smt3, dSmt3, DmSmt3, l(2)04493
a low molecular weight protein modifier that is vital for multicellular development - over 140 SUMO conjugates have been identified in the early embryo including Dorsal, Tramtrack, Vestigial, SoxNeuro, Medea, Mod(mdg4) and CP190 and the bi-functional tRNA charging enzyme glutamylprolyl-tRNA synthetase
Please see the JBrowse view of Dmel\Sumo for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.49
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.44
Gene model reviewed during 6.02
2.5, 1.5, 0.582 (longest cDNA)
90 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sumo using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Maternal Sumo transcripts are distributed throughout the embryo until stage 10 and then decrease gradually. From stage 14 until the end of embryogenesis, transcripts are observed in the embryonic gonads in the pole cells. Sumo is also strongly expressed in the CNS. Within ovaries, transcripts are weakly detected in the germarium, are strongly expressed in stage S1-10 nurse cells and are weakly detected in the oocyte up until stage S10. Sumo transcripts are weakly expressed in spermatogonial cells at the tip region and remain detectable in the spermatocytes and spermatids.
The 1.5 and 2.5 kb Sumo transcripts are detected in embryos, larvae, and adults. The 1.5 kb transcript is most abundant in larvae.
Comment: 24 hr APF
Sumo protein is expressed ubiquitously throughout embryonic and larval development. It accumulates at high levels in the nuclei of cells of the prothoracic gland.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Sumo in JBrowse2-23
2-22.2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Expression is enriched in embryonic gonads.
S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
smt3 plays a maternal role in A/P polarity and patterning.
6 alleles of l(2)SH0182 recovered in a P-insertion screen.
Area matching Drosophila gene SMT3, Acc. No. AF053083.
Source for merge of: smt3 l(2)04493
Source for merge of: smt3 anon- EST:Posey240
Source for merge of: smt3 l(2)SH0182
Source for identity of: smt3 SUMO
Source for identity of: Sumo smt3
Renamed from 'smt3' to 'Sumo' to reflect community usage and nomenclature used for orthologs, consistent with naming conventions of other D. melanogaster ubiquitin-like proteins.
