Kang, H., Cabrera, J.R., Zee, B.M., Kang, H.A., Jobe, J.M., Hegarty, M.B., Barry, A.E., Glotov, A., Schwartz, Y.B., Kuroda, M.I. (2022). Variant Polycomb complexes in Drosophila consistent with ancient functional diversity.  Sci. Adv. 8(36): eadd0103.

FBrf0254426

Research paper

Polycomb group (PcG) mutants were first identified in Drosophila on the basis of their failure to maintain proper Hox gene repression during development. The proteins encoded by the corresponding fly genes mainly assemble into one of two discrete Polycomb repressive complexes: PRC1 or PRC2. However, biochemical analyses in mammals have revealed alternative forms of PRC2 and multiple distinct types of noncanonical or variant PRC1. Through a series of proteomic analyses, we identify analogous PRC2 and variant PRC1 complexes in Drosophila, as well as a broader repertoire of interactions implicated in early development. Our data provide strong support for the ancient diversity of PcG complexes and a framework for future analysis in a longstanding and versatile genetic system.

PMC9451159 (PMC) (EuropePMC)