FB2024_03 , released June 25, 2024
Allele: Dmel\perSLIH
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General Information
Symbol
Dmel\perSLIH
Species
D. melanogaster
Name
Some Like It Hot
FlyBase ID
FBal0090193
Feature type
allele
Associated gene
Dmel\per
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Nucleotide substitution: C3035A (numbering system of FBrf0047067). Amino acid replacement: S45Y. 3bp are deleted from the 3' UTR with respect to the sequence published in FBrf0049579.

    (Hamblen et al., 1998)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    X:2,688,438..2,688,438 [+]
    Nucleotide change:

    C2688438A

    Reported nucleotide change:

    C3035A

    Amino acid change:

    S45Y | per-PA; S45Y | per-PB

    Reported amino acid change:

    S45Y

    (Hamblen et al., 1998)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        perSLIH flies show a defect in temperature compensation of the locomotion period length.

        (Rothenfluh et al., 2000)

        Long period mutant, showing locomotor rhythms of 27-28hr. Clock speeds up as the temperature is raised. Testing over 10o shows a range of effect of 1.5hr.

        (Hamblen et al., 1998)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        NOT Suppressor of
        Statement
        Reference

        perSLIH is a non-suppressor of abnormal circadian rhythm phenotype of Df(3R)tll-g/dcoar

        (Rothenfluh et al., 2000)

        perSLIH is a non-suppressor of abnormal circadian rhythm phenotype of dcoj3B9/dcoar

        (Rothenfluh et al., 2000)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The addition of perSLIH does not suppress the dcoar/dcoj3B9 or dcoar/Df(3R)tll-g arrhythmic phenotypes.

        (Rothenfluh et al., 2000)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer

        Induced on: CG2650T.

        (Hamblen et al., 1998)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (5)
        Reported As
        Symbol Synonym
        43Y
        (Hamblen et al., 1998)
        perSLIH
        (Singh et al., 2019, Agrawal and Hardin, 2016)
        perslih
        (Damulewicz et al., 2022)
        Name Synonyms
        Some Like It Hot
        (Hamblen et al., 1998)
        SomeLikeItHot
        (Stanewsky, 2003)
        Secondary FlyBase IDs
          References (9)