FlyBase Allele Report: Dmel\dco[ar]

General Information

Symbol

Dmel\dco^ar

Species

D. melanogaster

Name

FlyBase ID

FBal0119276

Feature type

allele

Associated gene

Dmel\dco

Associated Insertion(s)

Carried in Construct

Also Known As

dbt^ar

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Yu et al., 2006)

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: H126Y.

(Rothenfluh et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:31,057,476..31,057,476 [-]

Nucleotide change:

C31057476T

Amino acid change:

Reported amino acid change:

H126Y

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Rothenfluh et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

ommatidium (with dco^j3B9)

(Klein et al., 2006)

Detailed Description

Statement

Reference

dco^ar/+ flies have a lengthened circadian period.

(Huang et al., 2014)

In constant darkness, dco^ar/+ heterozygotes display a slightly longer period compared to wild type flies. Almost half of dco^EY02910/dco^ar flies are arrhythmic, while most of the remainder show weak rhythms and a longer period.

(Zheng et al., 2014)

Approximately 50% of dco^ar/dco^VIII flies display locomotor arrhythmicity.

(Sekine et al., 2008)

The eyes of dco^j3B9/dco^ar transheterozygotes show mild planar cell polarity defects.

(Klein et al., 2006)

Unlike other dco mutant flies, dco^ar homozygotes show an arrhythmic circadian locomotor activity. About 70% of homozygotes are viable. Heterozygotes show a strong semidominant period-lengthening, about 7% of flies are arrhythmic. About 2/3 of dco^ar/dco^j3B9 flies are arrhythmic, the rest show a period-lengthening phenotype. Over 4/5 of dco^ar/Df(3R)tll-g flies are arrhythmic, the rest show a period-lengthening phenotype.

(Rothenfluh et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Df(3R)tll-g/dco^ar has abnormal circadian rhythm phenotype, suppressible | partially by per^T

(Rothenfluh et al., 2000)

dco^j3B9/dco^ar has abnormal circadian rhythm phenotype, suppressible | partially by per^T

(Rothenfluh et al., 2000)

dco^j3B9/dco^ar has abnormal circadian rhythm phenotype, suppressible | partially by per^s

(Rothenfluh et al., 2000)

NOT suppressed by

Statement

Reference

dco^VIII/dco^ar has abnormal locomotor rhythm phenotype, non-suppressible by Scer\GAL4^arm.PS/Hsap\CSNK1E^UAS.cSa

(Sekine et al., 2008)

dco^VIII/dco^ar has abnormal locomotor rhythm phenotype, non-suppressible by Scer\GAL4^arm.PS/dco::Hsap\CSNK1E^UAS.cSa

(Sekine et al., 2008)

Df(3R)tll-g/dco^ar has abnormal circadian rhythm phenotype, non-suppressible by tim[+]/tim⁰¹

(Rothenfluh et al., 2000)

Df(3R)tll-g/dco^ar has abnormal circadian rhythm phenotype, non-suppressible by tim^S1/tim⁰¹

(Rothenfluh et al., 2000)

Df(3R)tll-g/dco^ar has abnormal circadian rhythm phenotype, non-suppressible by per^SLIH

(Rothenfluh et al., 2000)

dco^j3B9/dco^ar has abnormal circadian rhythm phenotype, non-suppressible by per^SLIH

(Rothenfluh et al., 2000)

dco^j3B9/dco^ar has abnormal circadian rhythm phenotype, non-suppressible by tim^S1/tim⁰¹

(Rothenfluh et al., 2000)

Other

Statement

Reference

Scer\GAL4^P2.4.Pdf, dco^ar, lark^UAS.Tag:HA has abnormal locomotor rhythm phenotype

(Huang et al., 2014)

Scer\GAL4^P2.4.Pdf, dco^ar, lark^RNAi.UAS.cSb has abnormal locomotor rhythm phenotype

(Huang et al., 2014)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Adult-specific expression (using TubGAL80ts) of lark^{Scer\UAS.T:Ivir\HA1} driven by Scer\GAL4^P2.4.Pdf significantly lengthens circadian period in dco^ar/+ flies; co-expression of lark^{dsRNA.Scer\UAS.cSb} significantly shortens circadian period.

(Huang et al., 2014)

The addition of per^s or per^T to dco^j3B9/dco^ar or Df(3R)tll-g/dco^ar flies suppresses the arrhythmicity phenotype seen in these flies. The addition of tim^S1/tim⁰¹, tim⁰¹/+, or per^SLIH does not suppress the dco^ar/dco^j3B9 and dco^ar/Df(3R)tll-g arrhythmic phenotypes.

(Rothenfluh et al., 2000)

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\CSNK1E^Scer\UAS.cSa under the control of Scer\GAL4^arm.PS fails to rescue the locomotor rhythm defects seen in dco^ar/dco^VIII.

(Sekine et al., 2008)

Complementation and Rescue Data

Fails to complement

dco^j3B9

(Rothenfluh et al., 2000)

Rescued by

dco^VIII/dco^ar is rescued by Scer\GAL4^arm.PS/dco^UAS.cSa

(Sekine et al., 2008)

Comments

Expression of dco^Scer\UAS.cSa under the control of Scer\GAL4^arm.PS rescues the locomotor rhythm defects seen in dco^VIII/dco^ar.

(Sekine et al., 2008)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

80979

y¹ w^*; dco^ar/TM3, Sb¹ Ser¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

dbt^AR

(Huang et al., 2014, Zheng et al., 2014, Garbe et al., 2013, Kivimäe et al., 2008, Klein et al., 2006)

dbt^ar

(Andreazza et al., 2015, Yu et al., 2009, Sekine et al., 2008, Kim and Edery, 2006, Yu et al., 2006, Cyran et al., 2005, Stanewsky, 2003, Weber and Kay, 2003, Stanewsky, 2002, Rothenfluh et al., 2000)

dco^ar

Name Synonyms

Secondary FlyBase IDs

References (15)

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