FlyBase Allele Report: Dmel\dco[UAS.cSa]

General Information

Symbol

Dmel\dco^UAS.cSa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Saez

FlyBase ID

FBal0135732

Feature type

allele

Associated gene

Dmel\dco

Associated Insertion(s)

Carried in Construct

P{UAS-dco.S}

Also Known As

UAS-dbt, UAS-dco

Key Links

Transgenic product class

wild_type

(Price and Kalderon, 2002)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Price and Kalderon, 2002)

Mutagen

in vitro construct

(Price and Kalderon, 2002)

Progenitor genotype

Carried in construct

P{UAS-dco.S}

Cytology

Description

UAS sequences drive expression of UAS.

(Price and Kalderon, 2002)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dco

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal flight, with Scer\GAL4^arm.PS, dco^VIII

(Sekine et al., 2008)

abnormal locomotor rhythm, with Scer\GAL4^tim.UAS

(Sekine et al., 2008)

abnormal planar polarity | adult stage, with Scer\GAL4^en-e16E

(Strutt and Strutt, 2020)

viable, with Scer\GAL4^arm.PS, dco^VIII

(Sekine et al., 2008)

Phenotype Manifest In

wing, with Scer\GAL4^arm.PS, dco^VIII

(Sekine et al., 2008)

wing, with Scer\GAL4^en-e16E

(Strutt and Strutt, 2020)

wing hair, with Scer\GAL4^en-e16E

(Strutt and Strutt, 2020)

Detailed Description

Statement

Reference

Expression of dco^UAS.cSa under the control of Scer\GAL4^en-e16E leads to a large trichome swirl close to the posterior cross vein, and a smaller swirl in the distal region of the wing when compared to controls.

(Strutt and Strutt, 2020)

Flies expressing dco^Scer\UAS.cSa under the control of Scer\GAL4^arm.PS in a dco^VIII mutant background display morphological abnormalities in wing angle and folding. Approximately 60% of flies cannot fold their wings properly and 80% are unable to vibrate their wings and fly. No locomotor rhythm defects are seen in these flies.

Expression of dco^Scer\UAS.cSa under the control of Scer\GAL4^tim.Scer\UAS in a wild type background lengthens the period of circadian locomotor activity to approximately 25 hours.

(Sekine et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^en-e16E, dco^UAS.cSa has abnormal planar polarity | adult stage phenotype, suppressible | partially by Bdbt^Δ79.1

(Strutt and Strutt, 2020)

Scer\GAL4^en-e16E, dco^UAS.cSa has abnormal planar polarity | adult stage phenotype, suppressible | partially by Ankrd49⁴

(Strutt and Strutt, 2020)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^en-e16E, dco^UAS.cSa has wing hair phenotype, suppressible | partially by Bdbt^Δ79.1

(Strutt and Strutt, 2020)

Scer\GAL4^en-e16E, dco^UAS.cSa has wing hair phenotype, suppressible | partially by Ankrd49⁴

(Strutt and Strutt, 2020)

Scer\GAL4^en-e16E, dco^UAS.cSa has wing phenotype, suppressible | partially by Bdbt^Δ79.1

(Strutt and Strutt, 2020)

Scer\GAL4^en-e16E, dco^UAS.cSa has wing phenotype, suppressible | partially by Ankrd49⁴

(Strutt and Strutt, 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of dco^Scer\UAS.cSa in the eye (under the control of Scer\GAL4^GMR.PF) strongly suppresses the pro-apoptotic activity of W^GMR.PG.

Expression of dco^Scer\UAS.cSa in the eye (under the control of Scer\GAL4^GMR.PF) suppresses the pro-apoptotic activity of rpr^GMR.PW.

Expression of dco^Scer\UAS.cSa in the eye (under the control of Scer\GAL4^GMR.PF) moderately suppresses the pro-apoptotic activity of grim^GMR.PC.

Expression of dco^Scer\UAS.cSa in the eye (under the control of Scer\GAL4^GMR.PF) strongly suppresses the pro-apoptotic activity of W^Ala5.GMR.

(Guan et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^arm.PS/dco^UAS.cSa rescues dco^VIII

(Sekine et al., 2008)

Scer\GAL4^arm.PS/dco^UAS.cSa rescues dco^VIII/dco^ar

(Sekine et al., 2008)

Comments

Expression of dco^Scer\UAS.cSa under the control of Scer\GAL4^arm.PS rescues the lethality associated with dco^VIII.

Expression of dco^Scer\UAS.cSa under the control of Scer\GAL4^arm.PS rescues the locomotor rhythm defects seen in dco^VIII/dco^ar.

(Sekine et al., 2008)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

dco^Scer\UAS.cSa

dco^UAS.cSa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Saez

(Price and Kalderon, 2002)

Secondary FlyBase IDs

References (7)

Report Sections

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