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General Information
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| Term |
s-LNv Pdf neuron |
ID (Ontology) |
FBbt:00003764 (Fly Anatomy) |
| Definition |
Adult s-LNv neuron that expresses Pdf (FBgn0023178). There are four of these in each ventral cluster of LNs. Short, fine fibers lacking presynaptic sites contact the accessory medulla, whilst longer processes project toward the dorsal protocerebrum and terminate dorsofrontal to the mushroom body calyx close to the pars lateralis and close to the DN2 neurons (Helfrich-Forster et al., 2007). Thes dorsal arbors contain both pre- and postsynaptic connections, including reciprocal connections to DN1p neurons (Yasuyama and Meinertzhagen, 2010, Fernandez et al., 2020), and their morphology and connectivity vary throughout the day (Gorostiza et al., 2014). Pdf rich dense-synaptic vesicles accumulate in terminal varicosities in these cells, but are not associated with presynaptic sites (Miskiewicz et al., 2004; Yasuyama and Meinertzhagen, 2010). They can be observed docked at the plasma membrane, suggesting paracrine release of Pdf. They drive the morning locomotor activity peak (Liang et al., 2016; Liang et al., 2017; Delventhal et al., 2019) and display a morning neural activity peak that precedes this increased locomotor activity (Liang et al., 2016).[ FlyBase:FBrf0179342 FlyBase:FBrf0191052 FlyBase:FBrf0193849 FlyBase:FBrf0209462 FlyBase:FBrf0225654 FlyBase:FBrf0226303 FlyBase:FBrf0231110 FlyBase:FBrf0235909 FlyBase:FBrf0243753 FlyBase:FBrf0246021 ] |
| Also Known As |
"M cell" ; "M oscillator" ; "M pacemaker" (for all, see Synonyms field below) |
| Comment |
Dorsal projections judged by curator to terminate in the superior lateral protocerebrum (SLP) as defined by the Ito et al. (2014) standard. This is the only group of pacemaker neurons currently classed as 'morning cells' (Liang et al., 2016; Liang et al., 2017; Delventhal et al., 2019). In some older papers, it is unclear whether l-LNvs are included as 'morning cells' (Grima et al., 2004 - FBrf0179741; Lear et al., 2009 - FBrf0208444). |
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Links to Extrernal Ontologies
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VFB:FBbt_00003764
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Annotations
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Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
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| Data Class | Field | Records |
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| Alleles (FBal) | PHENOTYPE_MANIFEST_IN | 28 | | Insertions (FBti) | EXPRESSION_STAGE_TISSUE_POSITION | 8 | | Insertions (FBti) | PHENOTYPE_MANIFEST_IN | 3 | | Constructs (FBtp) | PHENOTYPE_MANIFEST_IN | 21 |
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Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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| Full annotation statements | Relevant FlyBase reports |
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| Alleles | | Genes | Insertions | Constructs |
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s-LNv Pdf neuron (all annotations which use CV term, excluding "NOT" statements) | 29 | 1 | 8 | 11 | 31 | s-LNv Pdf neuron | adult stage | 3 | -- | -- | -- | 3 | s-LNv Pdf neuron | increased number | third instar larval stage | 1 | -- | -- | -- | -- |
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Relationships