FlyBase Allele Report: Dmel\dco[VIII]

General Information

Symbol

Dmel\dco^VIII

Species

D. melanogaster

Name

FlyBase ID

FBal0091518

Feature type

allele

Associated gene

Dmel\dco

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Kloss et al., 1998)

Progenitor genotype

dco^j3B9

(Kloss et al., 1998)

Cytology

Description

Excision of P{lacW} with additional sequence changes at dco.

(Kloss et al., 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

wing, with Scer\GAL4^arm.PS, dco^UAS.cSa

(Sekine et al., 2008)

Detailed Description

Statement

Reference

Approximately 50% of dco^ar/dco^VIII flies display locomotor arrhythmicity.

Flies expressing dco^Scer\UAS.cSa under the control of Scer\GAL4^arm.PS in a dco^VIII mutant background display morphological abnormalities in wing angle and folding. Approximately 60% of flies cannot fold their wings properly and 80% are unable to vibrate their wings and fly. No locomotor rhythm defects are seen in these flies.

No locomotor rhythm defects are seen when flies expressing dco^hs.PS in a dco^VIII mutant background are heat shocked. However when dco^hs.PS is expressed in the absence of heat shock approximately 71% of viable flies are arrhythmic.

(Sekine et al., 2008)

Short rhythm mutant.

(Kloss et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

dco^VIII has lethal phenotype, non-suppressible by Scer\GAL4^arm.PS/Hsap\CSNK1E^UAS.cSa

(Sekine et al., 2008)

dco^VIII/dco^ar has abnormal locomotor rhythm phenotype, non-suppressible by Scer\GAL4^arm.PS/Hsap\CSNK1E^UAS.cSa

(Sekine et al., 2008)

dco^VIII has lethal phenotype, non-suppressible by Scer\GAL4^arm.PS/dco::Hsap\CSNK1E^UAS.cSa

(Sekine et al., 2008)

dco^VIII/dco^ar has abnormal locomotor rhythm phenotype, non-suppressible by Scer\GAL4^arm.PS/dco::Hsap\CSNK1E^UAS.cSa

(Sekine et al., 2008)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\CSNK1E^Scer\UAS.cSa under the control of Scer\GAL4^arm.PS fails to rescue the lethality associated with dco^VIII.

Expression of Hsap\CSNK1E^Scer\UAS.cSa under the control of Scer\GAL4^arm.PS fails to rescue the locomotor rhythm defects seen in dco^ar/dco^VIII.

Expression of dco::Hsap\CSNK1E^Scer\UAS.cSa under the control of Scer\GAL4^arm.PS fails to rescue the lethality associated with dco^VIII.

Expression of dco::Hsap\CSNK1E^Scer\UAS.cSa under the control of Scer\GAL4^arm.PS fails to rescue the locomotor rhythm defects seen in dco^ar/dco^VIII.

(Sekine et al., 2008)

Complementation and Rescue Data

Rescued by

dco^VIII is rescued by Scer\GAL4^arm.PS/dco^UAS.cSa

(Sekine et al., 2008)

dco^VIII is rescued by dco^hs.PS

(Sekine et al., 2008)

dco^VIII/dco^ar is rescued by Scer\GAL4^arm.PS/dco^UAS.cSa

(Sekine et al., 2008)

Not rescued by

dco^VIII is not rescued by Scer\GAL4^arm.PS/dco^kinase.UAS

(Sekine et al., 2008)

Comments

Expression of dco^Scer\UAS.cSa under the control of Scer\GAL4^arm.PS rescues the lethality associated with dco^VIII.

Expression of dco^Scer\UAS.cSa under the control of Scer\GAL4^arm.PS rescues the locomotor rhythm defects seen in dco^VIII/dco^ar.

Expression of dco^hs.PS under heat shock conditions rescues the lethality associated with dco^VIII. Lethality is also rescued when heat shock is not applied.

(Sekine et al., 2008)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Revertant \partial.

(Kloss et al., 1998)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

dbt^VIII

(Kloss et al., 1998)

dbt^revVIII

(Sekine et al., 2008)

dco^VIII

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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