecundity in foxo^Δ94 mutants, but has an effect on body weight and protein content.

(Alic et al., 2014)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

42220

w¹¹¹⁸; foxo^Δ94/TM6B, Tb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (20)

Reported As

Symbol Synonym

FOXO^Δ94

(Tiebe et al., 2015)

FoxO^Δ94

(Koyama et al., 2014, Nowak et al., 2013)

Foxo-LOF

(Martin et al., 2021)

Foxo^D94

(Martin et al., 2021)

Foxo^Δ94

(Luo et al., 2020)

dFOXO⁹⁴

(Mahoney et al., 2016)

dFOXO^Δ94

(Chen et al., 2022)

dFoxO⁹⁴

(Obata et al., 2014)

dFoxO^Δ94

(Guo et al., 2022)

dFoxoΔ94

(Weigelt et al., 2020)

dfoxO^Δ94

(Binh et al., 2019, Hu et al., 2015, Wang et al., 2015)

dfoxo^Δ94

(Martínez Corrales et al., 2022, Tas et al., 2018, Tain et al., 2017, Slack et al., 2011)

dfoxo^Δ

(Bolukbasi et al., 2017, Tain et al., 2017)

dfoxoΔ

(Dobson et al., 2017)

dfoxoΔ⁹⁴

(Dobson et al., 2017)

foxO^Δ94

(Sears and Broihier, 2016)

foxo^D94

(Teseo et al., 2021)

foxo^Δ94

(Kosakamoto et al., 2024, Monteiro et al., 2023, Charroux and Royet, 2022, Poe et al., 2020, van Dam et al., 2020, Molaei et al., 2019, Toshniwal et al., 2019, Kang et al., 2017, Vasudevan et al., 2017, Kakanj et al., 2016, Alic et al., 2014, Liu et al., 2014, Metaxakis et al., 2014, Wang et al., 2014, Karpac et al., 2013, Nechipurenko and Broihier, 2012, Rynes et al., 2012)

foxoΔ94

(Slack et al., 2015)

Δ94

(Rigal et al., 2022, Donovan and Marr, 2016)

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