UAS regulatory sequences drive expression of the first 318 amino acids of Hsap\CSNK1E (including the kinase domain) fused to the last 146 amino acids of dco.
Expression of dco::Hsap\CSNK1EScer\UAS.cSa under the control of Scer\GAL4tim.Scer\UAS lengthens the circadian locomotor activity period to approximately 30 hours and many flies are arrhythmic.
Scer\GAL4arm.PS/dco::Hsap\CSNK1EUAS.cSa is a non-suppressor of lethal phenotype of dcoVIII
Scer\GAL4arm.PS/dco::Hsap\CSNK1EUAS.cSa is a non-suppressor of abnormal locomotor rhythm phenotype of dcoVIII/dcoar
Expression of dco::Hsap\CSNK1EScer\UAS.cSa under the control of Scer\GAL4arm.PS fails to rescue the lethality associated with dcoVIII.
Expression of dco::Hsap\CSNK1EScer\UAS.cSa under the control of Scer\GAL4arm.PS fails to rescue the locomotor rhythm defects seen in dcoar/dcoVIII.