FlyBase Allele Report: Dmel\dco[j3B9]

(Beaton, 2000.1.31, Loudon et al., 2000, Yang et al., 2000, Spradling et al., 1999, Kloss et al., 1998, Price et al., 1998, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell polarity (with dco^ar)

(Klein et al., 2006)

abnormal cell polarity | cell autonomous | somatic clone

(Klein et al., 2006)

abnormal cell size | somatic clone

(Klein et al., 2006)

abnormal circadian rhythm

(Rothenfluh et al., 2000, Kloss et al., 1998)

abnormal circadian rhythm (with dco^ar)

(Rothenfluh et al., 2000)

abnormal circadian rhythm | recessive

(Price et al., 1998)

abnormal eclosion rhythm | recessive

(Price et al., 1998)

abnormal locomotor rhythm | recessive

(Price et al., 1998)

lethal | recessive

(Beaton, 2000.1.31, Spradling et al., 1999)

lethal - all die before end of pupal stage

(Nanda et al., 2009)

lethal - all die before end of pupal stage | recessive

(Kloss et al., 1998, Price et al., 1998)

some die during pupal stage

(Nanda et al., 2009)

some die during pupal stage | recessive

(Kloss et al., 1998, Price et al., 1998)

viable (with dco^ar)

(Yu et al., 2006)

Phenotype Manifest In

neuron | larval stage | lateral

(Price et al., 1998)

ommatidium (with dco^ar)

(Klein et al., 2006)

ommatidium | cell autonomous

(Klein et al., 2006)

wing disc | somatic clone

(Strutt et al., 2006)

wing hair | cell non-autonomous | somatic clone

(Klein et al., 2006)

Detailed Description

Statement

Reference

The rough eye phenotype observed in Fmr1^sev.PW flies is suppressed in a dco^j3B9/+ background.

(Cziko et al., 2009)

Clones of dco^j3B9 are small.

dco^j3B9 clones (generated by the Minute technique) induced in the wing show loss of margin bristles and/or parts of the wing margin. dco^j3B9 clones also show autonomous planar cell polarity wing hair defects. dco^j3B9 Minute clones in the eye show strong planar cell polarity defects.

The eyes of dco^j3B9/dco^ar transheterozygotes show mild planar cell polarity defects.

(Klein et al., 2006)

In dco^j3B9 mutant clones in the pupal wing, trichome initiation is delayed and prehairs often emerge from the cell centre instead of the distal edge.

(Strutt et al., 2006)

About 2/3 of dco^ar/dco^j3B9 flies are arrhythmic, the rest show a period-lengthening phenotype.

(Rothenfluh et al., 2000)

Short rhythm mutant.

(Kloss et al., 1998)

Homozygous embryos take longer to develop than heterozygous siblings. Foraging motility and touch sensitivity appear normal. The larval lateral neurons (lvLNs) are found slightly more peripherally than in wild type.

(Price et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

dco^j3B9/dco^ar has abnormal circadian rhythm phenotype, suppressible | partially by per^T

(Rothenfluh et al., 2000)

dco^j3B9/dco^ar has abnormal circadian rhythm phenotype, suppressible | partially by per^s

(Rothenfluh et al., 2000)

NOT suppressed by

Statement

Reference

dco^j3B9/dco^ar has abnormal circadian rhythm phenotype, non-suppressible by per^SLIH

(Rothenfluh et al., 2000)

dco^j3B9/dco^ar has abnormal circadian rhythm phenotype, non-suppressible by tim^S1/tim⁰¹

(Rothenfluh et al., 2000)

Enhancer of

Statement

Reference

dco^j3B9/dco[+] is an enhancer of abnormal cell polarity phenotype of Scer\GAL4^hs.2sev, Vang^UAS.cWa

(Klein et al., 2006)

dco^j3B9/dco[+] is an enhancer of abnormal cell polarity phenotype of fz²⁰/fz¹⁹

(Strutt et al., 2006)

Suppressor of

Statement

Reference

dco^j3B9/dco[+] is a suppressor of abnormal cell polarity phenotype of fz^hs.sev

(Klein et al., 2006)

Other

Statement

Reference

Scer\GAL4^P2.4.Pdf, dco^j3B9, lark^UAS.Tag:HA has abnormal locomotor rhythm phenotype

(Huang et al., 2014)

Scer\GAL4^P2.4.Pdf, dco^j3B9, lark^RNAi.UAS.cSb has abnormal locomotor rhythm phenotype

(Huang et al., 2014)

Nek2^RNAi.UAS.cUa, Scer\GAL4^sd.PU, dco^j3B9/dco[+] has visible phenotype

(Schertel et al., 2013)

Phenotype Manifest In

Enhancer of

Statement

Reference

dco^j3B9/dco[+] is an enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, Vang^UAS.cWa

(Klein et al., 2006)

dco^j3B9/dco[+] is an enhancer of ommatidium phenotype of fz²⁰/fz¹⁹

(Strutt et al., 2006)

Suppressor of

Statement

Reference

dco^j3B9/dco[+] is a suppressor of eye phenotype of Fmr1^sev.PW

(Cziko et al., 2009)

dco^j3B9/dco[+] is a suppressor of eye photoreceptor cell phenotype of Scer\GAL4^hs.2sev, dsh^UAS.cNa

(Klein et al., 2006)

dco^j3B9/dco[+] is a suppressor of ommatidium phenotype of fz^hs.sev

(Klein et al., 2006)

Other

Statement

Reference

Nek2^RNAi.UAS.cUa, Scer\GAL4^sd.PU, dco^j3B9/dco[+] has wing margin bristle phenotype

(Schertel et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Adult-specific expression (using TubGAL80ts) of lark^{Scer\UAS.T:Ivir\HA1} driven by Scer\GAL4^P2.4.Pdf significantly lengthens circadian period in dco^j3B9/+ flies; co-expression of lark^{dsRNA.Scer\UAS.cSb} significantly shortens circadian period.

(Huang et al., 2014)

Expression of Nek2^{dsRNA.Scer\UAS.cUa} under the control of Scer\GAL4^sd.PU in a dco^j3B9/+ background results in loss of sensory bristles along the wing margin.

(Schertel et al., 2013)

The planar polarity defects seen in the eyes of fz^hs.sev/+ flies are significantly suppressed in fz^hs.sev/+, dco^j3B9/+ flies, although the eyes do not appear wild type.

The planar polarity defects seen in the eye when Vang^Scer\UAS.cWa is expressed under the control of Scer\GAL4^hs.2sev in a wild-type background are significantly enhanced in a dco^j3B9/+ background.

Expression of dsh^Scer\UAS.cNa under the control of Scer\GAL4^hs.2sev in a dco^j3B9/+ background results in a strong suppression of the loss of photoreceptor cell phenotype seen when the transgene is expressed in a wild-type background.

(Klein et al., 2006)

The ommatidial polarity defects of fz¹⁹/fz²⁰ mutants are enhanced in fz¹⁹/fz²⁰, dco^j3B9/+ double mutants.

(Strutt et al., 2006)

The addition of per^s or per^T to dco^j3B9/dco^ar flies suppresses the arrhythmicity phenotype seen in these flies. The addition of tim^S1/tim⁰¹, tim⁰¹/+, or per^SLIH does not suppress the dco^ar/dco^j3B9 and dco^ar/Df(3R)tll-g arrhythmic phenotypes.

(Rothenfluh et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

dco^ar

(Rothenfluh et al., 2000)

dco^L

(Price et al., 1998)

dco^S

(Price et al., 1998)

dco^rK215

(BDGP Project Members, 1994-1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

12164

y¹ w^*; P{lacW}dco^j3B9/TM3, Sb¹

Notes on Origin

Discoverer

L. and Y. Jan.

Comments

Reversion analysis confirms that the P{lacW} insertion is the cause of both the pupal lethality and the aberrant circadian rhythmicity.

(Kloss et al., 1998)

After six generations of outcrossing the lethality continued to segragate with the P{lacW} insertion.

(Beaton, 2000.1.31)

Complements: l(3)00720⁰⁰⁷²⁰. Complements: l(3)03670⁰³⁶⁷⁰. Complements: Aph-4⁰⁷⁰²⁸.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

dbt^P

(Huang et al., 2014, Zheng et al., 2014, Yu et al., 2009, Sekine et al., 2008, Klein et al., 2006, Yu et al., 2006, Cyran et al., 2005, Stanewsky, 2003, Stanewsky, 2002, Loudon et al., 2000, Rothenfluh et al., 2000, Yang et al., 2000, Subramanian and Lakhotia, 1999, Tyson et al., 1999, Hardin, 1998, Kloss et al., 1998, Price et al., 1998, Reppert, 1998, Wilsbacher and Takahashi, 1998)

dbt^j3B9

(Meister and Braun, 1995.10, BDGP Project Members, 1994-1999)

dco^dbt-P

(Klein et al., 2006)

dco^j3B9

(Strutt and Strutt, 2020, Schertel et al., 2013, Nanda et al., 2009, Strutt et al., 2006)

dco^j3b9

(Cziko et al., 2009)

l(3)j3B9

(Spradling et al., 1999)

l(3)j3B9^j3B9

Name Synonyms

Secondary FlyBase IDs

References (30)

Report Sections

Open Close